Timo Hamers

Summary

Affiliation: Institute for Environmental Studies
Country: The Netherlands

Publications

  1. ncbi request reprint In vitro profiling of the endocrine-disrupting potency of brominated flame retardants
    Timo Hamers
    Institute for Environmental Studies, Vrije Universiteit Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    Toxicol Sci 92:157-73. 2006
  2. doi request reprint Expert opinion on toxicity profiling--report from a NORMAN expert group meeting
    Timo Hamers
    VU University Amsterdam, Institute for Environmental Studies, Amsterdam, The Netherlands
    Integr Environ Assess Manag 9:185-91. 2013
  3. doi request reprint Toxicity profiling: An integrated effect-based tool for site-specific sediment quality assessment
    Timo Hamers
    Institute for Environmental Studies, VU University Amsterdam, The Netherlands
    Integr Environ Assess Manag 6:761-73. 2010
  4. ncbi request reprint Biotransformation of brominated flame retardants into potentially endocrine-disrupting metabolites, with special attention to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47)
    Timo Hamers
    Institute for Environmental Studies IVM, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    Mol Nutr Food Res 52:284-98. 2008
  5. doi request reprint In vitro toxicity profiling of ultrapure non-dioxin-like polychlorinated biphenyl congeners and their relative toxic contribution to PCB mixtures in humans
    Timo Hamers
    Institute for Environmental Studies IVM, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands
    Toxicol Sci 121:88-100. 2011
  6. doi request reprint Effect-directed analysis to explore the polar bear exposome: identification of thyroid hormone disrupting compounds in plasma
    Eszter Simon
    Institute for Environmental Studies IVM, VU University Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    Environ Sci Technol 47:8902-12. 2013
  7. doi request reprint Blood plasma sample preparation method for the assessment of thyroid hormone-disrupting potency in effect-directed analysis
    Eszter Simon
    Institute for Environmental Studies IVM, VU University Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    Environ Sci Technol 45:7936-44. 2011
  8. doi request reprint Competitive binding of poly- and perfluorinated compounds to the thyroid hormone transport protein transthyretin
    Jana M Weiss
    Institute for Environmental Studies, Department of Chemistry and Biology, VU University, 1081 HV Amsterdam, The Netherlands
    Toxicol Sci 109:206-16. 2009
  9. ncbi request reprint Toxicological profiling of sediments using in vitro bioassays, with emphasis on endocrine disruption
    Corine J Houtman
    Institute for Environmental Studies, Vrije Universiteit Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    Environ Toxicol Chem 23:32-40. 2004
  10. doi request reprint High-resolution fractionation after gas chromatography for effect-directed analysis
    Eelco Pieke
    AIMMS Division of BioAnalytical Chemistry, Faculty of Sciences, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    Anal Chem 85:8204-11. 2013

Collaborators

Detail Information

Publications22

  1. ncbi request reprint In vitro profiling of the endocrine-disrupting potency of brominated flame retardants
    Timo Hamers
    Institute for Environmental Studies, Vrije Universiteit Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    Toxicol Sci 92:157-73. 2006
    ..Based on their similarity in ED profiles, BFRs were classified into five different clusters. These findings support further investigation of the potential ED effects of these environmentally relevant BFRs in man and wildlife...
  2. doi request reprint Expert opinion on toxicity profiling--report from a NORMAN expert group meeting
    Timo Hamers
    VU University Amsterdam, Institute for Environmental Studies, Amsterdam, The Netherlands
    Integr Environ Assess Manag 9:185-91. 2013
    ....
  3. doi request reprint Toxicity profiling: An integrated effect-based tool for site-specific sediment quality assessment
    Timo Hamers
    Institute for Environmental Studies, VU University Amsterdam, The Netherlands
    Integr Environ Assess Manag 6:761-73. 2010
    ..Future perspectives in toxicity profiling include expansion of the battery of bioassays with test methods that cover other toxic endpoints or multiple endpoints, are high throughput, and improve the ecological relevance...
  4. ncbi request reprint Biotransformation of brominated flame retardants into potentially endocrine-disrupting metabolites, with special attention to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47)
    Timo Hamers
    Institute for Environmental Studies IVM, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    Mol Nutr Food Res 52:284-98. 2008
    ..In combination with other environmentally relevant hydroxylated organohalogens acting on TTR-binding and E2SULT inhibition, internal exposure to BFR metabolites may significantly contribute to the overall risk of endocrine disruption...
  5. doi request reprint In vitro toxicity profiling of ultrapure non-dioxin-like polychlorinated biphenyl congeners and their relative toxic contribution to PCB mixtures in humans
    Timo Hamers
    Institute for Environmental Studies IVM, VU University Amsterdam, 1081 HV Amsterdam, The Netherlands
    Toxicol Sci 121:88-100. 2011
    ..2% to any of these calculated potencies. PCB-168 is recommended as an additional indicator congener, given its relatively high abundance and antiandrogenic, TTR-binding, and GJIC-inhibiting potencies...
  6. doi request reprint Effect-directed analysis to explore the polar bear exposome: identification of thyroid hormone disrupting compounds in plasma
    Eszter Simon
    Institute for Environmental Studies IVM, VU University Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    Environ Sci Technol 47:8902-12. 2013
    ..In addition, branched NP, mono- and dihydroxylated-octaCBs showed TTR-binding potencies and could explain another 32 ± 2% of the total measured activities in the extracts. ..
  7. doi request reprint Blood plasma sample preparation method for the assessment of thyroid hormone-disrupting potency in effect-directed analysis
    Eszter Simon
    Institute for Environmental Studies IVM, VU University Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    Environ Sci Technol 45:7936-44. 2011
    ..A first screening revealed TTR-binding potency in the polar bear plasma extracts, which could be explained for 60-85% by the presence of OH-PCBs...
  8. doi request reprint Competitive binding of poly- and perfluorinated compounds to the thyroid hormone transport protein transthyretin
    Jana M Weiss
    Institute for Environmental Studies, Department of Chemistry and Biology, VU University, 1081 HV Amsterdam, The Netherlands
    Toxicol Sci 109:206-16. 2009
    ..In addition, this study contributes to the understanding of the bioaccumulation of PFCs in man and possibly in other wildlife species...
  9. ncbi request reprint Toxicological profiling of sediments using in vitro bioassays, with emphasis on endocrine disruption
    Corine J Houtman
    Institute for Environmental Studies, Vrije Universiteit Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    Environ Toxicol Chem 23:32-40. 2004
    ..The present study showed the occurrence of endocrine-disrupting potencies in sediments from the Dutch delta and the suitability of the ER- and DR-CALUX bioassays to direct endocrine-disruption TIE studies...
  10. doi request reprint High-resolution fractionation after gas chromatography for effect-directed analysis
    Eelco Pieke
    AIMMS Division of BioAnalytical Chemistry, Faculty of Sciences, VU University Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands
    Anal Chem 85:8204-11. 2013
    ....
  11. pmc Masking effect of anti-androgens on androgenic activity in European river sediment unveiled by effect-directed analysis
    Jana M Weiss
    Institute for Environmental Studies IVM, Faculty of Earth and Life Sciences, VU University, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    Anal Bioanal Chem 394:1385-97. 2009
    ..Seventy-one unidentified peaks, which represent potentially new endocrine disrupters, have been added to a database for future investigation...
  12. doi request reprint Testing endocrine disruption in biota samples: a method to remove interfering lipids and natural hormones
    Eszter Simon
    Institute for Environmental Studies IVM, VU University Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    Environ Sci Technol 44:8322-9. 2010
    ..The method can be used as a sample preparation method of biota samples for toxicity profiling and effect-directed analysis (EDA)...
  13. pmc Transcriptional and epigenetic mechanisms underlying enhanced in vitro adipocyte differentiation by the brominated flame retardant BDE-47
    Jorke H Kamstra
    Institute for Environmental Studies, VU University Amsterdam, Amsterdam, 1081HV, The Netherlands
    Environ Sci Technol 48:4110-9. 2014
    ....
  14. doi request reprint Effects of metal pollution on earthworm communities in a contaminated floodplain area: Linking biomarker, community and functional responses
    Cornelis A M Van Gestel
    Institute of Ecological Science, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Environ Pollut 157:895-903. 2009
    ..Effects at the biochemical level therefore did not result in a reduced functioning of earthworm communities...
  15. doi request reprint A 28-day oral dose toxicity study enhanced to detect endocrine effects of a purified technical pentabromodiphenyl ether (pentaBDE) mixture in Wistar rats
    Leo T M Van der Ven
    Laboratory for Health Protection Research, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Toxicology 245:109-22. 2008
    ..5 mkd in males and 2.3 mkd in females). These results contribute to refinement of the hazard identification of pentaBDE and improved risk assessment of human exposure to this industrial chemical and environmental pollutant...
  16. ncbi request reprint Disruption of thyroid hormone binding to sea bream recombinant transthyretin by ioxinyl and polybrominated diphenyl ethers
    Isabel Morgado
    Centro de Ciencias do Mar, Universidade do Algarve, Campus de Gambelas, 8005 139 Faro, Portugal
    Chemosphere 69:155-63. 2007
    ..The TTR competitive binding assay developed offers a quick and effective tool for preliminary risk assessment of chemicals which may disrupt the thyroid axis in teleost fish inhabiting vulnerable aquatic environments...
  17. ncbi request reprint Levels of hexabromocyclododecane in harbor porpoises and common dolphins from western European seas, with evidence for stereoisomer-specific biotransformation by cytochrome p450
    Bart N Zegers
    Royal Netherlands Institute for Sea Research NIOZ, 1790 AB Den Burg, Texel
    Environ Sci Technol 39:2095-100. 2005
    ....
  18. ncbi request reprint Quantitative structure-activity relationship modeling on in vitro endocrine effects and metabolic stability involving 26 selected brominated flame retardants
    Mikael Harju
    Environmental Chemistry, Department of Chemistry, Umea University, SE 90187 Umea, Sweden
    Environ Toxicol Chem 26:816-26. 2007
    ..Predictions made for the constituents of the technical flame retardant Bromkal 70-5DE found BDE 17 to be a potent androgen antagonist and BDE 66, which is a relevant PBDE in environmental samples, to be only a weak antagonist...
  19. ncbi request reprint A 28-day oral dose toxicity study enhanced to detect endocrine effects of hexabromocyclododecane in Wistar rats
    Leo T M Van der Ven
    Laboratory for Toxicology, Pathology and Genetics, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
    Toxicol Sci 94:281-92. 2006
    ..Overall, female rats appeared to be more sensitive to HBCD than male rats, and an overall BMDL is proposed at 1.6 mkd, based on a 10% increase of the thyroid weight, which was the most sensitive parameter in the sequence of events...
  20. ncbi request reprint Lutetium speciation and toxicity in a microbial bioassay: testing the free-ion model for lanthanides
    Lennart Weltje
    Department of Radiochemistry, Interfaculty Reactor Institute, Delft University of Technology, Mekelweg 15, NL 2629 JB Delft, The Netherlands
    Environ Sci Technol 38:6597-604. 2004
    ..57 microM, Lu3+ is more toxic than La3+, Cd2+, or Zn2+ and approximately equally as toxic as Cu2+. Although the pH increased slightly during the experiments, it was shown that the influence of pH on Lu speciation was limited...
  21. ncbi request reprint Applicability of the black slug Arion ater for monitoring exposure to polycyclic aromatic hydrocarbons and their subsequent bioactivation into DNA binding metabolites
    Timo Hamers
    Toxicology Group, Wageningen University, P O Box 8000 6700 EA Wageningen, The Netherlands
    Mutat Res 552:219-33. 2004
    ..25 microg/g fresh feed). Based on this lack of response after realistic exposure it is concluded that A. ater is not sensitive to BaP exposure and, therefore, not suitable for monitoring environmental exposure to PAHs...
  22. ncbi request reprint Estrogenic and esterase-inhibiting potency in rainwater in relation to pesticide concentrations, sampling season and location
    Timo Hamers
    Wageningen University Toxicology Group, PO Box 8000, 6700 EA, The, Wageningen, Netherlands
    Environ Pollut 123:47-65. 2003
    ....