Milou M L Dingemans

Summary

Affiliation: Institute for Risk Assessment Sciences
Country: The Netherlands

Publications

  1. pmc Neonatal exposure to brominated flame retardant BDE-47 reduces long-term potentiation and postsynaptic protein levels in mouse hippocampus
    Milou M L Dingemans
    Toxicology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Health Perspect 115:865-70. 2007
  2. doi request reprint Calcium-related processes involved in the inhibition of depolarization-evoked calcium increase by hydroxylated PBDEs in PC12 cells
    Milou M L Dingemans
    Neurotoxicology Research Group, Toxicology Division, Institute for Risk Assessment Sciences, Utrecht University, NL 3508 TD Utrecht, The Netherlands
    Toxicol Sci 114:302-9. 2010
  3. doi request reprint Hexabromocyclododecane inhibits depolarization-induced increase in intracellular calcium levels and neurotransmitter release in PC12 cells
    Milou M L Dingemans
    Institute for Risk Assessment Sciences IRAS, Utrecht University, NL 3508 TD Utrecht, The Netherlands
    Toxicol Sci 107:490-7. 2009
  4. pmc Bromination pattern of hydroxylated metabolites of BDE-47 affects their potency to release calcium from intracellular stores in PC12 cells
    Milou M L Dingemans
    Neurotoxicology Research Group, Toxicology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Health Perspect 118:519-25. 2010
  5. pmc Hydroxylation increases the neurotoxic potential of BDE-47 to affect exocytosis and calcium homeostasis in PC12 cells
    Milou M L Dingemans
    Toxicology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Health Perspect 116:637-43. 2008
  6. pmc Neurotoxicity of brominated flame retardants: (in)direct effects of parent and hydroxylated polybrominated diphenyl ethers on the (developing) nervous system
    Milou M L Dingemans
    Neurotoxicology Research Group, Toxicology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Health Perspect 119:900-7. 2011
  7. doi request reprint Don't judge a neuron only by its cover: neuronal function in in vitro developmental neurotoxicity testing
    Martje W G D M de Groot
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Toxicol Sci 132:1-7. 2013
  8. ncbi request reprint The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans
    Bas J Blaauboer
    Institute for Risk Assessment Sciences, Division of Toxicology, Utrecht University, The Netherlands
    ALTEX 29:411-25. 2012

Detail Information

Publications8

  1. pmc Neonatal exposure to brominated flame retardant BDE-47 reduces long-term potentiation and postsynaptic protein levels in mouse hippocampus
    Milou M L Dingemans
    Toxicology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Health Perspect 115:865-70. 2007
    ..Increasing environmental levels of brominated flame retardants raise concern about possible adverse effects, particularly through early developmental exposure...
  2. doi request reprint Calcium-related processes involved in the inhibition of depolarization-evoked calcium increase by hydroxylated PBDEs in PC12 cells
    Milou M L Dingemans
    Neurotoxicology Research Group, Toxicology Division, Institute for Risk Assessment Sciences, Utrecht University, NL 3508 TD Utrecht, The Netherlands
    Toxicol Sci 114:302-9. 2010
    ..g., polychlorinated biphenyls) may thus also inhibit depolarization-evoked [Ca(2+)](i), justifying further investigation of possible mixture effects of environmental pollutants on Ca(2+) homeostasis...
  3. doi request reprint Hexabromocyclododecane inhibits depolarization-induced increase in intracellular calcium levels and neurotransmitter release in PC12 cells
    Milou M L Dingemans
    Institute for Risk Assessment Sciences IRAS, Utrecht University, NL 3508 TD Utrecht, The Netherlands
    Toxicol Sci 107:490-7. 2009
    ..As increasing HBCD levels should be anticipated, these findings justify additional efforts to establish an adequate exposure, hazard and risk assessment...
  4. pmc Bromination pattern of hydroxylated metabolites of BDE-47 affects their potency to release calcium from intracellular stores in PC12 cells
    Milou M L Dingemans
    Neurotoxicology Research Group, Toxicology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Health Perspect 118:519-25. 2010
    ..Recently, several other hydroxylated BDE-47 metabolites, besides 6-OH-BDE-47, have been detected in human serum and cord blood...
  5. pmc Hydroxylation increases the neurotoxic potential of BDE-47 to affect exocytosis and calcium homeostasis in PC12 cells
    Milou M L Dingemans
    Toxicology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Health Perspect 116:637-43. 2008
    ..Oxidative metabolism, resulting in the formation of hydroxylated polybrominated diphenyl ether (PBDE) metabolites, may enhance the neurotoxic potential of brominated flame retardants...
  6. pmc Neurotoxicity of brominated flame retardants: (in)direct effects of parent and hydroxylated polybrominated diphenyl ethers on the (developing) nervous system
    Milou M L Dingemans
    Neurotoxicology Research Group, Toxicology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Health Perspect 119:900-7. 2011
    ..Because this raises concern about adverse effects on the developing brain, we reviewed the scientific literature on these mechanisms...
  7. doi request reprint Don't judge a neuron only by its cover: neuronal function in in vitro developmental neurotoxicity testing
    Martje W G D M de Groot
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Toxicol Sci 132:1-7. 2013
    ..We therefore argue that for risk assessment, biochemical and morphological approaches should be complemented with investigations of neuronal (network) functionality...
  8. ncbi request reprint The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans
    Bas J Blaauboer
    Institute for Risk Assessment Sciences, Division of Toxicology, Utrecht University, The Netherlands
    ALTEX 29:411-25. 2012
    ..Moreover, data selection and integration need to be driven by their usefulness in a quantitative in vitro-in vivo extrapolation (QIVIVE)...