Rick M Dijkhuizen

Summary

Affiliation: Image Sciences Institute
Country: The Netherlands

Publications

  1. ncbi request reprint Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study
    Rick M Dijkhuizen
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 23:510-7. 2003
  2. ncbi request reprint Magnetic resonance imaging in experimental models of brain disorders
    Rick M Dijkhuizen
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 23:1383-402. 2003
  3. ncbi request reprint fMRI of delayed albumin treatment during stroke recovery in rats: implication for fast neuronal habituation in recovering brains
    Young R Kim
    Athinoula Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 27:142-53. 2007
  4. pmc Early identification of potentially salvageable tissue with MRI-based predictive algorithms after experimental ischemic stroke
    Mark J R J Bouts
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 33:1075-82. 2013
  5. doi request reprint Longitudinal in vivo MRI of alterations in perilesional tissue after transient ischemic stroke in rats
    Jet P van der Zijden
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    Exp Neurol 212:207-12. 2008
  6. ncbi request reprint Manganese-enhanced MRI of brain plasticity in relation to functional recovery after experimental stroke
    Jet P van der Zijden
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 28:832-40. 2008
  7. pmc Characterization of functional and structural integrity in experimental focal epilepsy: reduced network efficiency coincides with white matter changes
    Willem M Otte
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e39078. 2012
  8. doi request reprint Extent of bilateral neuronal network reorganization and functional recovery in relation to stroke severity
    Maurits P A van Meer
    Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    J Neurosci 32:4495-507. 2012
  9. pmc Dynamic functional cerebral blood volume responses to normobaric hyperoxia in acute ischemic stroke
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 32:1800-9. 2012
  10. ncbi request reprint Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models
    Ona Wu
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 27:196-204. 2007

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study
    Rick M Dijkhuizen
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 23:510-7. 2003
    ....
  2. ncbi request reprint Magnetic resonance imaging in experimental models of brain disorders
    Rick M Dijkhuizen
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 23:1383-402. 2003
    ....
  3. ncbi request reprint fMRI of delayed albumin treatment during stroke recovery in rats: implication for fast neuronal habituation in recovering brains
    Young R Kim
    Athinoula Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 27:142-53. 2007
    ..Taken together, these data suggest that restoration of fMRI response magnitudes, temporal profiles, and correlations with structure may reveal the extent and specific traits of albumin treatment associated stroke recovery...
  4. pmc Early identification of potentially salvageable tissue with MRI-based predictive algorithms after experimental ischemic stroke
    Mark J R J Bouts
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 33:1075-82. 2013
    ..79±0.14). Our study shows that assessment of the heterogeneity of infarction probability with MRI-based algorithms enables estimation of the extent of potentially salvageable tissue after acute ischemic stroke. ..
  5. doi request reprint Longitudinal in vivo MRI of alterations in perilesional tissue after transient ischemic stroke in rats
    Jet P van der Zijden
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    Exp Neurol 212:207-12. 2008
    ....
  6. ncbi request reprint Manganese-enhanced MRI of brain plasticity in relation to functional recovery after experimental stroke
    Jet P van der Zijden
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 28:832-40. 2008
    ..Our data suggest that the plateau stage of functional recovery is associated with restoration of ipsilateral sensorimotor pathways and enhanced interhemispheric connectivity...
  7. pmc Characterization of functional and structural integrity in experimental focal epilepsy: reduced network efficiency coincides with white matter changes
    Willem M Otte
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e39078. 2012
    ....
  8. doi request reprint Extent of bilateral neuronal network reorganization and functional recovery in relation to stroke severity
    Maurits P A van Meer
    Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    J Neurosci 32:4495-507. 2012
    ....
  9. pmc Dynamic functional cerebral blood volume responses to normobaric hyperoxia in acute ischemic stroke
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 32:1800-9. 2012
    ..In addition, CBV responses to NBO challenge may have potential as an imaging marker to distinguish ischemic core from salvageable tissues...
  10. ncbi request reprint Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models
    Ona Wu
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 27:196-204. 2007
    ..Our study shows that predictive algorithms are promising metrics for diagnosis, prognosis and therapeutic evaluation after acute stroke that can translate readily from preclinical to clinical settings...
  11. doi request reprint Effect of interferon-β on neuroinflammation, brain injury and neurological outcome after experimental subarachnoid hemorrhage
    Ivo A C W Tiebosch
    Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurocrit Care 18:96-105. 2013
    ..Our goal was to test whether treatment with anti-inflammatory interferon-β, which has shown promise as a therapeutic agent in experimental ischaemic stroke, can protect the brain after SAH...
  12. doi request reprint Recovery of sensorimotor function after experimental stroke correlates with restoration of resting-state interhemispheric functional connectivity
    Maurits P A van Meer
    Biomedical Magnetic Resonance Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    J Neurosci 30:3964-72. 2010
    ....
  13. doi request reprint MRI of ICAM-1 upregulation after stroke: the importance of choosing the appropriate target-specific particulate contrast agent
    Lisette H Deddens
    Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, Yalelaan 2, 3584 CM, Utrecht, The Netherlands
    Mol Imaging Biol 15:411-22. 2013
    ..Our goal was to demonstrate the feasibility of this approach to detect the neuroinflammatory biomarker intercellular adhesion molecule-1 (ICAM-1) after stroke and to establish a most efficient imaging procedure...
  14. doi request reprint Impact of hemodynamic effects on diffusion-weighted fMRI signals
    Umesh S Rudrapatna
    Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Neuroimage 61:106-14. 2012
    ..If diffusion based functional contrasts immune to hemodynamics do exist, our results highlight the difficulty in discerning those diffusion changes from accompanying vascular changes...
  15. pmc Correspondence between altered functional and structural connectivity in the contralesional sensorimotor cortex after unilateral stroke in rats: a combined resting-state functional MRI and manganese-enhanced MRI study
    Maurits P A van Meer
    Image Sciences Institute, University Medical Center Utrecht, The Netherlands
    J Cereb Blood Flow Metab 30:1707-11. 2010
    ....
  16. doi request reprint Combined treatment with recombinant tissue plasminogen activator and dexamethasone phosphate-containing liposomes improves neurological outcome and restricts lesion progression after embolic stroke in rats
    Ivo A C W Tiebosch
    Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Neurochem 123:65-74. 2012
    ..Furthermore, magnetic resonance imaging-based predictive algorithms provide a sensitive means to measure treatment effects on lesion development...
  17. doi request reprint Increase in sensorimotor cortex response to somatosensory stimulation over subacute poststroke period correlates with motor recovery in hemiparetic patients
    Judith D Schaechter
    1MGH HST Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA, and Harvard Medical School, Boston, MA 02129, USA
    Neurorehabil Neural Repair 26:325-34. 2012
    ..Somatosensory input to the motor cortex may play a critical role in motor relearning after hemiparetic stroke...
  18. doi request reprint Imaging neuroinflammation after stroke: current status of cellular and molecular MRI strategies
    Lisette H Deddens
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 33:392-402. 2012
    ....
  19. ncbi request reprint Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model
    Rick M Dijkhuizen
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass, USA
    Stroke 33:2100-4. 2002
    ..Our aim was to characterize acute effects of rtPA administration on the integrity of microvascular barriers...
  20. doi request reprint PECAM-1-targeted micron-sized particles of iron oxide as MRI contrast agent for detection of vascular remodeling after cerebral ischemia
    Lisette H Deddens
    Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, Yalelaan 2, 3584 CM Utrecht, The Netherlands
    Contrast Media Mol Imaging 8:393-401. 2013
    ....
  21. doi request reprint A meta-analysis of white matter changes in temporal lobe epilepsy as studied with diffusion tensor imaging
    Willem M Otte
    Department of Pediatric Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Epilepsia 53:659-67. 2012
    ..The disturbance of white matter integrity varies across studies and between regions. We aimed to obtain a more consistent estimate of white matter diffusion characteristics and relate these to the distance from the seizure focus...
  22. doi request reprint Focal neocortical epilepsy affects hippocampal volume, shape, and structural integrity: a longitudinal MRI and immunohistochemistry study in a rat model
    Willem M Otte
    Department of Pediatric Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Epilepsia 53:1264-73. 2012
    ..Our goal was to longitudinally characterize the development of bilateral hippocampal pathology in an experimental neocortical focal epilepsy model...
  23. ncbi request reprint Motor recovery and cortical reorganization after constraint-induced movement therapy in stroke patients: a preliminary study
    Judith D Schaechter
    Massachusetts General Hospital NMR Center, Department of Radiology, Charlestown, MA 02129, USA
    Neurorehabil Neural Repair 16:326-38. 2002
    ..These data provide preliminary evidence that gains in motor function produced by CIMT in chronic stroke patients may be associated with a shift in laterality of motor cortical activation toward the undamaged hemisphere...
  24. ncbi request reprint Changes in neuronal connectivity after stroke in rats as studied by serial manganese-enhanced MRI
    Jet P van der Zijden
    Image Sciences Institute, University Medical Center Utrecht, Bolognalaan 50, 3584 CJ, Utrecht, The Netherlands
    Neuroimage 34:1650-7. 2007
    ..This study demonstrates that MEMRI enables in vivo assessment of spatiotemporal alterations in neuronal connectivity after stroke, which may lead to improved insights in mechanisms underlying functional loss and recovery after stroke...
  25. ncbi request reprint MRI of monocyte infiltration in an animal model of neuroinflammation using SPIO-labeled monocytes or free USPIO
    Raoul D Oude Engberink
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 28:841-51. 2008
    ..The use of SPIO-labeled monocytes provides a better tool to specifically assess the time window of monocyte infiltration...
  26. doi request reprint Contribution of the left and right inferior frontal gyrus in recovery from aphasia. A functional MRI study in stroke patients with preserved hemodynamic responsiveness
    Casper A M M van Oers
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Neuroimage 49:885-93. 2010
    ..Altered hemodynamic responsiveness seems an unlikely confounder in the interpretations of fMRI results...
  27. pmc Multiparametric magnetic resonance imaging of brain disorders
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Top Magn Reson Imaging 21:129-38. 2010
    ..We describe here various implementations for combining multiparametric imaging and their merits in the evaluation of brain diseases...
  28. ncbi request reprint Measurements of BOLD/CBV ratio show altered fMRI hemodynamics during stroke recovery in rats
    Young R Kim
    NMR Center MGH, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 25:820-9. 2005
    ..These results suggest that stroke affects not only local hemodynamics and coupling but also other factors including neural connectivity...
  29. doi request reprint 1H/13C MR spectroscopic imaging of regionally specific metabolic alterations after experimental stroke
    Jet P van der Zijden
    Department of Medical Imaging, Image Sciences Institute, University Medical Center Utrecht, Yalelaan 2, 3584 CM, Utrecht, The Netherlands
    Brain 131:2209-19. 2008
    ....
  30. ncbi request reprint Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke
    Aneesh B Singhal
    Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neurology 58:945-52. 2002
    ..Hyperbaric oxygen therapy is considered an important stroke treatment strategy...
  31. pmc MRI of bilateral sensorimotor network activation in response to direct intracortical stimulation in rats after unilateral stroke
    Maurits P A van Meer
    Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 31:1583-7. 2011
    ..This indicates that in spite of dysfunction, perilesional cortical tissue can be activated subacutely after stroke, while delay of the hemodynamic activation response suggests impaired neurovascular coupling...
  32. pmc Functional and structural neural network characterization of serotonin transporter knockout rats
    Kajo van der Marel
    Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 8:e57780. 2013
    ..Overall, the comparison of 5-HTT(-/-) and wild-type rats suggests mostly limited effects of 5-HTT genotype on MRI-based measures of brain morphology and function...
  33. doi request reprint In vivo diffusion tensor imaging and ex vivo histologic characterization of white matter pathology in a post-status epilepticus model of temporal lobe epilepsy
    Pieter van Eijsden
    Rudolf Magnus Institute of Neuroscience, Departments of Child Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
    Epilepsia 52:841-5. 2011
    ..We conclude that SE induces both transient and chronic white matter changes in the medial CC and FF that are to some degree related to myelin pathology...
  34. ncbi request reprint Application of magnetic resonance imaging to study pathophysiology in brain disease models
    Rick M Dijkhuizen
    Department of Medical Imaging, Image Sciences Institute, University Medical Center Utrecht, The Netherlands
    Methods Mol Med 124:251-78. 2006
    ....
  35. pmc Tumor angiogenesis phenotyping by nanoparticle-facilitated magnetic resonance and near-infrared fluorescence molecular imaging
    Peter A Jarzyna
    Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neoplasia 14:964-73. 2012
    ..NIRF imaging revealed significant differences in accumulation kinetics between the models. In conclusion, this technology can serve as an in vivo biomarker for antiangiogenesis treatment and angiogenesis phenotyping...
  36. pmc Magnetic resonance imaging of brain angiogenesis after stroke
    Peter R Seevinck
    Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, Yalelaan 2, 3584 CM, Utrecht, The Netherlands
    Angiogenesis 13:101-11. 2010
    ..Finally, we discuss some pitfalls and limitations that may critically affect the accuracy and interpretation of MRI-based measures of (neo)vascularization after stroke...
  37. pmc Interferon-β attenuates lung inflammation following experimental subarachnoid hemorrhage
    Pieter M Cobelens
    Department of Intensive Care Medicine, University Medical Center Utrecht, Heidelberglaan 100, Utrecht 3584 CX, The Netherlands
    Crit Care 14:R157. 2010
    ..The objective of this study was to assess the immunomodulatory effects of interferon-β (IFN-β) on inflammatory mediators in the lung after experimental SAH...