Hilleke E Hulshoff Pol

Summary

Country: The Netherlands

Publications

  1. ncbi request reprint Genetic contributions to human brain morphology and intelligence
    Hilleke E Hulshoff Pol
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    J Neurosci 26:10235-42. 2006
  2. ncbi request reprint Gray and white matter density changes in monozygotic and same-sex dizygotic twins discordant for schizophrenia using voxel-based morphometry
    Hilleke E Hulshoff Pol
    Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Center Utrecht, A01 126, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Neuroimage 31:482-8. 2006
  3. pmc Tract-based analysis of magnetization transfer ratio and diffusion tensor imaging of the frontal and frontotemporal connections in schizophrenia
    Rene C W Mandl
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Bull 36:778-87. 2010
  4. doi request reprint Heritability of changes in brain volume over time in twin pairs discordant for schizophrenia
    Rachel G H Brans
    Department of Psychiatry, A01 126, University Medical Center Utrecht, Heidelberglaan 100, Utrecht CX 3584, The Netherlands
    Arch Gen Psychiatry 65:1259-68. 2008
  5. doi request reprint Overlapping and segregating structural brain abnormalities in twins with schizophrenia or bipolar disorder
    Hilleke E Hulshoff Pol
    Department of Psychiatry, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, The Netherlands
    Arch Gen Psychiatry 69:349-59. 2012
  6. doi request reprint Genetic and environmental influences on focal brain density in bipolar disorder
    Astrid C van der Schot
    Department of Psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Brain 133:3080-92. 2010
  7. doi request reprint Changes in cortical thickness during the course of illness in schizophrenia
    Neeltje E M van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan, The Netherlands
    Arch Gen Psychiatry 68:871-80. 2011
  8. doi request reprint Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder
    Astrid C van der Schot
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Arch Gen Psychiatry 66:142-51. 2009
  9. ncbi request reprint Focal white matter density changes in schizophrenia: reduced inter-hemispheric connectivity
    Hilleke E Hulshoff Pol
    Neuroscience Division, A01 126, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
    Neuroimage 21:27-35. 2004
  10. doi request reprint Brain plasticity and intellectual ability are influenced by shared genes
    Rachel G H Brans
    Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands
    J Neurosci 30:5519-24. 2010

Detail Information

Publications64

  1. ncbi request reprint Genetic contributions to human brain morphology and intelligence
    Hilleke E Hulshoff Pol
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    J Neurosci 26:10235-42. 2006
    ..35). These findings point to a neural network that shares a common genetic origin with human intelligence...
  2. ncbi request reprint Gray and white matter density changes in monozygotic and same-sex dizygotic twins discordant for schizophrenia using voxel-based morphometry
    Hilleke E Hulshoff Pol
    Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Center Utrecht, A01 126, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Neuroimage 31:482-8. 2006
    ..Focal changes in the left anterior hemisphere may therefore be particularly relevant as endophenotype in genetic studies of schizophrenia...
  3. pmc Tract-based analysis of magnetization transfer ratio and diffusion tensor imaging of the frontal and frontotemporal connections in schizophrenia
    Rene C W Mandl
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Bull 36:778-87. 2010
    ..Focal reductions in myelin have been suggested in patients using magnetization transfer ratio (MTR) imaging but to what extent schizophrenia may be related to changes in MTR measured along entire fiber bundles is still unknown...
  4. doi request reprint Heritability of changes in brain volume over time in twin pairs discordant for schizophrenia
    Rachel G H Brans
    Department of Psychiatry, A01 126, University Medical Center Utrecht, Heidelberglaan 100, Utrecht CX 3584, The Netherlands
    Arch Gen Psychiatry 65:1259-68. 2008
    ..Some brain volume changes are progressive over the course of the illness. Whether these progressive brain volume changes are mediated by genetic or disease-related factors is unknown...
  5. doi request reprint Overlapping and segregating structural brain abnormalities in twins with schizophrenia or bipolar disorder
    Hilleke E Hulshoff Pol
    Department of Psychiatry, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, The Netherlands
    Arch Gen Psychiatry 69:349-59. 2012
    ..Although both disorders are characterized by changes in brain structure, family studies suggest more segregating than overlapping neuroanatomical abnormalities in both disorders...
  6. doi request reprint Genetic and environmental influences on focal brain density in bipolar disorder
    Astrid C van der Schot
    Department of Psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Brain 133:3080-92. 2010
    ....
  7. doi request reprint Changes in cortical thickness during the course of illness in schizophrenia
    Neeltje E M van Haren
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan, The Netherlands
    Arch Gen Psychiatry 68:871-80. 2011
    ..Whether cortical thickness changes in schizophrenia over time are more pronounced relative to the changes that can be attributed to normal aging has not been studied...
  8. doi request reprint Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder
    Astrid C van der Schot
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Arch Gen Psychiatry 66:142-51. 2009
    ..Structural neuroimaging studies suggest the presence of subtle abnormalities in the brains of patients with bipolar disorder. The influence of genetic and/or environmental factors on these brain abnormalities is unknown...
  9. ncbi request reprint Focal white matter density changes in schizophrenia: reduced inter-hemispheric connectivity
    Hilleke E Hulshoff Pol
    Neuroscience Division, A01 126, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
    Neuroimage 21:27-35. 2004
    ..These findings suggest aberrant inter-hemispheric connectivity of anterior cortical and sub-cortical brain regions in schizophrenia, reflecting decreased hemispheric specialisation in schizophrenia...
  10. doi request reprint Brain plasticity and intellectual ability are influenced by shared genes
    Rachel G H Brans
    Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, 3584 CX Utrecht, The Netherlands
    J Neurosci 30:5519-24. 2010
    ..Thus, not only does the brain continue to change well into adulthood, these changes are functionally relevant because they are related to intelligence...
  11. doi request reprint Hippocampal volume change in schizophrenia
    P Cédric M P Koolschijn
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, A 01 126, University Medical Center Utrecht, PO Box 85060, 3584 CX Utrecht, The Netherlands
    J Clin Psychiatry 71:737-44. 2010
    ..The aim of this study is to examine the extent to which hippocampal volume change in patients with schizophrenia is confounded by effects of age and/or antipsychotic medication...
  12. doi request reprint Does having a twin brother make for a bigger brain?
    Jiska S Peper
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Eur J Endocrinol 160:739-46. 2009
    ..For example, in litter-bearing mammals intrauterine position increases prenatal testosterone exposure through adjacent male fetuses, resulting in masculinization of brain morphology...
  13. ncbi request reprint Increased gray-matter volume in medication-naive high-functioning children with autism spectrum disorder
    Saskia J M C Palmen
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychol Med 35:561-70. 2005
    ....
  14. doi request reprint Cannabis use and progressive cortical thickness loss in areas rich in CB1 receptors during the first five years of schizophrenia
    Monica Rais
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:855-65. 2010
    ..First-episode schizophrenia patients who use cannabis show a more pronounced cortical thinning than non-using patients in areas known for their high density of CB1 receptors, such as the ACC and the DLPFC...
  15. doi request reprint Longitudinal MRI study in schizophrenia patients and their healthy siblings
    Rachel G H Brans
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, A01 126, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Br J Psychiatry 193:422-3. 2008
    ..Whole brain and cerebral grey matter volumes decreased excessively in patients compared with their siblings and the controls, suggesting that the progressive brain loss in schizophrenia may be related to the disease process...
  16. ncbi request reprint Gray and white matter volume abnormalities in monozygotic and same-gender dizygotic twins discordant for schizophrenia
    Hilleke E Hulshoff Pol
    Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 55:126-30. 2004
    ....
  17. pmc Focal and global brain measurements in siblings of patients with schizophrenia
    Heleen B M Boos
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Schizophr Bull 38:814-25. 2012
    ..This large magnetic resonance imaging study examined brain structures in patients with schizophrenia, their nonpsychotic siblings, and healthy control subjects using global and focal brain measurements...
  18. ncbi request reprint Progressive brain volume loss in schizophrenia over the course of the illness: evidence of maturational abnormalities in early adulthood
    Neeltje E M van Haren
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Biol Psychiatry 63:106-13. 2008
    ..Thus, one would expect the progression in brain volume change in schizophrenia to follow a more complex trajectory over time...
  19. ncbi request reprint Focal gray matter changes in schizophrenia across the course of the illness: a 5-year follow-up study
    Neeltje E M van Haren
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuropsychopharmacology 32:2057-66. 2007
    ..Moreover, the progression in left frontal density loss appears to be related to an increased number of psychotic episodes, with atypical antipsychotic medication attenuating these changes...
  20. doi request reprint Mapping reliability in multicenter MRI: voxel-based morphometry and cortical thickness
    Hugo G Schnack
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Brain Mapp 31:1967-82. 2010
    ..g., around the thalamus). These tools will facilitate the design and analysis of multisite VBM and CORT studies for detecting group differences and estimating heritability...
  21. ncbi request reprint Larger brains in medication naive high-functioning subjects with pervasive developmental disorder
    Saskia J M C Palmen
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    J Autism Dev Disord 34:603-13. 2004
    ....
  22. doi request reprint Heritability of volumetric brain changes and height in children entering puberty
    Inge L C van Soelen
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Brain Mapp 34:713-25. 2013
    ..Brain and body each expand at their own pace and through separate genetic pathways. There are distinct genetic processes acting on structural brain development, which cannot be explained by genetic increase in height...
  23. doi request reprint Genetic control of functional brain network efficiency in children
    Martijn P van den Heuvel
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3508 GA Utrecht, P O Box 85500, The Netherlands
    Eur Neuropsychopharmacol 23:19-23. 2013
    ..Thus our findings suggest that a set of genes is shaping the underlying architecture of functional brain communication during development...
  24. doi request reprint Classification of schizophrenia patients and healthy controls from structural MRI scans in two large independent samples
    Mireille Nieuwenhuis
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, P O Box 85500 3508 GA Utrecht, The Netherlands
    Neuroimage 61:606-12. 2012
    ..Larger training samples gave more reliable models: Models based on sample sizes smaller than N=130 should be considered unstable and can even score below chance...
  25. doi request reprint Duration of untreated illness in schizophrenia is not associated with 5-year brain volume change
    Geartsje Boonstra
    Department of Psychiatry, University Medical Center Utrecht, P B 85500, 3508 GA, Utrecht, The Netherlands
    Schizophr Res 132:84-90. 2011
    ..We aimed to investigate the relationship between DUI, outcome and brain volume at illness onset or brain volume change during the first five years of the illness in first-episode patients...
  26. doi request reprint Cortical thickness and voxel-based morphometry in depressed elderly
    P Cédric M P Koolschijn
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:398-404. 2010
    ..In contrast to most findings of the literature to date, the results from this study indicate that lifetime depression as well as current state does not seem to influence brain structure in depressed female elderly...
  27. doi request reprint Sex steroids and brain structure in pubertal boys and girls
    Jiska S Peper
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    Psychoneuroendocrinology 34:332-42. 2009
    ..We suggest that in pubertal girls, estradiol may be implicated in neuronal changes in the cerebral cortex during this important period of brain development...
  28. doi request reprint Cerebral white matter in early puberty is associated with luteinizing hormone concentrations
    Jiska S Peper
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Psychoneuroendocrinology 33:909-15. 2008
    ..In addition, genes involved in LH production may be promising candidate genes in neuropsychiatric illnesses with an onset in early adolescence...
  29. pmc The genetic and environmental determinants of the association between brain abnormalities and schizophrenia: the schizophrenia twins and relatives consortium
    Neeltje E M van Haren
    University Medical Center Utrecht, Department of Psychiatry, Division of Neuroscience, Rudolf Magnus Institute, Utrecht, The Netherlands
    Biol Psychiatry 71:915-21. 2012
    ..We aim to define the relative contributions of genetic and nongenetic factors to the association between structural brain abnormalities and Sz in a uniquely powered cohort (Schizophrenia Twins and Relatives consortium)...
  30. doi request reprint Heritability of regional and global brain structure at the onset of puberty: a magnetic resonance imaging study in 9-year-old twin pairs
    Jiska S Peper
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
    Hum Brain Mapp 30:2184-96. 2009
    ..Pubertal development may be directly involved in the decreases in gray matter areas that accompany the transition of our brains from childhood into adulthood...
  31. ncbi request reprint Cerebral volume measurements and subcortical white matter lesions and short-term treatment response in late life depression
    Joost Janssen
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Int J Geriatr Psychiatry 22:468-74. 2007
    ..In this study, quantitative and semi-quantitative magnetic resonance imaging (MRI) measures were studied in relation to response to a 12-week controlled antidepressant monotherapy trial...
  32. doi request reprint Aberrations in the arcuate fasciculus are associated with auditory verbal hallucinations in psychotic and in non-psychotic individuals
    Antoin D de Weijer
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Hum Brain Mapp 34:626-34. 2013
    ..As increased MTR in the arcuate fasciculus was present in both hallucinating groups, a specific association with AVH seems plausible. Decreases in FA, on the other hand, seem to be related to other disease processes of schizophrenia...
  33. doi request reprint Heritability of DTI and MTR in nine-year-old children
    Rachel M Brouwer
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Neuroimage 53:1085-92. 2010
    ....
  34. doi request reprint Aberrant frontal and temporal complex network structure in schizophrenia: a graph theoretical analysis
    Martijn P van den Heuvel
    Department of Psychiatry, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    J Neurosci 30:15915-26. 2010
    ....
  35. ncbi request reprint Brain anatomy in non-affected parents of autistic probands: a MRI study
    Saskia J M C Palmen
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Psychol Med 35:1411-20. 2005
    ..Identifying structural brain abnormalities under genetic control is of particular importance as these could represent endophenotypes of autism...
  36. doi request reprint Brain volume changes after withdrawal of atypical antipsychotics in patients with first-episode schizophrenia
    Geartsje Boonstra
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    J Clin Psychopharmacol 31:146-53. 2011
    ..We found evidence suggestive of decreasing volumes of the putamen and nucleus accumbens over time after discontinuation of medication. This might suggest that discontinuation reverses effects of atypical medication...
  37. ncbi request reprint Brain volumes as predictor of outcome in recent-onset schizophrenia: a multi-center MRI study
    Neeltje E M van Haren
    Department of Psychiatry A 01 126, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands
    Schizophr Res 64:41-52. 2003
    ..No significant correlations were found between the brain volume measures and any of these measures. Gray matter volume at illness onset does not predict outcome after 2 years in recent-onset schizophrenia...
  38. doi request reprint Hypothalamus volume in twin pairs discordant for schizophrenia
    P Cédric M P Koolschijn
    Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 18:312-5. 2008
    ..Higher within-twin pair similarities in monozygotic compared to dizygotic twin pairs, suggests that hypothalamus volume might be partly genetically controlled...
  39. doi request reprint Effects of brain-derived neurotrophic factor Val66Met polymorphism on hippocampal volume change in schizophrenia
    P Cédric M P Koolschijn
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Hippocampus 20:1010-7. 2010
    ..Nevertheless, our findings may support the possibility that BDNF affects brain morphology differently in schizophrenia patients and healthy subjects...
  40. ncbi request reprint A controlled study of brain structure in monozygotic twins concordant and discordant for schizophrenia
    Neeltje E M van Haren
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 56:454-61. 2004
    ..We examined monozygotic twins concordant and discordant for schizophrenia to clarify the role of genetic and environmental factors in determining brain abnormalities...
  41. pmc Glutamate in schizophrenia: a focused review and meta-analysis of ¹H-MRS studies
    Anouk Marsman
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Internal address A 01 126, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Schizophr Bull 39:120-9. 2013
    ..This could reflect aberrant processes in schizophrenia, such as altered synaptic activity, changed glutamate receptor functioning, abnormal glutamine-glutamate cycling, or dysfunctional glutamate transport...
  42. doi request reprint Tract-based diffusion tensor imaging in patients with schizophrenia and their non-psychotic siblings
    Heleen B M Boos
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands Electronic address
    Eur Neuropsychopharmacol 23:295-304. 2013
    ..However, changes in the arcuate fasciculus may be relevant to (the risk to develop) psychosis, while a general and widespread loss of fiber integrity may be related to illness progression...
  43. doi request reprint Decreased frontostriatal microstructural organization in attention deficit/hyperactivity disorder
    Patrick de Zeeuw
    Neuroimaging Lab, Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Hum Brain Mapp 33:1941-51. 2012
    ..A correlation with attention problems for controls suggests that frontostriatal organization is relevant to ADHD-related behaviors...
  44. ncbi request reprint Brain volume changes in first-episode schizophrenia: a 1-year follow-up study
    Wiepke Cahn
    Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Arch Gen Psychiatry 59:1002-10. 2002
    ..One would expect global gray matter to decrease progressively, particularly in first-episode patients, because clinical deterioration is greatest in the early stages of the disease...
  45. doi request reprint Brain volume abnormalities in major depressive disorder: a meta-analysis of magnetic resonance imaging studies
    P Cédric M P Koolschijn
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Brain Mapp 30:3719-35. 2009
    ..In this comprehensive meta-analysis the magnitude and extent of brain volume differences between 2,418 patients with major depressive disorder and 1,974 healthy individuals from 64 studies was determined...
  46. doi request reprint Exploring the brain network: a review on resting-state fMRI functional connectivity
    Martijn P van den Heuvel
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Neuroimaging Division, The Netherlands
    Eur Neuropsychopharmacol 20:519-34. 2010
    ..Specifically, we will discuss the value of these new functional connectivity tools in examining believed connectivity diseases, like Alzheimer's disease, dementia, schizophrenia and multiple sclerosis...
  47. doi request reprint Exercise therapy, cardiorespiratory fitness and their effect on brain volumes: a randomised controlled trial in patients with schizophrenia and healthy controls
    Thomas W Scheewe
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur Neuropsychopharmacol 23:675-85. 2013
    ..However, cardiorespiratory fitness improvement attenuated brain volume changes in schizophrenia patients and increased thickness in large areas of the left cortex in both schizophrenia patients and healthy controls...
  48. doi request reprint Altered white matter connectivity in never-medicated patients with schizophrenia
    Rene C W Mandl
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Brain Mapp 34:2353-65. 2013
    ..We interpret these group-related differences as disease-related axonal or glial aberrations that cannot be attributed to antipsychotic medication use. Hum Brain Mapp 34:2353-2365, 2013. © 2012 Wiley Periodicals, Inc. ..
  49. doi request reprint Hypothalamus and pituitary volume in schizophrenia: a structural MRI study
    Anne Klomp
    Rudolf Magnus Institute for Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Int J Neuropsychopharmacol 15:281-8. 2012
    ..These findings indicate that volume decreases in brain structures important for the normal functioning of the HPA axis are not present, either in recent-onset or chronically ill patients...
  50. doi request reprint Segmentation of MRI brain scans using non-uniform partial volume densities
    Rachel M Brouwer
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Neuroimage 49:467-77. 2010
    ..In conclusion, we have presented a new partial volume segmentation algorithm that allows for comparisons over scanners and voxel sizes...
  51. ncbi request reprint Association of depression duration with reduction of global cerebral gray matter volume in female patients with recurrent major depressive disorder
    Indrag K Lampe
    Rudolph Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Am J Psychiatry 160:2052-4. 2003
    ..The authors investigated the relationship between depression duration and cerebral gray matter volume in female patients with recurrent major depressive disorder...
  52. pmc Functional diffusion tensor imaging: measuring task-related fractional anisotropy changes in the human brain along white matter tracts
    Rene C W Mandl
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 3:e3631. 2008
    ..However, while providing important information on gray matter activation, no information is gathered on the co-activity along white matter tracts in neural networks...
  53. ncbi request reprint Reliability of brain volumes from multicenter MRI acquisition: a calibration study
    Hugo G Schnack
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Brain Mapp 22:312-20. 2004
    ..84 for gray matter, and > or = 0.78 for white matter volume. Calibration of segmentation procedures allows morphologic MRI data acquired at different research sites to be combined reliably in multicenter studies...
  54. doi request reprint Tract-based magnetic resonance spectroscopy of the cingulum bundles at 7 T
    Rene C W Mandl
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Hum Brain Mapp 33:1503-11. 2012
    ....
  55. doi request reprint Abnormal rich club organization and functional brain dynamics in schizophrenia
    Martijn P van den Heuvel
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    JAMA Psychiatry 70:783-92. 2013
    ....
  56. doi request reprint Family-wise automatic classification in schizophrenia
    Rene C W Mandl
    Department of Psychiatry, University Medical Center Utrecht, Rudolf Magnus Institute of Neuroscience, The Netherlands Electronic address
    Schizophr Res 149:108-11. 2013
    ..54 to 0.72 using a support vector machine model. This inclusion of contextual information is especially useful in diseases where the classification features carry a heritable component. ..
  57. doi request reprint Human brain changes across the life span: a review of 56 longitudinal magnetic resonance imaging studies
    Anna M Hedman
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, The Netherlands
    Hum Brain Mapp 33:1987-2002. 2012
    ..Hum Brain Mapp, 2012. © 2011 Wiley Periodicals, Inc...
  58. ncbi request reprint Genetic influences on human brain structure: a review of brain imaging studies in twins
    Jiska S Peper
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, A01 126, 3584 CX Utrecht, The Netherlands
    Hum Brain Mapp 28:464-73. 2007
    ..New techniques such as genome-wide scans may become helpful in the search for genes that are involved in the regulation of human brain volume throughout life...
  59. ncbi request reprint Volume changes in gray matter in patients with schizophrenia
    Hilleke E Hulshoff Pol
    Department of Psychiatry, University Medical Center Utrecht, The Netherlands
    Am J Psychiatry 159:244-50. 2002
    ..Although structural brain abnormalities, particularly decrements in gray matter volume, are considered important to the pathology of schizophrenia, it is not resolved whether the brain abnormalities become more prominent over time...
  60. ncbi request reprint Magnetic resonance imaging of boys with attention-deficit/hyperactivity disorder and their unaffected siblings
    Sarah Durston
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Acad Child Adolesc Psychiatry 43:332-40. 2004
    ..To study the influence of increased familial risk for attention-deficit/hyperactivity disorder (ADHD) on brain morphology...
  61. ncbi request reprint Global intellectual impairment does not accelerate with age in patients with schizophrenia: a cross-sectional analysis
    Ron Hijman
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Schizophr Bull 29:509-17. 2003
    ..The results confirm that there is global intellectual impairment in schizophrenia patients at the onset of illness but no age-accelerated decline and are consistent with the neurodevelopmental hypothesis of schizophrenia...
  62. doi request reprint Specific somatotopic organization of functional connections of the primary motor network during resting state
    Martijn P van den Heuvel
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Hum Brain Mapp 31:631-44. 2010
    ..Examining the specific organization of the functional connections within the primary motor network could enhance our overall understanding of the organization of resting-state functional communication within the brain...
  63. doi request reprint Efficiency of functional brain networks and intellectual performance
    Martijn P van den Heuvel
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    J Neurosci 29:7619-24. 2009
    ..Our findings indicate a strong positive association between the global efficiency of functional brain networks and intellectual performance...
  64. pmc What happens after the first episode? A review of progressive brain changes in chronically ill patients with schizophrenia
    Hilleke E Hulshoff Pol
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Bull 34:354-66. 2008
    ..The progressive brain changes present in chronic schizophrenia may represent a continuous pathophysiological process taking place in the brains of these patients that warrants further study...