R Q Hintzen

Summary

Country: The Netherlands

Publications

  1. ncbi Glioblastoma causing granulocytosis by secretion of granulocyte-colony-stimulating factor
    R Q Hintzen
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Neurology 54:259-61. 2000
  2. pmc Retinal nerve fiber layer thickness in subgroups of multiple sclerosis, measured by optical coherence tomography and scanning laser polarimetry
    Theodora A M Siepman
    Department of Neurology, MS Centre ErasMS, Erasmus MC, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
    J Neurol 257:1654-60. 2010
  3. ncbi Stem cell transplantation in multiple sclerosis: multiple choices and multiple challenges
    R Q Hintzen
    Department of Neurology, Erasmus Medical Centre Rotterdam, The Netherlands
    Mult Scler 8:155-60. 2002
  4. pmc Acute zonal occult outer retinopathy and multiple sclerosis
    R Q Hintzen
    MS Centre, Department of Neurology, Erasmus University Medical School, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 77:1373-5. 2006
  5. pmc Pregnancy in multiple sclerosis: clinical and self-report scales
    R F Neuteboom
    Department of Neurology, Erasmus MC, Erasmus University Medical Centre, Rotterdam, The Netherlands
    J Neurol 259:311-7. 2012
  6. ncbi The role of disability and depression in cognitive functioning within 2 years after multiple sclerosis diagnosis
    T A M Siepman
    Dept of Neurology, MS Centre ErasMS, Erasmus MC s Gravendijkwal 230, 3015, CE Rotterdam, The Netherlands
    J Neurol 255:910-6. 2008
  7. ncbi EVI5 is a risk gene for multiple sclerosis
    I A Hoppenbrouwers
    Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, The Netherlands
    Genes Immun 9:334-7. 2008
  8. ncbi Impact of recently diagnosed multiple sclerosis on quality of life, anxiety, depression and distress of patients and partners
    A C J W Janssens
    Department of Neurology, Erasmus MC, Rotterdam, The Netherlands
    Acta Neurol Scand 108:389-95. 2003
  9. pmc Incidence of acquired demyelinating syndromes of the CNS in Dutch children: a nationwide study
    I A Ketelslegers
    MS Centre ErasMS, Department of Neurology, Room Ee 2230, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    J Neurol 259:1929-35. 2012
  10. ncbi Patients with multiple sclerosis prefer early diagnosis
    A C J W Janssens
    Erasmus MC, Department of Neurology, Rotterdam, The Netherlands
    Eur J Neurol 11:335-7. 2004

Collaborators

Detail Information

Publications33

  1. ncbi Glioblastoma causing granulocytosis by secretion of granulocyte-colony-stimulating factor
    R Q Hintzen
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Neurology 54:259-61. 2000
    ..The paraneoplastic phenomenon described here partly mimicked a brain abscess. Production of G-CSF by (brain) tumor cells might be related to the granulocytosis common in malignant disease...
  2. pmc Retinal nerve fiber layer thickness in subgroups of multiple sclerosis, measured by optical coherence tomography and scanning laser polarimetry
    Theodora A M Siepman
    Department of Neurology, MS Centre ErasMS, Erasmus MC, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
    J Neurol 257:1654-60. 2010
    ..05), OCT means (r = -0.31-0.30, p < 0.05) and macular volume (r = -0.37, p < 0.01). For MSIS-29 physical impact score, significant correlations were found with MD (r = -0.48, p < 0.01) and PSD (r = 0.48, p < 0.01)...
  3. ncbi Stem cell transplantation in multiple sclerosis: multiple choices and multiple challenges
    R Q Hintzen
    Department of Neurology, Erasmus Medical Centre Rotterdam, The Netherlands
    Mult Scler 8:155-60. 2002
    ..For every step in the HSCT procedure, there are many different options. The time has come for a systematic analysis of the safety and efficacy associated with the different methodologies...
  4. pmc Acute zonal occult outer retinopathy and multiple sclerosis
    R Q Hintzen
    MS Centre, Department of Neurology, Erasmus University Medical School, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 77:1373-5. 2006
    ..AZOOR can have an onset with monocular visual field loss, and can be distinguished from optic neuritis. In addition, some observations suggest common neuropathological and inflammatory mechanisms between multiple sclerosis and AZOOR...
  5. pmc Pregnancy in multiple sclerosis: clinical and self-report scales
    R F Neuteboom
    Department of Neurology, Erasmus MC, Erasmus University Medical Centre, Rotterdam, The Netherlands
    J Neurol 259:311-7. 2012
    ..QoL is improved during pregnancy. Although relapse rate was increased directly after delivery, in the mid long term after delivery no adverse effects of pregnancy on MS were found...
  6. ncbi The role of disability and depression in cognitive functioning within 2 years after multiple sclerosis diagnosis
    T A M Siepman
    Dept of Neurology, MS Centre ErasMS, Erasmus MC s Gravendijkwal 230, 3015, CE Rotterdam, The Netherlands
    J Neurol 255:910-6. 2008
    ..To investigate cognitive functioning shortly after multiple sclerosis (MS) diagnosis and to examine the relationship with disability, depression and anxiety...
  7. ncbi EVI5 is a risk gene for multiple sclerosis
    I A Hoppenbrouwers
    Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, The Netherlands
    Genes Immun 9:334-7. 2008
    ..15; P=0.03 and OR 1.15; P=0.04). This study confirms EVI5 as another risk locus for MS; however, much of the genetic basis of MS remains unidentified...
  8. ncbi Impact of recently diagnosed multiple sclerosis on quality of life, anxiety, depression and distress of patients and partners
    A C J W Janssens
    Department of Neurology, Erasmus MC, Rotterdam, The Netherlands
    Acta Neurol Scand 108:389-95. 2003
    ..The aim of the present paper was to evaluate the emotional burden and quality of life of recently diagnosed MS patients and their partners...
  9. pmc Incidence of acquired demyelinating syndromes of the CNS in Dutch children: a nationwide study
    I A Ketelslegers
    MS Centre ErasMS, Department of Neurology, Room Ee 2230, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    J Neurol 259:1929-35. 2012
    ..001). During the study period, 23% of patients were subsequently diagnosed with MS. The annual incidence of ADS in the Netherlands is 0.66/1,00,000 children/year. A polyfocal disease onset of ADS was most common...
  10. ncbi Patients with multiple sclerosis prefer early diagnosis
    A C J W Janssens
    Erasmus MC, Department of Neurology, Rotterdam, The Netherlands
    Eur J Neurol 11:335-7. 2004
    ..We conclude that patients with MS prefer an early diagnosis...
  11. ncbi Anxiety and depression influence the relation between disability status and quality of life in multiple sclerosis
    A C J W Janssens
    Department of Neurology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Mult Scler 9:397-403. 2003
    ..Screening for symptoms of anxiety and depression is recommended in studies that use QoL as an outcome measure of treatment or intervention efficacy...
  12. doi Disease course and outcome of acute disseminated encephalomyelitis is more severe in adults than in children
    I A Ketelslegers
    Department of Neurology, Erasmus University Medical Centre, The Netherlands
    Mult Scler 17:441-8. 2011
    ..Acute disseminated encephalomyelitis (ADEM) affects children more frequently than adults. Current studies investigating ADEM in different age groups are difficult to compare...
  13. ncbi Callosal lesion predicts future attacks after clinically isolated syndrome
    N Jafari
    Department of Neurology, MS Centre ErasMS, 3000 CA Rotterdam, The Netherlands
    Neurology 73:1837-41. 2009
    ..This study assessed whether the presence of CC lesion on MRI could, next to the modified Barkhof criteria, further enhance prediction of conversion from CIS to MS...
  14. ncbi T-lymphocyte reconstitution following rigorously T-cell-depleted versus unmodified autologous stem cell transplants
    P A W te Boekhorst
    Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    Bone Marrow Transplant 37:763-72. 2006
    ..This susceptibility to apoptosis would interfere with a swift and sustained CD4(+) T-cell regeneration post SCT...
  15. doi Decreased systemic IL-7 and soluble IL-7Rα in multiple sclerosis patients
    K L Kreft
    Department of Neurology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Genes Immun 13:587-92. 2012
    ..The soluble IL-7Rα levels correlate with the rs6897932 [C] risk allele carriership. The skew at the IL-7 and IL-7Rα level may influence responsiveness of IL-7Rα(+) cells...
  16. doi A comparison of MRI criteria for diagnosing pediatric ADEM and MS
    I A Ketelslegers
    Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurology 74:1412-5. 2010
    ..We therefore compared the 4 current sets of MRI criteria in our Dutch pediatric cohort and determined which are the most useful in clinical practice for distinguishing ADEM from MS...
  17. ncbi Bone-marrow transplantation fails to halt intrathecal lymphocyte activation in multiple sclerosis
    T Mondria
    Department of Neurology, Erasmus University Medical School, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 79:1013-5. 2008
    ..Given the presumed key role for autoreactive lymphocytes in multiple sclerosis (MS), treatment strategies have been developed to ablate lymphocyte activity. Intrathecal lymphocyte activation can be measured by CSF-soluble(s)CD27...
  18. pmc Self reported stressful life events and exacerbations in multiple sclerosis: prospective study
    D Buljevac
    Department of Neurology, Erasmus MC, Postbox 2040, 3000 CA Rotterdam, Netherlands
    BMJ 327:646. 2003
    ..To study the relation between self reported stressful life events not related to multiple sclerosis and the occurrence of exacerbations in relapsing-remitting multiple sclerosis...
  19. pmc Epstein-Barr virus and disease activity in multiple sclerosis
    D Buljevac
    Department of Neurology, Erasmus MC, Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 76:1377-81. 2005
    ..To study in relapsing-remitting (RR) multiple sclerosis (MS) whether exacerbations and brain activity as measured by magnetic resonance imaging (MRI) are associated with plasma levels of anti-Epstein Barr (EBV) antibodies and EBV DNA...
  20. doi Serum leptin levels during pregnancy in multiple sclerosis
    R F Neuteboom
    Department of Neurology, Erasmus MC, Rotterdam, The Netherlands
    Mult Scler 15:907-12. 2009
    ..It is yet unclear, which immuno - endocrinological processes mediate these disease fluctuations. Leptin has been identified as a hormone that can influence inflammatory activity...
  21. ncbi Prediction of anxiety and distress following diagnosis of multiple sclerosis: a two-year longitudinal study
    A C J W Janssens
    Department of Public Health, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Mult Scler 12:794-801. 2006
    ..To investigate the course of anxiety, depression and disease-related distress of patients with multiple sclerosis (MS) and their partners in the first years after diagnosis...
  22. ncbi [Multiple sclerosis in children]
    R F Neuteboom
    Erasmus MC, afd Neurologie, MS centrum ErasMS, s Gravendijkwal 230, 3015 CE Rotterdam
    Ned Tijdschr Geneeskd 151:1464-8. 2007
    ..In both patients, the disease was controlled by prolonged pharmacotherapy, starting with methylprednisolone and followed in the first patient by intravenous infusions of immunoglobulins and in the second patient by beta-interferon...
  23. ncbi Expectations of wheelchair-dependency in recently diagnosed patients with multiple sclerosis and their partners
    A C J W Janssens
    Department of Neurology, Erasmus MC, Rotterdam, The Netherlands
    Eur J Neurol 10:287-93. 2003
    ..The overestimation of the short-term risks and the substantial differences in expectations within couples warrant further research on the impact of expectations on their treatment decisions and psychological well-being...
  24. pmc Resetting the adaptive immune system after autologous stem cell transplantation: lessons from responses to vaccines
    D M C Brinkman
    Department of Pediatrics, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
    J Clin Immunol 27:647-58. 2007
    ..Clinical outcome on a per case basis was not associated with the profile of the immune response toward the vaccination antigens after ASCT...
  25. doi Prognostic factors after a first attack of inflammatory CNS demyelination in children
    R F Neuteboom
    Department of Neurology, Erasmus MC, Rotterdam, The Netherlands
    Neurology 71:967-73. 2008
    ..To identify clinical, radiologic, or CSF factors that predict conversion to multiple sclerosis (MS) after a first attack of inflammatory demyelination in children...
  26. ncbi Magnetization transfer histogram parameters reflect all dimensions of MS pathology, including atrophy
    N F Kalkers
    Department of Neurology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Neurol Sci 184:155-62. 2001
    ..We studied correlations between MTR histogram and clinical parameters in MS subgroups. Contrary to earlier studies we placed special emphasis on the lower MTR range, to explore the effect of partial volume averaging effects with CSF...
  27. doi Application of the 2010 revised criteria for the diagnosis of multiple sclerosis to patients with clinically isolated syndromes
    T F Runia
    Department of Neurology, Erasmus MC University Hospital Rotterdam, Rotterdam, The Netherlands
    Eur J Neurol 20:1510-6. 2013
    ..To validate the 2010 revised criteria they were applied to a cohort of patients with clinically isolated syndromes (CIS)...
  28. ncbi Recent gains in clinical multiple sclerosis research
    T F Runia
    Department of Neurology, Erasmus MC, Rotterdam, The Netherlands
    CNS Neurol Disord Drug Targets 11:497-505. 2012
    ..Also another demyelinating disease of the CNS, neuromyelitis optica (NMO) is highlighted. Since NMO has been considered as a variant of MS and also has been misdiagnosed as MS, recent insights in the pathology of NMO are explained...
  29. ncbi Familial clustering of multiple sclerosis in a Dutch genetic isolate
    I A Hoppenbrouwers
    Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam 3015 GD, The Netherlands
    Mult Scler 13:17-24. 2007
    ..This study suggests familial aggregation in the genetically isolated population. The high level of inbreeding makes this population valuable for finding novel genes involved in MS...
  30. pmc Intense T cell depletion followed by autologous bone marrow transplantation for severe multiple sclerosis
    J P A Samijn
    Department of Neurology, MS Centre ErasErasmus MC, Postbox 2040, 3000 CA Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 77:46-50. 2006
    ..Certain stem cell transplantation procedures might slow down inflammatory pathology in multiple sclerosis (MS)...
  31. ncbi Baseline T cell reactivity in multiple sclerosis is correlated to efficacy of interferon-beta
    J Killestein
    Department of Neurology, VU Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    J Neuroimmunol 133:217-24. 2002
    ..Evidence suggests a role of T cell reactivity in autoimmune diseases. Interferon (IFN)-beta blocks in vitro proliferation of human T cells...
  32. ncbi [Neuromyelitis optica (Devic's disease): a severe variant of multiple sclerosis]
    R F Neuteboom
    Erasmus Medisch Centrum, afd Neurologie, MS centrum ErasMS, Dr Molewaterplein 40, 3015 GD Rotterdam
    Ned Tijdschr Geneeskd 148:1097-102. 2004
    ..In neuromyelitis optica the underlying condition seems to be in the field of the human immune response...
  33. ncbi A three-year study of brain atrophy after autologous hematopoietic stem cell transplantation in rapidly evolving secondary progressive multiple sclerosis
    M A Rocca
    Neuroimaging Research Unit, Scientific Institute and University San Raffaele, Milan, Italy
    AJNR Am J Neuroradiol 28:1659-61. 2007
    ..The aim of this study was to assess how AHSCT affects medium-term evolution of brain atrophy in MS...