Piet Eikelenboom

Summary

Affiliation: GGZ Buitenamstel
Country: The Netherlands

Publications

  1. ncbi request reprint Adult human microglia secrete cytokines when exposed to neurotoxic prion protein peptide: no intermediary role for prostaglandin E2
    Robert Veerhuis
    Research Institute Neurosciences Vrije Universiteit, Department of Psychiatry, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Brain Res 925:195-203. 2002
  2. ncbi request reprint Neuroinflammatory perspectives on the two faces of Alzheimer's disease
    P Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Neural Transm 111:281-94. 2004
  3. doi request reprint Neuroinflammation in plaque and vascular beta-amyloid disorders: clinical and therapeutic implications
    Piet Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurodegener Dis 5:190-3. 2008
  4. ncbi request reprint The significance of neuroinflammation in understanding Alzheimer's disease
    P Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Neural Transm 113:1685-95. 2006
  5. ncbi request reprint Neuroinflammation in Alzheimer's disease and prion disease
    P Eikelenboom
    Department of Psychiatry, Graduate School of Neurosciences, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Glia 40:232-9. 2002
  6. ncbi request reprint Immunological mechanisms and the spectrum of psychiatric syndromes in Alzheimer's disease
    P Eikelenboom
    Graduate School Neuroscience, Amsterdam, The Netherlands
    J Psychiatr Res 36:269-80. 2002
  7. ncbi request reprint The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E(2) secretion by cultured human adult microglia: implications for Alzheimer's disease
    Jeroen J M Hoozemans
    Department of Pathology, Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Brain Res 951:218-26. 2002
  8. doi request reprint Subjective quality of life and its determinants in a catchment area based population of elderly schizophrenia patients
    Paul D Meesters
    GGZ inGeest, VU University Medical Center, Amsterdam, The Netherlands
    Schizophr Res 147:275-80. 2013
  9. doi request reprint Value of diagnostic tests to predict conversion to Alzheimer's disease in young and old patients with amnestic mild cognitive impairment
    Ben Schmand
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    J Alzheimers Dis 29:641-8. 2012
  10. doi request reprint The care needs of elderly patients with schizophrenia spectrum disorders
    Paul D Meesters
    GGZ inGeest, VU University Medical Center, Amsterdam, The Netherlands
    Am J Geriatr Psychiatry 21:129-37. 2013

Detail Information

Publications48

  1. ncbi request reprint Adult human microglia secrete cytokines when exposed to neurotoxic prion protein peptide: no intermediary role for prostaglandin E2
    Robert Veerhuis
    Research Institute Neurosciences Vrije Universiteit, Department of Psychiatry, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Brain Res 925:195-203. 2002
    ..Furthermore, PrP105-132 did not stimulate microglial PGE(2) synthesis. We conclude that, unlike IL-1beta-induced IL-6 synthesis in astrocytes, the PrP-induced IL-6 synthesis in human adult microglia is not PGE2 mediated...
  2. ncbi request reprint Neuroinflammatory perspectives on the two faces of Alzheimer's disease
    P Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Neural Transm 111:281-94. 2004
    ..Here we review the evidence that inflammation related events could be a critical etiological factor in certain forms of the sporadic AD...
  3. doi request reprint Neuroinflammation in plaque and vascular beta-amyloid disorders: clinical and therapeutic implications
    Piet Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurodegener Dis 5:190-3. 2008
    ..The cerebral beta-amyloid (Abeta) disorders show a great variability in the distribution of parenchymal and vascular amyloid deposits...
  4. ncbi request reprint The significance of neuroinflammation in understanding Alzheimer's disease
    P Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Neural Transm 113:1685-95. 2006
    ..We also discuss the possibilities of inflammation-based therapeutic strategies in AD...
  5. ncbi request reprint Neuroinflammation in Alzheimer's disease and prion disease
    P Eikelenboom
    Department of Psychiatry, Graduate School of Neurosciences, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Glia 40:232-9. 2002
    ....
  6. ncbi request reprint Immunological mechanisms and the spectrum of psychiatric syndromes in Alzheimer's disease
    P Eikelenboom
    Graduate School Neuroscience, Amsterdam, The Netherlands
    J Psychiatr Res 36:269-80. 2002
    ....
  7. ncbi request reprint The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E(2) secretion by cultured human adult microglia: implications for Alzheimer's disease
    Jeroen J M Hoozemans
    Department of Pathology, Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Brain Res 951:218-26. 2002
    ....
  8. doi request reprint Subjective quality of life and its determinants in a catchment area based population of elderly schizophrenia patients
    Paul D Meesters
    GGZ inGeest, VU University Medical Center, Amsterdam, The Netherlands
    Schizophr Res 147:275-80. 2013
    ..In spite of the substantial proportion of elderly in the total schizophrenia population, evaluation of their SQOL and its determinants has been scarce and findings from epidemiological samples are lacking...
  9. doi request reprint Value of diagnostic tests to predict conversion to Alzheimer's disease in young and old patients with amnestic mild cognitive impairment
    Ben Schmand
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    J Alzheimers Dis 29:641-8. 2012
    ..MRI and neuropsychological assessment remain informative in patients older than 75 years, unlike CSF biomarkers...
  10. doi request reprint The care needs of elderly patients with schizophrenia spectrum disorders
    Paul D Meesters
    GGZ inGeest, VU University Medical Center, Amsterdam, The Netherlands
    Am J Geriatr Psychiatry 21:129-37. 2013
    ..Still, their needs for care are poorly understood. This study aimed to gain insight into the care needs of older patients with schizophrenia spectrum disorders...
  11. doi request reprint Schizophrenia spectrum disorders in later life: prevalence and distribution of age at onset and sex in a dutch catchment area
    Paul D Meesters
    GGZ inGeest, VU University Medical Center, Amsterdam, The Netherlands
    Am J Geriatr Psychiatry 20:18-28. 2012
    ..We assessed the prevalence of schizophrenia and spectrum disorders and their distribution according to age at onset and sex in an elderly population...
  12. ncbi request reprint The neuroinflammatory response in plaques and amyloid angiopathy in Alzheimer's disease: therapeutic implications
    Annemieke J M Rozemuller
    Dept Neuropathology, Academic Medical Center, 1100 DE Amsterdam, The Netherlands
    Curr Drug Targets CNS Neurol Disord 4:223-33. 2005
    ..The implications of the reviewed studies for an inflammation-based therapeutical approach in AD will be discussed...
  13. ncbi request reprint Activation of human microglia by fibrillar prion protein-related peptides is enhanced by amyloid-associated factors SAP and C1q
    Robert Veerhuis
    Institute for Clinical and Experimental Neurosciences VU ICEN VU, Department of Psychiatry, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    Neurobiol Dis 19:273-82. 2005
    ..Combined, ultrastructural and thioflavin assays, together with microglial cytokine release measurements, provide a test system to screen potential, fibrillarity impeding therapeutics for prion disease...
  14. ncbi request reprint Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex
    Jeroen J M Hoozemans
    Department of Psychiatry, Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Dis 15:492-9. 2004
    ..These results suggest that p38 MAPK does not mediate COX-2 expression and pRb inactivation, which are involved in cellular changes in pyramidal neurons early in AD pathogenesis...
  15. ncbi request reprint Minocycline does not affect amyloid beta phagocytosis by human microglial cells
    Atoosa Familian
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Neurosci Lett 416:87-91. 2007
    ..Here, we demonstrate that minocycline down-regulates the production of pro-inflammatory cytokines by human microglia without affecting their beneficial activity, phagocytosis of amyloid beta fibrils...
  16. doi request reprint Cognitive impairment in late life schizophrenia and bipolar I disorder
    Paul D Meesters
    GGZ inGeest, VU University Medical Center, Amsterdam, The Netherlands
    Int J Geriatr Psychiatry 28:82-90. 2013
    ..Evidence in younger populations suggests quantitative but not categorical differences in cognitive impairments between schizophrenia and bipolar disorder. It is uncertain whether a similar distinction applies to patients in later life...
  17. doi request reprint Morphometric changes in the cortical microvascular network in Alzheimer's disease
    Edo Richard
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Alzheimers Dis 22:811-8. 2010
    ..Our data indicate that morphometric changes in the cortical capillary network occur in AD in a region-specific manner and may be related to cortical atrophy in the affected regions...
  18. ncbi request reprint Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease
    Jeroen J M Hoozemans
    Department of Pathology, Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, VU University Medical Center, Amsterdam, The Netherlands
    Curr Drug Targets 4:461-8. 2003
    ..Understanding the role of COX in AD pathogenesis could contribute to the development of an anti-inflammatory therapy for the treatment or prevention of AD...
  19. ncbi request reprint Inhibitory effect of minocycline on amyloid beta fibril formation and human microglial activation
    Atoosa Familian
    Department of Psychiatry, Institute for Clinical and Experimental Neurosciences VU ICEN VU, VU University Medical Center, Amsterdam, The Netherlands
    Glia 53:233-40. 2006
    ..Our data suggest that minocycline and tetracycline at tolerable doses can inhibit human microglial activation. This activity in part is exerted by inhibition of (SAP and C1q enhanced) Abeta fibril formation...
  20. ncbi request reprint The unfolded protein response affects neuronal cell cycle protein expression: implications for Alzheimer's disease pathogenesis
    Jeroen J M Hoozemans
    Department of Neuropathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Exp Gerontol 41:380-6. 2006
    ..These data suggest that activation of the UPR affects cell cycle protein expression in neurons during neurodegeneration in AD...
  21. doi request reprint Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease
    Eric van Exel
    Department of Psychiatry, VU University Medical Center GGZ inGeest, Osdorpplein 880, 1068 TD, Amsterdam, The Netherlands
    Arch Gen Psychiatry 66:1263-70. 2009
    ..Alzheimer disease (AD) is a complex disorder with a strong heritable component. Amyloid pathology, vascular factors, and inflammation are postulated to be involved in its pathogenesis, but causality has not been established unequivocally...
  22. ncbi request reprint The structure of the geriatric depressed brain and response to electroconvulsive therapy
    Mardien L Oudega
    Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, The Netherlands Electronic address
    Psychiatry Res 222:1-9. 2014
    ..These results are possibly explained by the connectivity between these brain regions and an interconnected network that is particularly activated by the ECT-induced seizures. ..
  23. ncbi request reprint The Alzheimer myth and biomarker research in dementia
    Edo Richard
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Alzheimers Dis 31:S203-9. 2012
    ..Acknowledging that dementia in old age is an essentially different condition from dementia at relatively younger age is needed and should lead to new approaches in dementia research...
  24. doi request reprint Innate immunity and the etiology of late-onset Alzheimer's disease
    Piet Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurodegener Dis 10:271-3. 2012
    ..Neuropathological studies supported by experimental animal studies show that the constituents of the innate immunity are intimately involved in the early steps of the pathological cascade of Alzheimer's disease (AD)...
  25. doi request reprint Value of neuropsychological tests, neuroimaging, and biomarkers for diagnosing Alzheimer's disease in younger and older age cohorts
    Ben Schmand
    Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Am Geriatr Soc 59:1705-10. 2011
    ..To examine the influence of age on the value of four techniques for diagnosing Alzheimer's disease (AD)...
  26. ncbi request reprint Amyloid beta plaque-associated proteins C1q and SAP enhance the Abeta1-42 peptide-induced cytokine secretion by adult human microglia in vitro
    Robert Veerhuis
    Department of Pathology, Research Institute Neurosciences Vrije Universiteit, Vrije Universiteit Medical Center, DeBoelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Acta Neuropathol 105:135-44. 2003
    ....
  27. doi request reprint Symptomatic remission and associated factors in a catchment area based population of older patients with schizophrenia
    Paul D Meesters
    GGZ inGeest, VU University Medical Center, Amsterdam, The Netherlands
    Schizophr Res 126:237-44. 2011
    ....
  28. doi request reprint Neuroinflammation - an early event in both the history and pathogenesis of Alzheimer's disease
    Piet Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurodegener Dis 7:38-41. 2010
    ..Objectives: To show that the interest in inflammation in Alzheimer's disease (AD) is not only an early event in the history of AD but that inflammation is also an early event in the pathogenesis of AD...
  29. doi request reprint Systemic infection and delirium: when cytokines and acetylcholine collide
    Willem A van Gool
    Department of Neurology, Academic Medical Center, Amsterdam, Netherlands
    Lancet 375:773-5. 2010
    ..Agents that either restore cholinergic control of microglia or directly inhibit neuroinflammation warrant testing in clinical trials...
  30. doi request reprint Pre-operative inflammatory markers and the risk of postoperative delirium in elderly patients
    Afina W Lemstra
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    Int J Geriatr Psychiatry 23:943-8. 2008
    ..In light of the ageing/inflammation theory, we investigated the association of these markers with delirium in not acutely ill, elderly patients...
  31. pmc Preoperative cerebrospinal fluid cytokine levels and the risk of postoperative delirium in elderly hip fracture patients
    Dunja Westhoff
    Department of Neurology, Academic Medical Center University of Amsterdam, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    J Neuroinflammation 10:122. 2013
    ..We examined whether hip fracture patients who develop postoperative delirium have altered levels of inflammatory mediators in cerebrospinal fluid (CSF) prior to surgery...
  32. doi request reprint White matter hyperintensities and cognitive impairment during electroconvulsive therapy in severely depressed elderly patients
    Mardien L Oudega
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands EMGO Institute for Health and Care Research and VU University Medical Centre and GGZ in Geest, Amsterdam, The Netherlands Electronic address
    Am J Geriatr Psychiatry 22:157-66. 2014
    ..We hypothesized that both white matter hyperintensities and medial temporal lobe atrophy contribute to transient cognitive impairment during ECT...
  33. ncbi request reprint [Minority of elderly patients with schizophrenia in symptomatic remission]
    Paul D Meesters
    GGZ inGeest VUmc, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 156:A4701. 2012
    ..To investigate which percentage of elderly schizophrenia patients show remission of psychotic symptoms, and to determine which clinical and social characteristics are associated with this symptomatic remission...
  34. doi request reprint Neuroinflammation in delirium: a postmortem case-control study
    Barbara C van Munster
    Department of Internal Medicine, Academic Medical Center, University of Amsterdam, P O Box 22660, 1100 DD Amsterdam, The Netherlands
    Rejuvenation Res 14:615-22. 2011
    ..The purpose of this study was to investigate whether increased cerebral inflammation with microglial, astrocyte, and cytokine activation exists in patients with delirium compared to nondelirious patients...
  35. pmc Microglia activation in sepsis: a case-control study
    Afina W Lemstra
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    J Neuroinflammation 4:4. 2007
    ..The aim of this study was to investigate whether activation of microglia can be detected in patients who died of sepsis...
  36. doi request reprint Characteristics of dyshoric capillary cerebral amyloid angiopathy
    Edo Richard
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 69:1158-67. 2010
    ..These results suggest that capCAA is pathologically and possibly pathogenetically distinct from larger vessel CAA, and that it is associated with a high APOE-ε4 allele frequency...
  37. doi request reprint Association of vascular factors with apathy in community-dwelling elderly individuals
    Suzanne A Ligthart
    Department of General Practice, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arch Gen Psychiatry 69:636-42. 2012
    ..Apathy in community-dwelling elderly individuals has been associated with a history of stroke and other cardiovascular disease...
  38. doi request reprint White matter hyperintensities, medial temporal lobe atrophy, cortical atrophy, and response to electroconvulsive therapy in severely depressed elderly patients
    Mardien L Oudega
    Department of Psychiatry and Stichting Buitenamstel Geestgronden, VU University Medical Centre, AJ Ernststraat 887, 1081 HL Amsterdam, The Netherlands
    J Clin Psychiatry 72:104-12. 2011
    ..The respective value of these factors in response prediction is unclear...
  39. doi request reprint Social functioning among older community-dwelling patients with schizophrenia: a review
    Paul D Meesters
    GGZ inGeest, Amsterdam, The Netherlands
    Am J Geriatr Psychiatry 18:862-78. 2010
    ..Social support, impact of gender, and specific characteristics of older-old patients figure among areas that should be given priority in future research of social functioning in late life schizophrenia...
  40. ncbi request reprint The cholinergic deficiency syndrome and its therapeutic implications
    Afina W Lemstra
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Gerontology 49:55-60. 2003
    ..CDS is suggested to occur in various neurodegenerative diseases like Alzheimer's disease, Lewy body dementia and Parkinson's disease and to respond well to cholinesterase inhibitor therapy...
  41. ncbi request reprint Head trauma and Alzheimer's disease
    Rishi D S Nandoe
    Department of Neurology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    J Alzheimers Dis 4:303-8. 2002
    ..Extensive history taking disclosed no cognitive changes prior to the car accident. The case is discussed in view of the inflammation hypothesis regarding Alzheimer's disease and the role of the apolipoprotein E4 genotype of the patient...
  42. doi request reprint Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microglia in vitro
    Sandra D Mulder
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Glia 62:493-503. 2014
    ..Thus, targeting the association of Aβ with AAPs, such as ApoE and ApoJ, could serve as a therapeutic strategy to increase Aβ clearance by glial cells...
  43. pmc Steroid responsive encephalopathy in cerebral amyloid angiopathy: a case report and review of evidence for immunosuppressive treatment
    Raoul P Kloppenborg
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    J Neuroinflammation 7:18. 2010
    ..Immunosuppressive therapy appears to be an appropriate treatment for CAA encephalopathy...
  44. ncbi request reprint Microglia kill amyloid-beta1-42 damaged neurons by a CD14-dependent process
    Clive Bate
    Institute of Comparative Medicine, Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Neuroreport 15:1427-30. 2004
    ..These results indicate an important role for CD14 in the recognition and subsequent killing of amyloid-beta damaged neurons by microglia...
  45. ncbi request reprint How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes
    Imrich Blasko
    Department of Psychiatry, University Hospital of Innsbruck, Innsbruck, Austria
    Aging Cell 3:169-76. 2004
    ..A disturbed balance between the production and the degradation of A beta can trigger chronic inflammatory processes in microglial cells and astrocytes and thus initiate a vicious circle. This leads to a perpetuation of the disease...
  46. ncbi request reprint The pathological cascade of Alzheimer's disease: the role of inflammation and its therapeutic implications
    Jeroen J M Hoozemans
    Department of Pathology, Graduate School of Neurosciences Amsterdam, Research Institute Neurosciences Vrije Universiteit, VU University Medical Center, The Netherlands
    Drugs Today (Barc) 38:429-43. 2002
    ..This review will outline several pathological mechanisms in Alzheimer's disease as well as some means of therapeutic intervention following the amyloid cascade hypothesis...
  47. ncbi request reprint Neurones treated with cyclo-oxygenase-1 inhibitors are resistant to amyloid-beta1-42
    Clive Bate
    Institute of Comparative Medicine, Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Neuroreport 14:2099-103. 2003
    ..Although the production of neuronal prostaglandin E2 in response to amyloid-beta1-42 was reduced by the presence of COX-1 inhibitors, no neurotoxic effects of prostaglandin E2, or any other prostaglandin, were observed...
  48. ncbi request reprint Cyclin D1 and cyclin E are co-localized with cyclo-oxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortex
    Jeroen J M Hoozemans
    Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, Vrije Universiteit, Department of Pathology, VU University Medical Center, The Netherlands
    J Neuropathol Exp Neurol 61:678-88. 2002
    ..Our findings suggest a relationship between the neuronal expression of COX-2 and cell cycle markers, which may be involved early in AD pathology...