M C Zillikens

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12 and folic acid on fracture incidence
    Janneke P van Wijngaarden
    Department of Human Nutrition, Wageningen University, P, O, Box 8129 6700 EV Wageningen, The Netherlands
    BMC Geriatr 11:80. 2011
  2. doi request reprint Sex-specific genetic effects influence variation in body composition
    M C Zillikens
    Department of Internal Medicine, Erasmus Medical Centre, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Diabetologia 51:2233-41. 2008
  3. doi request reprint SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Free Radic Biol Med 46:836-41. 2009
  4. ncbi request reprint [A young woman with headaches and skull anomalies: a long road to the diagnosis 'Paget's disease']
    M C Zillikens
    Erasmus MC, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 150:2150-4. 2006
  5. doi request reprint Images in clinical medicine. Extracapsular hemorrhage from a parathyroid adenoma
    M Carola Zillikens
    Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    N Engl J Med 359:1155. 2008
  6. pmc SIRT1 genetic variation is related to BMI and risk of obesity
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes 58:2828-34. 2009
  7. pmc The role of body mass index, insulin, and adiponectin in the relation between fat distribution and bone mineral density
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Calcif Tissue Int 86:116-25. 2010
  8. doi request reprint Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index
    M Carola Zillikens
    Department of Internal Medicine, Room D428, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Am J Clin Nutr 91:1387-93. 2010
  9. doi request reprint Body composition by dual-energy X-ray absorptiometry in women with previous pre-eclampsia or small-for-gestational-age offspring
    A L Berends
    Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, University Medical Center, Rotterdam, The Netherlands
    BJOG 116:442-51. 2009
  10. doi request reprint The effect of thiazide and loop diuretics on urinary levels of free deoxypyridinoline: an osteoclastic bone-resorption marker
    R Ruiter
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
    J Clin Pharm Ther 38:225-9. 2013

Collaborators

Detail Information

Publications31

  1. pmc Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12 and folic acid on fracture incidence
    Janneke P van Wijngaarden
    Department of Human Nutrition, Wageningen University, P, O, Box 8129 6700 EV Wageningen, The Netherlands
    BMC Geriatr 11:80. 2011
    ....
  2. doi request reprint Sex-specific genetic effects influence variation in body composition
    M C Zillikens
    Department of Internal Medicine, Erasmus Medical Centre, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Diabetologia 51:2233-41. 2008
    ..Despite well-known sex differences in body composition it is not known whether sex-specific genetic or environmental effects contribute to these differences...
  3. doi request reprint SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Free Radic Biol Med 46:836-41. 2009
    ..Correction of niacin deficiency and SIRT1 modulators may prolong the life span of patients with diabetes...
  4. ncbi request reprint [A young woman with headaches and skull anomalies: a long road to the diagnosis 'Paget's disease']
    M C Zillikens
    Erasmus MC, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 150:2150-4. 2006
    ..Because Paget's disease has a relatively high prevalence in the elderly, it is important to know that it is not always recognised as such on MRI and that a simple X-ray can lead to the correct diagnosis...
  5. doi request reprint Images in clinical medicine. Extracapsular hemorrhage from a parathyroid adenoma
    M Carola Zillikens
    Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    N Engl J Med 359:1155. 2008
  6. pmc SIRT1 genetic variation is related to BMI and risk of obesity
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes 58:2828-34. 2009
    ..SIRT1 has pleiotropic metabolic functions. We investigated whether SIRT1 genetic variation is associated with obesity...
  7. pmc The role of body mass index, insulin, and adiponectin in the relation between fat distribution and bone mineral density
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Calcif Tissue Int 86:116-25. 2010
    ..Inverse associations after adjustment for BMI suggest that android fat deposition as measured by the WHR, WTR, and DXA-based android-to-gynoid fat ratio is not beneficial and possibly even deleterious for bone...
  8. doi request reprint Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index
    M Carola Zillikens
    Department of Internal Medicine, Room D428, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Am J Clin Nutr 91:1387-93. 2010
    ..Genetic variation in SIRT1 has been associated with body mass index (BMI) and risk of obesity. SIRT1 may be influenced by diet...
  9. doi request reprint Body composition by dual-energy X-ray absorptiometry in women with previous pre-eclampsia or small-for-gestational-age offspring
    A L Berends
    Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, University Medical Center, Rotterdam, The Netherlands
    BJOG 116:442-51. 2009
    ..To investigate differences in body composition and fat distribution between women with previous pre-eclampsia or small-for-gestational-age (SGA) offspring and those with uncomplicated pregnancies...
  10. doi request reprint The effect of thiazide and loop diuretics on urinary levels of free deoxypyridinoline: an osteoclastic bone-resorption marker
    R Ruiter
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
    J Clin Pharm Ther 38:225-9. 2013
    ..Deoxypyridinoline (DP) acts as a cross-link between adjacent collagen chains to provide structural rigidity. Our aim was to investigate the association between use of thiazides and loop diuretics and urinary levels FDP...
  11. pmc Insulin-resistance and metabolic syndrome are related to executive function in women in a large family-based study
    M Schuur
    Genetic Epidemiology Unit Ee2173, Department of Epidemiology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 25:561-8. 2010
    ..MetS and high HOMA-IR were associated with poorer executive function in women (P = 0.03 and P = 0.009). MetS and HOMA-IR are associated with poorer executive function in women...
  12. doi request reprint The association between plasma homocysteine levels, methylation capacity and incident osteoporotic fractures
    A W Enneman
    Erasmus MC, Department of Internal Medicine, Postbus 2040, 3000 CA Rotterdam, The Netherlands
    Bone 50:1401-5. 2012
    ....
  13. ncbi request reprint Heritability of the function and structure of the arterial wall: findings of the Erasmus Rucphen Family (ERF) study
    F A Sayed-Tabatabaei
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Postbus 1738, 3000 DR Rotterdam, The Netherlands
    Stroke 36:2351-6. 2005
    ....
  14. ncbi request reprint Heritability of fasting glucose levels in a young genetically isolated population
    R L P Santos
    Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus MC Rotterdam, P O Box 1738, 3000 DR, Rotterdam, The Netherlands
    Diabetologia 49:667-72. 2006
    ..We also studied the relationship between FPG and components of the metabolic syndrome...
  15. ncbi request reprint Measures of body composition and risk of heart failure in the elderly: the Rotterdam study
    M A W Van Lieshout
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Nutr Health Aging 15:393-7. 2011
    ..The incidence of heart failure increases with aging. Aim of the present study was to determine whether measures body composition predict incident heart failure in older adults...
  16. ncbi request reprint Heritability of serum iron, ferritin and transferrin saturation in a genetically isolated population, the Erasmus Rucphen Family (ERF) Study
    O T Njajou
    Genetic Epidemiology Unit, Departments of Epidemiology and Biostatistics and Clinical Genetics, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Hum Hered 61:222-8. 2006
    ..Mutations in the HFE gene are associated with an increase in serum iron parameters. The aim of this study was to estimate the heritability in serum iron parameters explained by HFE...
  17. ncbi request reprint Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction
    Stephanie C E Schuit
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    JAMA 291:2969-77. 2004
    ..Evidence suggests that genetic variations in the estrogen receptor alpha (ESR1) gene may influence IHD risk, but the role of common sequence variations in the ESR1 gene is unclear...
  18. ncbi request reprint Low dietary riboflavin but not folate predicts increased fracture risk in postmenopausal women homozygous for the MTHFR 677 T allele
    Nahid Yazdanpanah
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 23:86-94. 2008
    ..We found that the MTHFR C677T variant interacts with dietary riboflavin intake to influence fracture risk in women...
  19. pmc The -1997 G/T and Sp1 polymorphisms in the collagen type I alpha1 (COLIA1) gene in relation to changes in femoral neck bone mineral density and the risk of fracture in the elderly: the Rotterdam study
    Nahid Yazdanpanah
    Netherlands Institute for Health Science, Rotterdam, The Netherlands
    Calcif Tissue Int 81:18-25. 2007
    ..7, P = 0.001). We confirm that the COLIA1 Sp1 polymorphism influences BMD and the risk of fracture in postmenopausal Caucasian women. In contrast, we found no independent effect of the -1997 G/T promoter polymorphism on BMD or fracture...
  20. ncbi request reprint Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women
    Fernando Rivadeneira
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 21:1443-56. 2006
    ..Interaction of ESR2 with ESR1 and IGF1 was determined and revealed a deleterious genetic combination that enhances the risk of osteoporotic fracture...
  21. ncbi request reprint Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women
    Stephanie C E Schuit
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Endocrinol 153:327-34. 2005
    ..It has been suggested that the estrogen receptor alpha (ESR1) gene may influence peripheral E(2) levels, but the role of common sequence variations in the ESR1 gene is unclear...
  22. doi request reprint Low bone mass in Pompe disease: muscular strength as a predictor of bone mineral density
    Linda E M van den Berg
    Department of Pediatrics, Division of Metabolic Diseases and Genetics, Center for Lysosomal and Metabolic Diseases, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Bone 47:643-9. 2010
    ..The introduction of enzyme replacement therapy as treatment for the disease may change prospects for patients and may require that more attention be paid to co-morbidities such as osteoporosis...
  23. ncbi request reprint Femoral neck BMD is a strong predictor of hip fracture susceptibility in elderly men and women because it detects cortical bone instability: the Rotterdam Study
    Fernando Rivadeneira
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 22:1781-90. 2007
    ..Cortical instability (propensity of thinner cortices in wide diameters to buckle) explains why hip fracture risk at different BMD levels is the same across sexes...
  24. pmc Genetic architecture of plasma adiponectin overlaps with the genetics of metabolic syndrome-related traits
    Peter Henneman
    Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes Care 33:908-13. 2010
    ....
  25. doi request reprint 5-HIAA excretion is not associated with bone metabolism in carcinoid syndrome patients
    S C van Dijk
    Department of Internal Medicine, Sector of Endocrinology, Erasmus MC, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Bone 50:1260-5. 2012
    ..In conclusion, the current study in a unique group of untreated carcinoid patients could not demonstrate a major role for circulating serotonin in the control of bone metabolism...
  26. pmc An RBP4 promoter polymorphism increases risk of type 2 diabetes
    M van Hoek
    Department of Internal Medicine, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Diabetologia 51:1423-8. 2008
    ..We hypothesised that the RBP4 -803GA polymorphism increases type 2 diabetes risk at a population-based level. In addition, information on retinol intake and plasma vitamin A levels enabled us to explore the possible underlying mechanism...
  27. pmc Association between type 2 diabetes loci and measures of fatness
    Slavica Pecioska
    Department of Epidemiology and Biostatistics and Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 5:e8541. 2010
    ..Our aim was to evaluate whether the recently identified T2D risk alleles are associated with human measures of fatness as characterized with Dual Energy X-ray Absorptiometry (DEXA)...
  28. ncbi request reprint Effect of dietary B vitamins on BMD and risk of fracture in elderly men and women: the Rotterdam study
    Nahid Yazdanpanah
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Bone 41:987-94. 2007
    ..These findings highlight the importance of considering nutritional factors in epidemiological studies of osteoporosis and fractures...
  29. pmc Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
    Fernando Rivadeneira
    Department of Internal Medicine, Rotterdam, The Netherlands
    Nat Genet 41:1199-206. 2009
    ..The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD...
  30. ncbi request reprint Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes
    Marie Josee E van Rijn
    Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Hypertens 25:565-70. 2007
    ..To study the heritability of four blood pressure traits and the proportion of variance explained by four blood-pressure-related genes...
  31. pmc Heritabilities, apolipoprotein E, and effects of inbreeding on plasma lipids in a genetically isolated population: the Erasmus Rucphen Family Study
    Aaron Isaacs
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Postbus 1738, 3000 DR Rotterdam, The Netherlands
    Eur J Epidemiol 22:99-105. 2007
    ..02 and p (trend) = 0.05, respectively). These data provide estimates of lipid heritability unbiased due to selection and suggest that this population represents a good opportunity to localize novel genes influencing plasma lipid levels...