Rob Willemsen

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Characterisation of Fmrp in zebrafish: evolutionary dynamics of the fmr1 gene
    Sandra van 't Padje
    Department of Clinical Genetics, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Dev Genes Evol 215:198-206. 2005
  2. pmc Generation and characterization of FMR1 knockout zebrafish
    Marjo J den Broeder
    Hubrecht Institute, Royal Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 4:e7910. 2009
  3. ncbi request reprint The fragile X syndrome: from molecular genetics to neurobiology
    Rob Willemsen
    CBG Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    Ment Retard Dev Disabil Res Rev 10:60-7. 2004
  4. ncbi request reprint FXTAS: a progressive neurologic syndrome associated with Fragile X premutation
    Rob Willemsen
    Department of Clinical Genetics, Erasmus MC, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Curr Neurol Neurosci Rep 5:405-10. 2005
  5. ncbi request reprint Transport kinetics of FMRP containing the I304N mutation of severe fragile X syndrome in neurites of living rat PC12 cells
    Mariette Schrier
    Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    Exp Neurol 189:343-53. 2004
  6. pmc Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons
    Josien Levenga
    CBG Department of Clinical Genetics, Erasmus MC, Dr Molewaterplein 50, 3015 GE, P O Box 2040, Rotterdam 3000 CA, The Netherlands
    Neurobiol Dis 35:241-50. 2009
  7. ncbi request reprint Reduction in fragile X related 1 protein causes cardiomyopathy and muscular dystrophy in zebrafish
    Sandra Van't Padje
    CBG Department of Clinical Genetics, Erasmus MC, 3015 CE Rotterdam, The Netherlands
    J Exp Biol 212:2564-70. 2009
  8. doi request reprint The clinical and pathological phenotype of C9ORF72 hexanucleotide repeat expansions
    Javier Simon-Sanchez
    Department of Clinical Genetics, VU University Medical Centre, 1007 MB Amsterdam, The Netherlands
    Brain 135:723-35. 2012
  9. ncbi request reprint Prospects of TAT-mediated protein therapy for fragile X syndrome
    Surya A Reis
    CBG Department of Clinical Genetics, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    J Mol Histol 35:389-95. 2004
  10. doi request reprint FBXO7 immunoreactivity in α-synuclein-containing inclusions in Parkinson disease and multiple system atrophy
    Tianna Zhao
    Departments of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    J Neuropathol Exp Neurol 72:482-8. 2013

Detail Information

Publications54

  1. ncbi request reprint Characterisation of Fmrp in zebrafish: evolutionary dynamics of the fmr1 gene
    Sandra van 't Padje
    Department of Clinical Genetics, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Dev Genes Evol 215:198-206. 2005
    ....
  2. pmc Generation and characterization of FMR1 knockout zebrafish
    Marjo J den Broeder
    Hubrecht Institute, Royal Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 4:e7910. 2009
    ..Importantly, a true genetic zebrafish model is now available which can be used to study FXS and to derive potential drugs for FXS treatment...
  3. ncbi request reprint The fragile X syndrome: from molecular genetics to neurobiology
    Rob Willemsen
    CBG Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    Ment Retard Dev Disabil Res Rev 10:60-7. 2004
    ..This review highlights the role of FMRP in dendritic mRNA transport/translation in relation to synaptic plasticity, a molecular mechanism implicated in learning and memory...
  4. ncbi request reprint FXTAS: a progressive neurologic syndrome associated with Fragile X premutation
    Rob Willemsen
    Department of Clinical Genetics, Erasmus MC, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Curr Neurol Neurosci Rep 5:405-10. 2005
    ..This review discusses recent developments in the clinical phenotype, prevalence and screening, animal models, and molecular mechanisms of RNA-based pathogenesis in FXTAS...
  5. ncbi request reprint Transport kinetics of FMRP containing the I304N mutation of severe fragile X syndrome in neurites of living rat PC12 cells
    Mariette Schrier
    Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    Exp Neurol 189:343-53. 2004
    ....
  6. pmc Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons
    Josien Levenga
    CBG Department of Clinical Genetics, Erasmus MC, Dr Molewaterplein 50, 3015 GE, P O Box 2040, Rotterdam 3000 CA, The Netherlands
    Neurobiol Dis 35:241-50. 2009
    ..In conclusion, we show that wild-type FMRP and FXR2P are able to recruit FMRP variants into RNA-granules and that the G-quartet-structure in FMR1 mRNA is not essential for its incorporation in RNA-granules...
  7. ncbi request reprint Reduction in fragile X related 1 protein causes cardiomyopathy and muscular dystrophy in zebrafish
    Sandra Van't Padje
    CBG Department of Clinical Genetics, Erasmus MC, 3015 CE Rotterdam, The Netherlands
    J Exp Biol 212:2564-70. 2009
    ..This cardiac phenotype has not been previously described and suggests that fxr1 is essential for normal cardiac form and function...
  8. doi request reprint The clinical and pathological phenotype of C9ORF72 hexanucleotide repeat expansions
    Javier Simon-Sanchez
    Department of Clinical Genetics, VU University Medical Centre, 1007 MB Amsterdam, The Netherlands
    Brain 135:723-35. 2012
    ..Neuropathological hallmarks include neuronal and glial inclusions, and dystrophic neurites containing transactive response DNA binding protein. Future studies are needed to explain the wide variation in clinical presentation...
  9. ncbi request reprint Prospects of TAT-mediated protein therapy for fragile X syndrome
    Surya A Reis
    CBG Department of Clinical Genetics, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    J Mol Histol 35:389-95. 2004
    ..However, uptake efficiency and velocity was lower than expected. Neuronal uptake was highly inefficient and the fusion protein demonstrated toxicity...
  10. doi request reprint FBXO7 immunoreactivity in α-synuclein-containing inclusions in Parkinson disease and multiple system atrophy
    Tianna Zhao
    Departments of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    J Neuropathol Exp Neurol 72:482-8. 2013
    ..By contrast, weak FBXO7 immunoreactivity was occasionally detected in tau-positive inclusions in AD and PSP. These findings suggest a role for FBXO7 in the pathogenesis of the synucleinopathies...
  11. pmc Dopaminergic neuronal loss and dopamine-dependent locomotor defects in Fbxo7-deficient zebrafish
    Tianna Zhao
    Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 7:e48911. 2012
    ....
  12. pmc Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice
    Femke M S de Vrij
    Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    Neurobiol Dis 31:127-32. 2008
    ..Moreover, we show for the first time a structural rescue of Fragile X related protrusion morphology with two independent mGluR5 antagonists...
  13. doi request reprint Caldesmon is essential for cardiac morphogenesis and function: in vivo study using a zebrafish model
    Ping Pin Zheng
    Department of Pathology, Erasmus Medical Center, JNI Room 230 c, Dr Molewaterplein 50, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Biochem Biophys Res Commun 378:37-40. 2009
    ..Because caldesmon expression remarkably influences cardiac muscularization, the findings are relevant for designing future therapeutic strategies in the regeneration of cardiac damage...
  14. ncbi request reprint The FMR1 CGG repeat mouse displays ubiquitin-positive intranuclear neuronal inclusions; implications for the cerebellar tremor/ataxia syndrome
    Rob Willemsen
    CBG Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    Hum Mol Genet 12:949-59. 2003
    ..This mouse model will facilitate the possibilities to perform studies at the molecular level from onset of symptoms until the final stage of the disease...
  15. ncbi request reprint The DeltaK280 mutation in MAP tau favors exon 10 skipping in vivo
    John C van Swieten
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neuropathol Exp Neurol 66:17-25. 2007
    ..These observations confirm the postulated hypothesis that the DeltaK280 mutation abolishes a splice enhancer element, which overrules the decreased microtubule binding and enhanced self-aggregation...
  16. ncbi request reprint Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo
    Edwin J Mientjes
    Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands
    Hum Mol Genet 13:1291-302. 2004
    ..The results presented here point towards a role for Fxr1p in muscle mRNA transport/translation control similar to that seen for Fmrp in neuronal cells...
  17. doi request reprint AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome
    Josien Levenga
    Department of Clinical Genetics, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Neurobiol Dis 42:311-7. 2011
    ..These results suggest that AFQ056 might be a potent mGluR5 antagonist to rescue various aspects of the fragile X phenotype...
  18. pmc NPHP4 variants are associated with pleiotropic heart malformations
    Vanessa M French
    Department of Clinical Genetics, Erasmus MC Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Circ Res 110:1564-74. 2012
    ..Failure to establish normal left-right (L-R) asymmetry often results in cardiovascular malformations and other laterality defects of visceral organs...
  19. doi request reprint Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice
    Josien Levenga
    CBG Department of Clinical Genetics, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Neurobiol Learn Mem 95:467-72. 2011
    ..Our results show a hippocampal CA1-specific altered protrusion phenotype, which was absent in the CA3 region of the hippocampus. This suggests a subregion-specific function of FMRP in synaptic plasticity in the brain...
  20. ncbi request reprint A fragile balance: FMR1 expression levels
    Ben A Oostra
    Department of Clinical Genetics, Erasmus MC, The Netherlands
    Hum Mol Genet 12:R249-57. 2003
    ..The level of FMR1 mRNA is in fragile balance and is therefore critical for normal functioning...
  21. doi request reprint Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant
    Andreea S Pop
    CBG Department of Clinical Genetics, Erasmus Medical Centre, Dr Molewaterplein 55, 3015GE, Rotterdam, The Netherlands
    Psychopharmacology (Berl) 231:1227-35. 2014
    ..This finding suggests that long-term treatment at later stage is sufficient to reverse the structural spine abnormalities and represents a starting point for future studies aimed at improving treatments for FXS...
  22. ncbi request reprint Timing of the absence of FMR1 expression in full mutation chorionic villi
    Rob Willemsen
    CBG Department of Clinical Genetics, Erasmus University, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Hum Genet 110:601-5. 2002
    ..In addition, our results indicate that the timing of both X-inactivation and full mutation FMR1 allele inactivation is different, i.e. X-inactivation occurs earlier in development than inactivation of the full mutation...
  23. pmc Transport of fragile X mental retardation protein via granules in neurites of PC12 cells
    Yolanda De Diego Otero
    CBG Department of Clinical Genetics Department of Endocrinology and Reproduction, Erasmus University, Rotterdam, The Netherlands
    Mol Cell Biol 22:8332-41. 2002
    ..This report is the first example of trafficking of RNA-containing granules with FMRP as a core constituent in living PC12 cells...
  24. ncbi request reprint The DNA repair-ubiquitin-associated HR23 proteins are constituents of neuronal inclusions in specific neurodegenerative disorders without hampering DNA repair
    Steven Bergink
    MGC CBG Department of Cell Biology and Genetics, Erasmus MC, P O Box 1738, 3000DR, Rotterdam, The Netherlands
    Neurobiol Dis 23:708-16. 2006
    ..This illustrates that impairment of the ubiquitin-proteasome system (UPS) by expanded glutamine repeats, including the sequestration of HR23B, is not affecting NER...
  25. pmc Loss of nuclear activity of the FBXO7 protein in patients with parkinsonian-pyramidal syndrome (PARK15)
    Tianna Zhao
    Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 6:e16983. 2011
    ..The activity of FBXO7 in the nucleus appears therefore crucial for the maintenance of brain neurons and the pathogenesis of PARK15...
  26. pmc CGG-repeat length and neuropathological and molecular correlates in a mouse model for fragile X-associated tremor/ataxia syndrome
    Judith R Brouwer
    Department of Clinical Genetics, Erasmus MC Rotterdam, GE Rotterdam, The Netherlands
    J Neurochem 107:1671-82. 2008
    ..Contrary to existing hypotheses, our results suggest that inclusion formation may not depend on the elevation per se of Fmr1 transcript levels in aged CGG mice...
  27. pmc FMR1: a gene with three faces
    Ben A Oostra
    Department of Clinical Genetics, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Biochim Biophys Acta 1790:467-77. 2009
    ..The presence of elevated FMR1 mRNA in FXTAS suggests that FXTAS may represent a toxic RNA gain-of-function effect. The molecular basis of POI is yet unknown. The role of the FMR1 gene in these disorders is discussed...
  28. ncbi request reprint TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without Progranulin mutations
    Harro Seelaar
    Department of Neurology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Brain 130:1375-85. 2007
    ..NII are also found in some cases of familial FTD + MND without Progranulin mutations. The observation of glial TDP-43 positive inclusions in one brain is very interesting, although their pathophysiological significance is yet unknown...
  29. doi request reprint HeNe laser (633 nm)-coupled confocal microscope allows simulating magnetic resonance imaging/computed tomography scan of the brain and eye: a noninvasive optical approach applicable to small laboratory animals
    Ping Pin Zheng
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    Zebrafish 8:83-5. 2011
    ..It represents a noninvasive imaging method with high resolution while not requiring contrast agents, enabling the detection of differential signals from normal and pathological organs such as brain and eye...
  30. doi request reprint Microsatellite repeat instability and neurological disease
    Judith R Brouwer
    Department of Clinical Genetics, ErasmusMC, Rotterdam, The Netherlands
    Bioessays 31:71-83. 2009
    ..Finally, the question of why the often harmful unstable repeats have been maintained throughout evolution is addressed...
  31. ncbi request reprint Characterization of Fxr1 in Danio rerio; a simple vertebrate model to study costamere development
    Bart Engels
    Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    J Exp Biol 207:3329-38. 2004
    ....
  32. pmc Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease
    Marialuisa Quadri
    Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    Am J Hum Genet 90:467-77. 2012
    ..This work has broad implications for understanding of the manganese biology and pathophysiology in multiple human organs...
  33. doi request reprint Glut1/SLC2A1 is crucial for the development of the blood-brain barrier in vivo
    Ping Pin Zheng
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ann Neurol 68:835-44. 2010
    ..To date, there is no information on the role of Glut1 during the development of BBB. In the present study, the in vivo effects of Glut1 knockdown on the cerebral vascular development were investigated...
  34. ncbi request reprint Fragile X syndrome, the Fragile X related proteins, and animal models
    Andre T Hoogeveen
    Department of Clinical Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands
    Microsc Res Tech 57:148-55. 2002
    ..Phenotypic features of the FMR1 knockout mouse, the FMR1 transgenic rescue mouse, and other novel strategies for manipulating and delivering FMRP and FXRPs to the brain and other tissues are described...
  35. doi request reprint A crucial role of caldesmon in vascular development in vivo
    Ping Pin Zheng
    Department of Pathology, Erasmus Medical Center, JNI Room 230 c, Dr Molewaterplein 50, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Cardiovasc Res 81:362-9. 2009
    ..We explored the in vivo effects of knockdown of caldesmon on vascular development in zebrafish...
  36. pmc Potential therapeutic interventions for fragile X syndrome
    Josien Levenga
    CBG Department of Clinical Genetics, Erasmus MC, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Trends Mol Med 16:516-27. 2010
    ....
  37. pmc Cd1d-dependent regulation of bacterial colonization in the intestine of mice
    Edward E S Nieuwenhuis
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 119:1241-50. 2009
    ..Together, these data support a role for Cd1d in regulating intestinal colonization through mechanisms that include the control of Paneth cell function...
  38. doi request reprint Oxazolone-induced enterocolitis in zebrafish depends on the composition of the intestinal microbiota
    Sylvia Brugman
    Laboratory of Pediatrics, Pediatric Gastroenterology, Erasmus Medical Center, Rotterdam, The Netherlands
    Gastroenterology 137:1757-67.e1. 2009
    ..Interactions between host cells and bacteria are complicated, making it a challenge to assess their relative contribution to intestinal pathology. We developed a zebrafish model of enterocolitis to study these interactions...
  39. doi request reprint Haemoglobin staining for in vivo portraying of functional vasculature in experimental zebrafish embryos
    Ping Pin Zheng
    Department of Pathology, Erasmus Medical Center, Office JNI Room 230 c, Dr Molewaterplein 50, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Biochem Biophys Res Commun 380:823-4. 2009
    ..We conclude that Hb staining offers an informative and rapid method for in vivo portraying of functional vasculature in experimental zebrafish embryos. It is also suitable for large scale experiments...
  40. ncbi request reprint A novel tau mutation, S320F, causes a tauopathy with inclusions similar to those in Pick's disease
    Sonia M Rosso
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ann Neurol 51:373-6. 2002
    ..Recombinant tau protein with the S320F mutation showed a greatly reduced ability to promote microtubule assembly...
  41. ncbi request reprint Knockout mouse model for Fxr2: a model for mental retardation
    Carola J M Bontekoe
    CBG Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands
    Hum Mol Genet 11:487-98. 2002
    ..The findings implicate a role for Fxr2 in central nervous system function...
  42. ncbi request reprint Variable phenotypic expression and extensive tau pathology in two families with the novel tau mutation L315R
    Esther van Herpen
    Department of Clinical Genetics, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Ann Neurol 54:573-81. 2003
    ..All six tau isoforms were present in soluble brain tau. Recombinant tau proteins with the L315R mutation showed a reduced ability to promote microtubule assembly...
  43. doi request reprint Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis
    Ingrid M B H van de Laar
    Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 43:121-6. 2011
    ..Our findings endorse the TGF-β pathway as the primary pharmacological target for the development of new treatments for aortic aneurysms and osteoarthritis...
  44. ncbi request reprint Dauer pheromone and G-protein signaling modulate the coordination of intraflagellar transport kinesin motor proteins in C. elegans
    Jan Burghoorn
    Department of Cell Biology and Genetics, Erasmus MC, Rotterdam, The Netherlands
    J Cell Sci 123:2077-84. 2010
    ..We propose a model in which GPA-3-regulated docking of kinesin-II and/or OSM-3 determines entry of IFT particles into the cilia subdomains, allowing structural and functional plasticity of cilia in response to environmental cues...
  45. ncbi request reprint Proteomic analysis of exosomes isolated from human malignant pleural effusions
    Martin P Bard
    Department of Pulmonary Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Respir Cell Mol Biol 31:114-21. 2004
    ..However, pleural fluid proteins and especially immunoglobulins are coisolated and may hamper the use of exosomes isolated from malignant effusion for immunotherapy programs...
  46. ncbi request reprint NUFIP1 (nuclear FMRP interacting protein 1) is a nucleocytoplasmic shuttling protein associated with active synaptoneurosomes
    Barbara Bardoni
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 10142, 67404 Illkirch, C U de Strasbourg, France
    Exp Cell Res 289:95-107. 2003
    ..These findings suggest the involvement of NUFIP1 in the export and localization of mRNA and, in association with FMRP, in the regulation of local protein synthesis near synapses...
  47. ncbi request reprint Fragile X syndrome phenotype with normal FMR1 gene studies
    Nigel F Clarke
    Am J Med Genet A 129:326-8. 2004
  48. ncbi request reprint Clinical features of boys with fragile X premutations and intermediate alleles
    Monica Aziz
    Child Mental Health Learning Disability Service, South West London and St George s Mental Health NHS Trust, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 121:119-27. 2003
    ..Replication on larger independent samples is required to confirm our impression that fragile X premutations and intermediate alleles may be associated with important developmental disabilities and physical features...
  49. pmc Mutation of the MAP kinase DYF-5 affects docking and undocking of kinesin-2 motors and reduces their speed in the cilia of Caenorhabditis elegans
    Jan Burghoorn
    Department of Cell Biology and Genetics, and Center for Biomedical Genetics, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 104:7157-62. 2007
    ..We propose that DYF-5 plays a role in the undocking of kinesin II from IFT particles and in the docking of OSM-3 onto IFT particles...
  50. ncbi request reprint Expression profiling suggests underexpression of the GABA(A) receptor subunit delta in the fragile X knockout mouse model
    Ilse Gantois
    Department of Medical Genetics, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    Neurobiol Dis 21:346-57. 2006
    ..We consider their differential expression as provisional. It is possible that these differentially expressed genes play an important role in the cognitive and behavioral problems observed in the fragile X syndrome...
  51. ncbi request reprint The severe G480C cystic fibrosis mutation, when replicated in the mouse, demonstrates mistrafficking, normal survival and organ-specific bioelectrics
    Paul Dickinson
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Hum Mol Genet 11:243-51. 2002
    ....
  52. ncbi request reprint Two members of the Fxr gene family, Fmr1 and Fxr1, are differentially expressed in Xenopus tropicalis
    Lau Blonden
    CBG Dept of Clinical Genetics, Erasmus MC Rotterdam, The Netherlands
    Int J Dev Biol 49:437-41. 2005
    ..Thus, for in vivo gene function studies, this relative simple animal model may serve as a highly advantageous and complementary model...
  53. ncbi request reprint Timing and sequence of differentiation of embryonic rat hepatocytes along the biliary epithelial lineage
    Robbert G E Notenboom
    AMC Liver Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Hepatology 38:683-91. 2003
    ....
  54. ncbi request reprint Cognitive decline, neuromotor and behavioural disturbances in a mouse model for fragile-X-associated tremor/ataxia syndrome (FXTAS)
    Debby Van Dam
    Laboratory of Neurochemistry and Behaviour, Institute Born Bunge, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Behav Brain Res 162:233-9. 2005
    ..The age-dependent cognitive decline and neuromotor disturbances may be related to the progressive cognitive and behavioural difficulties observed in FXTAS patients...