E D Wildschut

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi request reprint Effect of hypothermia and extracorporeal life support on drug disposition in neonates
    Enno D Wildschut
    Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Semin Fetal Neonatal Med 18:23-7. 2013
  2. pmc The impact of extracorporeal life support and hypothermia on drug disposition in critically ill infants and children
    Enno D Wildschut
    Department of Pediatric Surgery, Intensive Care, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Pediatr Clin North Am 59:1183-204. 2012
  3. ncbi request reprint Pharmacotherapy in neonatal and pediatric extracorporeal membrane oxygenation (ECMO)
    E D Wildschut
    Intensive Care Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3000 CB Rotterdam, The Netherlands
    Curr Drug Metab 13:767-77. 2012
  4. ncbi request reprint Challenges in non-neonatal extracorporeal membrane oxygenation
    R J Houmes
    Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children s Hospital Rotterdam, The Netherlands
    Minerva Pediatr 64:439-45. 2012
  5. pmc An exploratory study with an adaptive continuous intravenous furosemide regimen in neonates treated with extracorporeal membrane oxygenation
    Maria M J van der Vorst
    Centre for Human Drug Research, Leiden, The Netherlands
    Crit Care 11:R111. 2007
  6. pmc Evaluation of furosemide regimens in neonates treated with extracorporeal membrane oxygenation
    Maria M J van der Vorst
    Department of Paediatrics, University of Kuwait, Safat, Kuwait
    Crit Care 10:R168. 2006
  7. pmc Haemofiltration in newborns treated with extracorporeal membrane oxygenation: a case-comparison study
    Karin Blijdorp
    Department of Intensive Care, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Crit Care 13:R48. 2009
  8. pmc Determinants of drug absorption in different ECMO circuits
    E D Wildschut
    Intensive Care and Department of Paediatric Surgery, Sophia Children s Hospital, Erasmus MC, Dr Molewaterplein 60, 3000 CB, Rotterdam, The Netherlands
    Intensive Care Med 36:2109-16. 2010
  9. pmc Feasibility of sedation and analgesia interruption following cannulation in neonates on extracorporeal membrane oxygenation
    E D Wildschut
    Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3000 CB, Rotterdam, The Netherlands
    Intensive Care Med 36:1587-91. 2010
  10. ncbi request reprint The Impact of Hypothermia on the Pharmacokinetics of Drugs Used in Neonates and Young Infants
    P Pokorna
    Intensive Care and Dept of Pediatric Surgery, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ The Netherlands
    Curr Pharm Des 21:5705-24. 2015

Collaborators

  • D Tibboel
  • Saskia N de Wildt
  • K Allegaert
  • P Pokorna
  • R J Houmes
  • Maria M J van der Vorst
  • E A Buijs
  • V Vobruba
  • Karin Blijdorp
  • Saskia J Gischler
  • Jacobus Burggraaf
  • John N van den Anker
  • I K Reiss
  • D Rizopoulos
  • C Ince
  • U Kraemer
  • I Reiss
  • Robert Jan Houmes
  • Karlien Cransberg
  • Eric D Wolff
  • Jan Den Hartigh
  • Robbert J Houmes
  • Joana E Kist-van Holthe
  • Albert J Van Der Heijden

Detail Information

Publications11

  1. doi request reprint Effect of hypothermia and extracorporeal life support on drug disposition in neonates
    Enno D Wildschut
    Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Semin Fetal Neonatal Med 18:23-7. 2013
    ..However, little is known about the combined effects of these treatment modalities. This review will explore the available literature, identify possible changes in pharmacokinetics and make suggestions for future research directions...
  2. pmc The impact of extracorporeal life support and hypothermia on drug disposition in critically ill infants and children
    Enno D Wildschut
    Department of Pediatric Surgery, Intensive Care, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Pediatr Clin North Am 59:1183-204. 2012
    ..By combining data from pharmacokinetic studies in children on ECMO and CPB and during hypothermia, this review elucidates the possible effects of hypothermia during ECMO on drug disposition...
  3. ncbi request reprint Pharmacotherapy in neonatal and pediatric extracorporeal membrane oxygenation (ECMO)
    E D Wildschut
    Intensive Care Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3000 CB Rotterdam, The Netherlands
    Curr Drug Metab 13:767-77. 2012
    ..This article gives an overview of the available PK and PD studies in neonates and children on ECMO, suggests possible mechanisms of altered PK and PD and identifies areas of interest for further research...
  4. ncbi request reprint Challenges in non-neonatal extracorporeal membrane oxygenation
    R J Houmes
    Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children s Hospital Rotterdam, The Netherlands
    Minerva Pediatr 64:439-45. 2012
    ..Furthermore we will try to define optimal treatment goals, identify primary outcome parameters and calculate the expected need for non-neonatal ECMO per 1.000.000 inhabitants...
  5. pmc An exploratory study with an adaptive continuous intravenous furosemide regimen in neonates treated with extracorporeal membrane oxygenation
    Maria M J van der Vorst
    Centre for Human Drug Research, Leiden, The Netherlands
    Crit Care 11:R111. 2007
    ..The objective of the present study was to explore a continuous intravenous furosemide regimen that adapts to urine output in neonates treated with extracorporeal membrane oxygenation (ECMO)...
  6. pmc Evaluation of furosemide regimens in neonates treated with extracorporeal membrane oxygenation
    Maria M J van der Vorst
    Department of Paediatrics, University of Kuwait, Safat, Kuwait
    Crit Care 10:R168. 2006
    ..Because ECMO and CPB are 'comparable' procedures, continuous furosemide infusion is used in newborns on ECMO. We report on the use of continuous intravenous furosemide in neonates treated with ECMO...
  7. pmc Haemofiltration in newborns treated with extracorporeal membrane oxygenation: a case-comparison study
    Karin Blijdorp
    Department of Intensive Care, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Crit Care 13:R48. 2009
    ..The current study aimed at comparing clinical outcomes of newborns on extracorporeal membrane oxygenation with and without continuous haemofiltration...
  8. pmc Determinants of drug absorption in different ECMO circuits
    E D Wildschut
    Intensive Care and Department of Paediatric Surgery, Sophia Children s Hospital, Erasmus MC, Dr Molewaterplein 60, 3000 CB, Rotterdam, The Netherlands
    Intensive Care Med 36:2109-16. 2010
    ..The aim of this in vitro study was to evaluate potential determinants of drug loss in different ECMO circuits...
  9. pmc Feasibility of sedation and analgesia interruption following cannulation in neonates on extracorporeal membrane oxygenation
    E D Wildschut
    Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3000 CB, Rotterdam, The Netherlands
    Intensive Care Med 36:1587-91. 2010
    ..In ventilated adults not on ECMO, daily sedation interruption protocols improve short- and long-term outcome. This study aims to evaluate safety and feasibility of sedation interruption following cannulation in neonates on ECMO...
  10. ncbi request reprint The Impact of Hypothermia on the Pharmacokinetics of Drugs Used in Neonates and Young Infants
    P Pokorna
    Intensive Care and Dept of Pediatric Surgery, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ The Netherlands
    Curr Pharm Des 21:5705-24. 2015
    ..Ultimately, these investigations are warranted to obtain specific dosing nomograms of medicines for use in clinical practice and to improve the treatment results of this vulnerable group of pediatric patients. ..
  11. ncbi request reprint Arterial lactate for predicting mortality in children requiring extracorporeal membrane oxygenation
    E A Buijs
    Intensive Care and Department of Pediatric Surgery, Erasmus MC, Sophia Children s Hospital, Rotterdam, The Netherlands
    Minerva Anestesiol 80:1282-93. 2014
    ..The current study evaluates whether this also applies to children with primary respiratory disease requiring extracorporeal membrane oxygenation (ECMO)...