Research Topics
Species | Tonya WhiteSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
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Publications
White matter 'potholes' in early-onset schizophrenia: a new approach to evaluate white matter microstructure using diffusion tensor imagingTonya White
Division of Child and Adolescent Psychiatry, F256 2B, University of Minnesota, Fairview University Medical Center, 2450 Riverside Avenue, Minneapolis, MN 55454, United States
Psychiatry Res 174:110-5. 2009..This algorithm may be also be well suited to detect white matter abnormalities in disorders such as substance abuse, head trauma, or specific neurological conditions affecting white matter...
Verbal and visuospatial working memory development and deficits in children and adolescents with schizophreniaTonya White
Department of Psychiatry, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA
Early Interv Psychiatry 4:305-13. 2010..Differences in the developmental trajectories in patients compared with controls may reflect differential effects within specific neural networks involved in working memory performance...
Brain connectivity and gyrification as endophenotypes for schizophrenia: weight of the evidenceT White
Department of Child and Adolescent Psychiatry, Erasmus Medical Centre, Rotterdam, Netherlands
Curr Top Med Chem 12:2393-403. 2012..Thus, the goal of this paper is to conduct a critical review of the evidence linking both structural and functional connectivity as an endophenotype for schizophrenia...- Pediatric population-based neuroimaging and the Generation R Study: the intersection of developmental neuroscience and epidemiologyTonya White
Department of Child and Adolescent Psychiatry, Erasmus Medical Centre Sophia, Kamer SP 2869, Postbus 2060, 3000 CB Rotterdam, The Netherlands
Eur J Epidemiol 28:99-111. 2013..The infusion of imaging into the Generation R Study will set the stage for evaluating the role of multiple environmental and genetic factors in both typical and atypical neurodevelopment... - Evidence for intact local connectivity but disrupted regional function in the occipital lobe in children and adolescents with schizophreniaTonya White
Department of Child and Adolescent Psychiatry, Erasmus Medical Centre, Rotterdam, Netherlands
Hum Brain Mapp 33:1803-11. 2012..These results are consistent with abnormalities in regional connectivity with preserved local connectivity in early-onset schizophrenia... - Gyrification and neural connectivity in schizophreniaTonya White
Erasmus Medical Centre, Rotterdam, The Netherlands
Dev Psychopathol 23:339-52. 2011..This altered form may provide helpful clues in understanding the neurobiological abnormalities associated with schizophrenia... - Increased anterior cingulate and temporal lobe activity during visuospatial working memory in children and adolescents with schizophreniaTonya White
Department of Child and Adolescent Psychiatry, Erasmus University Medical Center Sophia, Rotterdam, The Netherlands
Schizophr Res 125:118-28. 2011..The goal of this study was to evaluate the functional neurobiology of WkM in patients with EOS... - Disrupted functional brain connectivity during verbal working memory in children and adolescents with schizophreniaTonya White
Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands
Cereb Cortex 21:510-8. 2011..Patients with early-onset schizophrenia demonstrate abnormal functional connectivity in networks involving limbic, temporal lobe, cerebellum, and early visual processing streams... - Global white matter abnormalities in schizophrenia: a multisite diffusion tensor imaging studyTonya White
Department of Child and Adolescent Psychiatry, Erasmus University, 3000 CB Rotterdam, The Netherlands
Schizophr Bull 37:222-32. 2011..Our goal was to assess whether WM findings occurred early in the illness or whether these abnormalities developed with the illness over time... - Trajectories of social withdrawal and cognitive decline in the schizophrenia prodromeKathryn Cullen
Department of Psychiatry, University of Minnesota School of Medicine, Minneapolis, MN, USA
Clin Schizophr Relat Psychoses 4:229-38. 2011..This study aimed to characterize developmental trajectories of premorbid social withdrawal and cognitive decline between patients with high versus low levels of negative symptoms in youth with schizophrenia-spectrum disorders... - Structural and diffusion tensor imaging of the fornix in childhood- and adolescent-onset schizophreniaMustafa Kendi
University of Minnesota, Minneapolis, MN 55454, USA
J Am Acad Child Adolesc Psychiatry 47:826-32. 2008..The fornix is the primary efferent neural pathway of the hippocampus and has been shown to be abnormal in adults with schizophrenia... - Gray matter volume deficits are associated with motor and attentional impairments in adolescents with schizophreniaSanjiv Kumra
University of Minnesota, Department of Psychiatry, Minneapolis, MN 55454, USA
Prog Neuropsychopharmacol Biol Psychiatry 35:939-43. 2011..Our findings point to widespread, perhaps multifocal, pathology as contributing to cognitive dysfunction in adolescents with schizophrenia... - Cigarette smoking and white matter microstructure in schizophreniaKathryn R Cullen
Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN, USA
Psychiatry Res 201:152-8. 2012..Further, low FA in specific brain areas may be a neural marker for complex pathophysiology and risk for diverse problems such as schizophrenia, low IQ, and nicotine addiction... - Disruption of hippocampal connectivity in children and adolescents with schizophrenia--a voxel-based diffusion tensor imaging studyTonya White
Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA
Schizophr Res 90:302-7. 2007..As white matter provides rapid and efficient communication between brain regions, this study was initiated to assess the early disruption of white matter pathways in children and adolescent with schizophrenia... - Oculomotor and pupillometric indices of pro- and antisaccade performance in youth-onset psychosis and attention deficit/hyperactivity disorderCanan Karatekin
Institute of Child Development, University of Minnesota, 51 East River Road, Minneapolis, MN 55455, USA
Schizophr Bull 36:1167-86. 2010..Thus, results show inhibitory deficits in the context of more general attentional impairments in both disorders... - Regulation of cognitive resources during an n-back task in youth-onset psychosis and attention-deficit/hyperactivity disorder (ADHD)Canan Karatekin
Institute of Child Development, University of Minnesota, 51 East River Road, Minneapolis, MN 55455, United States
Int J Psychophysiol 73:294-307. 2009..It is likely that these attentional problems prevented the clinical groups from encoding the stimuli effectively and contributed to their general performance deficits... - MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> MetJoshua L Roffman
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 105:17573-8. 2008..The findings also suggest the importance of weighing COMT effects on prefrontal function within the context of MTHFR genotype... - Differential fractional anisotropy abnormalities in adolescents with ADHD or schizophreniaNicholas D Davenport
Department of Psychology, University of Minnesota, Minneapolis, MN, United States
Psychiatry Res 181:193-8. 2010.... - Clinical and neurocognitive course in early-onset psychosis: a longitudinal study of adolescents with schizophrenia-spectrum disordersJeffrey R Wozniak
Department of Psychiatry, University of Minnesota Medical Center Twin Cities, Minneapolis, Minnesota 55454, USA
Early Interv Psychiatry 2:169-77. 2008..The goals of this study were to examine these relationships in a larger sample at baseline, and also to examine the longitudinal course of these deficits in a smaller subset of adolescents... - Shared and nonshared symptoms in youth-onset psychosis and ADHDCanan Karatekin
Institute of Child Development, University of Minnesota, Minneapolis, MN 55455, USA
J Atten Disord 14:121-31. 2010..We compared ratings of behavior and attention problems between youth-onset psychosis and ADHD, two disorders in which attentional impairments play a key role, and examined the effect of psychostimulant use on age of onset in psychosis... - Limbic structures and networks in children and adolescents with schizophreniaTonya White
Department of Psychiatry, Fairview University Medical Center, University of Minnesota, Minneapolis, MN 55454, USA
Schizophr Bull 34:18-29. 2008..Additional research within a developmental framework is necessary to determine the putative etiologic roles for limbic and other brain abnormalities in early-onset schizophrenia... - Divided attention in youth-onset psychosis and attention deficit/hyperactivity disorderCanan Karatekin
Institute of Child Development, University of Minnesota, 51 East River Road, Minneapolis, MN 55455, USA
J Abnorm Psychol 117:881-95. 2008..Findings also demonstrate the importance of taking into account difficulties that constrain performance on simple tasks before interpreting impairments on complex tasks... - Variations in the catechol O-methyltransferase polymorphism and prefrontally guided behaviors in adolescentsDustin Wahlstrom
Department of Psychology, Center for Neurobehavorial Development, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, USA
Biol Psychiatry 61:626-32. 2007..These genotypic variations and their associations with executive functions have been described in adults and prepubescent children, but there is a paucity of research assessing these relations in adolescent samples... - A comparative pilot study of second-generation antipsychotics in children and adolescents with schizophrenia-spectrum disordersJonathan B Jensen
University of Minnesota, Department of Psychiatry, Minneapolis, Minnesota 55454, USA
J Child Adolesc Psychopharmacol 18:317-26. 2008..To plan the design of a subsequent randomized controlled trial (RCT), the authors conducted this pilot study to demonstrate the feasibility of the treatment and measurement protocols... - Developmental changes in dopamine neurotransmission in adolescence: behavioral implications and issues in assessmentDustin Wahlstrom
Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
Brain Cogn 72:146-59. 2010..Furthermore, we will suggest how these techniques can be combined with other methods such as pharmacology to measure the impact of dopamine activity on behavior and how this relation changes through the lifespan... - Neuropsychological performance in first-episode adolescents with schizophrenia: a comparison with first-episode adults and adolescent control subjectsTonya White
Division of Child and Adolescent Psychiatry, Center for Neurobehavioral Development, University of Minnesota School of Medicine, Minneapolis, MN 55454, USA
Biol Psychiatry 60:463-71. 2006..The goal of this study was to compare the extent of cognitive deficits between adolescents and adults early in the course of schizophrenia... - Diffusion tensor imaging in psychiatric disordersTonya White
Department of Psychiatry, University of Minnesota, Fairview University Medical Center, 2450 Riverside Ave, Minneapolis, MN 55454, USA
Top Magn Reson Imaging 19:97-109. 2008..The goal of this article is to provide an overview of DTI and its application to psychiatric disorders... - Neurobehavioral evidence for changes in dopamine system activity during adolescenceDustin Wahlstrom
Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
Neurosci Biobehav Rev 34:631-48. 2010..Implications for the understanding of adolescent behavioral development are discussed... - The development of gyrification in childhood and adolescenceTonya White
Department of Child and Adolescent Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands
Brain Cogn 72:36-45. 2010..We also present recent findings involving alterations in gyrification during childhood and adolescence... - The schizophrenia prodromeTonya White
Department of Psychiatry, University of Minnesota School of Medicine, Minneapolis, MN 55454, USA
Am J Psychiatry 163:376-80. 2006 - Infant brain structures, executive function, and attention deficit/hyperactivity problems at preschool age. A prospective studyAkhgar Ghassabian
The Generation R Study Group, Erasmus MC Department of Child and Adolescent Psychiatry, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
J Child Psychol Psychiatry 54:96-104. 2013..In a population-based study, we aimed to characterize the prospective association between brain structures measured during infancy and executive function and attention deficit/hyperactivity problems assessed at preschool age... - Oculomotor and manual indexes of incidental and intentional spatial sequence learning during middle childhood and adolescenceCanan Karatekin
Institute of Child Development, University of Minnesota, Minneapolis, MN 55455, USA
J Exp Child Psychol 96:107-30. 2007..In contrast, the ability to learn a sequence intentionally, which requires cognitive resources and strategies, continues to develop through adolescence... - Adherence and psychopathology in children and adolescents with cystic fibrosisTonya White
University of Minnesota, Minneapolis, 55454, USA
Eur Child Adolesc Psychiatry 18:96-104. 2009..The objective of this study was to investigate the association between psychopathology and treatment adherence in children and adolescents with CF... - Adaptation and adjustment in children of transsexual parentsTonya White
Division of Child and Adolescent Psychiatry, Dept of Psychiatry, University of Minnesota School of Medicine, Minneapolis, MN 55454, USA
Eur Child Adolesc Psychiatry 16:215-21. 2007..In addition, parental conflict that continues after the transition period tends to reflect greater family conflict between the transitioned parent and their child... - Noninvasive quantification of ascorbate and glutathione concentration in the elderly human brainUzay E Emir
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA
NMR Biomed 24:888-94. 2011..In conclusion, GSH and Asc concentrations were compared noninvasively for the first time in young vs elderly subjects... - Affective bias and response modulation following tyrosine depletion in healthy adultsSuzanne Vrshek-Schallhorn
Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
Neuropsychopharmacology 31:2523-36. 2006..Basic motor functions were not impacted. Findings are discussed in relation to dopamine's role in switching signals within neural networks that are important for response modulation and affective control...