H F L Wertheim

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Mupirocin prophylaxis against nosocomial Staphylococcus aureus infections in nonsurgical patients: a randomized study
    Heiman F L Wertheim
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
    Ann Intern Med 140:419-25. 2004
  2. ncbi request reprint Low prevalence of methicillin-resistant Staphylococcus aureus (MRSA) at hospital admission in the Netherlands: the value of search and destroy and restrictive antibiotic use
    H F L Wertheim
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Hosp Infect 56:321-5. 2004
  3. ncbi request reprint Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers
    Heiman F L Wertheim
    Erasmus MC, University Medical Centre, Rotterdam, Department of Medical Microbiology and Infectious Diseases, Dr Molewaterplein 40, 3015 GD Rotterdam, Netherlands
    Lancet 364:703-5. 2004
  4. pmc Effect of mupirocin treatment on nasal, pharyngeal, and perineal carriage of Staphylococcus aureus in healthy adults
    Heiman F L Wertheim
    Erasmus MC, University Hospital Rotterdam, Department of Clinical Microbiology and Infectious Diseases, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Antimicrob Agents Chemother 49:1465-7. 2005
  5. pmc Can mupirocin prevent methicillin-resistant Staphylococcus aureus infections?
    Heiman F L Wertheim
    Department of Medical Microbiology and Infectious Disease, Erasmus MC, Rotterdam, The Netherlands
    Crit Care 9:257-8. 2005
  6. ncbi request reprint Associations between Staphylococcus aureus Genotype, Infection, and In-Hospital Mortality: A Nested Case-Control Study
    Heiman F L Wertheim
    Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Infect Dis 192:1196-200. 2005
  7. pmc Key role for clumping factor B in Staphylococcus aureus nasal colonization of humans
    Heiman F L Wertheim
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    PLoS Med 5:e17. 2008
  8. ncbi request reprint The role of nasal carriage in Staphylococcus aureus infections
    Heiman F L Wertheim
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands
    Lancet Infect Dis 5:751-62. 2005
  9. ncbi request reprint Nose picking and nasal carriage of Staphylococcus aureus
    Heiman F L Wertheim
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
    Infect Control Hosp Epidemiol 27:863-7. 2006
  10. doi request reprint Sustained low prevalence of meticillin-resistant Staphylococcus aureus upon admission to hospital in The Netherlands
    L G M Bode
    Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Hosp Infect 79:198-201. 2011

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Mupirocin prophylaxis against nosocomial Staphylococcus aureus infections in nonsurgical patients: a randomized study
    Heiman F L Wertheim
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
    Ann Intern Med 140:419-25. 2004
    ..aureus infection. Studies show that intranasal mupirocin can prevent nosocomial surgical site infections. No data are available on the efficacy of mupirocin in nonsurgical patients...
  2. ncbi request reprint Low prevalence of methicillin-resistant Staphylococcus aureus (MRSA) at hospital admission in the Netherlands: the value of search and destroy and restrictive antibiotic use
    H F L Wertheim
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Hosp Infect 56:321-5. 2004
    ..We conclude that at routine admission to a Dutch hospital (excluding high-risk foreign admissions) the MRSA prevalence is low (0.03%), due to the Dutch search and destroy policy and restrictive antibiotic prescribing...
  3. ncbi request reprint Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers
    Heiman F L Wertheim
    Erasmus MC, University Medical Centre, Rotterdam, Department of Medical Microbiology and Infectious Diseases, Dr Molewaterplein 40, 3015 GD Rotterdam, Netherlands
    Lancet 364:703-5. 2004
    ..006). S aureus nasal carriers and non-carriers differ significantly in risk and outcome of nosocomial S aureus bacteraemia. Genotyping revealed that 80% of strains causing bacteraemia in carriers were endogenous...
  4. pmc Effect of mupirocin treatment on nasal, pharyngeal, and perineal carriage of Staphylococcus aureus in healthy adults
    Heiman F L Wertheim
    Erasmus MC, University Hospital Rotterdam, Department of Clinical Microbiology and Infectious Diseases, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Antimicrob Agents Chemother 49:1465-7. 2005
    ..The finding warrants the use of mupirocin only in proven carriers for decolonization purposes. Mupirocin is effective overall in decolonizing nasal carriers but less effective in decolonizing extranasal sites...
  5. pmc Can mupirocin prevent methicillin-resistant Staphylococcus aureus infections?
    Heiman F L Wertheim
    Department of Medical Microbiology and Infectious Disease, Erasmus MC, Rotterdam, The Netherlands
    Crit Care 9:257-8. 2005
    ..In general: early identification, isolation and treatment of all MRSA carriers, including health care workers, and disinfection of contaminated environments, are the main 'ingredients' of an effective MRSA 'search and destroy' program...
  6. ncbi request reprint Associations between Staphylococcus aureus Genotype, Infection, and In-Hospital Mortality: A Nested Case-Control Study
    Heiman F L Wertheim
    Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Infect Dis 192:1196-200. 2005
    ..Those infected with S. aureus strains belonging to a CC had higher mortality than those infected with strains not belonging to a CC (P<.05), which indicates the coevolution of S. aureus virulence and spread in humans...
  7. pmc Key role for clumping factor B in Staphylococcus aureus nasal colonization of humans
    Heiman F L Wertheim
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    PLoS Med 5:e17. 2008
    ..aureus colonizes the nose are still unknown. The staphylococcal cell-wall protein clumping factor B (ClfB) promotes adhesion to squamous epithelial cells in vitro and might be a physiologically relevant colonization factor...
  8. ncbi request reprint The role of nasal carriage in Staphylococcus aureus infections
    Heiman F L Wertheim
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands
    Lancet Infect Dis 5:751-62. 2005
    ..We present an overview of the current knowledge of the determinants (both human and bacterial) and risks of S aureus nasal carriage. Studies on the population dynamics of S aureus are also summarised...
  9. ncbi request reprint Nose picking and nasal carriage of Staphylococcus aureus
    Heiman F L Wertheim
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
    Infect Control Hosp Epidemiol 27:863-7. 2006
    ..Nasal carriage of Staphylococcus aureus is an important risk factor for S. aureus infection and a reservoir for methicillin-resistant S. aureus. We investigated whether nose picking was among the determinants of S. aureus nasal carriage...
  10. doi request reprint Sustained low prevalence of meticillin-resistant Staphylococcus aureus upon admission to hospital in The Netherlands
    L G M Bode
    Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Hosp Infect 79:198-201. 2011
    ..06, Fisher's exact test). This prevalence is still among the lowest in the world, probably as a result of the stringent Dutch infection control policy, and the restrictive use of antibiotics in The Netherlands...
  11. pmc Clonal distribution and differential occurrence of the enterotoxin gene cluster, egc, in carriage- versus bacteremia-associated isolates of Staphylococcus aureus
    Alex van Belkum
    Erasmus MC, University Medical Center Rotterdam, room L 313, Department of Medical Microbiology and Infectious Diseases, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Clin Microbiol 44:1555-7. 2006
    ..7% of carriage-associated isolates versus 52.9% of invasive isolates; P = 0.03). Multilocus sequence typing revealed that successful staphylococcal clones usually harbor the egc locus...
  12. doi request reprint Reclassification of Staphylococcus aureus nasal carriage types
    Alex van Belkum
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
    J Infect Dis 199:1820-6. 2009
    ..This study was performed to provide additional insight into staphylococcal carriage types...
  13. ncbi request reprint Direct detection of human Staphylococcus aureus carriage in the nose using the Lightcycler Staphylococcus kit
    Roos S R Choudhurry
    Erasmus MC, Department of Medical Microbiology and Infectious Diseases, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Microbiol Methods 65:354-6. 2006
    ..However the test is well suited for species identification after culture and the identification of high-load S. aureus carriers...
  14. doi request reprint Co-evolutionary aspects of human colonisation and infection by Staphylococcus aureus
    Alex van Belkum
    Department of Medical Microbiology and Infectious Diseases, Unit Research and Development, Erasmus MC, Rotterdam, The Netherlands
    Infect Genet Evol 9:32-47. 2009
    ..When the nature of these states would be known in more detail, this knowledge could be used to design novel and empirical, knowledge-driven means of preventing colonisation from proceeding into S. aureus infection...
  15. doi request reprint Genotypes, superantigen gene profiles, and presence of exfoliative toxin genes in clinical methicillin-susceptible Staphylococcus aureus isolates
    Marijke J C A van Trijp
    Maasstad Hospital, HT Rotterdam, The Netherlands
    Diagn Microbiol Infect Dis 66:222-4. 2010
    ..Superantigen gene profiles and presence of exfoliative toxin genes A and D were associated with clonal complex rather than with invasive disease...
  16. doi request reprint Preventing surgical-site infections in nasal carriers of Staphylococcus aureus
    Lonneke G M Bode
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 362:9-17. 2010
    ..Nasal carriers of Staphylococcus aureus are at increased risk for health care-associated infections with this organism. Decolonization of nasal and extranasal sites on hospital admission may reduce this risk...
  17. ncbi request reprint Global prevalence of meticillin-resistant Staphylococcus aureus
    Heiman F L Wertheim
    Lancet 368:1866; author reply 1866-7. 2006