H Weinans

Summary

Affiliation: Erasmus University
Country: The Netherlands

Publications

  1. ncbi Is osteoporosis a matter of over-adaptation?
    H Weinans
    Erasmus Orthopaedic Research Lab, Erasmus University Rotterdam, The Netherlands
    Technol Health Care 6:299-306. 1998
  2. ncbi Sensitivity of periprosthetic stress-shielding to load and the bone density-modulus relationship in subject-specific finite element models
    H Weinans
    Erasmus Orthopaedic Research Laboratory, Departments of Orthopaedics, Erasmus University EE1614, P O Box 1738, 3000, Rotterdam, The Netherlands
    J Biomech 33:809-17. 2000
  3. doi CT arthrography of the human knee to measure cartilage quality with low radiation dose
    J van Tiel
    Department of Orthopedic Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 20:678-85. 2012
  4. ncbi Cartilage damage pattern in relation to subchondral plate thickness in a collagenase-induced model of osteoarthritis
    S M Botter
    Erasmus MC, University Medical Centre Rotterdam, Department of Orthopaedics, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 16:506-14. 2008
  5. ncbi A decreased subchondral trabecular bone tissue elastic modulus is associated with pre-arthritic cartilage damage
    J S Day
    Orthopedics Department, Erasmus University, Rotterdam, The Netherlands
    J Orthop Res 19:914-8. 2001
  6. doi Development of osteoarthritic features in estrogen receptor knockout mice
    Y H Sniekers
    Department of Orthopaedics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 17:1356-61. 2009
  7. ncbi Adaptation of subchondral bone in osteoarthritis
    J S Day
    Erasmus Orthopaedic Research Lab, University Rotterdam, Rotterdam, The Netherlands
    Biorheology 41:359-68. 2004
  8. doi Mesenchymal stem cells secrete factors that inhibit inflammatory processes in short-term osteoarthritic synovium and cartilage explant culture
    G M van Buul
    Department of Orthopaedics, Erasmus MC, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 20:1186-96. 2012
  9. ncbi In vivo imaging of cartilage degeneration using microCT-arthrography
    T M Piscaer
    Department of Orthopaedics, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 16:1011-7. 2008
  10. doi Clinically applied CT arthrography to measure the sulphated glycosaminoglycan content of cartilage
    M Siebelt
    Department of Orthopedic Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 19:1183-9. 2011

Collaborators

Detail Information

Publications45

  1. ncbi Is osteoporosis a matter of over-adaptation?
    H Weinans
    Erasmus Orthopaedic Research Lab, Erasmus University Rotterdam, The Netherlands
    Technol Health Care 6:299-306. 1998
    ..This stronger adaptation might be related to a compromised safety factor against bone loss, or diminished intrinsic matrix properties (e.g., microdamage)...
  2. ncbi Sensitivity of periprosthetic stress-shielding to load and the bone density-modulus relationship in subject-specific finite element models
    H Weinans
    Erasmus Orthopaedic Research Laboratory, Departments of Orthopaedics, Erasmus University EE1614, P O Box 1738, 3000, Rotterdam, The Netherlands
    J Biomech 33:809-17. 2000
    ....
  3. doi CT arthrography of the human knee to measure cartilage quality with low radiation dose
    J van Tiel
    Department of Orthopedic Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 20:678-85. 2012
    ..Furthermore, we studied the ability of (lower radiation) CTa to distinguish between local sulphated glycosaminoglycan (sGAG) content differences...
  4. ncbi Cartilage damage pattern in relation to subchondral plate thickness in a collagenase-induced model of osteoarthritis
    S M Botter
    Erasmus MC, University Medical Centre Rotterdam, Department of Orthopaedics, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 16:506-14. 2008
    ..To see how initial differences in subchondral bone phenotype influence the development of cartilage damage and changes in subchondral bone architecture in an osteoarthritis (OA)-induced mouse model...
  5. ncbi A decreased subchondral trabecular bone tissue elastic modulus is associated with pre-arthritic cartilage damage
    J S Day
    Orthopedics Department, Erasmus University, Rotterdam, The Netherlands
    J Orthop Res 19:914-8. 2001
    ..It seems likely that the normal equilibrium between cartilage properties, bone tissue properties and bone volume fraction is disrupted early in the development of osteoarthritis...
  6. doi Development of osteoarthritic features in estrogen receptor knockout mice
    Y H Sniekers
    Department of Orthopaedics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 17:1356-61. 2009
    ..We studied whether deletion of the estrogen receptor (ER) alpha, beta, or both in female mice results in cartilage damage, osteophytosis, and changes in subchondral bone of skeletally mature animals...
  7. ncbi Adaptation of subchondral bone in osteoarthritis
    J S Day
    Erasmus Orthopaedic Research Lab, University Rotterdam, Rotterdam, The Netherlands
    Biorheology 41:359-68. 2004
    ....
  8. doi Mesenchymal stem cells secrete factors that inhibit inflammatory processes in short-term osteoarthritic synovium and cartilage explant culture
    G M van Buul
    Department of Orthopaedics, Erasmus MC, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 20:1186-96. 2012
    ..MSCs have recently been discovered to secrete anti-inflammatory cytokines and growth factors. We studied the paracrine effects of MSCs on OA cartilage and synovial explants in vitro...
  9. ncbi In vivo imaging of cartilage degeneration using microCT-arthrography
    T M Piscaer
    Department of Orthopaedics, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 16:1011-7. 2008
    ..In the present study, we investigated the use of micro-computed tomography (microCT) in combination with a negatively charged ionic iodine dimer (ioxaglate) for in vivo assessment of cartilage degeneration in a small animal model...
  10. doi Clinically applied CT arthrography to measure the sulphated glycosaminoglycan content of cartilage
    M Siebelt
    Department of Orthopedic Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 19:1183-9. 2011
    ..This study assessed the potential of CTa as a clinically applicable tool to evaluate cartilage quality in terms of sulphated glycosaminoglycan content (sGAG) and structural composition of the extra-cellular matrix (ECM)...
  11. ncbi A three-dimensional simulation of age-related remodeling in trabecular bone
    J C van der Linden
    Department of Orthopedics, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 16:688-96. 2001
    ..Decreasing the formation deficit helps to prevent bone loss, but reducing resorption depth is more effective in preventing loss of mechanical stiffness...
  12. doi Real-time assessment of bone metabolism in small animal models for osteoarthritis using multi pinhole-SPECT/CT
    T M Piscaer
    Department of Orthopaedics, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 21:882-8. 2013
    ....
  13. ncbi Bisphosphonate treatment affects trabecular bone apparent modulus through micro-architecture rather than matrix properties
    J S Day
    Erasmus Orthopaedic Research Laboratory, Erasmus MC, University Medical Centre of Rotterdam, Ee1614, P O Box 1738, Dr, Rotterdam 3000, The Netherlands
    J Orthop Res 22:465-71. 2004
    ..We hypothesize that the expected increase in the Young's modulus of the calcified matrix due to the increased calcified matrix density was counteracted by the accumulation of microdamage...
  14. doi Reproducibility of 3D delayed gadolinium enhanced MRI of cartilage (dGEMRIC) of the knee at 3.0 T in patients with early stage osteoarthritis
    J van Tiel
    Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur Radiol 23:496-504. 2013
    ..To assess the reproducibility of 3D delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 3 T in early stage knee osteoarthritis (OA) patients...
  15. ncbi Quantification of subchondral bone changes in a murine osteoarthritis model using micro-CT
    S M Botter
    Department of Orthopaedics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Biorheology 43:379-88. 2006
    ..In conclusion, four weeks after induction of osteoarthritis in the murine knee subtle but significant changes in subchondral bone architecture could be detected and quantified in 3D with micro-CT analysis...
  16. ncbi Altered tissue properties induce changes in cancellous bone architecture in aging and diseases
    J C van der Linden
    Erasmus MC, Department of Orthopaedics, Ee1614, P O Box 1738, 3000 DR, Rotterdam, The Netherlands
    J Biomech 37:367-74. 2004
    ..Concluding, we showed that changes in trabecular bone in aging and diseases can be partly explained from changes in tissue properties...
  17. doi Total hip replacement but not clinical osteoarthritis can be predicted by the shape of the hip: a prospective cohort study (CHECK)
    R Agricola
    Department of Orthopaedics, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 21:559-64. 2013
    ..To investigate the association between baseline hip shape and both clinical hip osteoarthritis (OA) and total hip replacement (THR) at 5-year follow-up...
  18. doi Variation in joint shape of osteoarthritic knees
    D J Haverkamp
    Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Arthritis Rheum 63:3401-7. 2011
    ..To investigate the role of joint shape in knee osteoarthritis (OA) by determining which aspects of bone shape are different in OA knees compared with control knees...
  19. doi Animal models for osteoarthritis: the effect of ovariectomy and estrogen treatment - a systematic approach
    Y H Sniekers
    Department of Orthopaedics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 16:533-41. 2008
    ..Animal models are used to study the effects of hormone depletion [by ovariectomy (OVX)] and estrogen treatment on OA. This review summarizes these animal studies, in order to get a better insight in the role of hormones on OA...
  20. ncbi Imaging of experimental osteoarthritis in small animal models
    T M Piscaer
    Department of Orthopaedics, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Biorheology 45:355-64. 2008
    ..These new techniques demonstrate the possibilities of quantitative experimental OA assessment in small animal models such as mice and rats and might enable substitution of the conventional destructive methods...
  21. doi A statistical model of shape and density of the proximal femur in relation to radiological and clinical OA of the hip
    J H Waarsing
    Dept of Orthopedics, Erasmus MC, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 18:787-94. 2010
    ..We created a statistical model of shape and density to see if Dual Energy X-ray (DXA) images of the hip contain symptom-related information that is not captured by common radiological measures...
  22. ncbi ERK activation and alpha v beta 3 integrin signaling through Shc recruitment in response to mechanical stimulation in human osteoblasts
    F A A Weyts
    Department of Orthopaedics, Department of Internal Medicine, Erasmus University Medical Center Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Cell Biochem 87:85-92. 2002
    ....
  23. ncbi Longitudinal micro-CT scans to evaluate bone architecture
    J H Waarsing
    Orthopaedic Research Lab, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Musculoskelet Neuronal Interact 5:310-2. 2005
  24. doi Osteoarthritis susceptibility genes influence the association between hip morphology and osteoarthritis
    J H Waarsing
    Erasmus Medical Center, Rotterdam, The Netherlands
    Arthritis Rheum 63:1349-54. 2011
    ..Because nonoptimal joint geometry is a risk factor for the development of OA, we investigated if and how the path that leads from nonoptimal joint geometry to OA of the hip is influenced by these genes...
  25. doi The contribution of hip geometry to the prediction of hip osteoarthritis
    M C Castaño-Betancourt
    Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands The Netherlands Genomics Initiative sponsored Netherlands Consortium for Healthy Aging NGI NCHA, Rotterdam Leiden, The Netherlands
    Osteoarthritis Cartilage 21:1530-6. 2013
    ..To determine how well measures of hip geometry can predict radiological incident hip osteoarthritis (HOA) compared to well known clinical risk factors...
  26. ncbi Mechanical control of human osteoblast apoptosis and proliferation in relation to differentiation
    F A A Weyts
    Department of Orthopaedics, Room Ee 1614, P O Box 1738, Erasmus University Medical Center Rotterdam, The Netherlands
    Calcif Tissue Int 72:505-12. 2003
    ....
  27. ncbi Ferumoxides-protamine sulfate is more effective than ferucarbotran for cell labeling: implications for clinically applicable cell tracking using MRI
    G M van Buul
    Department of Radiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Contrast Media Mol Imaging 4:230-6. 2009
    ..Consequently, hBMSC and chondrocyte labeling with ferumoxides-protamine is more effective and results in more specific cell labeling than ferucarbotran...
  28. doi No effects of PRP on ultrasonographic tendon structure and neovascularisation in chronic midportion Achilles tendinopathy
    R J de Vos
    Department of Orthopaedic Surgery, Erasmus Medical Centre, Rotterdam, The Netherlands
    Br J Sports Med 45:387-92. 2011
    ..To assess whether a platelet-rich plasma (PRP) injection leads to an enhanced tendon structure and neovascularisation, measured with ultrasonographic techniques, in chronic midportion Achilles tendinopathy...
  29. ncbi Long-term fluoxetine administration does not result in major changes in bone architecture and strength in growing rats
    I Westbroek
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Cell Biochem 101:360-8. 2007
    ..Leptin and adiponectin levels were not different between the control group and fluoxetine-treated group, indicating that these factors were not involved in the observed changes in bone geometry and quality...
  30. ncbi Strength of cancellous bone trabecular tissue from normal, ovariectomized and drug-treated rats over the course of ageing
    L M McNamara
    Trinity Centre for Bioengineering, School of Engineering, Trinity College, Dublin, Ireland
    Bone 39:392-400. 2006
    ..These findings suggest that, in addition to the effects of osteoporosis and subsequent treatment on bone architecture, there are also more subtle processes ongoing to alter bone strength at the tissue level...
  31. ncbi Stretch-induced phosphorylation of ERK1/2 depends on differentiation stage of osteoblasts
    J H W Jansen
    Orthopaedic Research Laboratory, Department of Orthopaedics, Erasmus MC, The Netherlands
    J Cell Biochem 93:542-51. 2004
    ..The presence of an extracellular matrix, but not per se mineralization, seems to be the predominant determinant of osteoblastic response to strain...
  32. ncbi Mechanical consequences of bone loss in cancellous bone
    J C van der Linden
    Department of Orthopedics, Erasmus University Medical Center Rotterdam, The Netherlands
    J Bone Miner Res 16:457-65. 2001
    ..Strains in trabeculae surrounding a cavity increased by up to 1,000 microstrains, which could lead to bone apposition. These results give insight in the mechanical effects of bone remodeling and resorption at trabecular level...
  33. ncbi In vitro expansion affects the response of chondrocytes to mechanical stimulation
    R H J Das
    Department of Orthopaedics, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA, The Netherlands
    Osteoarthritis Cartilage 16:385-91. 2008
    ..Therefore, we examined the response of primary and expanded human articular chondrocytes to mechanical loading...
  34. ncbi A simulation model at trabecular level to predict effects of antiresorptive treatment after menopause
    J C van der Linden
    Erasmus MC, Department of Orthopaedics, Ee1614, 3000 DR Rotterdam, The Netherlands
    Calcif Tissue Int 73:537-44. 2003
    ..This kind of simulation model may be used to preclinically test new pharmaceuticals and treatment protocols and to predict long-term effects of treatment before patient data become available...
  35. ncbi Canine cancellous bone microarchitecture after one year of high-dose bisphosphonates
    M Ding
    Orthopaedic Research Laboratory, Department of Orthopaedics, Aarhus University Hospital, Aarhus C, Denmark
    Calcif Tissue Int 72:737-44. 2003
    ..We conclude that bisphosphonates enhance mechanical properties and reduce fracture risk by improving architectural anisotropy of cancellous bone 3-D microarchitecture...
  36. ncbi The osteoporotic vertebral structure is well adapted to the loads of daily life, but not to infrequent "error" loads
    J Homminga
    Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands
    Bone 34:510-6. 2004
    ..If future clinical imaging techniques would enable such high-resolution images to be obtained in vivo, the combination of microCT and microFEA would produce a powerful tool to diagnose osteoporosis...
  37. ncbi The mechanical consequences of mineralization in embryonic bone
    E Tanck
    Orthopaedic Research Laboratory, University Medical Center Nijmegen, 6500 HB, The Netherlands
    Bone 35:186-90. 2004
    ..The subsequent resorption of calcified cartilage and the expansion of the marrow cavity could be consequential to stress shielding...
  38. ncbi Fibroblast growth factor-2 in serum-free medium is a potent mitogen and reduces dedifferentiation of human ear chondrocytes in monolayer culture
    E W Mandl
    Department of Orthopaedics, Erasmus MC, Room Ee 1659b, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Matrix Biol 23:231-41. 2004
    ..The observed beneficial effects of the serum-free medium with FGF2 on the chondrocyte phenotype at the end of monolayer culture were sustained on both transcriptional and extracellular level throughout both redifferentiation methods...
  39. ncbi Trabecular bone's mechanical properties are affected by its non-uniform mineral distribution
    J C van der Linden
    Department of Orthopaedics, Erasmus University Medical Center Rotterdam, Ee1614, P.O. Box 1738, 3000 DR Rotterdam, Netherlands
    J Biomech 34:1573-80. 2001
    ....
  40. ncbi Prediction of mechanical properties of human trabecular bone by electrical measurements
    J Sierpowska
    Department of Applied Physics, University of Kuopio, POB 1627, FIN 70211 Kuopio, Finland
    Physiol Meas 26:S119-31. 2005
    ..In the future, these measurement techniques may be further developed for use during open surgery, such as bone grafting or total hip replacement surgery...
  41. ncbi Stress-concentrating effect of resorption lacunae in trabecular bone
    L M McNamara
    Centre for Bioengineering, Department of Mechanical Engineering, Trinity College, Dublin 2, Ireland
    J Biomech 39:734-41. 2006
    ....
  42. ncbi Osteoporosis changes the amount of vertebral trabecular bone at risk of fracture but not the vertebral load distribution
    J Homminga
    Orthopedic Research Lab, University of Nijmegen, The Netherlands
    Spine (Phila Pa 1976) 26:1555-61. 2001
    ..Our finite-element models indicated that osteoporosis had a significant effect on the amount of trabecular bone at risk of fracture, which increased from about 1% in healthy vertebrae to about 16% for osteoporotic vertebrae...
  43. ncbi Interrelationships between electrical properties and microstructure of human trabecular bone
    J Sierpowska
    Department of Physics, University of Kuopio, PO Box 1627, FI 70211, Kuopio University Hospital, Finland
    Phys Med Biol 51:5289-303. 2006
    ..The data gathered in this study constitute a useful basis for theoretical and experimental work towards the development of impedance spectroscopy techniques for detection of bone quality in vitro or in special cases of open surgery...
  44. ncbi Contribution of collagen network features to functional properties of engineered cartilage
    Y M Bastiaansen-Jenniskens
    TNO Quality of Life, Business Unit Biosciences, Leiden, The Netherlands Erasmus MC, University Medical Centre Rotterdam, Department of Orthopaedics, The Netherlands
    Osteoarthritis Cartilage 16:359-66. 2008
    ..Therefore, our aim was to study the contribution of collagen amount and number of crosslinks on the functionality of newly formed matrix during cartilage repair...
  45. ncbi Cancellous bone mechanical properties from normals and patients with hip fractures differ on the structure level, not on the bone hard tissue level
    J Homminga
    Orthopedic Research Laboratory, University of Nijmegen, Nijmegen, The Netherlands
    Bone 30:759-64. 2002
    ..We conclude that individuals with a history of osteoporotic fractures do not have weaker bone tissue. Architectural and mechanical anisotropy alone renders their bone weaker in the nonprimary loading direction...