Willem Weimar

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc Phospho-specific flow cytometry for pharmacodynamic monitoring of immunosuppressive therapy in transplantation
    Carla Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Transplant Res 1:20. 2012
  2. pmc Uremia causes premature ageing of the T cell compartment in end-stage renal disease patients
    Ruud Wj Meijers
    Department of Internal Medicine, section Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands
    Immun Ageing 9:19. 2012
  3. pmc Multisystemic engagement and nephrology based educational intervention: a randomized controlled trial protocol on the KidneyTteam At Home study
    Sohal Y Ismail
    Department of Medical Psychology, Erasmus MC, Burg, s Jacobplein 51, Rotterdam, CA, 3015, The Netherlands
    BMC Nephrol 13:62. 2012
  4. ncbi request reprint Tapering immunosuppression in recipients of living donor kidney transplants
    Willem Weimar
    Department of Internal Medicine, Section of Transplantation, Room D 410, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Nephrol Dial Transplant 19:iv61-3. 2004
  5. ncbi request reprint Donor-reactive cytokine profiles after HLA-identical living-related kidney transplantation
    Jeroen H Gerrits
    Department of Internal Medicine Transplantation, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Nephrol Dial Transplant 23:2016-23. 2008
  6. doi request reprint Characterization of rabbit antithymocyte globulins-induced CD25+ regulatory T cells from cells of patients with end-stage renal disease
    Varsha D K D Sewgobind
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplantation 89:655-66. 2010
  7. ncbi request reprint Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic polymorphisms in the MDR-1, CYP3A4, and CYP3A5 genes
    Dennis A Hesselink
    Department of Internal Medicine, Renal Transplant Unit, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    Clin Pharmacol Ther 76:545-56. 2004
  8. doi request reprint Deficient TNF-alpha and IFN-gamma production correlates with nondetectable donor-specific cytotoxicity after clinical kidney transplantation
    Nicole M van Besouw
    Department of Internal Medicine Transplantation, Erasmus MC, University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Transplantation 87:1451-4. 2009
  9. ncbi request reprint Intragraft FOXP3 mRNA expression reflects antidonor immune reactivity in cardiac allograft patients
    I Esmé Dijke
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Transplantation 83:1477-84. 2007
  10. doi request reprint Monitoring of the immunomodulatory effect of CP-690,550 by analysis of the JAK/STAT pathway in kidney transplant patients
    Monique E Quaedackers
    Erasmus MC, University Medical Center Rotterdam, Internal Medicine Transplantation, Rotterdam, The Netherlands
    Transplantation 88:1002-9. 2009

Detail Information

Publications128 found, 100 shown here

  1. pmc Phospho-specific flow cytometry for pharmacodynamic monitoring of immunosuppressive therapy in transplantation
    Carla Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Transplant Res 1:20. 2012
    ..Through this tool the efficacy of immunosuppressive medication can be assessed, novel targets can be identified, and differences in drug sensitivity between cells and patients can be clarified...
  2. pmc Uremia causes premature ageing of the T cell compartment in end-stage renal disease patients
    Ruud Wj Meijers
    Department of Internal Medicine, section Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands
    Immun Ageing 9:19. 2012
    ..abstract:..
  3. pmc Multisystemic engagement and nephrology based educational intervention: a randomized controlled trial protocol on the KidneyTteam At Home study
    Sohal Y Ismail
    Department of Medical Psychology, Erasmus MC, Burg, s Jacobplein 51, Rotterdam, CA, 3015, The Netherlands
    BMC Nephrol 13:62. 2012
    ..This manuscript is a detailed description of the Kidney Team At Home-study protocol...
  4. ncbi request reprint Tapering immunosuppression in recipients of living donor kidney transplants
    Willem Weimar
    Department of Internal Medicine, Section of Transplantation, Room D 410, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Nephrol Dial Transplant 19:iv61-3. 2004
    ..Only in one patient, who had stopped all his medication, was a rejection episode diagnosed. We conclude that in patients with a low donor-specific CTLp frequency it is safe to reduce the immunosuppression...
  5. ncbi request reprint Donor-reactive cytokine profiles after HLA-identical living-related kidney transplantation
    Jeroen H Gerrits
    Department of Internal Medicine Transplantation, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Nephrol Dial Transplant 23:2016-23. 2008
    ..Healthy individuals served as controls...
  6. doi request reprint Characterization of rabbit antithymocyte globulins-induced CD25+ regulatory T cells from cells of patients with end-stage renal disease
    Varsha D K D Sewgobind
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplantation 89:655-66. 2010
    ..In comparison with natural Tregs, the rATG-induced Tregs are phenotypically distinct but have similar regulatory activities. rATG may beneficially contribute to the mechanisms that control alloreactivity...
  7. ncbi request reprint Population pharmacokinetics of cyclosporine in kidney and heart transplant recipients and the influence of ethnicity and genetic polymorphisms in the MDR-1, CYP3A4, and CYP3A5 genes
    Dennis A Hesselink
    Department of Internal Medicine, Renal Transplant Unit, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    Clin Pharmacol Ther 76:545-56. 2004
    ....
  8. doi request reprint Deficient TNF-alpha and IFN-gamma production correlates with nondetectable donor-specific cytotoxicity after clinical kidney transplantation
    Nicole M van Besouw
    Department of Internal Medicine Transplantation, Erasmus MC, University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Transplantation 87:1451-4. 2009
    ....
  9. ncbi request reprint Intragraft FOXP3 mRNA expression reflects antidonor immune reactivity in cardiac allograft patients
    I Esmé Dijke
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Transplantation 83:1477-84. 2007
    ..Therefore, we analyzed the gene expression profiles of regulatory and effector T-cell markers during immunological quiescence and acute rejection...
  10. doi request reprint Monitoring of the immunomodulatory effect of CP-690,550 by analysis of the JAK/STAT pathway in kidney transplant patients
    Monique E Quaedackers
    Erasmus MC, University Medical Center Rotterdam, Internal Medicine Transplantation, Rotterdam, The Netherlands
    Transplantation 88:1002-9. 2009
    ..CONCLUSION.: Analysis of P-STAT5 may, therefore, be used to determine the immunomodulatory effect of CP-690,550 at the cellular level in transplant patients...
  11. doi request reprint Pharmacodynamic analysis of tofacitinib and basiliximab in kidney allograft recipients
    Ramin Vafadari
    Department of Internal Medicine, Erasmus Medical Center, University Hospital Rotterdam, Rotterdam, The Netherlands
    Transplantation 94:465-72. 2012
    ..We investigated the effect of immunosuppressive drugs targeting this pathway, the JAK inhibitor tofacitinib (CP-690,550) and the anti-interleukin (IL)-2R antibody basiliximab, as part of a phase 2 study...
  12. pmc FoxP3 T cells and the pathophysiologic effects of brain death and warm ischemia in donor kidneys
    Carla C Baan
    Department of Internal Medicine, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands
    Clin J Am Soc Nephrol 7:1481-9. 2012
    ..Additionally, the interaction between forkhead box P3+ T cells and kidney injury molecule-1 by activated primary tubular epithelial cells was studied...
  13. doi request reprint Mesenchymal stem cells derived from adipose tissue are not affected by renal disease
    Marieke Roemeling-van Rhijn
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Kidney Int 82:748-58. 2012
    ..Hence, our results indicate the feasibility of their use in autologous cell therapy in patients with renal disease...
  14. ncbi request reprint Interleukin-21: an interleukin-2 dependent player in rejection processes
    Carla C Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Transplantation 83:1485-92. 2007
    ..Interleukin (IL)-21 is the most recently described cytokine that signals via the common cytokine receptor (gammac), is produced by activated CD4+ T-cells, and regulates expansion and effector function of CD8+ T-cells...
  15. doi request reprint Donor-derived mesenchymal stem cells suppress alloreactivity of kidney transplant patients
    Meindert J Crop
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Transplantation 87:896-906. 2009
    ..In this study, the immunosuppressive effect of MSC on recipient anti-donor reactivity was examined before and after clinical kidney transplantation...
  16. doi request reprint Discontinuation of calcineurin inhibitors treatment allows the development of FOXP3+ regulatory T-cells in patients after kidney transplantation
    Jacqueline van de Wetering
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Clin Transplant 25:40-6. 2011
    ..Moreover, discontinuation of CNIs' treatment allows FOXP3+ regulatory T-cells development, resulting in a significant decrease of anti-donor immune reactivity...
  17. doi request reprint Generation of donor-specific regulatory T-cell function in kidney transplant patients
    Thijs K Hendrikx
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplantation 87:376-83. 2009
    ..However, it remains to be demonstrated, whether these cells are generated after clinical transplantation...
  18. doi request reprint T-cell reactivity during tapering of immunosuppression to low-dose monotherapy prednisolone in HLA-identical living-related renal transplant recipients
    Jeroen H Gerrits
    Department of Internal Medicine Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplantation 87:907-14. 2009
    ..We questioned whether discontinuation of azathioprine (AZA) or mycophenolate mofetil (MMF) influenced T-cell reactivity, circulating dendritic cell (DC) subsets numbers and their maturation status...
  19. ncbi request reprint Functional heme oxygenase-1 promoter polymorphism in relation to heart failure and cardiac transplantation
    Cecile T J Holweg
    Department of Internal Medicine, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Heart Lung Transplant 24:493-7. 2005
    ..No influence of the polymorphism on the development of heart failure, graft survival, acute rejection, or transplant atherosclerosis was found...
  20. ncbi request reprint FOXP3 mRNA expression analysis in the peripheral blood and allograft of heart transplant patients
    I Esmé Dijke
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Transpl Immunol 18:250-4. 2008
    ....
  21. ncbi request reprint Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells
    Carla C Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Transplantation 80:110-7. 2005
    ..The transcription factor FOXP3 has been identified as the molecule associated with the regulatory function of CD25+ T cells...
  22. ncbi request reprint Preferential depletion of blood myeloid dendritic cells during acute cardiac allograft rejection under controlled immunosuppression
    Petros Athanassopoulos
    Department of Cardiothoracic Surgery, Transplantation Section, University Medical Center Rotterdam, Erasmus MC, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Am J Transplant 5:810-20. 2005
    ..Furthermore, patients during AR exhibited low proportions of mDCs positive for CD83 or CCR7. These findings suggest peripheral blood mDC depletion in association with selective lymphoid homing of this subset during AR after clinical HTx...
  23. ncbi request reprint Functional CD25(bright+) alloresponsive T cells in fully immunosuppressed renal allograft recipients
    Carla C Baan
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Clin Transplant 21:63-71. 2007
    ..Evidence from animal studies indicate a crucial role for CD25(bright+) regulatory T cells in transplantation tolerance...
  24. doi request reprint Inadequate immune regulatory function of CD4+CD25bright+FoxP3+ T cells in heart transplant patients who experience acute cellular rejection
    I Esmé Dijke
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Transplantation 87:1191-200. 2009
    ..CD4CD25FoxP3 regulatory T cells are suppressors of antigen-activated immune reactivity. Here, we assessed the clinically relevant role of these cells in the control of immune responses directed to a transplanted heart...
  25. ncbi request reprint FTY720 treatment of kidney transplant patients: a differential effect on B cells, naïve T cells, memory T cells and NK cells
    Leonard M B Vaessen
    Department of Internal Medicine Transplantation, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, Room Ee559, P O Box 1738, NL 3000 DR Rotterdam, The Netherlands
    Transpl Immunol 15:281-8. 2006
    ..25mg FTY/day. Elispot assays revealed no IL-4 producing cells and a low frequency of IFN-gamma producing cells. We suggest that both CCR7 dependent and independent mechanisms are involved in the depletion of T cells from peripheral blood...
  26. doi request reprint Successful tapering of immunosuppression to low-dose monotherapy steroids after living-related human leukocyte antigen-identical renal transplantation
    Jacqueline van de Wetering
    Department of Internal Medicine and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplantation 87:740-4. 2009
    ..No data are available on the need for immunosuppression for these specific patients. We wondered whether their immunosuppressive load could be radically reduced...
  27. doi request reprint After discontinuation of calcineurin inhibitors, tapering of mycophenolate mofetil further impairs donor-directed cytotoxicity
    Nicole M van Besouw
    Department of Internal Medicine Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Clin Transplant 22:129-35. 2008
    ....
  28. ncbi request reprint Impaired circulating dendritic cell reconstitution identifies rejecting recipients after clinical heart transplantation independent of rejection therapy
    Petros Athanassopoulos
    Department of Cardiothoracic Surgery, University Medical Center Rotterdam, Erasmus MC, Rotterdam, The Netherlands
    Eur J Cardiothorac Surg 27:783-9. 2005
    ....
  29. doi request reprint Human adipose tissue-derived mesenchymal stem cells induce explosive T-cell proliferation
    Meindert J Crop
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Stem Cells Dev 19:1843-53. 2010
    ..In conclusion, MSCs can stimulate the activation and proliferation of resting T-cells and generate regulatory T-cells. These findings are important when MSCs are applied in the clinic...
  30. doi request reprint Modifiable factors in access to living-donor kidney transplantation among diverse populations
    Sohal Y Ismail
    1 Psychiatry Medical Psychology and Psychotherapy, Erasmus MC, CA Rotterdam, The Netherlands 2 Internal Medicine Nephrology and Transplantation, Erasmus MC, CA Rotterdam, The Netherlands 3 Address correspondence to Sohal Y Ismail, M Sc, Psychiatry Medical Psychology and Psychotherapy, Erasmus MC, Postbox 2040, Room GK 1252, 3000 CA Rotterdam, The Netherlands
    Transplantation 96:586-90. 2013
    ..The aim of this study was to investigate modifiable factors that could be used as potential targets for an intervention in an attempt to reduce this inequality...
  31. doi request reprint Living donor kidney transplantation among ethnic minorities in the Netherlands: a model for breaking the hurdles
    Sohal Y Ismail
    Erasmus MC, Department of Medical Psychology, Rotterdam, The Netherlands
    Patient Educ Couns 90:118-24. 2013
    ..We conducted a focus group study to explore modifiable hurdles to LDKT...
  32. doi request reprint Monotherapy rapamycin allows an increase of CD4 CD25 FoxP3 T cells in renal recipients
    Thijs K Hendrikx
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transpl Int 22:884-91. 2009
    ....
  33. doi request reprint Cell contact interaction between adipose-derived stromal cells and allo-activated T lymphocytes
    Monique E Quaedackers
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Eur J Immunol 39:3436-46. 2009
    ....
  34. doi request reprint The effect of rabbit anti-thymocyte globulin induction therapy on regulatory T cells in kidney transplant patients
    Varsha D K D Sewgobind
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Room Ee563a, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Nephrol Dial Transplant 24:1635-44. 2009
    ..In the present prospective and controlled study, we investigated the effect of rATG on the frequency, function and phenotype of peripheral immunoregulatory CD4+ T cells in kidney transplant (KTx) patients...
  35. doi request reprint Susceptibility of human mesenchymal stem cells to tacrolimus, mycophenolic acid, and rapamycin
    Martin J Hoogduijn
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Transplantation 86:1283-91. 2008
    ..The molecular targets of these drugs are expressed in MSC, but the effect of their inhibition on MSC functioning is unknown...
  36. pmc CMV seropositivity determines epoetin dose and hemoglobin levels in patients with CKD
    Michiel G H Betjes
    Erasmus Medical Center, Department of Internal Medicine, Division of Nephrology, Dr Molewaterplein 40, Rotterdam, Netherlands
    J Am Soc Nephrol 20:2661-6. 2009
    ..In conclusion, expansion of CD4(+)CD28null T cells in CMV-seropositive patients with ESRD associates with increased demand for epoetin...
  37. doi request reprint Genetic variants of FOXP3 influence graft survival in kidney transplant patients
    Anja U Engela
    Department of Internal Medicine, Transplantation Laboratory, Erasmus University Medical Center, Rotterdam, The Netherlands
    Hum Immunol 74:751-7. 2013
    ..67, 95% CI 0.48-0.94, p=0.02). This gene association study identified a beneficial effect of FOXP3 genetic variants on graft survival in kidney transplant patients...
  38. doi request reprint The relative importance of donor age in deceased and living donor kidney transplantation
    Mirjam Laging
    Erasmus Medical Center Rotterdam, Department of Internal Medicine, Rotterdam, The Netherlands
    Transpl Int 25:1150-7. 2012
    ..The graft failure risk of deceased donor transplantation is almost twice that of living donor transplantation so that a 60-year-old living donor kidney has the same graft failure risk as a 20-year-old deceased donor kidney...
  39. ncbi request reprint Norepinephrine-induced vasoconstriction results in decreased blood volume in dialysis patients
    Robert W Nette
    Erasmus MC, Department of Internal Medicine, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Nephrol Dial Transplant 21:1305-11. 2006
    ..Hypotension during haemodialysis results from an inadequate cardiovascular response to ultrafiltration-induced hypovolaemia. It has been suggested that plasma volume could be increased as a result of systemic vasoconstriction...
  40. ncbi request reprint Calcineurin inhibitor withdrawal in stable kidney transplant patients decreases the donor-specific cytotoxic T lymphocyte precursor frequency
    Barbara J van der Mast
    Department of Internal Medicine Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplantation 80:1220-5. 2005
    ..We questioned whether stopping CNI had an effect on the donor-specific reactivity, as CNI might hinder immune responses leading to graft acceptance...
  41. doi request reprint The optimal chain length for kidney paired exchanges: an analysis of the Dutch program
    Marry de Klerk
    Department of Internal Medicine Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transpl Int 23:1120-5. 2010
    ..Unlimited chain length did not significantly affect the results. The optimal chain length for living donor kidney exchange programs is 3. Longer chains with their inherent logistic burden do not lead to significantly more transplants...
  42. ncbi request reprint Stable T-cell reactivity after successful tapering of azathioprine in HLA-identical living-related kidney transplant recipients despite minor histocompatibility antigen mismatches
    Jeroen H Gerrits
    Erasmus MC, University Medical Center Rotterdam, Department of Internal Medicine Transplantation, Room Ee 563a, P O Box 2040, NL 3000 CA Rotterdam, The Netherlands
    Nephrol Dial Transplant 22:353-61. 2007
    ..Safe tapering of immunosuppression should not result in rejection and high donor-directed T-cell responses. In the present study, we investigated the effect of tapering azathioprine (AZA) on T-cell reactivity...
  43. doi request reprint Systemic varicella zoster virus reactive effector memory T-cells impaired in the elderly and in kidney transplant recipients
    Nicole M van Besouw
    Department of Internal Medicine Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Med Virol 84:2018-25. 2012
    ..The data suggest that VZV-reactive EM T-cells are impaired in the elderly and renal transplant recipients...
  44. doi request reprint Persistently low transplantation rate of ABO blood type O and highly sensitised patients despite alternative transplantation programs
    Joke I Roodnat
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Transpl Int 25:987-93. 2012
    ..Beside increasing LD ABOi transplantation, a new DD allocation model favouring both highly immunised and blood type O patients is essential...
  45. doi request reprint Accumulation of unfavorable clinical and socioeconomic factors precludes living donor kidney transplantation
    Joke I Roodnat
    Department of Internal Medicine, Erasmus MC Rotterdam, The Netherlands
    Transplantation 93:518-23. 2012
    ..We investigated which socioeconomic and clinical factors influence who undergoes living or deceased donor kidney transplantation...
  46. doi request reprint Hurdles, barriers, and successes of a national living donor kidney exchange program
    Marry de Klerk
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplantation 86:1749-53. 2008
    ..Living donor kidney exchange is now performed in several countries. However, no information is available on the practical problems inherent to these programs. Here, we describe our experiences with 276 couples enrolled in the Dutch program...
  47. doi request reprint The effect of the JAK inhibitor CP-690,550 on peripheral immune parameters in stable kidney allograft patients
    Evelien A F J van Gurp
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplantation 87:79-86. 2009
    ..These cytokines play key roles in lymphocyte function and homeostasis. As part of a phase 1 trial, we evaluated the effect of CP-690,550 on immune parameters...
  48. doi request reprint End-stage renal failure and regulatory activities of CD4+CD25bright+FoxP3+ T-cells
    Thijs K Hendrikx
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Nephrol Dial Transplant 24:1969-78. 2009
    ..This state of immune incompetence is associated with continuous activation of the immune system. An additional explanation for this state of activation may be the disturbed function of CD4(+)CD25(bright+)FoxP3(+) regulatory T-cells...
  49. doi request reprint CYP3A5 genotype is not related to the intrapatient variability of tacrolimus clearance
    Nilufar Pashaee
    Department of Hospital Pharmacy, Clinical Pharmacology Unit, Erasmus MC, Rotterdam, The Netherlands
    Ther Drug Monit 33:369-71. 2011
    ..The risk of long-term chronic allograft nephropathy and graft loss after kidney transplantation is increased in patients with a high intrapatient variability of tacrolimus (Tac) clearance...
  50. doi request reprint Kinetics of homeostatic proliferation and thymopoiesis after rATG induction therapy in kidney transplant patients
    Anne P Bouvy
    1 Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands 2 Address correspondence to Anne P Bouvy, M D, Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center Rotterdam, Gravendijkwal 230, Room Na 522, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Transplantation 96:904-13. 2013
    ..The mechanisms of T-cell repopulation and their posttransplantation kinetics are not fully understood...
  51. doi request reprint Systematic review and meta-analysis of the relation between body mass index and short-term donor outcome of laparoscopic donor nephrectomy
    Jeffrey A Lafranca
    Department of Surgery, Division of Transplant Surgery, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Kidney Int 83:931-9. 2013
    ..05 mg/dl (CI 0.01-0.09)), and risk ratio for conversion (1.69 (CI 1.12-2.56)). Thus, a high body mass index (BMI) alone is no contraindication for live kidney donation regarding short-term outcome...
  52. doi request reprint The effect of rabbit antithymocyte globulin on human mesenchymal stem cells
    Marcella Franquesa
    Transplantation Laboratory, Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Transpl Int 26:651-8. 2013
    ..rATG reduces the viability and antiproliferative capacity of MSCs in a dose-dependent manner and converts them into targets for CD8 T cells and NKT cell lysis...
  53. pmc Tacrolimus inhibits NF-κB activation in peripheral human T cells
    Ramin Vafadari
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    PLoS ONE 8:e60784. 2013
    ..p<0.01 vs. no drug), confirming impaired NF-κB signaling. This study shows the suppressive effect of TAC on NF-κB signaling in peripheral human T cell subsets, measured at three specific positions in the NF-κB activation cascade...
  54. doi request reprint Quality of life of elderly live kidney donors
    Karel W J Klop
    1 Department of Surgery, Erasmus MC, University Medical Center, Rotterdam, The Netherlands 2 Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands 3 Department of Nephrology, Radboud University Nijmegen Medical Center, The Netherlands 4 Address correspondence to Niels F M Kok, M D, Ph D, Department of Surgery, Erasmus MC, University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Transplantation 96:644-8. 2013
    ..The aim of this study was to quantify the effect of the surgical procedure on the quality of life (QOL) of elderly donors compared with younger donors...
  55. doi request reprint Optimizing left-sided live kidney donation: hand-assisted retroperitoneoscopic as alternative to standard laparoscopic donor nephrectomy
    Leonienke F C Dols
    Department of Surgery, Erasmus MC, Rotterdam, The Netherlands
    Transpl Int 23:358-63. 2010
    ..Hand-assisted retroperitoneoscopic donor nephrectomy reduces operation and warm ischemia times, and provides at least equal safety. Hand-assisted retroperitoneoscopic may be a valuable alternative for left-sided LDN...
  56. doi request reprint Laparoscopic donor nephrectomy: a plea for the right-sided approach
    Leonienke F C Dols
    Department of Surgery, Erasmus MC, Rotterdam, The Netherlands
    Transplantation 87:745-50. 2009
    ..Laparoscopic donor nephrectomy (LDN) has become the preferred procedure for live donor nephrectomy. Most transplant surgeons are reluctant toward right-sided LDN (R-LDN) fearing short vessels and renal vein thrombosis...
  57. ncbi request reprint Laparoscopic donor nephrectomy in obese donors: easier to implement in overweight women?
    Niels F M Kok
    Department of Surgery, Erasmus MC, Rotterdam, The Netherlands
    Transpl Int 20:956-61. 2007
    ..In contrast, the outcome in obese males seems to be less advantageous, indicating that total LDN in overweight women can be advocated as a routine procedure but in obese men reluctance seems justified...
  58. ncbi request reprint Steroid-withdrawal at 3 days after renal transplantation with anti-IL-2 receptor alpha therapy: a prospective, randomized, multicenter study
    Cornelis G ter Meulen
    Department of Internal Medicine, Division of Nephrology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Am J Transplant 4:803-10. 2004
    ..In conclusion, with the use of anti-IL-2Ra induction and daily therapy with tacrolimus and MMF it is feasible to withdraw steroids at 3 days after renal transplantation...
  59. ncbi request reprint The impact of transforming growth factor-beta1 gene polymorphism on end-stage renal failure after heart transplantation
    Jacqueline van de Wetering
    Department of Internal Medicine, Erasmus MC, University Hospital Rotterdam, The Netherlands
    Transplantation 82:1744-8. 2006
    ....
  60. doi request reprint Polymorphisms in CYP3A5, CYP3A4, and ABCB1 are not associated with cyclosporine pharmacokinetics nor with cyclosporine clinical end points after renal transplantation
    Rachida Bouamar
    Department of Hospital Pharmacy, Clinical Pharmacology Unit, Erasmus MC, Rotterdam, The Netherlands
    Ther Drug Monit 33:178-84. 2011
    ..The authors studied the influence of these SNPs on CsA pharmacokinetics as well as on the incidence of biopsy-proven acute rejection (BPAR) and renal function after kidney transplantation...
  61. doi request reprint Advancement of mesenchymal stem cell therapy in solid organ transplantation (MISOT)
    Martin J Hoogduijn
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Transplantation 90:124-6. 2010
    ..Continued discussion is required for definition of safety and eventually efficacy endpoints for MSC therapy in solid organ transplantation...
  62. ncbi request reprint Formation of donor-specific human leukocyte antigen antibodies after kidney transplantation: correlation with acute rejection and tapering of immunosuppression
    Barbara J van der Mast
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Transplantation 75:871-7. 2003
    ....
  63. ncbi request reprint Withdrawal of cyclosporine or prednisone six months after kidney transplantation in patients on triple drug therapy: a randomized, prospective, multicenter study
    Peter J H Smak Gregoor
    Department of Internal Medicine, University Hospital Rotterdam, Rotterdam, The Netherlands
    J Am Soc Nephrol 13:1365-73. 2002
    ..Pred withdrawal was safe and resulted in a reduction in mean arterial pressure. However, patient and graft survival and renal function 2 yr after RTx were not different among groups...
  64. doi request reprint Inhibitory effect of tacrolimus on p38 mitogen-activated protein kinase signaling in kidney transplant recipients measured by whole-blood phosphospecific flow cytometry
    Ramin Vafadari
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplantation 93:1245-51. 2012
    ..We studied whether TAC inhibits p38 MAPK signaling in primary human T cells and ex vivo in healthy volunteers and kidney transplant recipients...
  65. pmc Hand-assisted retroperitoneoscopic versus standard laparoscopic donor nephrectomy: HARP-trial
    Leonienke F C Dols
    Department of Surgery, Erasmus MC, Rotterdam, The Netherlands
    BMC Surg 10:11. 2010
    ..The feasibility of this method has been demonstrated recently, but as to date there are no data available advocating the use of one technique above the other...
  66. ncbi request reprint Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus
    Dennis A Hesselink
    Department of Internal Medicine, Renal Tranplant Unit, Erasmus Medical Center, Rotterdam, The Netherlands
    Clin Pharmacol Ther 74:245-54. 2003
    ..The low oral bioavailability of calcineurin inhibitors is thought to result from the actions of the metabolizing enzymes cytochrome P450 (CYP) 3A4 and CYP3A5 and the multidrug efflux pump P-glycoprotein, encoded by MDR-1...
  67. ncbi request reprint Altered chemokine receptor profile on circulating leukocytes in human heart failure
    Petros Athanassopoulos
    Department of Cardiothoracic Surgery, Erasmus MC, Rotterdam, The Netherlands
    Cell Biochem Biophys 44:83-101. 2006
    ..Modulation of the chemokine network could offer interesting novel therapeutic modalities for end-stage HF...
  68. ncbi request reprint Psychosocial and physical impairment after mini-incision open and laparoscopic donor nephrectomy: A prospective study
    Niels F M Kok
    Department of Surgery, Erasmus MC, Rotterdam, The Netherlands
    Transplantation 82:1291-7. 2006
    ..The aim of the present study was to prospectively investigate how mini-incision donor nephrectomy (MIDN) and laparoscopic donor nephrectomy (LDN) affected the donor's quality of life and fatigue...
  69. ncbi request reprint Strategies to expand the living donor pool for kidney transplantation
    Marry de Klerk
    Department of Internal Medicine Transplantation, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Front Biosci 13:3373-80. 2008
    ..In our opinion logistic solutions like paired exchange, list exchange and altruistic donation programs are to be preferred over the more medical demanding programs e.g. desensitization and transplantation across the blood type barrier...
  70. ncbi request reprint A highly efficient living donor kidney exchange program for both blood type and crossmatch incompatible donor-recipient combinations
    Marry de Klerk
    Department of Internal Medicine Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplantation 82:1616-20. 2006
    ..A national donor kidney exchange was considered as a possible solution...
  71. ncbi request reprint The beneficial effects of recipient-derived vascular endothelial growth factor on graft survival after kidney transplantation
    Francine B C Lemos
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplantation 79:1221-5. 2005
    ..Vascular endothelial growth factor (VEGF) is crucial for preservation of microvasculature and contributes to cytoprotection of the graft after kidney transplantation...
  72. doi request reprint Terminally differentiated CD8+ Temra cells are associated with the risk for acute kidney allograft rejection
    Michiel G H Betjes
    Division of Nephrology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Transplantation 94:63-9. 2012
    ..This may cause a relevant reduction in T-cell immunity, yielding a lowered risk for acute rejection (AR) of kidney allografts...
  73. doi request reprint Justification for a home-based education programme for kidney patients and their social network prior to initiation of renal replacement therapy
    Emma K Massey
    Department of Internal Medicine, Kidney Transplant Unit, Erasmus MC, Room D 408, Postbus 2040, 3000 CA Rotterdam, The Netherlands
    J Med Ethics 37:677-81. 2011
    ..Finally, reflecting on these ethical considerations, essential conditions for carrying out such a programme are outlined. The goal is to develop an ethically justified and responsible educational programme...
  74. ncbi request reprint The effects of chronic kidney disease and renal replacement therapy on circulating dendritic cells
    Dennis A Hesselink
    Department of Internal Medicine, Division of Nephrology and Renal Transplantation, Room Ee 563 A, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Nephrol Dial Transplant 20:1868-73. 2005
    ..In this study, we analysed whether this reduction resulted from CKD or from renal replacement therapy (RRT)...
  75. doi request reprint Attitudes towards medication non-adherence in elderly kidney transplant patients: a Q methodology study
    Mirjam Tielen
    Department of Internal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Nephrol Dial Transplant 26:1723-8. 2011
    ..This study investigated attitudes towards the post-transplant regime of immunosuppressive medication among the ever growing population of elderly kidney recipients...
  76. ncbi request reprint Cyclosporine interacts with mycophenolic acid by inhibiting the multidrug resistance-associated protein 2
    Dennis A Hesselink
    Department of Internal Medicine, Renal Transplant Unit, Erasmus University Medical Center, Rotterdam, The Netherlands
    Am J Transplant 5:987-94. 2005
    ..This finding suggests that CsA-mediated inhibition of the biliary excretion of MPAG by the Mrp2 transporter is the mechanism responsible for the interaction between CsA and MMF...
  77. ncbi request reprint The current practice of live donor nephrectomy in Europe
    Niels F M Kok
    Department of Surgery, Erasmus MC, Rotterdam, The Netherlands
    Transplantation 82:892-7. 2006
    ..The increasing number of live kidney donors in the last decade has stimulated interest in the surgical technique of donor nephrectomy. In this study, we evaluated the current status of the surgical approach in European transplant centers...
  78. doi request reprint Ethnically diverse populations and their participation in living kidney donation programs
    Joke I Roodnat
    Department of Internal Medicine, Erasmus MC Rotterdam, The Netherlands
    Transplantation 89:1263-9. 2010
    ..We wondered whether a low attendance or a high decline of potential non-European donors could explain this difference...
  79. doi request reprint Complex vascular anatomy in live kidney donation: imaging and consequences for clinical outcome
    Niels F M Kok
    Department of Surgery, Erasmus MC, Rotterdam, The Netherlands
    Transplantation 85:1760-5. 2008
    ..We evaluated the outcome of vascular imaging and the clinical consequences of multiple arteries and veins...
  80. ncbi request reprint Differential intragraft cytokine messenger RNA profiles during rejection and repair of clinical heart transplants. A longitudinal study
    Hester A de Groot-Kruseman
    Department of Internal Medicine, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Transpl Int 16:9-14. 2003
    ..Elevated growth factor expression levels indicate repair responses after tissue damage due to either the transplantation procedure (surgery, ischemia, reperfusion) or acute allograft rejection...
  81. doi request reprint Tapering immunosuppressive therapy significantly improves in vivo cutaneous delayed type hypersensitivity responses
    Nicole M van Besouw
    Department of Internal Medicine Transplantation, Erasmus MC, University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Transpl Immunol 19:229-34. 2008
    ....
  82. ncbi request reprint The granzyme B and interferon-gamma enzyme-linked immunospot assay as alternatives for cytotoxic T-lymphocyte precursor frequency after renal transplantation
    Nicole M van Besouw
    Department of Internal Medicine Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transplantation 79:1062-6. 2005
    ..The authors determined the CTL precursor frequency (CTLpf) and simultaneously measured the number of IFN-gamma- and GrB-producing cells (pc) by ELISPOT assay...
  83. doi request reprint Expansion of cytolytic CD4+CD28- T cells in end-stage renal disease
    Michiel G H Betjes
    Division of Nephrology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Kidney Int 74:760-7. 2008
    ..These findings are highly suggestive of repetitive antigenic stimulation of the immune system in patients with end stage disease by subclinical CMV reactivation which might contribute to increased atherosclerotic risk...
  84. doi request reprint Regulatory T cells after organ transplantation: where does their action take place?
    I Esmé Dijke
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hum Immunol 69:389-98. 2008
    ..In addition, we discuss the importance of the appropriate localization for the control of anti-donor immune reactivity...
  85. ncbi request reprint Sequential monitoring of intragraft cytokine mRNA expression in relation to diastolic left ventricular wall thickness and function early after heart transplantation
    Hester A de Groot-Kruseman
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Clin Transplant 16:433-41. 2002
    ..Our data suggest that the improvement in diastolic left ventricular function is associated with a general reduction of inflammation within the allograft, rather than related to a specific cytokine expression pattern...
  86. ncbi request reprint Living kidney donors and hypoxia-inducible factor-1alpha
    Carla Baan
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Transplantation 75:570-1. 2003
    ..We speculate that prolonged ischemia and hypoxia time leads to the production of HIF-1alpha, which in turn induces the production of fibrogenic cytokines in the graft...
  87. ncbi request reprint Effect of HLA-DR matching on acute rejection after clinical heart transplantation might be influenced by an IL-2 gene polymorphism
    Cecile T J Holweg
    Department of Internal Medicine, Cardiology, Diagnostic Institute of Molecular Biology, and Thoracic Surgery, University Hospital Rotterdam Dijkzigt, The Netherlands
    Transplantation 73:1353-6. 2002
    ..To examine whether genetic factors are involved in the development of acute rejection (AR), we investigated a (CA)m(CT)n repeat in the 3'-flanking region of the interleukin (IL)-2 gene...
  88. ncbi request reprint Functional impairment of monocyte-derived dendritic cells in patients with severe chronic kidney disease
    Martijn Anton Verkade
    Erasmus Medical Center, Department of Internal Medicine, Division of Nephrology, Bd336, Dr Molewater plein 40, 3015 GD Rotterdam, The Netherlands
    Nephrol Dial Transplant 22:128-38. 2007
    ..Patients with chronic kidney disease (CKD) with or without chronic intermittent haemodialysis (CIHD) show an impaired immune response. Dysfunction of DCs may underlie this phenomenon...
  89. ncbi request reprint Frequencies of donor-reactive helper T lymphocytes correlate with rejection of aortic valve allografts in rats
    Frank J M F Dor
    Department of Internal Medicine, University Hospital Rotterdam Dijkzigt, The Netherlands
    J Heart Valve Dis 11:326-34. 2002
    ..The value of this parameter in valve transplantation was studied using the 'Rotterdam' implantation model in rats...
  90. ncbi request reprint Starting a crossover kidney transplantation program in the Netherlands: ethical and psychological considerations
    Leonieke W Kranenburg
    Erasmus University Medical Center, Department of Medical Psychology and Psychotherapy, Rm cf 228, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Transplantation 78:194-7. 2004
    ..We concluded that whether viewed separately or in combination, these issues do not impede the efficient organization of a crossover program or raise worrying ethical issues...
  91. ncbi request reprint Donor-specific cytotoxic hyporesponsiveness associated with high interleukin-10 messenger RNA expression in cardiac allograft patients
    I Esmé Dijke
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Heart Lung Transplant 25:955-64. 2006
    ..In this study, we determined whether cardiac allograft recipients show donor-specific hyporesponsiveness and studied the underlying mechanisms...
  92. ncbi request reprint Predicting the usefulness of therapeutic drug monitoring of mycophenolic acid: a computer simulation
    Reinier van Hest
    Department of Hospital Pharmacy, Clinical Pharmacology Unit, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Ther Drug Monit 27:163-7. 2005
    ..To reach target AUC levels as soon as possible in this cyclosporine-treated population, it appears that larger MMF doses as currently recommended are necessary in the first month after transplantation...
  93. ncbi request reprint Myocardial contractility does not determine the haemodynamic response during dialysis
    Eric H Y Ie
    Department of Medicine, Erasmus MC, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Nephrol Dial Transplant 20:2465-71. 2005
    ....
  94. doi request reprint Current immunosuppressive treatment after kidney transplantation
    Marcia Kho
    Erasmus Medical Centre, Department of Internal Medicine, Rotterdam, The Netherlands
    Expert Opin Pharmacother 12:1217-31. 2011
    ..Since 1995, several immunosuppressive drugs have entered the field of organ transplantation: tacrolimus, mycophenolate and the mTOR-inhibitors. Now treating physicians have a choice...
  95. pmc Tacrolimus dose requirement in renal transplant recipients is significantly higher when used in combination with corticosteroids
    Dennis A Hesselink
    Department of Internal Medicine, Renal Transplant Unit, Room D 412, Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Br J Clin Pharmacol 56:327-30. 2003
    ..To evaluate the effect of corticosteroids on tacrolimus pharmacokinetics...
  96. ncbi request reprint The frequency of interferon-gproducing cells reflects alloreactivity against minor histocompatibility antigens
    Nicole M van Besouw
    Department of Internal Medicine Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands
    Transplantation 75:1400-4. 2003
    ..We questioned whether a more sensitive method like the Elispot-assay could be more appropriate...
  97. ncbi request reprint Oral ulcers in kidney transplant recipients treated with sirolimus and mycophenolate mofetil
    Teun van Gelder
    Department of Internal Medicine Nephrology, University Hospital Rotterdam, Rotterdam, The Netherlands
    Transplantation 75:788-91. 2003
    ..In an attempt to reduce calcineurin inhibitor toxicity, transplant patients treated with tacrolimus can be switched to maintenance treatment with sirolimus...
  98. ncbi request reprint Peripheral blood dendritic cells and GM-CSF as an adjuvant for hepatitis B vaccination in hemodialysis patients
    Martijn A Verkade
    Erasmus Medical Center, Department of Internal Medicine, Division of Nephrology, Dijkzigt Rottterdam, The Netherlands
    Kidney Int 66:614-21. 2004
    ..Although GM-CSF acts on both monocytes and dendritic cells, the mechanisms underlying its adjuvant quality are largely unknown...
  99. ncbi request reprint Preload dependence of new Doppler techniques limits their utility for left ventricular diastolic function assessment in hemodialysis patients
    Eric H Y Ie
    Department of Medicine, Erasmus MC, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Am Soc Nephrol 14:1858-62. 2003
    ..Assessment of LV diastolic function should not be performed shortly before HD, and its time relation to HD is essential...
  100. doi request reprint Ingredients for a successful living donor kidney exchange program
    Marry de Klerk
    Erasmus Medical Center Rotterdam, Department of Internal Medicine Transplantation, Office D 408, P O Box 2040, 3000 CA Rotterdam The Netherlands
    Transplantation 86:511-2. 2008
  101. doi request reprint Potential of mesenchymal stem cells as immune therapy in solid-organ transplantation
    Meindert Crop
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Transpl Int 22:365-76. 2009
    ..We discuss these topics and assess the feasibility of MSCs therapy in organ transplantation...