G Weeda

Summary

Affiliation: Erasmus University
Country: The Netherlands

Publications

  1. pmc The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor
    G Weeda
    Department of Cell Biology, Medical Genetics Center, Erasmus University, Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Nucleic Acids Res 25:2274-83. 1997
  2. pmc A mutation in the XPB/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy
    G Weeda
    MGC Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Am J Hum Genet 60:320-9. 1997
  3. ncbi request reprint Mouse model for the DNA repair/basal transcription disorder trichothiodystrophy reveals cancer predisposition
    J de Boer
    MGC Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Cancer Res 59:3489-94. 1999
  4. ncbi request reprint A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy
    J de Boer
    MGC Department of Cell Biology and Genetics Erasmus University, Rotterdam, The Netherlands
    Mol Cell 1:981-90. 1998
  5. pmc Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases
    T Seroz
    MGC Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Nucleic Acids Res 28:4506-13. 2000
  6. pmc The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells
    L J Niedernhofer
    Department of Cell Biology and Genetics, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    EMBO J 20:6540-9. 2001
  7. ncbi request reprint Disruption of the mouse xeroderma pigmentosum group D DNA repair/basal transcription gene results in preimplantation lethality
    J de Boer
    Medical Genetics Center, Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Cancer Res 58:89-94. 1998
  8. pmc Clinical heterogeneity within xeroderma pigmentosum associated with mutations in the DNA repair and transcription gene ERCC3
    W Vermeulen
    MGC Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Am J Hum Genet 54:191-200. 1994
  9. pmc Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH)
    A J van Vuuren
    Department of Cell Biology and Genetics, Erasmus University, The Netherlands
    EMBO J 13:1645-53. 1994
  10. ncbi request reprint Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence
    G Weeda
    Department of Cell Biology and Genetics, Medical Genetics Center, Erasmus University, Rotterdam P O Box 1738, 3000 DR, Rotterdam, The Netherlands
    Curr Biol 7:427-39. 1997

Collaborators

  • J H Hoeijmakers
  • H van Steeg
  • J M Egly
  • F R de Gruijl
  • Seema R Lalani
  • L Ma
  • A R Lehmann
  • J C Eeken
  • R Janssens
  • A Pastink
  • J Garssen
  • R J Scott
  • W J Kleijer
  • N G Jaspers
  • R Roy
  • Alain Sarasin
  • J de Boer
  • J de Wit
  • W Vermeulen
  • G T van der Horst
  • T Seroz
  • D Bootsma
  • R J Berg
  • L J Niedernhofer
  • B P Engelward
  • J Essers
  • P P Van Sloun
  • R B Beems
  • H Jacobs
  • C F van Kreijl
  • H Morreau
  • I Donker
  • J C Marinoni
  • R Kanaar
  • M Muijtjens
  • B Beverloo
  • H Odijk
  • A P Eker
  • J Brouwer
  • J Auriol
  • G S Winkler
  • R A Verhage
  • B Smit
  • L H Mullenders
  • H Vrieling
  • A A van Zeeland
  • P H Lohman
  • C T van Oostrum
  • J G Jansen
  • H te Riele
  • M Duran
  • A J van Vuuren
  • L Schaeffer
  • G de Murcia
  • Y Fukita
  • N de Wind
  • S Verbeek
  • L Samson
  • P Visser
  • J M de Murcia
  • K Rajewsky
  • C F Arlett
  • D M Gomez
  • B Gold
  • J L Broekhof
  • J M Allan
  • M Mezzina
  • M D Wyatt
  • P Miniou
  • L D Samson
  • A J van Gool
  • Y Lutz
  • M Stefanini
  • H J Muller
  • S Humbert
  • A Staub
  • M H Koken
  • J Cole
  • A J van der Eb
  • S Rodgers
  • V Moncollin
  • E Appeldoorn
  • S Giliani
  • T Nardo
  • J I Harper
  • N C Cheng
  • C Vreeken
  • S A Bol
  • I Jaspers-Dekker

Detail Information

Publications26

  1. pmc The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor
    G Weeda
    Department of Cell Biology, Medical Genetics Center, Erasmus University, Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Nucleic Acids Res 25:2274-83. 1997
    ..Since SUG1 is an integral component of the 26S proteasome and may be part of the mediator, our findings disclose a SUG1-dependent link between TFIIH and the cellular machinery involved in protein modelling/degradation...
  2. pmc A mutation in the XPB/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy
    G Weeda
    MGC Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Am J Hum Genet 60:320-9. 1997
    ..quot;..
  3. ncbi request reprint Mouse model for the DNA repair/basal transcription disorder trichothiodystrophy reveals cancer predisposition
    J de Boer
    MGC Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Cancer Res 59:3489-94. 1999
    ..These findings have important implications for the etiology of the human disorder and for the impact of NER on carcinogenesis...
  4. ncbi request reprint A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy
    J de Boer
    MGC Department of Cell Biology and Genetics Erasmus University, Rotterdam, The Netherlands
    Mol Cell 1:981-90. 1998
    ..The cutaneous symptoms are associated with reduced transcription of a skin-specific gene strongly supporting the concept of TTD as a human disease due to inborn defects in basal transcription and DNA repair...
  5. pmc Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases
    T Seroz
    MGC Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Nucleic Acids Res 28:4506-13. 2000
    ..These findings extend the conservation of the NER apparatus and the link between NER and basal transcription and suggest that hMMS19 exerts its function in repair and transcription by interacting with the XPB and XPD helicases...
  6. pmc The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells
    L J Niedernhofer
    Department of Cell Biology and Genetics, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    EMBO J 20:6540-9. 2001
    ..We propose a model for the mechanism of targeted gene replacement that invokes a role for Ercc1-Xpf in making the recipient genomic locus receptive for gene replacement...
  7. ncbi request reprint Disruption of the mouse xeroderma pigmentosum group D DNA repair/basal transcription gene results in preimplantation lethality
    J de Boer
    Medical Genetics Center, Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Cancer Res 58:89-94. 1998
    ....
  8. pmc Clinical heterogeneity within xeroderma pigmentosum associated with mutations in the DNA repair and transcription gene ERCC3
    W Vermeulen
    MGC Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Am J Hum Genet 54:191-200. 1994
    ..Factors in addition to NER deficiency may be required for the development of cutaneous tumors...
  9. pmc Correction of xeroderma pigmentosum repair defect by basal transcription factor BTF2 (TFIIH)
    A J van Vuuren
    Department of Cell Biology and Genetics, Erasmus University, The Netherlands
    EMBO J 13:1645-53. 1994
    ..The remarkable dual role of ERCC3 in NER and transcription provides a clue in understanding the complex clinical features of some inherited repair syndromes...
  10. ncbi request reprint Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence
    G Weeda
    Department of Cell Biology and Genetics, Medical Genetics Center, Erasmus University, Rotterdam P O Box 1738, 3000 DR, Rotterdam, The Netherlands
    Curr Biol 7:427-39. 1997
    ....
  11. ncbi request reprint Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition
    G T van der Horst
    Medical Genetics Center, Department of Cell Biology and Genetics, Erasmus University Rotterdam, The Netherlands
    Cell 89:425-35. 1997
    ..Further, they suggest that the lack of cancer predisposition in CS patients is attributable to a global genome repair process that in humans is more effective than in rodents...
  12. pmc Cloning and characterization of the Drosophila homolog of the xeroderma pigmentosum complementation-group B correcting gene, ERCC3
    M H Koken
    Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Nucleic Acids Res 20:5541-8. 1992
    ..g. B) fibroblasts and group 3 rodent mutants did not yield detectable correction. One of the possibilities to explain these negative findings is that the D.melanogaster protein may be unable to function in a mammalian repair context...
  13. pmc A new nucleotide-excision-repair gene associated with the disorder trichothiodystrophy
    M Stefanini
    Consiglio Nazionale delle Richerche, Instituto di Genetica Biochemica Evoluzionistica, Pavia, Italy
    Am J Hum Genet 53:817-21. 1993
    ..The finding of a second DNA repair gene that is associated with the clinical features of TTD argues strongly for an involvement of repair proteins in hair-shaft development...
  14. pmc Molecular and functional analysis of the XPBC/ERCC-3 promoter: transcription activity is dependent on the integrity of an Sp1-binding site
    L Ma
    Sylvius Laboratories, University of Leiden, The Netherlands
    Nucleic Acids Res 20:217-24. 1992
    ..Band shift assays showed that this putative Sp1-binding site can interact specifically with a nuclear factor, most likely transcription factor Sp1 (or an Sp1-like factor) in vitro...
  15. ncbi request reprint Transcription-coupled and global genome repair differentially influence UV-B-induced acute skin effects and systemic immunosuppression
    J Garssen
    Laboratory for Pathology and Immunobiology and Laboratory of Health Effects Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Immunol 164:6199-205. 2000
    ....
  16. pmc The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damage
    P P Van Sloun
    Department of Radiation Genetics and Chemical Mutagenesis MGC, Leiden University Medical Center, PO Box 9503, 2300 RA Leiden, The Netherlands
    Nucleic Acids Res 27:3276-82. 1999
    ..Possibly, to avoid the accumulation of mutated cells, ES cells rely on the induction of a strong apoptotic response with a simultaneous shutting down of NER activity...
  17. ncbi request reprint Characterization of the mouse homolog of the XPBC/ERCC-3 gene implicated in xeroderma pigmentosum and Cockayne's syndrome
    G Weeda
    Laboratory for Molecular Carcinogenesis, Sylvius Laboratory, Leiden, The Netherlands
    Carcinogenesis 12:2361-8. 1991
    ..The mouse XPBC/ERCC-3 gene is expressed constitutively at low levels in all tissues examined except for testis, where its expression is significantly enhanced...
  18. ncbi request reprint Localization of the xeroderma pigmentosum group B-correcting gene ERCC3 to human chromosome 2q21
    G Weeda
    Laboratory for Molecular Carcinogenesis, Sylvius Laboratory, Leiden, The Netherlands
    Genomics 10:1035-40. 1991
    ..Cell Genet. 13: 539-551). Here we report its subchromosomal localization in the q21 region of chromosome 2 via somatic cell hybrids containing a translocated chromosome 2 and in situ hybridization with fluorescently labeled ERCC3 probes...
  19. pmc Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH
    J C Marinoni
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Universite Louis Pasteur, Strasbourg, France
    EMBO J 16:1093-102. 1997
    ....
  20. pmc Structure and expression of the human XPBC/ERCC-3 gene involved in DNA repair disorders xeroderma pigmentosum and Cockayne's syndrome
    G Weeda
    Laboratory for Molecular Carcinogenesis, Sylvius Laboratory, Leiden, The Netherlands
    Nucleic Acids Res 19:6301-8. 1991
    ..Southern blot analysis revealed the presence of XPBC/ERCC-3 cross-hybridizing fragments elsewhere in the genome, which may belong to a related gene...
  21. pmc Molecular cloning and biological characterization of the human excision repair gene ERCC-3
    G Weeda
    Laboratory for Molecular Carcinogenesis, Sylvius Laboratory, Leiden, The Netherlands
    Mol Cell Biol 10:2570-81. 1990
    ..H. Thompson, A. V. Carrano, K. Sato, E. P. Salazar, B. F. White, S. A. Stewart, J. L. Minkler, and M. J. Siciliano, Somat. Cell. Mol. Genet. 13:539-551, 1987)...
  22. ncbi request reprint A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome
    G Weeda
    Laboratory for Molecular Carcinogenesis, Sylvius Laboratory, Leiden, The Netherlands
    Cell 62:777-91. 1990
    ..Because XP is associated with predisposition to skin cancer, ERCC-3 can be considered a tumor-preventing gene...
  23. ncbi request reprint The DNA-dependent ATPase activity associated with the class II basic transcription factor BTF2/TFIIH
    R Roy
    UPR 6520 Centre National de la Recherche Scientifique, Unité 184 Institut National de la Santé et de la Recherche Médicale, Faculte de Medecine, Strasbourg, France
    J Biol Chem 269:9826-32. 1994
    ..Using recombinant wild type or mutated p89/ERCC3 polypeptides and different forms of DNA template, we show the connection between ATPase and the helicase...
  24. pmc The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor
    L Schaeffer
    UPR 6520 CNRS, Unité 184 INSERM, Faculte de Medecine, Strasbourg, France
    EMBO J 13:2388-92. 1994
    ..This includes clinical features that lack an adequate rationalization on the basis of nucleotide excision repair (NER) deficiency but which may now be explained better in terms of a partial transcription deficiency...
  25. pmc Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase
    B P Engelward
    Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:13087-92. 1997
    ..Fibroblasts derived from Aag -/- mice are alkylation sensitive, indicating that Aag -/- mice may be similarly sensitive...
  26. pmc Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice
    H Jacobs
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 187:1735-43. 1998
    ..This appears also to be true for mismatch repair, RAD54-dependent double-strand-break repair, and AAG-mediated base excision repair...