A C Ward

Summary

Affiliation: Erasmus University
Country: The Netherlands

Publications

  1. ncbi request reprint Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia
    M H Hermans
    Institute of Hematology, Daniel den Hoed Cancer Center and Erasmus University Rotterdam, Rotterdam, The Netherlands
    Blood 92:32-9. 1998
  2. ncbi request reprint Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptor
    A C Ward
    Institute of Hematology, Room Ee 1330e, Erasmus University Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Biochim Biophys Acta 1448:70-6. 1998
  3. ncbi request reprint STAT3beta does not interfere with granulocyte colony-stimulating factor-induced neutrophilic differentiation
    J P de Koning
    Institute of Hematology, Erasmus University, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Hematol J 1:220-5. 2000
  4. ncbi request reprint Sequence analysis of the influenza virus strain A/shearwater/Australia/1/72 (H6N5)
    A C Ward
    Biomolecular Research Institute, Parkville, Victoria, Australia
    Microbiol Immunol 41:509-12. 1997
  5. pmc Novel point mutation in the extracellular domain of the granulocyte colony-stimulating factor (G-CSF) receptor in a case of severe congenital neutropenia hyporesponsive to G-CSF treatment
    A C Ward
    Institute of Hematology, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Exp Med 190:497-507. 1999
  6. ncbi request reprint Multiple signals mediate proliferation, differentiation, and survival from the granulocyte colony-stimulating factor receptor in myeloid 32D cells
    A C Ward
    Institute of Hematology, Erasmus University, 3000 DR Rotterdam, The Netherlands
    J Biol Chem 274:14956-62. 1999
  7. ncbi request reprint Defective internalization and sustained activation of truncated granulocyte colony-stimulating factor receptor found in severe congenital neutropenia/acute myeloid leukemia
    A C Ward
    Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
    Blood 93:447-58. 1999
  8. ncbi request reprint Tyrosine-dependent and -independent mechanisms of STAT3 activation by the human granulocyte colony-stimulating factor (G-CSF) receptor are differentially utilized depending on G-CSF concentration
    A C Ward
    Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
    Blood 93:113-24. 1999
  9. ncbi request reprint STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kip1)
    J P de Koning
    Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
    Oncogene 19:3290-8. 2000
  10. pmc Sustained receptor activation and hyperproliferation in response to granulocyte colony-stimulating factor (G-CSF) in mice with a severe congenital neutropenia/acute myeloid leukemia-derived mutation in the G-CSF receptor gene
    M H Hermans
    Institute of Hematology, Daniel den Hoed Cancer Center and Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Exp Med 189:683-92. 1999

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia
    M H Hermans
    Institute of Hematology, Daniel den Hoed Cancer Center and Erasmus University Rotterdam, Rotterdam, The Netherlands
    Blood 92:32-9. 1998
    ..These findings indicate that depending on G-CSF levels in mice, the triangle Delta715 mutation can contribute both to neutropenia and to neutrophilia...
  2. ncbi request reprint Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptor
    A C Ward
    Institute of Hematology, Room Ee 1330e, Erasmus University Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Biochim Biophys Acta 1448:70-6. 1998
    ..In addition, we have identified an unknown p40 molecule which is associated with the G-CSF-R transiently following G-CSF stimulation, and a constitutively-associated p37 molecule...
  3. ncbi request reprint STAT3beta does not interfere with granulocyte colony-stimulating factor-induced neutrophilic differentiation
    J P de Koning
    Institute of Hematology, Erasmus University, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Hematol J 1:220-5. 2000
    ..STAT3beta is known to be expressed in hematopoietic cells, but its role in controlling the balance between proliferation and differentiation has not been established...
  4. ncbi request reprint Sequence analysis of the influenza virus strain A/shearwater/Australia/1/72 (H6N5)
    A C Ward
    Biomolecular Research Institute, Parkville, Victoria, Australia
    Microbiol Immunol 41:509-12. 1997
    ....
  5. pmc Novel point mutation in the extracellular domain of the granulocyte colony-stimulating factor (G-CSF) receptor in a case of severe congenital neutropenia hyporesponsive to G-CSF treatment
    A C Ward
    Institute of Hematology, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Exp Med 190:497-507. 1999
    ..Together these data add to our understanding of the mechanisms of cytokine receptor signaling, emphasize the role of GCSFR mutations in the etiology of SCN, and implicate such mutations in G-CSF hyporesponsiveness...
  6. ncbi request reprint Multiple signals mediate proliferation, differentiation, and survival from the granulocyte colony-stimulating factor receptor in myeloid 32D cells
    A C Ward
    Institute of Hematology, Erasmus University, 3000 DR Rotterdam, The Netherlands
    J Biol Chem 274:14956-62. 1999
    ..In addition, we show that a tyrosine-independent "differentiation domain" in the membrane-distal region of the G-CSF-R appears necessary but not sufficient for mediating neutrophilic differentiation in these cells...
  7. ncbi request reprint Defective internalization and sustained activation of truncated granulocyte colony-stimulating factor receptor found in severe congenital neutropenia/acute myeloid leukemia
    A C Ward
    Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
    Blood 93:447-58. 1999
    ....
  8. ncbi request reprint Tyrosine-dependent and -independent mechanisms of STAT3 activation by the human granulocyte colony-stimulating factor (G-CSF) receptor are differentially utilized depending on G-CSF concentration
    A C Ward
    Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
    Blood 93:113-24. 1999
    ....
  9. ncbi request reprint STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kip1)
    J P de Koning
    Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
    Oncogene 19:3290-8. 2000
    ..These findings indicate that STAT3 controls myeloid differentiation, at least partly, via upregulation of p27(Kip1)...
  10. pmc Sustained receptor activation and hyperproliferation in response to granulocyte colony-stimulating factor (G-CSF) in mice with a severe congenital neutropenia/acute myeloid leukemia-derived mutation in the G-CSF receptor gene
    M H Hermans
    Institute of Hematology, Daniel den Hoed Cancer Center and Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Exp Med 189:683-92. 1999
    ....
  11. ncbi request reprint Expression of a Y559F mutant CSF-1 receptor in M1 myeloid cells: a role for Src kinases in CSF-1 receptor-mediated differentiation
    D C Marks
    Inflammation Research Centre, Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
    Mol Cell Biol Res Commun 1:144-52. 1999
    ..These data suggest that the reduced Src binding observed in the M1/Y559F cells may contribute to their reduced ability to differentiate...
  12. ncbi request reprint Proteomic analysis of macrophage differentiation. p46/52(Shc) Tyrosine phosphorylation is required for CSF-1-mediated macrophage differentiation
    X F Csar
    Arthritis and Inflammation Research Centre, University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia 3050
    J Biol Chem 276:26211-7. 2001
    ..This group of molecules may contain novel signaling molecules important in macrophage differentiation...
  13. ncbi request reprint The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor
    A C Ward
    Institute of Hematology, Erasmus University Rotterdam, The
    Biochem Biophys Res Commun 251:117-23. 1998
    ..In addition, we show that Hck becomes activated upon G-CSF treatment and is, in turn, able to phosphorylate the G-CSF-R, indicating a clear functional and physical involvement in G-CSF signaling...
  14. ncbi request reprint Somatostatin modulates G-CSF-induced but not interleukin-3-induced proliferative responses in myeloid 32D cells via activation of somatostatin receptor subtype 2
    S P Oomen
    Institute of Hematology, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Hematol J 2:322-9. 2001
    ..While 0.1-1 x 10(-9) M of somatostatin, or its synthetic stable analog octreotide, can inhibit G-CSF-induced proliferation of AML cells, little or no effects are seen on GM-CSF- or IL-3-induced responses...
  15. ncbi request reprint Signaling mechanisms of cytokine receptors and their perturbances in disease
    I P Touw
    Institute of Hematology, Erasmus University Rotterdam Room 1314, PO Box 1738, 3000DR, Rotterdam, The Netherlands
    Mol Cell Endocrinol 160:1-9. 2000
    ..In this review we will summarize these recent insights and discuss their implications for a variety of pathological conditions...
  16. ncbi request reprint Copper/zinc superoxide dismutase is phosphorylated and modulated specifically by granulocyte-colony stimulating factor in myeloid cells
    X F Csar
    University of Melbourne, Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, Parkville 3050, Victoria, Australia
    Proteomics 1:435-43. 2001
    ..This new protocol combining 2-D SDS-PAGE and HTP-chromatography allows the characterization of low abundance phosphoproteins involved in the cellular responses to G-CSF and presumably to other cytokines/growth factors...
  17. ncbi request reprint Morphologic and functional characterization of granulocytes and macrophages in embryonic and adult zebrafish
    G J Lieschke
    Ludwig Institute for Cancer Research, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    Blood 98:3087-96. 2001
    ..These observations will facilitate the application of this genetically tractable organism to the study of myelopoiesis...
  18. ncbi request reprint Multiple pathways contribute to the hyperproliferative responses from truncated granulocyte colony-stimulating factor receptors
    J Gits
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Leukemia 20:2111-8. 2006
    ..These data suggest that sustained JAK2/STAT5 activation is a major contributor to the hyperproliferative function of truncated G-CSF receptors, with pathways involving MEK and PI 3-kinase playing a reduced role...
  19. ncbi request reprint C/EBPalpha and G-CSF receptor signals cooperate to induce the myeloperoxidase and neutrophil elastase genes
    W Wang
    The Johns Hopkins Oncology Center, Division of Pediatric Oncology, Baltimore, MD 21231, USA
    Leukemia 15:779-86. 2001
    ..GCSFR signals or related signals from other receptors may cooperate with C/EBPalpha to direct differentiation of normal myeloid stem cells...