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Genomes and Genes | A C WardSummaryAffiliation: Erasmus University Country: The Netherlands Publications
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Publications
Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropeniaM H Hermans
Institute of Hematology, Daniel den Hoed Cancer Center and Erasmus University Rotterdam, Rotterdam, The Netherlands
Blood 92:32-9. 1998..These findings indicate that depending on G-CSF levels in mice, the triangle Delta715 mutation can contribute both to neutropenia and to neutrophilia...- Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptorA C Ward
Institute of Hematology, Room Ee 1330e, Erasmus University Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
Biochim Biophys Acta 1448:70-6. 1998..In addition, we have identified an unknown p40 molecule which is associated with the G-CSF-R transiently following G-CSF stimulation, and a constitutively-associated p37 molecule... - STAT3beta does not interfere with granulocyte colony-stimulating factor-induced neutrophilic differentiationJ P de Koning
Institute of Hematology, Erasmus University, P O Box 1738, 3000 DR Rotterdam, The Netherlands
Hematol J 1:220-5. 2000..STAT3beta is known to be expressed in hematopoietic cells, but its role in controlling the balance between proliferation and differentiation has not been established... - Sequence analysis of the influenza virus strain A/shearwater/Australia/1/72 (H6N5)A C Ward
Biomolecular Research Institute, Parkville, Victoria, Australia
Microbiol Immunol 41:509-12. 1997.... - Novel point mutation in the extracellular domain of the granulocyte colony-stimulating factor (G-CSF) receptor in a case of severe congenital neutropenia hyporesponsive to G-CSF treatmentA C Ward
Institute of Hematology, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
J Exp Med 190:497-507. 1999..Together these data add to our understanding of the mechanisms of cytokine receptor signaling, emphasize the role of GCSFR mutations in the etiology of SCN, and implicate such mutations in G-CSF hyporesponsiveness... - Multiple signals mediate proliferation, differentiation, and survival from the granulocyte colony-stimulating factor receptor in myeloid 32D cellsA C Ward
Institute of Hematology, Erasmus University, 3000 DR Rotterdam, The Netherlands
J Biol Chem 274:14956-62. 1999..In addition, we show that a tyrosine-independent "differentiation domain" in the membrane-distal region of the G-CSF-R appears necessary but not sufficient for mediating neutrophilic differentiation in these cells... - Defective internalization and sustained activation of truncated granulocyte colony-stimulating factor receptor found in severe congenital neutropenia/acute myeloid leukemiaA C Ward
Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
Blood 93:447-58. 1999.... - Tyrosine-dependent and -independent mechanisms of STAT3 activation by the human granulocyte colony-stimulating factor (G-CSF) receptor are differentially utilized depending on G-CSF concentrationA C Ward
Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
Blood 93:113-24. 1999.... - STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kip1)J P de Koning
Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
Oncogene 19:3290-8. 2000..These findings indicate that STAT3 controls myeloid differentiation, at least partly, via upregulation of p27(Kip1)... - Sustained receptor activation and hyperproliferation in response to granulocyte colony-stimulating factor (G-CSF) in mice with a severe congenital neutropenia/acute myeloid leukemia-derived mutation in the G-CSF receptor geneM H Hermans
Institute of Hematology, Daniel den Hoed Cancer Center and Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
J Exp Med 189:683-92. 1999.... - Expression of a Y559F mutant CSF-1 receptor in M1 myeloid cells: a role for Src kinases in CSF-1 receptor-mediated differentiationD C Marks
Inflammation Research Centre, Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
Mol Cell Biol Res Commun 1:144-52. 1999..These data suggest that the reduced Src binding observed in the M1/Y559F cells may contribute to their reduced ability to differentiate... - Proteomic analysis of macrophage differentiation. p46/52(Shc) Tyrosine phosphorylation is required for CSF-1-mediated macrophage differentiationX F Csar
Arthritis and Inflammation Research Centre, University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia 3050
J Biol Chem 276:26211-7. 2001..This group of molecules may contain novel signaling molecules important in macrophage differentiation... - The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptorA C Ward
Institute of Hematology, Erasmus University Rotterdam, The
Biochem Biophys Res Commun 251:117-23. 1998..In addition, we show that Hck becomes activated upon G-CSF treatment and is, in turn, able to phosphorylate the G-CSF-R, indicating a clear functional and physical involvement in G-CSF signaling... - Somatostatin modulates G-CSF-induced but not interleukin-3-induced proliferative responses in myeloid 32D cells via activation of somatostatin receptor subtype 2S P Oomen
Institute of Hematology, Erasmus University Rotterdam, Rotterdam, The Netherlands
Hematol J 2:322-9. 2001..While 0.1-1 x 10(-9) M of somatostatin, or its synthetic stable analog octreotide, can inhibit G-CSF-induced proliferation of AML cells, little or no effects are seen on GM-CSF- or IL-3-induced responses... - Signaling mechanisms of cytokine receptors and their perturbances in diseaseI P Touw
Institute of Hematology, Erasmus University Rotterdam Room 1314, PO Box 1738, 3000DR, Rotterdam, The Netherlands
Mol Cell Endocrinol 160:1-9. 2000..In this review we will summarize these recent insights and discuss their implications for a variety of pathological conditions... - Copper/zinc superoxide dismutase is phosphorylated and modulated specifically by granulocyte-colony stimulating factor in myeloid cellsX F Csar
University of Melbourne, Arthritis and Inflammation Research Centre, Department of Medicine, Royal Melbourne Hospital, Parkville 3050, Victoria, Australia
Proteomics 1:435-43. 2001..This new protocol combining 2-D SDS-PAGE and HTP-chromatography allows the characterization of low abundance phosphoproteins involved in the cellular responses to G-CSF and presumably to other cytokines/growth factors... - Morphologic and functional characterization of granulocytes and macrophages in embryonic and adult zebrafishG J Lieschke
Ludwig Institute for Cancer Research, The Royal Melbourne Hospital, Parkville, Victoria, Australia
Blood 98:3087-96. 2001..These observations will facilitate the application of this genetically tractable organism to the study of myelopoiesis... - Multiple pathways contribute to the hyperproliferative responses from truncated granulocyte colony-stimulating factor receptorsJ Gits
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Leukemia 20:2111-8. 2006..These data suggest that sustained JAK2/STAT5 activation is a major contributor to the hyperproliferative function of truncated G-CSF receptors, with pathways involving MEK and PI 3-kinase playing a reduced role... - C/EBPalpha and G-CSF receptor signals cooperate to induce the myeloperoxidase and neutrophil elastase genesW Wang
The Johns Hopkins Oncology Center, Division of Pediatric Oncology, Baltimore, MD 21231, USA
Leukemia 15:779-86. 2001..GCSFR signals or related signals from other receptors may cooperate with C/EBPalpha to direct differentiation of normal myeloid stem cells...