Affiliation: Erasmus MC
Country: The Netherlands
Ribeiro Silva C, Vermeulen W, Lans H. SWI/SNF: Complex complexes in genome stability and cancer. DNA Repair (Amst). 2019;77:87-95 pubmed publisher
..Here, we review current knowledge on SWI/SNF activity in the DDR and discuss the potential of exploiting DDR-related vulnerabilities due to SWI/SNF dysfunction for precision cancer therapy. ..
Ribeiro Silva C, Aydin O, Mesquita Ribeiro R, Slyskova J, Helfricht A, Marteijn J, et al
. DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1. Nat Commun. 2018;9:4067 pubmed publisher
..Together, our results expose GTF2H1 as a potential novel predictive marker of platinum drug sensitivity in SWI/SNF-deficient cancer cells. ..
Lans H, Marteijn J, Vermeulen W. ATP-dependent chromatin remodeling in the DNA-damage response. Epigenetics Chromatin. 2012;5:4 pubmed publisher
..Moreover, several complexes seem to have multiple functions, and are implicated in various mechanistically distinct repair pathways. ..
Vermeulen W. Dynamics of mammalian NER proteins. DNA Repair (Amst). 2011;10:760-71 pubmed publisher
..The spatio-temporal analysis tools developed for the study of NER and the kinetic model derived from these studies can serve as a paradigm for the understanding of other chromatin-associated processes. ..
Gourdin A, van Cuijk L, Tresini M, Luijsterburg M, Nigg A, Giglia Mari G, et al
. Differential binding kinetics of replication protein A during replication and the pre- and post-incision steps of nucleotide excision repair. DNA Repair (Amst). 2014;24:46-56 pubmed publisher
..Together our data show that RPA is an intrinsically highly dynamic ssDNA-binding complex during both replication and distinct steps of NER. ..
Lans H, Vermeulen W. Tissue specific response to DNA damage: C. elegans as role model. DNA Repair (Amst). 2015;32:141-148 pubmed publisher
..In this mini-review, we describe tissue-specific differences in DDR mechanisms that have been uncovered utilizing C. elegans as role model. ..
Pines A, Dijk M, Makowski M, Meulenbroek E, Vrouwe M, van der Weegen Y, et al
. TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A. Nat Commun. 2018;9:1040 pubmed publisher
..Thus, we uncover CSA as a TRiC substrate and reveal that TRiC regulates CSA-dependent TC-NER and the development of CS. ..