Georges M G M Verjans

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc T-Cell tropism of simian varicella virus during primary infection
    Werner J D Ouwendijk
    Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands
    PLoS Pathog 9:e1003368. 2013
  2. pmc Simian varicella virus infection of Chinese rhesus macaques produces ganglionic infection in the absence of rash
    Werner J D Ouwendijk
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurovirol 18:91-9. 2012
  3. ncbi request reprint Isopentenyl pyrophosphate-reactive Vgamma9Vdelta 2 T helper 1-like cells are the major gammadelta T cell subset recovered from lesions of patients with genital herpes
    Georges M G M Verjans
    Institute of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Infect Dis 190:489-93. 2004
  4. pmc Selective retention of herpes simplex virus-specific T cells in latently infected human trigeminal ganglia
    Georges M G M Verjans
    Department of Virology, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 104:3496-501. 2007
  5. pmc T-cell infiltration correlates with CXCL10 expression in ganglia of cynomolgus macaques with reactivated simian varicella virus
    Werner J D Ouwendijk
    Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands
    J Virol 87:2979-82. 2013
  6. ncbi request reprint Identification of viral antigens recognized by ocular infiltrating T cells from patients with varicella zoster virus-induced uveitis
    Johannes C M Milikan
    Institute of Virology, Erasmus Medical Center, Rotterdam
    Invest Ophthalmol Vis Sci 48:3689-97. 2007
  7. doi request reprint Acyclovir-resistant herpes simplex virus type 1 in intra-ocular fluid samples of herpetic uveitis patients
    Monique van Velzen
    Viroscience Lab, Erasmus MC, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    J Clin Virol 57:215-21. 2013
  8. doi request reprint Prevalence and clinical consequences of herpes simplex virus type 1 DNA in human cornea tissues
    Lies Remeijer
    Rotterdam Eye Hospital, Rotterdam, The Netherlands
    J Infect Dis 200:11-9. 2009
  9. doi request reprint Latent acyclovir-resistant herpes simplex virus type 1 in trigeminal ganglia of immunocompetent individuals
    Monique van Velzen
    Department of Virology, Laboratory of Neuro Oncology and Clinical and Cancer Proteomics, Erasmus Medical Center, The Netherlands
    J Infect Dis 205:1539-43. 2012
  10. pmc Local CD4 and CD8 T-cell reactivity to HSV-1 antigens documents broad viral protein expression and immune competence in latently infected human trigeminal ganglia
    Monique van Velzen
    Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands
    PLoS Pathog 9:e1003547. 2013

Collaborators

Detail Information

Publications37

  1. pmc T-Cell tropism of simian varicella virus during primary infection
    Werner J D Ouwendijk
    Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands
    PLoS Pathog 9:e1003368. 2013
    ..In conclusion, the data suggest the role of memory T-cells in disseminating SVV to its target organs during primary infection of its natural and immunocompetent host...
  2. pmc Simian varicella virus infection of Chinese rhesus macaques produces ganglionic infection in the absence of rash
    Werner J D Ouwendijk
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurovirol 18:91-9. 2012
    ..Our findings demonstrate that acute SVV infection of Chinese rhesus macaques leads to ganglionic infection by the hematogenous route and the induction of a virus-specific adaptive memory response in the absence of skin rash...
  3. ncbi request reprint Isopentenyl pyrophosphate-reactive Vgamma9Vdelta 2 T helper 1-like cells are the major gammadelta T cell subset recovered from lesions of patients with genital herpes
    Georges M G M Verjans
    Institute of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Infect Dis 190:489-93. 2004
    ..The results of the present study suggest the infiltration and putative involvement of isopentenyl pyrophosphate-reactive V gamma 9V delta 2 T helper 1-like cells in individuals with GH...
  4. pmc Selective retention of herpes simplex virus-specific T cells in latently infected human trigeminal ganglia
    Georges M G M Verjans
    Department of Virology, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 104:3496-501. 2007
    ..In contrast, T cells do not seem to be directly involved in controlling VZV latency in human TG...
  5. pmc T-cell infiltration correlates with CXCL10 expression in ganglia of cynomolgus macaques with reactivated simian varicella virus
    Werner J D Ouwendijk
    Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands
    J Virol 87:2979-82. 2013
    ..CXCL10 RNA colocalized with T-cell clusters. After SVV reactivation, transient T-cell infiltration, possibly mediated by CXCL10, parallels varicella zoster virus (VZV) reactivation in humans...
  6. ncbi request reprint Identification of viral antigens recognized by ocular infiltrating T cells from patients with varicella zoster virus-induced uveitis
    Johannes C M Milikan
    Institute of Virology, Erasmus Medical Center, Rotterdam
    Invest Ophthalmol Vis Sci 48:3689-97. 2007
    ..In the current study, the functional characteristics and the antigen specificity of VZV-reactive T cells recovered from intraocular fluid (IOF) samples of five patients with VZV were determined...
  7. doi request reprint Acyclovir-resistant herpes simplex virus type 1 in intra-ocular fluid samples of herpetic uveitis patients
    Monique van Velzen
    Viroscience Lab, Erasmus MC, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    J Clin Virol 57:215-21. 2013
    ..In addition to its predictive value on ACV susceptibility, the polymorphic HSV-1 thymidine kinase (TK) gene facilitates differentiation between HSV-1 strains...
  8. doi request reprint Prevalence and clinical consequences of herpes simplex virus type 1 DNA in human cornea tissues
    Lies Remeijer
    Rotterdam Eye Hospital, Rotterdam, The Netherlands
    J Infect Dis 200:11-9. 2009
    ..We determined the prevalence and clinical consequences of herpes simplex virus (HSV) type 1 (HSV-1), HSV type 2 (HSV-2), and varicella-zoster virus (VZV) in cornea tissues obtained after penetrating keratoplasty (PKP) was performed...
  9. doi request reprint Latent acyclovir-resistant herpes simplex virus type 1 in trigeminal ganglia of immunocompetent individuals
    Monique van Velzen
    Department of Virology, Laboratory of Neuro Oncology and Clinical and Cancer Proteomics, Erasmus Medical Center, The Netherlands
    J Infect Dis 205:1539-43. 2012
    ..Contrary to minor variants, major TK variants were shared between paired TG. The data demonstrate the coexistence of phylogenetic-related ACV(S) and ACV(R) latent HSV-1 in human TG...
  10. pmc Local CD4 and CD8 T-cell reactivity to HSV-1 antigens documents broad viral protein expression and immune competence in latently infected human trigeminal ganglia
    Monique van Velzen
    Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands
    PLoS Pathog 9:e1003547. 2013
    ..HSV-1 proteins recognized by TG-resident T-cells, particularly ICP6 and VP16, are potential HSV-1 vaccine candidates...
  11. pmc Longitudinal study on oral shedding of herpes simplex virus 1 and varicella-zoster virus in individuals infected with HIV
    Monique van Velzen
    Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands
    J Med Virol 85:1669-77. 2013
    ..Compared to HSV-1, oral VZV shedding is rare in individuals infected with HIV. Recurrent oral HSV-1 shedding is likely due to reactivation of the same latent HSV-1 strain...
  12. doi request reprint Acyclovir prophylaxis predisposes to antiviral-resistant recurrent herpetic keratitis
    Monique van Velzen
    Department of Viroscience, Erasmus MC
    J Infect Dis 208:1359-65. 2013
    ..We determined the effect of ACV prophylaxis on the prevalence of corneal ACV-resistant (ACV(R)) HSV-1 and clinical consequences thereof in patients with recurrent HSV-1 keratitis (rHK)...
  13. ncbi request reprint High incidence of genotypic variance between sequential herpes simplex virus type 2 isolates from HIV-1-seropositive patients with recurrent genital herpes
    R Wim Roest
    Department of Dermatology and Venereology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Infect Dis 194:1115-8. 2006
    ..The PCR approach developed distinguishes unrelated HSV-2 strains efficiently and indicated a high incidence of genotype variance between sequential HSV-2 isolates of HIV-1-seropositive patients with RGH...
  14. ncbi request reprint Acyclovir susceptibility and genetic characteristics of sequential herpes simplex virus type 1 corneal isolates from patients with recurrent herpetic keratitis
    Rui Duan
    Department of Virology, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Infect Dis 200:1402-14. 2009
    ..The incidence and clinical significance of herpes simplex virus type 1 (HSV-1) acyclovir resistance were determined in patients with recurrent herpetic keratitis (RHK)...
  15. ncbi request reprint Granulocyte macrophage colony-stimulating factor expression in human herpetic stromal keratitis: implications for the role of neutrophils in HSK
    Rui Duan
    Institute of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 48:277-84. 2007
    ..The objective of this study was to determine the putative role of GM-CSF in the pathogenesis of human herpetic stromal keratitis (HSK)...
  16. ncbi request reprint Functional characterization of ocular-derived human alphaherpesvirus cross-reactive CD4 T cells
    Werner J D Ouwendijk
    Department of Viroscience, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands
    J Immunol 192:3730-9. 2014
    ..Moreover, ocular-derived peptide-specific CD4 TCC controlled VZV but not HSV-1 infection of RPE cells, suggesting that HSV-1 actively inhibits CD4 T cell activation by infected human RPE cells. ..
  17. doi request reprint Human ocular-derived virus-specific CD4+ T cells control varicella zoster virus replication in human retinal pigment epithelial cells
    Johannes C M Milikan
    Institute of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 50:743-51. 2009
    ..Herein, the susceptibility of human retinal pigment epithelial (RPE) cells to VZV infection and the ability of virus-specific CD4(+) T cells to control VZV infection in RPE cells in vitro is addressed...
  18. ncbi request reprint Restricted T cell receptor beta-chain variable region protein use by cornea-derived CD4+ and CD8+ herpes simplex virus-specific T cells in patients with herpetic stromal keratitis
    Jeroen Maertzdorf
    Institute of Virology, Erasmus Medical Centre, Erasmus, The Netherlands
    J Infect Dis 187:550-8. 2003
    ..The data demonstrate that both CD4(+) and CD8(+) T cells may be involved in the HSV-specific T cell response in the corneas of patients with HSK and suggest that restricted TCRBV use by cornea-residing HSV-specific T cells occurs...
  19. ncbi request reprint Acyclovir-resistant corneal HSV-1 isolates from patients with herpetic keratitis
    Rui Duan
    Department of Virology, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Infect Dis 198:659-63. 2008
    ..These data demonstrate a relatively high prevalence of corneal HSV-1 ACV(R) isolates in patients with HK, which emphasizes the need to monitor for ACV susceptibility in patients with HK who are refractory to therapy with ACV...
  20. ncbi request reprint Characterization of the varicella zoster virus (VZV)-specific intra-ocular T-cell response in patients with VZV-induced uveitis
    Johannes C M Milikan
    Institute of Virology, Erasmus Medical Center, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Exp Eye Res 83:69-75. 2006
    ..The data implicate that VZV-reactive T-cells infiltrate and participate in the local inflammatory response in eyes of patients with VZV-induced uveitis...
  21. doi request reprint Systemic varicella zoster virus reactive effector memory T-cells impaired in the elderly and in kidney transplant recipients
    Nicole M van Besouw
    Department of Internal Medicine Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Med Virol 84:2018-25. 2012
    ..The data suggest that VZV-reactive EM T-cells are impaired in the elderly and renal transplant recipients...
  22. doi request reprint Monitoring the inflammatory process in herpetic stromal keratitis: the role of in vivo confocal microscopy
    Toine Hillenaar
    Rotterdam Ophthalmic Institute, Rotterdam, The Netherlands
    Ophthalmology 119:1102-10. 2012
    ..To investigate the role of in vivo confocal microscopy (IVCM) in the detection of inflammatory activity and follow-up of herpetic stromal keratitis (HSK)...
  23. pmc Restricted varicella-zoster virus transcription in human trigeminal ganglia obtained soon after death
    Werner J D Ouwendijk
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Virol 86:10203-6. 2012
    ..02) in VZV ORF63 transcript levels but not the virus DNA burden with longer PMI. Overall, both the breadth of the VZV transcriptome and the VZV ORF63 transcript levels in human cadaver TG increased with longer PMI...
  24. doi request reprint Immunohistochemical detection of intra-neuronal VZV proteins in snap-frozen human ganglia is confounded by antibodies directed against blood group A1-associated antigens
    Werner J D Ouwendijk
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurovirol 18:172-80. 2012
    ....
  25. doi request reprint Neuron-interacting satellite glial cells in human trigeminal ganglia have an APC phenotype
    Monique van Velzen
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Immunol 183:2456-61. 2009
    ....
  26. doi request reprint High prevalence of anelloviruses in vitreous fluid of children with seasonal hyperacute panuveitis
    Saskia L Smits
    Department of Virology, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Infect Dis 205:1877-84. 2012
    ..The detection of anelloviruses in VF samples of uveitis patients, profoundly so in SHAPU patients, is imperative and warrants elucidation of its clinical significance...
  27. ncbi request reprint IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts
    Jeroen Maertzdorf
    Institute of Virology, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Immunol 169:5897-903. 2002
    ....
  28. ncbi request reprint Vgamma9Vdelta2 T cells recovered from eyes of patients with Behçet's disease recognize non-peptide prenyl pyrophosphate antigens
    Georges M G M Verjans
    Rotterdam Eye Hospital, PO Box 70030, 3000 LM, Rotterdam, The Netherlands
    J Neuroimmunol 130:46-54. 2002
    ..The data presented suggest the infiltration of PPP-specific Vgamma9Vdelta2 Th1-like cells into the eye of BD patients with uveitis...
  29. ncbi request reprint Prevalence of human Herpesviridae in cerebrospinal fluid of patients with multiple sclerosis and noninfectious neurological disease in the Netherlands
    Gijsbert P van Nierop
    Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Neurovirol 20:412-8. 2014
    ..However, intrathecal HHV infection was not detected. Data indicate that HHV1-8 are rarely detected in CSF of Dutch NIND patients and do not support the role of intrathecal HHV infection early after onset of disease symptoms in MS. ..
  30. pmc T-cell immunity to human alphaherpesviruses
    Werner J D Ouwendijk
    Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    Curr Opin Virol 3:452-60. 2013
    ..These recent advances hold promise in the design of new vaccine candidates...
  31. pmc High Seroprevalence of Human Herpesviruses in HIV-Infected Individuals Attending Primary Healthcare Facilities in Rural South Africa
    Erik Schaftenaar
    Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands ANOVA Health Institute, Johannesburg and Tzaneen, South Africa
    PLoS ONE 9:e99243. 2014
    ..Moreover, IgG titres of HSV-1 and 2, VZV and CMV, and CMV and EBV were positively correlated. The high HHV seroprevalence emphasises the importance of awareness of these viral infections in HIV-infected individuals in South Africa. ..
  32. doi request reprint No evidence for intrathecal IgG synthesis to Epstein Barr virus nuclear antigen-1 in multiple sclerosis
    Naghmeh Jafari
    Department of Neurology, MS center ErasMS, Erasmus MC, Dr Molewaterplein 50 60, 3015 GE Rotterdam, The Netherlands
    J Clin Virol 49:26-31. 2010
    ..Recent studies suggest an intrathecal IgG response against Epstein Barr virus (EBV) in multiple sclerosis (MS), implicating a pathogenic role for the virus in MS...
  33. doi request reprint Zipper cell endotheliopathy: a new subset of idiopathic corneal edema
    Toine Hillenaar
    Rotterdam Ophthalmic Institute, Rotterdam, The Netherlands
    Ophthalmology 117:2255-62. 2010
    ..To report the clinical and histologic findings of a new subset of idiopathic corneal edema: zipper cell endotheliopathy...
  34. ncbi request reprint Corneal herpes simplex virus type 1 superinfection in patients with recrudescent herpetic keratitis
    Lies Remeijer
    Rotterdam Eye Hospital, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 43:358-63. 2002
    ..Recurrences may be caused by reactivation of endogenous HSV-1 or reinfection with exogenous HSV-1. The objective of this study was to determine the incidence and risk factors involved of HSV-1 superinfection in patients with RHK...
  35. ncbi request reprint In vitro and in vivo replication of seal gammaherpesviruses in cells of multiple species
    Byron E Martina
    Erasmus Medical Centre, Institute of Virology, P O Box 1738, 3000 DR Rotterdam, Netherlands
    Microbes Infect 9:40-6. 2007
    ..The development of myoepitheliomas and spleen hyperplasia upon cyclosporin A treatment in some of the PhHV-2-infected animals warrants further investigation of the oncogenic and zoonotic potential of this virus...
  36. ncbi request reprint Genotypic analysis of sequential genital herpes simplex virus type 1 (HSV-1) isolates of patients with recurrent HSV-1 associated genital herpes
    R W Roest
    Departments of Dermatology and Venereology, Glasgow, Scotland
    J Med Virol 73:601-4. 2004
    ..The data suggest that HSV-1-induced recurrent genital herpes can be associated with genital reinfection with an exogenous HSV-1 strain...
  37. ncbi request reprint Herpes simplex virus infection of the human eye induces a compartmentalized virus-specific B cell response
    Ron Peek
    Netherlands Ophthalmic Research Institute, Amsterdam, The Netherlands
    J Infect Dis 186:1539-46. 2002
    ..The results presented here indicate that the inflamed eyes of patients with HSV-induced uveitis display a compartmentalized B cell response directed toward the triggering virus...