Roel G W Verhaak

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Prognostically useful gene-expression profiles in acute myeloid leukemia
    Peter J M Valk
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 350:1617-28. 2004
  2. pmc The effect of oligonucleotide microarray data pre-processing on the analysis of patient-cohort studies
    Roel G W Verhaak
    Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Bioinformatics 7:105. 2006
  3. pmc HeatMapper: powerful combined visualization of gene expression profile correlations, genotypes, phenotypes and sample characteristics
    Roel G W Verhaak
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Bioinformatics 7:337. 2006
  4. ncbi request reprint Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance
    Roel G W Verhaak
    Department of Hematology, Erasmus University Medical Center Rotterdam, Ee1391a, Dr Molewaterplein 50, 3015 GE Rotterdam Z H, The Netherlands
    Blood 106:3747-54. 2005
  5. pmc Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling
    Roel G W Verhaak
    Erasmus University Medical Center Rotterdam, Department of Hematology, Rotterdam, The Netherlands
    Haematologica 94:131-4. 2009
  6. pmc SNPExpress: integrated visualization of genome-wide genotypes, copy numbers and gene expression levels
    Mathijs A Sanders
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Genomics 9:41. 2008
  7. ncbi request reprint Significance of murine retroviral mutagenesis for identification of disease genes in human acute myeloid leukemia
    Stefan J Erkeland
    Department of Hematology, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Cancer Res 66:622-6. 2006
  8. doi request reprint Genes predictive of outcome and novel molecular classification schemes in adult acute myeloid leukemia
    Roel G W Verhaak
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Cancer Treat Res 145:67-83. 2010
  9. pmc Differential regulation of Foxo3a target genes in erythropoiesis
    Walbert J Bakker
    Department of Hematology, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    Mol Cell Biol 27:3839-3854. 2007
  10. pmc Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1
    Bas J Wouters
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 110:3706-14. 2007

Detail Information

Publications13

  1. ncbi request reprint Prognostically useful gene-expression profiles in acute myeloid leukemia
    Peter J M Valk
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 350:1617-28. 2004
    ..However, this combined approach provides correct therapeutic and prognostic information in only 50 percent of cases...
  2. pmc The effect of oligonucleotide microarray data pre-processing on the analysis of patient-cohort studies
    Roel G W Verhaak
    Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Bioinformatics 7:105. 2006
    ..By focusing on practical applications of microarray-based research, this study provides insight into the relevance of pre-processing procedures to biology-oriented researchers...
  3. pmc HeatMapper: powerful combined visualization of gene expression profile correlations, genotypes, phenotypes and sample characteristics
    Roel G W Verhaak
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Bioinformatics 7:337. 2006
    ..Here, we describe an approach to visually integrate the results of unsupervised and supervised cluster analysis using a correlation plot and additional sample metadata...
  4. ncbi request reprint Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance
    Roel G W Verhaak
    Department of Hematology, Erasmus University Medical Center Rotterdam, Ee1391a, Dr Molewaterplein 50, 3015 GE Rotterdam Z H, The Netherlands
    Blood 106:3747-54. 2005
    ..Finally, in multivariable analysis NPM1 mutations express independent favorable prognostic value with regard to OS, EFS, and disease-free survival (DFS)...
  5. pmc Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling
    Roel G W Verhaak
    Erasmus University Medical Center Rotterdam, Department of Hematology, Rotterdam, The Netherlands
    Haematologica 94:131-4. 2009
    ..g. those characterized by expression of chimeric transcription factors. However, detection of mutations affecting signaling molecules and numerical abnormalities still requires alternative molecular methods...
  6. pmc SNPExpress: integrated visualization of genome-wide genotypes, copy numbers and gene expression levels
    Mathijs A Sanders
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Genomics 9:41. 2008
    ..In fact, obtaining an integrated view of both large scale SNP genotyping and gene expression is currently complicated since only a limited number of appropriate software tools are available...
  7. ncbi request reprint Significance of murine retroviral mutagenesis for identification of disease genes in human acute myeloid leukemia
    Stefan J Erkeland
    Department of Hematology, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Cancer Res 66:622-6. 2006
    ....
  8. doi request reprint Genes predictive of outcome and novel molecular classification schemes in adult acute myeloid leukemia
    Roel G W Verhaak
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Cancer Treat Res 145:67-83. 2010
    ..The current advances made in molecular understanding of AML will ultimately lead to a further refinement of prognostics of AML...
  9. pmc Differential regulation of Foxo3a target genes in erythropoiesis
    Walbert J Bakker
    Department of Hematology, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    Mol Cell Biol 27:3839-3854. 2007
    ..Thus, Foxo3a not only is an effector of PKB but also integrates distinct signals to regulate gene expression in erythropoiesis...
  10. pmc Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1
    Bas J Wouters
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 110:3706-14. 2007
    ..A gene expression prediction signature allowed the detection of similar cases of leukemia in independent series of AML...
  11. pmc Characterizing the cancer genome in lung adenocarcinoma
    Barbara A Weir
    Department of Medical Oncology and Center for Cancer Genome Discovery, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 450:893-8. 2007
    ..More generally, our results indicate that many of the genes that are involved in lung adenocarcinoma remain to be discovered...
  12. pmc A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia
    Ulrich Steidl
    Harvard Institutes of Medicine, Harvard Medical School, and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
    J Clin Invest 117:2611-20. 2007
    ..Thus we have identified a SNP within a distal enhancer that is associated with a subtype of leukemia and exerts a deleterious effect through remote transcriptional dysregulation in specific progenitor subtypes...