Research Topics
Genomes and Genes | Roel G W VerhaakSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
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Detail Information
Publications
Prognostically useful gene-expression profiles in acute myeloid leukemiaPeter J M Valk
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
N Engl J Med 350:1617-28. 2004..However, this combined approach provides correct therapeutic and prognostic information in only 50 percent of cases...
The effect of oligonucleotide microarray data pre-processing on the analysis of patient-cohort studiesRoel G W Verhaak
Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
BMC Bioinformatics 7:105. 2006..By focusing on practical applications of microarray-based research, this study provides insight into the relevance of pre-processing procedures to biology-oriented researchers...- HeatMapper: powerful combined visualization of gene expression profile correlations, genotypes, phenotypes and sample characteristicsRoel G W Verhaak
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
BMC Bioinformatics 7:337. 2006..Here, we describe an approach to visually integrate the results of unsupervised and supervised cluster analysis using a correlation plot and additional sample metadata... - Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significanceRoel G W Verhaak
Department of Hematology, Erasmus University Medical Center Rotterdam, Ee1391a, Dr Molewaterplein 50, 3015 GE Rotterdam Z-H, The Netherlands
Blood 106:3747-54. 2005..Finally, in multivariable analysis NPM1 mutations express independent favorable prognostic value with regard to OS, EFS, and disease-free survival (DFS)... - Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profilingRoel G W Verhaak
Erasmus University Medical Center Rotterdam, Department of Hematology, Rotterdam, The Netherlands
Haematologica 94:131-4. 2009..g. those characterized by expression of chimeric transcription factors. However, detection of mutations affecting signaling molecules and numerical abnormalities still requires alternative molecular methods... - SNPExpress: integrated visualization of genome-wide genotypes, copy numbers and gene expression levelsMathijs A Sanders
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
BMC Genomics 9:41. 2008..In fact, obtaining an integrated view of both large scale SNP genotyping and gene expression is currently complicated since only a limited number of appropriate software tools are available... - Significance of murine retroviral mutagenesis for identification of disease genes in human acute myeloid leukemiaStefan J Erkeland
Department of Hematology, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
Cancer Res 66:622-6. 2006.... 
Genes predictive of outcome and novel molecular classification schemes in adult acute myeloid leukemiaRoel G W Verhaak
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Cancer Treat Res 145:67-83. 2010..The current advances made in molecular understanding of AML will ultimately lead to a further refinement of prognostics of AML...- Differential regulation of Foxo3a target genes in erythropoiesisWalbert J Bakker
Department of Hematology, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
Mol Cell Biol 27:3839-3854. 2007..Thus, Foxo3a not only is an effector of PKB but also integrates distinct signals to regulate gene expression in erythropoiesis... - Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1Bas J Wouters
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Blood 110:3706-14. 2007..A gene expression prediction signature allowed the detection of similar cases of leukemia in independent series of AML... - Characterizing the cancer genome in lung adenocarcinomaBarbara A Weir
Department of Medical Oncology and Center for Cancer Genome Discovery, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Nature 450:893-8. 2007..More generally, our results indicate that many of the genes that are involved in lung adenocarcinoma remain to be discovered... - A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemiaUlrich Steidl
Harvard Institutes of Medicine, Harvard Medical School, and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
J Clin Invest 117:2611-20. 2007..Thus we have identified a SNP within a distal enhancer that is associated with a subtype of leukemia and exerts a deleterious effect through remote transcriptional dysregulation in specific progenitor subtypes... - Comprehensive genomic characterization defines human glioblastoma genes and core pathwaysRoger McLendon
Nature 455:1061-8. 2008..Together, these findings establish the feasibility and power of TCGA, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer...