Wendy W J van de Sande

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc Active matrix metalloprotease-9 is associated with the collagen capsule surrounding the Madurella mycetomatis grain in mycetoma
    Kirsten Geneugelijk
    Erasmus MC, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    PLoS Negl Trop Dis 8:e2754. 2014
  2. pmc Association of eumycetoma and schistosomiasis
    Jaap J van Hellemond
    Erasmus MC, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    PLoS Negl Trop Dis 7:e2241. 2013
  3. pmc Global burden of human mycetoma: a systematic review and meta-analysis
    Wendy W J van de Sande
    ErasmusMC, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    PLoS Negl Trop Dis 7:e2550. 2013
  4. pmc New species of Madurella, causative agents of black-grain mycetoma
    G Sybren de Hoog
    Centraalbureau voor Schimmelcultures KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands
    J Clin Microbiol 50:988-94. 2012
  5. pmc Madurella mycetomatis is not susceptible to the echinocandin class of antifungal agents
    Wendy W J van de Sande
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases CE Rotterdam, The Netherlands
    Antimicrob Agents Chemother 54:2738-40. 2010
  6. doi request reprint Polymorphisms in catechol-O-methyltransferase and cytochrome p450 subfamily 19 genes predispose towards Madurella mycetomatis-induced mycetoma susceptibility
    Wendy W J van de Sande
    Erasmus MC, University Medical Centre Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    Med Mycol 48:959-68. 2010
  7. doi request reprint The effects of antifungal agents to conidial and hyphal forms of Aspergillus fumigatus
    Wendy W J van de Sande
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Med Mycol 48:48-55. 2010
  8. pmc Combination therapy of advanced invasive pulmonary aspergillosis in transiently neutropenic rats using human pharmacokinetic equivalent doses of voriconazole and anidulafungin
    Wendy W J van de Sande
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Antimicrob Agents Chemother 53:2005-13. 2009
  9. pmc Caspofungin prolongs survival of transiently neutropenic rats with advanced-stage invasive pulmonary aspergillosis
    Wendy W J van de Sande
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 52:1345-50. 2008
  10. ncbi request reprint Polymorphisms in genes involved in innate immunity predispose toward mycetoma susceptibility
    Wendy W J van de Sande
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    J Immunol 179:3065-74. 2007

Collaborators

Detail Information

Publications25

  1. pmc Active matrix metalloprotease-9 is associated with the collagen capsule surrounding the Madurella mycetomatis grain in mycetoma
    Kirsten Geneugelijk
    Erasmus MC, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    PLoS Negl Trop Dis 8:e2754. 2014
    ..mycetomatis infection. Inhibiting MMP-9 activity with doxycycline could prevent collagen accumulation in mycetoma, which in its turn might make the fungus more accessible to antifungal agents. ..
  2. pmc Association of eumycetoma and schistosomiasis
    Jaap J van Hellemond
    Erasmus MC, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    PLoS Negl Trop Dis 7:e2241. 2013
    ..18-8.46), but not for toxoplasmosis, an infection inducing a Th1-type response (p = 0.6; odds ratio 1.5, 95% CI 0.58-3.83). Here, we show that schistosomiasis is correlated to susceptibility for a fungal disease for the first time...
  3. pmc Global burden of human mycetoma: a systematic review and meta-analysis
    Wendy W J van de Sande
    ErasmusMC, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    PLoS Negl Trop Dis 7:e2550. 2013
    ..By erecting (inter)national surveillance programs a more accurate estimation of the global burden on mycetoma can be obtained. ..
  4. pmc New species of Madurella, causative agents of black-grain mycetoma
    G Sybren de Hoog
    Centraalbureau voor Schimmelcultures KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands
    J Clin Microbiol 50:988-94. 2012
    ..Since eumycetoma is still treated only with azoles, correct species identification is important for the optimal choice of antifungal therapy...
  5. pmc Madurella mycetomatis is not susceptible to the echinocandin class of antifungal agents
    Wendy W J van de Sande
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases CE Rotterdam, The Netherlands
    Antimicrob Agents Chemother 54:2738-40. 2010
    ..As a comparator fungus, Aspergillus fumigatus was used. Minimal effective concentrations (MECs) and MICs were assessed and compared to those of ketoconazole. M. mycetomatis isolates were not susceptible to the echinocandins...
  6. doi request reprint Polymorphisms in catechol-O-methyltransferase and cytochrome p450 subfamily 19 genes predispose towards Madurella mycetomatis-induced mycetoma susceptibility
    Wendy W J van de Sande
    Erasmus MC, University Medical Centre Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    Med Mycol 48:959-68. 2010
    ..Indirect effects on the patients' hormone regulated immune states are the more likely explanations for mycetoma susceptibility...
  7. doi request reprint The effects of antifungal agents to conidial and hyphal forms of Aspergillus fumigatus
    Wendy W J van de Sande
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Med Mycol 48:48-55. 2010
    ..Antifungal susceptibility of conidia was also determined using the E-test in which it was found that the XTT assaygave comparable ICs for amphotericin B, itraconazole and voriconazole but not for caspofungin...
  8. pmc Combination therapy of advanced invasive pulmonary aspergillosis in transiently neutropenic rats using human pharmacokinetic equivalent doses of voriconazole and anidulafungin
    Wendy W J van de Sande
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Antimicrob Agents Chemother 53:2005-13. 2009
    ..In conclusion, VOR monotherapy is therapeutically effective in the treatment of advanced-stage IPA and superior to the use of ANI. Combining both agents does not significantly improve the therapeutic outcome...
  9. pmc Caspofungin prolongs survival of transiently neutropenic rats with advanced-stage invasive pulmonary aspergillosis
    Wendy W J van de Sande
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 52:1345-50. 2008
    ..In this model, the administration of high-dose-step-down treatment was as effective as treatment with high doses for the whole treatment period...
  10. ncbi request reprint Polymorphisms in genes involved in innate immunity predispose toward mycetoma susceptibility
    Wendy W J van de Sande
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    J Immunol 179:3065-74. 2007
    ..We present the first evidence of human genetic predisposition toward susceptibility to mycetoma, a neglected infection of the poor...
  11. ncbi request reprint Melanin biosynthesis in Madurella mycetomatis and its effect on susceptibility to itraconazole and ketoconazole
    Wendy W J van de Sande
    Erasmus MC, University Medical Centre Rotterdam, Department of Medical Microbiology and Infectious Diseases, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Microbes Infect 9:1114-23. 2007
    ..Since itraconazole and ketoconazole are the main antifungal agents used to treat mycetoma, the clinical relevance of the in vitro rise in MIC should be studied further...
  12. ncbi request reprint In vitro susceptibility of Madurella mycetomatis, prime agent of Madura foot, to tea tree oil and artemisinin
    Wendy W J van de Sande
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Antimicrob Chemother 59:553-5. 2007
    ..Eumycetoma caused by Madurella mycetomatis is treated with surgery and high doses of itraconazole and ketoconazole. These agents are toxic, and new therapies are required...
  13. ncbi request reprint Translationally controlled tumor protein from Madurella mycetomatis, a marker for tumorous mycetoma progression
    Wendy W J van de Sande
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    J Immunol 177:1997-2005. 2006
    ..After 6-15 years of disease duration the Ab levels were the highest. TCTP is the first well-characterized immunogenic Ag, simultaneously the first monomolecular vaccine candidate, identified for the fungus M. mycetomatis...
  14. pmc Genotyping of Madurella mycetomatis by selective amplification of restriction fragments (amplified fragment length polymorphism) and subtype correlation with geographical origin and lesion size
    Wendy W J van de Sande
    Erasmus MC University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, The Netherlands
    J Clin Microbiol 43:4349-56. 2005
    ..001). This is the first report on a genotypic study where genetic markers which may be used to study pathogenicity in M. mycetomatis were obtained...
  15. pmc Testing of the in vitro susceptibilities of Madurella mycetomatis to six antifungal agents by using the Sensititre system in comparison with a viability-based 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5- [(phenylamino)carbonyl]-2H-tetrazolium hydroxide (XT
    Wendy W J van de Sande
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Antimicrob Agents Chemother 49:1364-8. 2005
    ..Based on the relatively broad range of MICs obtained for the antifungal agents, routine testing of M. mycetomatis isolates for susceptibility to antifungal agents seems to be relevant to adequate therapeutic management...
  16. pmc Phylogenetic analysis of the complete mitochondrial genome of Madurella mycetomatis confirms its taxonomic position within the order Sordariales
    Wendy W J van de Sande
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 7:e38654. 2012
    ..Mitochondria are of monophyletic origin and mitochondrial genomes have been proven to be useful in phylogenetic analyses...
  17. pmc In vitro antifungal activity of isavuconazole against Madurella mycetomatis
    Wendy Kloezen
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 56:6054-6. 2012
    ..mycetomatis, with MICs ranging from ≤0.016 to 0.125 μg/ml. Due to its favorable pharmacokinetics, isavuconazole could be a promising antifungal agent in the treatment of mycetoma...
  18. pmc In vitro susceptibility of Madurella mycetomatis to posaconazole and terbinafine
    Alex van Belkum
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, s Gravendijkwal 230, 3015 GD Rotterdam, Netherlands
    Antimicrob Agents Chemother 55:1771-3. 2011
    ..It appeared that posaconazole was highly active against M. mycetomatis but terbinafine was only moderately active. Since posaconazole has an excellent safety profile, it might provide an important alternative in mycetoma therapy...
  19. ncbi request reprint A murine model of Madurella mycetomatis eumycetoma
    Abdalla O Ahmed
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    FEMS Immunol Med Microbiol 37:29-36. 2003
    ..This model will enable further studies on the pathogenesis as well as prevention and treatment of the fungal infection...
  20. pmc Evidence supporting a role for mammalian chitinases in efficacy of caspofungin against experimental aspergillosis in immunocompromised rats
    Patricia E B Verwer
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
    PLoS ONE 8:e75848. 2013
    ..Mammals produce two chitinases, chitotriosidase and AMCase, which can hydrolyse chitin. We hypothesized that the mammalian chitinases play a role in the in vivo efficacy of caspofungin...
  21. doi request reprint Fructose-bisphosphate aldolase and pyruvate kinase, two novel immunogens in Madurella mycetomatis
    Nele de Klerk
    Erasmus MC, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    Med Mycol 50:143-51. 2012
    ..mycetomatis next to the translationally controlled tumour protein (TCTP): the glycolytic enzymes FBA and PK. These antigens might be useful as vaccine-candidates in the prevention of mycetoma...
  22. pmc Reshuffling of Aspergillus fumigatus cell wall components chitin and β-glucan under the influence of caspofungin or nikkomycin Z alone or in combination
    Patricia E B Verwer
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 56:1595-8. 2012
    ..This could explain the synergistic activity of this combination of drugs...
  23. pmc Double-stranded RNA mycovirus infection of Aspergillus fumigatus is not dependent on the genetic make-up of the host
    Jeannine M Refos
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 8:e77381. 2013
    ..DsRNA mycovirus infections in A. fumigatus are not related to either CSP or mating type and therefore represent an interesting future therapeutic tool to combat fungal infections. ..
  24. pmc The mycetoma knowledge gap: identification of research priorities
    Wendy W J van de Sande
    ErasmusMC, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    PLoS Negl Trop Dis 8:e2667. 2014
    ..Improved strategies for treating eumycetoma and actinomycetoma are also considered. ..
  25. doi request reprint Diagnosis of active tuberculosis by e-nose analysis of exhaled air
    Marcel Bruins
    Consultatie Implementatie Technisch Beheer B V C it, Marspoortstraat 2, 7201 JB Zutphen, The Netherlands
    Tuberculosis (Edinb) 93:232-8. 2013
    ..The portability and fast time-to-result of the DiagNose enables a proactive screening search for new TB cases in rural areas, without the need for highly-skilled operators or a hospital center infrastructure...