Tischa JM Van der Cammen

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc The epidemic of hip fractures: are we on the right track?
    Klaas A Hartholt
    Department of Internal Medicine Section of Geriatric Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    PLoS ONE 6:e22227. 2011
  2. pmc Adverse drug reactions related hospital admissions in persons aged 60 years and over, The Netherlands, 1981-2007: less rapid increase, different drugs
    Klaas A Hartholt
    Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 5:e13977. 2010
  3. pmc Can echocardiographic findings predict falls in older persons?
    Nathalie van der Velde
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands Section of Geriatrics, Erasmus University Medical Center, Rotterdam, Netherlands Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, Netherlands
    PLoS ONE 2:e654. 2007
  4. doi request reprint New insights: dose-response relationship between psychotropic drugs and falls: a study in nursing home residents with dementia
    Carolyn S Sterke
    De StromenOpmaatGroep, Nursing Home Smeetsland, Rotterdam, The Netherlands
    J Clin Pharmacol 52:947-55. 2012
  5. pmc [Cost] effectiveness of withdrawal of fall-risk increasing drugs versus conservative treatment in older fallers: design of a multicenter randomized controlled trial (IMPROveFALL-study)
    Klaas A Hartholt
    Department of Internal Medicine Section Geriatric Medicine, Erasmus MC, University Medical Rotterdam, P, O, Box 2040, 3000 CA Rotterdam, The Netherlands
    BMC Geriatr 11:48. 2011
  6. ncbi request reprint Genetic testing has no place as a routine diagnostic test in sporadic and familial cases of Alzheimer's disease
    Tischa J M van der Cammen
    Memory Clinic, Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    J Am Geriatr Soc 52:2110-3. 2004
  7. ncbi request reprint Abnormal neurotransmitter metabolite levels in Alzheimer patients with a delirium
    Tischa J M van der Cammen
    Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Int J Geriatr Psychiatry 21:838-43. 2006
  8. ncbi request reprint Trends in fall-related hospital admissions in older persons in the Netherlands
    Klaas A Hartholt
    Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Arch Intern Med 170:905-11. 2010
  9. pmc The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample
    Bart Dermaut
    Department of Molecular Genetics, University of Antwerp, Universiteitsplein 1, B 2610 Antwerpen, Belgium
    Am J Hum Genet 70:1568-74. 2002
  10. ncbi request reprint Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum
    Bart Dermaut
    Department of Molecular Genetics VIB 8, Flanders Interuniversity Institute for Biotechnology, Neurodegenerative Brain Diseases Group, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, B 2610 Antwerpen, Belgium
    Trends Genet 21:664-72. 2005

Collaborators

Detail Information

Publications26

  1. pmc The epidemic of hip fractures: are we on the right track?
    Klaas A Hartholt
    Department of Internal Medicine Section of Geriatric Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    PLoS ONE 6:e22227. 2011
    ..The aim of this study was to determine time trends in numbers and incidence rates of hip fracture-related hospitalizations and admission duration in the older Dutch population...
  2. pmc Adverse drug reactions related hospital admissions in persons aged 60 years and over, The Netherlands, 1981-2007: less rapid increase, different drugs
    Klaas A Hartholt
    Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 5:e13977. 2010
    ..Because of raised awareness of ADR, a decrease in ADR might be expected. The aim of this study was to determine trends in ADR-related hospitalizations in the older Dutch population...
  3. pmc Can echocardiographic findings predict falls in older persons?
    Nathalie van der Velde
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands Section of Geriatrics, Erasmus University Medical Center, Rotterdam, Netherlands Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, Netherlands
    PLoS ONE 2:e654. 2007
    ..50% of older adults with syncope present with a fall. Nonetheless, up to now no data have been published addressing echocardiographic abnormalities in older fallers...
  4. doi request reprint New insights: dose-response relationship between psychotropic drugs and falls: a study in nursing home residents with dementia
    Carolyn S Sterke
    De StromenOpmaatGroep, Nursing Home Smeetsland, Rotterdam, The Netherlands
    J Clin Pharmacol 52:947-55. 2012
    ..Even at low dosages, psychotropic drugs are associated with increased fall risk in nursing home residents with dementia...
  5. pmc [Cost] effectiveness of withdrawal of fall-risk increasing drugs versus conservative treatment in older fallers: design of a multicenter randomized controlled trial (IMPROveFALL-study)
    Klaas A Hartholt
    Department of Internal Medicine Section Geriatric Medicine, Erasmus MC, University Medical Rotterdam, P, O, Box 2040, 3000 CA Rotterdam, The Netherlands
    BMC Geriatr 11:48. 2011
    ....
  6. ncbi request reprint Genetic testing has no place as a routine diagnostic test in sporadic and familial cases of Alzheimer's disease
    Tischa J M van der Cammen
    Memory Clinic, Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    J Am Geriatr Soc 52:2110-3. 2004
    ..Arguments as to why we think routine genetic assessment should not be part of the diagnostic examination of the patient suspected of Alzheimer's disease are given...
  7. ncbi request reprint Abnormal neurotransmitter metabolite levels in Alzheimer patients with a delirium
    Tischa J M van der Cammen
    Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Int J Geriatr Psychiatry 21:838-43. 2006
    ..The aim of this study was to investigate amino acid and neurotransmitter metabolite levels in plasma of AD patients with a concurrent delirium...
  8. ncbi request reprint Trends in fall-related hospital admissions in older persons in the Netherlands
    Klaas A Hartholt
    Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Arch Intern Med 170:905-11. 2010
    ..Owing to aging societies worldwide, a major impact on fall-related health care demand can be expected. We determined time trends in numbers and incidence of fall-related hospital admissions and in admission duration in older adults...
  9. pmc The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample
    Bart Dermaut
    Department of Molecular Genetics, University of Antwerp, Universiteitsplein 1, B 2610 Antwerpen, Belgium
    Am J Hum Genet 70:1568-74. 2002
    ..1; 95% confidence interval 1.2-13.3; P=.01). These results are compatible with an important role of gamma-secretase dysfunction in the etiology of familial EOAD...
  10. ncbi request reprint Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum
    Bart Dermaut
    Department of Molecular Genetics VIB 8, Flanders Interuniversity Institute for Biotechnology, Neurodegenerative Brain Diseases Group, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, B 2610 Antwerpen, Belgium
    Trends Genet 21:664-72. 2005
    ..Together, these studies suggest that AD and FTD are linked in a genetic spectrum of presenile degenerative brain disorders in which tau appears to be the central player...
  11. ncbi request reprint Diagnostic accuracy of the Preclinical AD Scale (PAS) in cognitively mildly impaired subjects
    Pieter Jelle Visser
    Department of Psychiatry and Neuropsychology, Institute of Brain and Behaviour, University of Maastricht, The Netherlands
    J Neurol 249:312-9. 2002
    ..Step-wise scoring of the PAS can reduce the number of elaborate or expensive diagnostic procedures considerably...
  12. ncbi request reprint PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease
    Bart Dermaut
    Department of Molecular Genetics, Flanders Interuniversity Institute of Biotechnology VIB8, University of Antwerp, Antwerpen, Belgium
    Ann Neurol 53:409-12. 2003
    ..2; 95% CI, 1.4-7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3-5.3; p < 0.01) and 3.5 (95% CI, 1.3-9.3; p = 0.01), respectively...
  13. ncbi request reprint Alzheimer-associated C allele of the promoter polymorphism -22C>T causes a critical neuron-specific decrease of presenilin 1 expression
    Jessie Theuns
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Hum Mol Genet 12:869-77. 2003
    ..Together, these studies provide evidence that the increased risk for AD associated with PSEN1 may result from genetic variations in the regulatory region, leading to altered expression levels of PSEN1 in neurons...
  14. ncbi request reprint Genetics of early-onset Alzheimer dementia
    Rosa Rademakers
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology VIB, University of Antwerp, Antwerpen, Belgium
    ScientificWorldJournal 3:497-519. 2003
    ..Now, transgenic mice are produced to study the influence of EOAD mutations in vivo, eventually leading to the development of novel therapeutic strategies...
  15. ncbi request reprint Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family
    Nathalie Brouwers
    VIB Department of Molecular Genetics, Neurodegenerative Brain Diseases Group, University of Antwerp CDE, Universiteitsplein 1, BE 2610 Antwerpen, Belgium
    Arch Neurol 64:1436-46. 2007
    ..Progranulin gene (PGRN) haploinsufficiency was recently associated with ubiquitin-positive frontotemporal lobar degeneration linked to chromosome 17q21 (FTLDU-17)...
  16. ncbi request reprint Novel APP mutation V715A associated with presenile Alzheimer's disease in a German family
    Marc Cruts
    J Neurol 250:1374-5. 2003
  17. ncbi request reprint Progranulin null mutations in both sporadic and familial frontotemporal dementia
    Isabelle Le Ber
    INSERM, UMR679, Paris, France
    Hum Mutat 28:846-55. 2007
    ..Taking this into account, genetic testing should be now considered more systematically, even in patients without obvious familial history of FTD...
  18. ncbi request reprint Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia
    Julie van der Zee
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium
    Hum Mutat 28:416. 2007
    ..Our findings extend the mutation spectrum in PGRN leading to loss of functional PGRN as the basis for FTD...
  19. pmc Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample
    Rosa Rademakers
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerp, Belgium
    Am J Hum Genet 77:643-52. 2005
    ....
  20. ncbi request reprint APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy
    Kristel Sleegers
    Neurodegenerative Brain Diseases Group Antwerp, Belgium
    Brain 129:2977-83. 2006
    ..Our findings corroborated a recent French study, and indicated that investigating genomic duplications in the APP locus in families segregating Alzheimer's disease and CAA should be considered...
  21. ncbi request reprint Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40
    Samir Kumar-Singh
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute of Biotechnology, University of Antwerp, Antwerpen, Belgium
    Hum Mutat 27:686-95. 2006
    ..Also, the in vitro method we describe here is a valid tool for assaying the pathogenic potential of clinical PSEN mutations in a molecular diagnostic setting...
  22. ncbi request reprint High-density SNP haplotyping suggests altered regulation of tau gene expression in progressive supranuclear palsy
    Rosa Rademakers
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Belgium
    Hum Mol Genet 14:3281-92. 2005
    ..Thus, risk variants on different H1 htSNP haplotypes and protective variants on H2 contribute to population risk for PSP...
  23. ncbi request reprint A Belgian ancestral haplotype harbours a highly prevalent mutation for 17q21-linked tau-negative FTLD
    Julie van der Zee
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium
    Brain 129:841-52. 2006
    ..Together, these results strongly suggest that the DR2-DR8 founder haplotype at 17q21 harbours a tau-negative FTLD causing mutation that is a much more frequent cause of FTLD in Belgium than MAPT mutations...
  24. ncbi request reprint Reduced hippocampal volume in non-demented carriers of the apolipoprotein E epsilon4: relation to chronological age and recognition memory
    Johanna Lind
    Department of Clinical Neuroscience, MR Research Center, Karolinska Hospital N 8, S 171 76 Stockholm, Sweden
    Neurosci Lett 396:23-7. 2006
    ..A question for the future is whether smaller hippocampal volume represents early-onset hippocampal volume reduction or an inherent trait...
  25. ncbi request reprint Dose dependent effect of APOE epsilon4 on behavioral symptoms in frontal lobe dementia
    Sebastiaan Engelborghs
    Department of Neurology and Memory Clinic, Middelheim General Hospital, ZNA, Antwerp, Belgium
    Neurobiol Aging 27:285-92. 2006
    ..In conclusion, APOE has disease-specific effects on BPSD in FTD and PDD/DLB patients, given the reported associations of APOE epsilon4 with aggression (FTD) and of APOE epsilon2 with delusions (PDD/DLB)...
  26. ncbi request reprint Reduced functional brain activity response in cognitively intact apolipoprotein E epsilon4 carriers
    Johanna Lind
    Department of Clinical Neuroscience, MR Research Center, Karolinska Hospital N 8, Stockholm, Sweden
    Brain 129:1240-8. 2006
    ..Collectively, these findings indicate that genetic risk translates into reduced functional brain activity, in regions pertinent to Alzheimer's disease, well before alterations can be detected at the behavioural level...