Tischa JM Van der CammenSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
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Publications
New insights: dose-response relationship between psychotropic drugs and falls: a study in nursing home residents with dementiaCarolyn S Sterke
De StromenOpmaatGroep, Nursing Home Smeetsland, Rotterdam, The Netherlands
J Clin Pharmacol 52:947-55. 2012..Even at low dosages, psychotropic drugs are associated with increased fall risk in nursing home residents with dementia...
[Cost] effectiveness of withdrawal of fall-risk increasing drugs versus conservative treatment in older fallers: design of a multicenter randomized controlled trial (IMPROveFALL-study)Klaas A Hartholt
Department of Internal Medicine Section Geriatric Medicine, Erasmus MC, University Medical Rotterdam, P, O, Box 2040, 3000 CA Rotterdam, The Netherlands
BMC Geriatr 11:48. 2011....
Abnormal neurotransmitter metabolite levels in Alzheimer patients with a deliriumTischa J M van der Cammen
Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
Int J Geriatr Psychiatry 21:838-43. 2006..The aim of this study was to investigate amino acid and neurotransmitter metabolite levels in plasma of AD patients with a concurrent delirium...- Genetic testing has no place as a routine diagnostic test in sporadic and familial cases of Alzheimer's diseaseTischa J M van der Cammen
Memory Clinic, Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
J Am Geriatr Soc 52:2110-3. 2004..Arguments as to why we think routine genetic assessment should not be part of the diagnostic examination of the patient suspected of Alzheimer's disease are given... - Trends in fall-related hospital admissions in older persons in the NetherlandsKlaas A Hartholt
Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
Arch Intern Med 170:905-11. 2010..Owing to aging societies worldwide, a major impact on fall-related health care demand can be expected. We determined time trends in numbers and incidence of fall-related hospital admissions and in admission duration in older adults... - The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sampleBart Dermaut
Department of Molecular Genetics, University of Antwerp, Universiteitsplein 1, B 2610 Antwerpen, Belgium
Am J Hum Genet 70:1568-74. 2002..1; 95% confidence interval 1.2-13.3; P=.01). These results are compatible with an important role of gamma-secretase dysfunction in the etiology of familial EOAD... - Novel APP mutation V715A associated with presenile Alzheimer's disease in a German familyMarc Cruts
J Neurol 250:1374-5. 2003 - Diagnostic accuracy of the Preclinical AD Scale (PAS) in cognitively mildly impaired subjectsPieter Jelle Visser
Department of Psychiatry and Neuropsychology, Institute of Brain and Behaviour, University of Maastricht, The Netherlands
J Neurol 249:312-9. 2002..Step-wise scoring of the PAS can reduce the number of elaborate or expensive diagnostic procedures considerably... - PRNP Val129 homozygosity increases risk for early-onset Alzheimer's diseaseBart Dermaut
Department of Molecular Genetics, Flanders Interuniversity Institute of Biotechnology VIB8, University of Antwerp, Antwerpen, Belgium
Ann Neurol 53:409-12. 2003..2; 95% CI, 1.4-7.1; p < 0.01). In patients with a positive family history, these risks increased to 2.6 (95% CI, 1.3-5.3; p < 0.01) and 3.5 (95% CI, 1.3-9.3; p = 0.01), respectively... - Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder familyNathalie Brouwers
VIB Department of Molecular Genetics, Neurodegenerative Brain Diseases Group, University of Antwerp CDE, Universiteitsplein 1, BE 2610 Antwerpen, Belgium
Arch Neurol 64:1436-46. 2007..Progranulin gene (PGRN) haploinsufficiency was recently associated with ubiquitin-positive frontotemporal lobar degeneration linked to chromosome 17q21 (FTLDU-17)... - Progranulin null mutations in both sporadic and familial frontotemporal dementiaIsabelle Le Ber
INSERM, UMR679, Paris, France
Hum Mutat 28:846-55. 2007..Taking this into account, genetic testing should be now considered more systematically, even in patients without obvious familial history of FTD... - Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementiaJulie van der Zee
Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium
Hum Mutat 28:416. 2007..Our findings extend the mutation spectrum in PGRN leading to loss of functional PGRN as the basis for FTD... - Alzheimer-associated C allele of the promoter polymorphism -22C>T causes a critical neuron-specific decrease of presenilin 1 expressionJessie Theuns
Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
Hum Mol Genet 12:869-77. 2003..Together, these studies provide evidence that the increased risk for AD associated with PSEN1 may result from genetic variations in the regulatory region, leading to altered expression levels of PSEN1 in neurons... - APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathyKristel Sleegers
Neurodegenerative Brain Diseases Group Antwerp, Belgium
Brain 129:2977-83. 2006..Our findings corroborated a recent French study, and indicated that investigating genomic duplications in the APP locus in families segregating Alzheimer's disease and CAA should be considered... - Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40Samir Kumar-Singh
Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute of Biotechnology, University of Antwerp, Antwerpen, Belgium
Hum Mutat 27:686-95. 2006..Also, the in vitro method we describe here is a valid tool for assaying the pathogenic potential of clinical PSEN mutations in a molecular diagnostic setting... - Reduced functional brain activity response in cognitively intact apolipoprotein E epsilon4 carriersJohanna Lind
Department of Clinical Neuroscience, MR Research Center, Karolinska Hospital N 8, Stockholm, Sweden
Brain 129:1240-8. 2006..Collectively, these findings indicate that genetic risk translates into reduced functional brain activity, in regions pertinent to Alzheimer's disease, well before alterations can be detected at the behavioural level... - A Belgian ancestral haplotype harbours a highly prevalent mutation for 17q21-linked tau-negative FTLDJulie van der Zee
Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium
Brain 129:841-52. 2006..Together, these results strongly suggest that the DR2-DR8 founder haplotype at 17q21 harbours a tau-negative FTLD causing mutation that is a much more frequent cause of FTLD in Belgium than MAPT mutations... - Genetics of early-onset Alzheimer dementiaRosa Rademakers
Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology (VIB, University of Antwerp, Antwerpen, Belgium
ScientificWorldJournal 3:497-519. 2003..Now, transgenic mice are produced to study the influence of EOAD mutations in vivo, eventually leading to the development of novel therapeutic strategies... - Dose dependent effect of APOE epsilon4 on behavioral symptoms in frontal lobe dementiaSebastiaan Engelborghs
Department of Neurology and Memory Clinic, Middelheim General Hospital, ZNA, Antwerp, Belgium
Neurobiol Aging 27:285-92. 2006..In conclusion, APOE has disease-specific effects on BPSD in FTD and PDD/DLB patients, given the reported associations of APOE epsilon4 with aggression (FTD) and of APOE epsilon2 with delusions (PDD/DLB)... - Tau is central in the genetic Alzheimer-frontotemporal dementia spectrumBart Dermaut
Department of Molecular Genetics (VIB 8, Flanders Interuniversity Institute for Biotechnology, Neurodegenerative Brain Diseases Group, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, B-2610 Antwerpen, Belgium
Trends Genet 21:664-72. 2005..Together, these studies suggest that AD and FTD are linked in a genetic spectrum of presenile degenerative brain disorders in which tau appears to be the central player... - High-density SNP haplotyping suggests altered regulation of tau gene expression in progressive supranuclear palsyRosa Rademakers
Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Belgium
Hum Mol Genet 14:3281-92. 2005..Thus, risk variants on different H1 htSNP haplotypes and protective variants on H2 contribute to population risk for PSP... - Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sampleRosa Rademakers
Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerp, Belgium
Am J Hum Genet 77:643-52. 2005.... - Reduced hippocampal volume in non-demented carriers of the apolipoprotein E epsilon4: relation to chronological age and recognition memoryJohanna Lind
Department of Clinical Neuroscience, MR Research Center, Karolinska Hospital N 8, S 171 76 Stockholm, Sweden
Neurosci Lett 396:23-7. 2006..A question for the future is whether smaller hippocampal volume represents early-onset hippocampal volume reduction or an inherent trait...