Marry M van den Heuvel-Eibrink

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint ABCB1 gene polymorphisms are not associated with treatment outcome in elderly acute myeloid leukemia patients
    Bronno van der Holt
    Department of Trials and Statistics HOVON Dutch Belgian Hemato Oncology Cooperative Group Data Center, Erasmus MC Daniel den Hoed Cancer Center and Sophia Children s Hospital, Rotterdam, The Netherlands
    Clin Pharmacol Ther 80:427-39. 2006
  2. ncbi request reprint Characteristics and survival of 750 children diagnosed with a renal tumor in the first seven months of life: A collaborative study by the SIOP/GPOH/SFOP, NWTSG, and UKCCSG Wilms tumor study groups
    Marry M van den Heuvel-Eibrink
    Department of Pediatric Oncology Hematology Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 50:1130-4. 2008
  3. pmc Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia
    Iris H I M Hollink
    Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Haematologica 96:384-92. 2011
  4. pmc CD34-related coexpression of MDR1 and BCRP indicates a clinically resistant phenotype in patients with acute myeloid leukemia (AML) of older age
    Marry M van den Heuvel-Eibrink
    Department of Hematology, P O Erasmus MC, Dr Molewaterplein 40, 3015 GJ, Rotterdam, The Netherlands
    Ann Hematol 86:329-37. 2007
  5. pmc Abdominal radiotherapy: a major determinant of metabolic syndrome in nephroblastoma and neuroblastoma survivors
    Marjolein van Waas
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital Rotterdam, Rotterdam, The Netherlands
    PLoS ONE 7:e52237. 2012
  6. pmc Management and treatment of osteonecrosis in children and adolescents with acute lymphoblastic leukemia
    Mariel L te Winkel
    Haematologica 99:430-6. 2014
  7. pmc A nationwide study on reproductive function, ovarian reserve, and risk of premature menopause in female survivors of childhood cancer: design and methodological challenges
    Annelies Overbeek
    Department of Paediatrics, Division of Paediatric Oncology Haematology, VU University Medical Center, PO Box 7057, Amsterdam, 1007MB, The Netherlands
    BMC Cancer 12:363. 2012
  8. ncbi request reprint Sudden death due to pulmonary embolism as presenting symptom of renal tumors
    M M van den Heuvel-Eibrink
    Department of Pediatric Oncology Hematology, ErasmusMC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Pediatr Blood Cancer 50:1062-4. 2008
  9. doi request reprint Malignant rhabdoid tumours of the kidney (MRTKs), registered on recent SIOP protocols from 1993 to 2005: a report of the SIOP renal tumour study group
    Marry M van den Heuvel-Eibrink
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 56:733-7. 2011
  10. ncbi request reprint Paroxysmal nocturnal hemoglobinuria in children
    Marry M van den Heuvel-Eibrink
    Department of Pediatric Oncology Hematology, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Paediatr Drugs 9:11-6. 2007

Detail Information

Publications76

  1. ncbi request reprint ABCB1 gene polymorphisms are not associated with treatment outcome in elderly acute myeloid leukemia patients
    Bronno van der Holt
    Department of Trials and Statistics HOVON Dutch Belgian Hemato Oncology Cooperative Group Data Center, Erasmus MC Daniel den Hoed Cancer Center and Sophia Children s Hospital, Rotterdam, The Netherlands
    Clin Pharmacol Ther 80:427-39. 2006
    ....
  2. ncbi request reprint Characteristics and survival of 750 children diagnosed with a renal tumor in the first seven months of life: A collaborative study by the SIOP/GPOH/SFOP, NWTSG, and UKCCSG Wilms tumor study groups
    Marry M van den Heuvel-Eibrink
    Department of Pediatric Oncology Hematology Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 50:1130-4. 2008
    ..To review the clinical characteristics and survival of infants diagnosed with a primary renal tumor in the first 7 months of life...
  3. pmc Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia
    Iris H I M Hollink
    Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Haematologica 96:384-92. 2011
    ..Our objective was to investigate the characteristics, gene expression profiles and prognostic impact of the different CEBPA aberrations in pediatric acute myeloid leukemia...
  4. pmc CD34-related coexpression of MDR1 and BCRP indicates a clinically resistant phenotype in patients with acute myeloid leukemia (AML) of older age
    Marry M van den Heuvel-Eibrink
    Department of Hematology, P O Erasmus MC, Dr Molewaterplein 40, 3015 GJ, Rotterdam, The Netherlands
    Ann Hematol 86:329-37. 2007
    ..When adjusted for other prognostic actors, only CD34-related MDR1/BCRP coexpression remained significantly associated with a lower CR rate (p = 0.03), thereby identifying a clinically resistant subgroup of elderly AML patients...
  5. pmc Abdominal radiotherapy: a major determinant of metabolic syndrome in nephroblastoma and neuroblastoma survivors
    Marjolein van Waas
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital Rotterdam, Rotterdam, The Netherlands
    PLoS ONE 7:e52237. 2012
    ..Reports on metabolic syndrome in nephroblastoma and neuroblastoma survivors are scarce. Aim was to evaluate the occurrence of and the contribution of treatment regimens to the metabolic syndrome...
  6. pmc Management and treatment of osteonecrosis in children and adolescents with acute lymphoblastic leukemia
    Mariel L te Winkel
    Haematologica 99:430-6. 2014
    ..The questions as to how to treat childhood acute lymphoblastic leukemia patients with osteonecrosis cannot be answered as good-quality studies are lacking. ..
  7. pmc A nationwide study on reproductive function, ovarian reserve, and risk of premature menopause in female survivors of childhood cancer: design and methodological challenges
    Annelies Overbeek
    Department of Paediatrics, Division of Paediatric Oncology Haematology, VU University Medical Center, PO Box 7057, Amsterdam, 1007MB, The Netherlands
    BMC Cancer 12:363. 2012
    ....
  8. ncbi request reprint Sudden death due to pulmonary embolism as presenting symptom of renal tumors
    M M van den Heuvel-Eibrink
    Department of Pediatric Oncology Hematology, ErasmusMC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Pediatr Blood Cancer 50:1062-4. 2008
    ..This report describes two recent cases of sudden death in patients with renal tumors in which a fatal pulmonary embolus was the first presentation...
  9. doi request reprint Malignant rhabdoid tumours of the kidney (MRTKs), registered on recent SIOP protocols from 1993 to 2005: a report of the SIOP renal tumour study group
    Marry M van den Heuvel-Eibrink
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 56:733-7. 2011
    ..Survival data of malignant rhabdoid tumour of the kidney (MRTK) registered in SIOP trials, advocating preoperative chemotherapy, are not available...
  10. ncbi request reprint Paroxysmal nocturnal hemoglobinuria in children
    Marry M van den Heuvel-Eibrink
    Department of Pediatric Oncology Hematology, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Paediatr Drugs 9:11-6. 2007
    ..This article reviews the reported cases of PNH in children using the recently published guidelines for classification, diagnostics, and treatment...
  11. ncbi request reprint Childhood paroxysmal nocturnal haemoglobinuria (PNH), a report of 11 cases in the Netherlands
    M M van den Heuvel-Eibrink
    Erasmus Medical Centre Sophia Children s Hospital, 3015 GJ Rotterdam, The Netherlands
    Br J Haematol 128:571-7. 2005
    ..PNH, diagnosed by immunophenotypic GPI-linked anchor protein analysis, should be considered in all children with AA or MDS. BMT should be considered as a therapeutic option in every paediatric PNH patient with BM failure...
  12. ncbi request reprint Inhibin B is superior to FSH as a serum marker for spermatogenesis in men treated for Hodgkin's lymphoma with chemotherapy during childhood
    Robert D van Beek
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Room Sp3435, PO Box 2060, 3000 CB Rotterdam, The Netherlands
    Hum Reprod 22:3215-22. 2007
    ....
  13. doi request reprint Bone mineral density, growth, and thyroid function in long-term survivors of pediatric Hodgkin's lymphoma treated with chemotherapy only
    Robert D van Beek
    Department of Pediatric Oncology Hematology, Erasmus Medical Center Sophia Children s Hospital, Rotterdam 3000 CB, The Netherlands
    J Clin Endocrinol Metab 94:1904-9. 2009
    ..The aim of this study was to investigate the long-term side effects of treatment for childhood Hodgkin's lymphoma with chemotherapy only on growth, bone mineral density (BMD), body composition, and thyroid function...
  14. pmc Integrative analysis of type-I and type-II aberrations underscores the genetic heterogeneity of pediatric acute myeloid leukemia
    Brian V Balgobind
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Haematologica 96:1478-87. 2011
    ..However, there has been no recent comprehensive overview of these genetic aberrations in one large pediatric acute myeloid leukemia cohort...
  15. doi request reprint Topotecan distribution in an anephric infant with therapy-resistant bilateral Wilms tumor with a novel germline WT1 gene mutation
    Rieneke T Lugtenberg
    Department of Pediatric Hematology Oncology, Erasmus MC Sophia Children s Hospital, Room Sp2568, P O Box 2060, 3000 CB Rotterdam, The Netherlands
    Cancer Chemother Pharmacol 62:1039-44. 2008
    ..This case showed a novel germline WT1 gene mutation of which the correlation with resistant phenotype has to be confirmed in larger cohorts of WT patients...
  16. doi request reprint High-frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine
    Costa Bachas
    Department of Pediatric Oncology Hematology, VU University Medical Center, Amsterdam, The Netherlands
    Blood 116:2752-8. 2010
    ..We hence propose that risk stratification, malignant cell detection, and selection of personalized treatment should be based on status of type I/II mutations both at initial diagnosis and during follow-up...
  17. pmc Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study
    Eva A Coenen
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Blood 117:7102-11. 2011
    ..003) in univariate analysis only. In conclusion, like TP, specific ACAs have independent prognostic significance in pediatric 11q23/MLL-rearranged AML, and the mechanism underlying these prognostic differences should be studied...
  18. pmc Long-term nephrotoxicity in adult survivors of childhood cancer
    Ilona A Dekkers
    Department of Pediatric Oncology Hematology, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Clin J Am Soc Nephrol 8:922-9. 2013
    ..Because little is known about long-term treatment-related nephrotoxicity, the aim was to determine risk factors for renal impairment long after childhood cancer treatment...
  19. doi request reprint Prospective study on incidence, risk factors, and long-term outcome of osteonecrosis in pediatric acute lymphoblastic leukemia
    Mariel L te Winkel
    Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    J Clin Oncol 29:4143-50. 2011
    ..We studied cumulative incidence, risk factors, therapeutic strategies, and outcome of symptomatic osteonecrosis in pediatric patients with acute lymphoblastic leukemia (ALL)...
  20. doi request reprint CBL mutations do not frequently occur in paediatric acute myeloid leukaemia
    Eva A Coenen
    Department of Paediatric Oncology Haematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Br J Haematol 159:577-84. 2012
    ..In conclusion, we report a very low CBL mutation frequency in paediatric AML, which, together with the lack of difference in protein and mRNA expression, illustrates the limited role of CBL in paediatric AML...
  21. doi request reprint Adrenal function in adult long-term survivors of nephroblastoma and neuroblastoma
    Marjolein van Waas
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital Rotterdam, Dr Molewaterplein 60, Rotterdam, The Netherlands
    Eur J Cancer 48:1159-66. 2012
    ..Adrenal insufficiency, or relative insufficiency, might partly explain increased mortality rates in nephroblastoma and neuroblastoma survivors after unilateral adrenalectomy...
  22. ncbi request reprint Low frequency of MLL-partial tandem duplications in paediatric acute myeloid leukaemia using MLPA as a novel DNA screenings technique
    Brian V Balgobind
    Paediatric Oncology Haematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Eur J Cancer 46:1892-9. 2010
    ..Larger prospective studies are needed to further define the prognostic relevance of MLL-PTD in paediatric AML...
  23. doi request reprint High IGSF4 expression in pediatric M5 acute myeloid leukemia with t(9;11)(p22;q23)
    Jenny E Kuipers
    Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Blood 117:928-35. 2011
    ..70 vs 0.37, P = .03) In conclusion, we identified IGSF4 overexpression to be discriminative for t(9;11)(p22;q23) patients with FAB-M5, regulated partially by promoter methylation and resulting in survival benefit...
  24. doi request reprint Emotional distress in 652 Dutch very long-term survivors of childhood cancer, using the hospital anxiety and depression scale (HADS)
    Ivana M M van der Geest
    Department of Paediatric Oncology Haematology, Erasmus MC Sophia Children s Hospital Department of Obstetrics and Gynaecology, Division of Reproductive Medicine Department of Biostatistics Department of Internal Medicine Endocrinology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    J Pediatr Hematol Oncol 35:525-9. 2013
    ..After a more successful treatment of pediatric cancer, the number of childhood cancer survivors is progressively increasing. Consequently, awareness of psychological late sequelae is important...
  25. doi request reprint Daily life physical activity in long-term survivors of nephroblastoma and neuroblastoma
    Marjolein van Waas
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    J Pediatr Hematol Oncol 35:361-5. 2013
    ..108). Adjusted means for physical activity scores in females were not different from their controls. In conclusions, male neuroblastoma survivors were identified as performing less daily physical activity. ..
  26. doi request reprint Gonadal function recovery in very long-term male survivors of childhood cancer
    Wendy van Dorp
    Department of Paediatric Oncology Haematology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Eur J Cancer 49:1280-6. 2013
    ....
  27. doi request reprint Differentially expressed miRNAs in cytogenetic and molecular subtypes of pediatric acute myeloid leukemia
    Astrid A Danen-van Oorschot
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 58:715-21. 2012
    ..Aberrant miRNA expression patterns have been found in various types of cancer. So far, information about the expression of miRNAs in pediatric acute myeloid leukemia is limited...
  28. doi request reprint Treatment factors rather than genetic variation determine metabolic syndrome in childhood cancer survivors
    Marjolein van Waas
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital Rotterdam, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Eur J Cancer 49:668-75. 2013
    ..Genetic variation that regulates insulin resistance, blood pressure and adiposity in the normal population might determine differential vulnerability for metabolic syndrome after treatment for childhood cancer...
  29. pmc Pharmacogenetic risk factors for altered bone mineral density and body composition in pediatric acute lymphoblastic leukemia
    Mariel L te Winkel
    Department of Pediatric Oncology Hematology, Erasmus MC, Sophia Children s Hospital, 3015 GJ Rotterdam, The Netherlands
    Haematologica 95:752-9. 2010
    ..This study investigates pharmacogenetic risk factors for bone mineral (apparent) density (BM(A)D) and body composition in pediatric acute lymphoblastic leukemia..
  30. doi request reprint NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern
    Iris H I M Hollink
    Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Blood 118:3645-56. 2011
    ..Taken together, NUP98/NSD1 identifies a previously unrecognized group of young AML patients, with distinct characteristics and dismal prognosis, for whom new treatment strategies are urgently needed...
  31. pmc Obesity is underestimated using body mass index and waist-hip ratio in long-term adult survivors of childhood cancer
    Karin Blijdorp
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    PLoS ONE 7:e43269. 2012
    ..In this study longitudinal changes of BMI and body composition, as well as the value of BMI and waist-hip ratio representing obesity, were evaluated in adult childhood cancer survivors...
  32. doi request reprint CD34 expression is associated with poor survival in pediatric T-cell acute lymphoblastic leukemia
    Martine van Grotel
    Department of Pediatric Oncology Hematology, Erasmus University Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 51:737-40. 2008
    ....
  33. pmc Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group
    Trudy D Buitenkamp
    Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Blood 123:70-7. 2014
    ..Future strategies to improve outcome in DS-ALL should include improved supportive care throughout therapy and reduction of therapy in newly identified good-prognosis subgroups. ..
  34. ncbi request reprint Bone mineral density at diagnosis determines fracture rate in children with acute lymphoblastic leukemia treated according to the DCOG-ALL9 protocol
    Mariel L te Winkel
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Bone 59:223-8. 2014
    ..To elucidate incidence and risk factors of bone mineral density and fracture risk in children with Acute Lymphoblastic Leukemia (ALL)...
  35. doi request reprint Management of adults with Wilms' tumor: recommendations based on international consensus
    Heidi Segers
    Deptartment of Oncology Hematology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein, 603015 GJ, Rotterdam, The Netherlands
    Expert Rev Anticancer Ther 11:1105-13. 2011
    ..They provide a critical evaluation of the current evidence for the management of adult Wilms' tumors and propose details of how current pediatric therapeutic guidelines could be adapted for use in adults...
  36. ncbi request reprint Electroejaculation as a method of fertility preservation in boys diagnosed with cancer: a single-center experience and review of the literature
    Maria C Adank
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Fertil Steril 102:199-205.e1. 2014
    ..To evaluate the feasibility of electroejaculation to perform semen cryopreservation in pubertal boys before gonadotoxic therapy and to review the literature on this topic...
  37. doi request reprint The metabolic syndrome in adult survivors of childhood cancer, a review
    Marjolein van Waas
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    J Pediatr Hematol Oncol 32:171-9. 2010
    ..Accordingly, it is important to identify the predisposing factors of the metabolic syndrome in cohorts of survivors, to introduce medical interventions, and to subsequently decrease the risk of cerebrovascular and cardiovascular events...
  38. doi request reprint Leukemia-associated NF1 inactivation in patients with pediatric T-ALL and AML lacking evidence for neurofibromatosis
    Brian V Balgobind
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Blood 111:4322-8. 2008
    ..NF1 inactivation may provide an additional proliferative signal toward the development of leukemia...
  39. doi request reprint KIAA1524: A novel MLL translocation partner in acute myeloid leukemia
    Eva A Coenen
    Department of Pediatric Oncology and Hematology, Sophia Children s Hospital, Rotterdam, The Netherlands
    Leuk Res 35:133-5. 2011
    ..KIAA1524 has never been related to hematologic malignancies before, and the current AML case is the first case in which an MLL-KIAA1524 fusion was described...
  40. doi request reprint No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment
    Anne E Bras
    Department of Immunology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Br J Haematol 161:861-4. 2013
    ..Therefore, BCP regeneration does not reflect good response to treatment in paediatric AML, possibly due to the relatively high base-line levels of BCP in children...
  41. ncbi request reprint Defects in the DNA mismatch repair system do not contribute to the development of childhood wilms tumors
    Heidi Segers
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Pediatr Dev Pathol 16:14-9. 2013
    ....
  42. doi request reprint Peripheral stem cell harvest using regular chemotherapy schedules in childhood cancer
    Saskia L Gooskens
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Transplant 16:758-65. 2012
    ..The optimal moment for harvesting in different types of tumors was highly variable, although most consistent in patients diagnosed with Ewing's sarcoma or brain tumors and after cyclophosphamide priming...
  43. doi request reprint Cystic nephroma, cystic partially differentiated nephroblastoma and cystic Wilms' tumor in children: a spectrum with therapeutic dilemmas
    Joop van den Hoek
    Department of Pediatric Urology, Erasmus MC, Sophia Children s Hospital, Rotterdam, The Netherlands
    Urol Int 82:65-70. 2009
    ..There are difficulties in differentiating the three types using imaging techniques. Therefore, controversies exist regarding the optimal treatment...
  44. pmc Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study
    Brian V Balgobind
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Blood 114:2489-96. 2009
    ..Screening for these translocation partners is needed for accurate treatment stratification at diagnosis...
  45. doi request reprint Imatinib mesylate for children with dermatofibrosarcoma protuberans (DFSP)
    Saskia L M Gooskens
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 55:369-73. 2010
    ..In the current report, we describe the first small pediatric DFSP series, in which response to imatinib mesylate contributed to successful treatment outcome...
  46. doi request reprint Pediatric acute myeloid leukemia with t(8;16)(p11;p13), a distinct clinical and biological entity: a collaborative study by the International-Berlin-Frankfurt-Munster AML-study group
    Eva A Coenen
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Blood 122:2704-13. 2013
    ..In conclusion, pediatric t(8;16)(p11;p13) AML is a rare entity defined by a unique gene expression signature and distinct clinical features in whom spontaneous remissions occur in a subset of neonatal cases. ..
  47. ncbi request reprint NUT midline carcinoma of the parotid gland with mesenchymal differentiation
    Michael A Den Bakker
    Department of Pathology, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Am J Surg Pathol 33:1253-8. 2009
    ..The findings demonstrate the first case of NMC arising within salivary gland, and the first example of mesenchymal differentiation in this group of tumors...
  48. doi request reprint Impaired dexamethasone-related increase of anticoagulants is associated with the development of osteonecrosis in childhood acute lymphoblastic leukemia
    Mariel L te Winkel
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Haematologica 93:1570-4. 2008
    ....
  49. doi request reprint Effect of childhood cancer treatment on fertility markers in adult male long-term survivors
    Niels J van Casteren
    Department of Urology, Section of Andrology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Pediatr Blood Cancer 52:108-12. 2009
    ..Although it is accepted that pediatric cancer treatment harbors a risk of gonadal damage, large cohort studies using up-to-date fertility markers are lacking...
  50. ncbi request reprint Osteoporosis in children with cancer
    Inge M van der Sluis
    Department of Pediatric Oncology Hematology, Erasmus Medical Center, Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 50:474-8; discussion 486. 2008
    ..Therefore, optimizing peak bone mass is of clinical importance. Preventive and therapeutic strategies, such as calcium and vitamin D supplementation, physical activity and bisphosphonates, are considered...
  51. doi request reprint Characteristics and outcome of pediatric non-Hodgkin lymphoma patients with ovarian infiltration at presentation
    Wendy van Dorp
    Department of Pediatric Oncology Hematology, Erasmus MC University Medical Center Sophia s Children s Hospital, Rotterdam, The Netherlands Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Pediatr Blood Cancer 60:2054-9. 2013
    ..Ovarian infiltration in pediatric non-Hodgkin lymphoma (NHL) at presentation is rare and information on outcome is scarce and mainly based on case reports and small series...
  52. doi request reprint KCNQ1OT1 hypomethylation: a novel disguised genetic predisposition in sporadic pediatric adrenocortical tumors?
    Mark Wijnen
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 59:565-6. 2012
    ..This represents a likely novel genetic predisposition in patients with adrenocortical tumors without clear phenotypic features of the Beckwith-Wiedemann syndrome...
  53. ncbi request reprint Semen cryopreservation in pubertal boys before gonadotoxic treatment and the role of endocrinologic evaluation in predicting sperm yield
    Niels J van Casteren
    Department of Urology, Andrology Unit, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Fertil Steril 90:1119-25. 2008
    ..To evaluate the feasibility of semen cryopreservation in pubertal boys before they receive gonadotoxic therapy and to identify which pretreatment parameters might predict successful cryopreservation...
  54. ncbi request reprint A longitudinal study using tibial ultrasonometry as a bone assessment technique in children with acute lymphoblastic leukaemia
    Maarten H Lequin
    Department of Paediatric Radiology, Sophia Children s Hospital, University Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Pediatr Radiol 33:162-7. 2003
    ..Several longitudinal studies have shown contradictory results regarding the change in bone status in children with acute lymphoblastic leukaemia (ALL) using dual-energy X-ray absorptiometry as the bone assessment technique...
  55. ncbi request reprint Parents' experiences of pediatric palliative care and the impact on long-term parental grief
    Ivana M M van der Geest
    Department of Paediatric Oncology Haematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands Electronic address
    J Pain Symptom Manage 47:1043-53. 2014
    ..Approximately 25% of children diagnosed with cancer eventually die. Losing a child puts parents at increased risk for developing psychological problems...
  56. ncbi request reprint Parenting stress as a mediator of parents' negative mood state and behavior problems in children with newly diagnosed cancer
    Ivana M van der Geest
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Psychooncology 23:758-65. 2014
    ..The aim was to investigate the influence of parents' negative mood state and parenting stress on behavior in children with newly diagnosed cancer...
  57. ncbi request reprint Pediatric aggressive fibromatosis: a retrospective analysis of 13 patients and review of literature
    Saskia Buitendijk
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Cancer 104:1090-9. 2005
    ..Aggressive fibromatosis (AF) is a soft tissue tumor and is rare in childhood, with high potential for local invasiveness and recurrence. General recommendations for the clinical management of pediatric patients with AF remain undetermined...
  58. doi request reprint Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia
    Iris H I M Hollink
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Blood 113:5951-60. 2009
    ..001). Patients with both a WT1 mutation and a FLT3/ITD had a dismal prognosis (5-year pOS 21%). WT1 mutations occur at a significant rate in childhood AML and are a novel independent poor prognostic marker...
  59. ncbi request reprint High relapse rate in children with non-advanced nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL or nodular paragranuloma) treated with chemotherapy only
    Martine van Grotel
    Department of Pediatric Oncology Hematology, Erasmus University Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Leuk Lymphoma 47:1504-10. 2006
    ..Moreover, it illustrates that although cure of pediatric NLPHL is feasible with chemotherapy only, high dosages of cytotoxic drugs are necessary as salvage treatment in a relatively high proportion of patients after relapse...
  60. doi request reprint Successful treatment of congenital acute myeloid leukemia (AML-M6) in a premature infant
    Joyce C A van Dongen
    Department of Pediatric Oncology Hematology, Erasmus University, Rotterdam, The Netherlands
    J Pediatr Hematol Oncol 31:853-4. 2009
    ..After treatment with a sequential low-dose cytarabine after birth and full-dose AML treatment according to the MRC-12 protocol at the age of 2 months, she now is in continuous complete remission for 4 years...
  61. ncbi request reprint Role of mutation independent constitutive activation of FLT3 in juvenile myelomonocytic leukemia
    Andrica C H De Vries
    ErasmusMC Sophia Children s Hospital, Department of Pediatric Hematology Oncology, Room Sp 2568, Dr Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands
    Haematologica 92:1557-60. 2007
    ..No evidence for constitutively activation of FLT3/FLT3L was found in JMML, indicating that FLT3 inhibitors are unlikely to be effective in JMML...
  62. ncbi request reprint An exclusive case of juvenile myelomonocytic leukemia in association with Kikuchi's disease and hemophagocytic lymphohistiocytosis and a review of the literature
    Annemieke Gerritsen
    Department of Pediatric Oncology Hematology, Erasmus University Medical Center, Sophia Children s Hospital, Rotterdam, The Netherlands
    Leuk Res 30:1299-303. 2006
    ..Our patient was treated with prednisolone according to the few described cases of HLH and Kikuchi's disease in non-JMML patients, resulting in disappearance of the clinical symptoms...
  63. ncbi request reprint Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene
    Laura J C M van Zutven
    Department of Genetics, Centre for Biomedical Genetics, Erasmus MC, Rotterdam, The Netherlands
    Genes Chromosomes Cancer 45:437-46. 2006
    ..JARID1A, at 12p13, codes for retinoblastoma binding protein 2, a protein implicated in transcriptional regulation. This is the first report of JARID1A as a partner gene in leukemia...
  64. ncbi request reprint No difference between prednisolone and dexamethasone treatment in bone mineral density and growth in long term survivors of childhood acute lymphoblastic leukemia
    Robert D van Beek
    Department of Pediatric Hematology Oncology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 46:88-93. 2006
    ..In this study, we compared the long-term effects of dexamethasone and prednisolone on bone mineral density (BMD), body composition and growth in long-term survivors of ALL in first complete remission...
  65. doi request reprint A U-HPLC-ESI-MS/MS-based stable isotope dilution method for the detection and quantitation of methotrexate in plasma
    Ethan den Boer
    Department of Clinical Chemistry, Erasmus MC, Sophia Children s Hospital, Erasmus MC, University Medical Centre Rotterdam, s Gravendijkwal, Rotterdam, The Netherlands
    Ther Drug Monit 34:432-9. 2012
    ..The authors aimed to develop a liquid chromatography, electrospray ionization, tandem mass spectrometry (LC-ESI-MS/MS)-based method to determine MTX in plasma for therapeutic drug monitoring and pharmacokinetic studies...
  66. ncbi request reprint [An infant with sternal swelling]
    Naomi Ketharanathan
    Erasmus MC Sophia Kinderziekenhuis, Rotterdam, afd Kindergeneeskunde, The Netherlands
    Ned Tijdschr Geneeskd 156:A3981. 2012
    ..Sternal tumours in childhood are rare and alarming. These can be differentiated into benign and malignant tumours. This differentiation is important for the prevention of unnecessary diagnostic testing...
  67. doi request reprint Improvement of neurological status and quality of life in children with opsoclonus myoclonus syndrome at long-term follow-up
    Coriene E Catsman-Berrevoets
    Department of Pediatric Neurology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Blood Cancer 53:1048-53. 2009
    ..In general, the outcome of neurologic and behavioral symptoms is poor. Studies on quality of life (Qol) and recovery after very long-term follow-up of children with OMS are lacking...
  68. ncbi request reprint Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial
    Franco Locatelli
    Oncoematologia Pediatrica, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy
    Blood 105:410-9. 2005
    ..Disease recurrence remains the major cause of treatment failure. Outcome of UD-HSCT recipients is comparable to that of children receiving transplants from an HLA-identical sibling...
  69. ncbi request reprint Altered bone mineral density and body composition, and increased fracture risk in childhood acute lymphoblastic leukemia
    Inge M van der Sluis
    Division of Endocrinology and Oncology Hematology, Department of Pediatrics, Sophia Children s Hospital Rotterdam, The Netherlands
    J Pediatr 141:204-10. 2002
    ..To evaluate fracture rate and bone mineral density (BMD) and body composition in children with acute lymphoblastic leukemia (ALL) treated with dexamethasone-based chemotherapy...
  70. doi request reprint Genotype-phenotype correlation in cases of juvenile myelomonocytic leukemia with clonal RAS mutations
    Christian Flotho
    Blood 111:966-7; author reply 967-8. 2008
  71. ncbi request reprint Bone mineral density in childhood acute lymphoblastic leukemia (ALL) during and after treatment
    Inge M van der Sluis
    Pediatr Blood Cancer 43:182-3; discussion 184. 2004
  72. ncbi request reprint Anti-Mullerian hormone is a sensitive serum marker for gonadal function in women treated for Hodgkin's lymphoma during childhood
    Robert D van Beek
    Department of Pediatric Hematology Oncology, Erasmus MC Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:3869-74. 2007
    ..The aim of this study was to evaluate the long-term effects of combination chemotherapy treatment for girls with Hodgkin's lymphoma (HL) on gonadal function using anti-Müllerian hormone (AMH) and inhibin B as ovarian reserve parameters...
  73. ncbi request reprint Direct X-ray radiogrammetry versus dual-energy X-ray absorptiometry: assessment of bone density in children treated for acute lymphoblastic leukaemia and growth hormone deficiency
    Rick R van Rijn
    Department of Radiology, Academic Medical Centre Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam Zuid Oost, The Netherlands
    Pediatr Radiol 36:227-32. 2006
    ..In recent years interest in bone densitometry in children has increased...
  74. ncbi request reprint Immunosuppressive therapy with anti-thymocyte globulin and cyclosporine A in selected children with hypoplastic refractory cytopenia
    Ayami Yoshimi
    Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Germany
    Haematologica 92:397-400. 2007
    ..Six patients subsequently received a transplant because of non-response, progression to advanced myelodysplastic syndrome or evolution of monosomy 7. Overall and failure-free survival rates at 3 years were 88% and 57%, respectively...
  75. ncbi request reprint Visuomotor control in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only
    Annemieke I Buizer
    Department of Pediatrics, VU University Medical Center, Amsterdam, The Netherlands
    J Int Neuropsychol Soc 11:554-65. 2005
    ..The results indicate that chemotherapy-induced central neurotoxicity in childhood ALL treatment is associated with higher order visuomotor control deficits. Girls appear to be particularly vulnerable...
  76. ncbi request reprint Behavioral and educational limitations after chemotherapy for childhood acute lymphoblastic leukemia or Wilms tumor
    Annemieke I Buizer
    Department of Pediatric Hematology Oncology, VU University Medical Center, Amsterdam, Netherlands
    Cancer 106:2067-75. 2006
    ..In this study, children with ALL received central nervous system directed chemotherapy without cranial irradiation...