Research Topics
Genomes and GenesSpecies | Elisabeth Fc van RossumSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
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Detail Information
Publications
Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R StudyMiranda J J Geelhoed
The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
BMC Med Genet 11:39. 2010..We examined whether these glucocorticoid receptor gene polymorphisms are associated with growth in fetal and early postnatal life...- Polymorphisms in the glucocorticoid receptor gene that modulate glucocorticoid sensitivity are associated with rheumatoid arthritisManon J M van Oosten
Department of Internal Medicine, Section of Endocrinology, Erasmus MC, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
Arthritis Res Ther 12:R159. 2010..Because differences in GC sensitivity may influence immune effector functions, we examined whether these polymorphisms are associated with the susceptibility to develop Rheumatoid Arthritis (RA) and RA disease severity... 
Characterization of a promoter polymorphism in the glucocorticoid receptor gene and its relationship to three other polymorphismsElisabeth F C van Rossum
Department of Internal Medicine, Erasumus Medical Center, Rotterdam, The Netherlands
Clin Endocrinol (Oxf) 61:573-81. 2004..We investigated the exact sequence alteration of a TthIIII polymorphism in the GR gene, whether it is associated with glucocorticoid sensitivity, and its relationship to 3 polymorphisms of the GR gene (N363S, BclI, ER22/23EK)...- The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adultsElisabeth F C van Rossum
Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
J Clin Endocrinol Metab 89:4004-9. 2004..Thus, the ER22/23EK polymorphism is associated with a sex-specific, beneficial body composition at young-adult age, as well as greater muscle strength in males... - Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly menElisabeth F C van Rossum
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Am J Med 117:158-62. 2004..In the present study, we investigated whether the ER22/23EK polymorphism is associated with survival, cholesterol levels, and two predictors of mortality: serum C-reactive protein and interleukin 6 levels... - Genetic polymorphisms and multifactorial diseases: facts and fallacies revealed by the glucocorticoid receptor geneElisabeth F C van Rossum
Department of Internal Medicine, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Trends Endocrinol Metab 16:445-50. 2005..In this review we describe a number of the limitations related to this type of research; from both our own experience with studies on polymorphisms in the glucocorticoid receptor gene, and shortcomings and solutions from the literature... - Polymorphisms of the glucocorticoid receptor gene and major depressionElisabeth F C van Rossum
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Biol Psychiatry 59:681-8. 2006..The N363S and BclI polymorphisms have been associated with hypersensitivity to glucocorticoids, whereas the ER22/23EK polymorphism is related to glucocorticoid resistance... - Glucocorticoid resistance syndrome: A diagnostic and therapeutic approachElisabeth F C van Rossum
University Medical Center, Department of Internal Medicine Room D400, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Best Pract Res Clin Endocrinol Metab 20:611-26. 2006..Diagnosis of generalized GC resistance can be difficult. This review highlights the diagnostic process and therapeutic options for treating patients with this disease... - Neuroendocrine, cognitive and structural imaging characteristics of women on longterm sickleave with job stress-induced depressionIngrid Rydmark
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
Biol Psychiatry 60:867-73. 2006..This is opposite to what has been described in major depression. It remains to be established whether this impairment is the end result of prolonged stress exposure, or a pre-existing susceptibility factor... - The combined dexamethasone/CRH test as a potential surrogate marker in depressionMarcus Ising
Max Planck Institute of Psychiatry, Kraepelinstr 10, D 80804 Munich, Germany
Prog Neuropsychopharmacol Biol Psychiatry 29:1085-93. 2005..Further systematic research is required and already ongoing to confirm the suitability of the combined dex/CRH test as a surrogate marker in depression... - Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatmentElisabeth B Binder
Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
Nat Genet 36:1319-25. 2004..These findings support a central role of genes regulating the HPA axis in the causality of depression and the mechanism of action of antidepressant drugs... - Association between response to lithium augmentation and the combined DEX/CRH test in major depressive disorderTom Bschor
Department of Psychiatry, Technische Universitat Dresden, Fetscherstrasse 74, D 01307, Dresden, Germany
J Psychiatr Res 37:135-43. 2003..Results of this study should be confirmed in a larger study group... - The Munich Vulnerability Study on Affective Disorders: risk factors for unipolarity versus bipolaritySieglinde Modell
Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
J Affect Disord 74:173-84. 2003..The aim of this study was to differentiate between healthy members of unipolar and bipolar families without a previous history of any psychiatric disorder according to the neurobiological and psychometric findings... - Lithium augmentation increases the ACTH and cortisol response in the combined DEX/CRH test in unipolar major depressionTom Bschor
Department of Psychiatry, Technische Universitat Dresden, Dresden, Germany
Neuropsychopharmacology 27:470-8. 2002..This effect might be explained by the serotonergic effects of lithium... - Prediction of the development of a first major depressive episode with a rapid eye movement sleep induction test using the cholinergic agonist RS 86Christoph J Lauer
J Clin Psychopharmacol 24:356-7. 2004 - Long-latency somatosensory potentials in high risk probands for affective disordersMarcus Ising
J Psychiatr Res 38:219-21. 2004 - Paroxetine treatment improves motor symptoms in patients with multiple system atrophyElisabeth Friess
Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
Parkinsonism Relat Disord 12:432-7. 2006..In addition, we assessed the effects on the psychopathological status of the patients... - Rapid eye movement (REM) sleep: an endophenotype for depressionSieglinde Modell
Bristol Myers Squibb GmbH and Company KGaA, Sapporobogen 6 8, 80637, Munchen, Germany
Curr Psychiatry Rep 9:480-5. 2007..This could facilitate development of preventive and therapeutic measures... - The Munich Vulnerability Study on Affective Disorders: stability of polysomnographic findings over timeSieglinde Modell
Max Planck Institute of Psychiatry, Munich, Germany
Biol Psychiatry 52:430-7. 2002..CONCLUSIONS: The increased REM density in high-risk subjects for an affective disorder at index investigation was stable over time, so that one of the requirements for a true vulnerability marker is fulfilled...