Research Topics
Genomes and Genes | Dik C van GentSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
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Detail Information
Publications
Pathway choice in DNA double strand break repair: observations of a balancing actInger Brandsma
Department of Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Genome Integr 3:9. 2012..In this review we describe several repair assays to determine the efficiencies of both pathways. We discuss how disturbance of the balance between HR and NHEJ can lead to disease, but also how it can be exploited for cancer treatment...
Reaching out for the other end with p53-binding protein 1Dik C van Gent
Department of Cell Biology and Genetics, Erasmus MC Rotterdam, The Netherlands
Trends Biochem Sci 34:226-9. 2009..These studies refine our understanding of the specific subset of DNA double-strand breaks that require the accessory end-joining factor 53BP1...
Non-homologous end-joining, a sticky affairD C van Gent
Department of Cell Biology and Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Oncogene 26:7731-40. 2007..We discuss how the ATM protein kinase and the Mre11/Rad50/Nbs1 complex might function in DSB repair and what role ionizing radiation-induced foci may play in this process...- End-joining of blunt DNA double-strand breaks in mammalian fibroblasts is precise and requires DNA-PK and XRCC4Diana van Heemst
Department of Cell Biology and Genetics, Erasmus Medical Center, P O Box 1738, 3000 DR, Rotterdam, The Netherlands
DNA Repair (Amst) 3:43-50. 2004..Interestingly, the severity of the end-joining defect differs between the various mutants, which may explain the difference in the severity of the phenotypes, which have been observed in the corresponding mouse models... - A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joiningMirjam van der Burg
Department of Immunology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands
J Clin Invest 119:91-8. 2009..Further, the data suggest that residual DNA-PKcs activity is indispensable in humans... - The role of DNA dependent protein kinase in synapsis of DNA endsEric Weterings
Department of Cell Biology and Genetics, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Nucleic Acids Res 31:7238-46. 2003..We infer that joining of synapsed DNA termini would require an additional protein factor... - The mechanism of non-homologous end-joining: a synopsis of synapsisEric Weterings
Department of Cell Biology and Genetics, Erasmus Medical Center, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
DNA Repair (Amst) 3:1425-35. 2004..This review concentrates on novel insights into damage recognition and subsequent tethering, processing and joining of DNA ends... - NBS1 cooperates with homologous recombination to counteract chromosome breakage during replicationLinda Brugmans
Department of Cell Biology and Genetics, Cancer Genomics Center, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
DNA Repair (Amst) 8:1363-70. 2009..We conclude that Nbs1 and Rad54 function cooperatively, but in separate pathways to counteract this type of DNA damage and discuss mechanistic implications of these findings... - DNA-PKcs deficiency in human: long predicted, finally foundMirjam van der Burg
Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
Curr Opin Allergy Clin Immunol 9:503-9. 2009.... - MicroRNA responses and stress granule formation modulate the DNA damage responseJoris Pothof
Department of Cell Biology and Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Cell Cycle 8:3462-8. 2009..We discuss the implications of these findings for our understanding of the DNA damage response... - Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cellsNicole S Verkaik
Department of Cell Biology and Genetics, Erasmus University Rotterdam, Rotterdam, The Netherlands
Eur J Immunol 32:701-9. 2002..These results suggest that direct end-joining and microhomology-directed end-joining constitute genetically distinct DSB repair pathways... - MicroRNAs, the DNA damage response and cancerMaikel D Wouters
Department of Genetics, Cancer Genomics Center, Erasmus MC, The Netherlands
Mutat Res 717:54-66. 2011..We end by discussing the role of DNA damage response microRNAs in cancer etiology and sensitivity to ionizing radiation and other DNA damaging therapeutic agents... - MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage responseJoris Pothof
Department of Cell Biology and Genetics, Erasmus MC, CA Rotterdam 3000, The Netherlands
EMBO J 28:2090-9. 2009..We conclude that microRNA-mediated gene regulation adds a new dimension to the DNA-damage response... - Defective Artemis nuclease is characterized by coding joints with microhomology in long palindromic-nucleotide stretchesMirjam van der Burg
Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
Eur J Immunol 37:3522-8. 2007..The V(D)J recombination assays used in this study contribute to the diagnostic strategy for T-B-NK+ SCID patients... - Spatiotemporal aspects of MicroRNA-mediated gene regulationJoris Pothof
Department of Genetics, Erasmus MC, University Medical Center, Netherlands
Adv Exp Med Biol 722:75-85. 2011..Insight into the spatiotemporal aspects of the microRNA response will be indispensable for a full understanding of this level of gene regulation... - The immunophenotypic and immunogenotypic B-cell differentiation arrest in bone marrow of RAG-deficient SCID patients corresponds to residual recombination activities of mutated RAG proteinsJeroen G Noordzij
Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Blood 100:2145-52. 2002.... - Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4Pierre Olivier Mari
Department of Biochemistry, Center for Biomics, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands
Proc Natl Acad Sci U S A 103:18597-602. 2006..Our results suggest that this assembly constitutes the core of the NHEJ reaction and that XRCC4 may serve as a flexible tether between Ku70/80 and ligase IV... - A new type of radiosensitive T-B-NK+ severe combined immunodeficiency caused by a LIG4 mutationMirjam van der Burg
Department of Immunology and Department of Cell Biology and Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
J Clin Invest 116:137-45. 2006..In conclusion, different LIG4 mutations can result in either a developmental defect with minor immunological abnormalities or a SCID picture with normal development... - DNA end-binding specificity of human Rad50/Mre11 is influenced by ATPMartijn de Jager
Department of Cell Biology and Genetics, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Nucleic Acids Res 30:4425-31. 2002..Interestingly, ATP binding, but not hydrolysis, increased the preference of R/M binding to DNA substrates with 3'-overhangs relative to substrates with blunt ends and 5'-overhangs... - A mouse model for chronic lymphocytic leukemia based on expression of the SV40 large T antigenPetra J ter Brugge
Departments of Immunology, Erasmus MC Rotterdam, Rotterdam, The Netherlands
Blood 114:119-27. 2009..Our findings provide an animal model for B-CLL and show that pathways activated by SV40 T antigen play important roles in the pathogenesis of B-CLL...