Research Topics
Genomes and Genes
| C Janneke van der WoudeSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
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Detail Information
Publications
Chronic inflammation, apoptosis and (pre-)malignant lesions in the gastro-intestinal tractC J van der Woude
Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands
Apoptosis 9:123-30. 2004....
Expression of apoptosis related proteins during malignant progression in chronic ulcerative colitisC J van der Woude
Departments of Gastroenterology and Hepatology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
J Clin Pathol 58:811-4. 2005..Chronic ulcerative colitis (CUC) is associated with increased risk of developing colon cancer through a dysplasia (intraepithelial neoplasia)-carcinoma sequence...
Are we ready for top-down therapy for inflammatory bowel diseases: proC Janneke van der Woude
Erasmus Medical Center, Department of Gastroenterology and Hepatology, Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
Expert Rev Gastroenterol Hepatol 1:243-8. 2007..Important factors that are relevant for this discussion are quality of life, need for corticosteroids and surgery. This article aims to explore whether we are indeed ready for a top-down approach toward biologics...- Biologics in Crohn's disease: searching indicators for outcomeC Janneke van der Woude
Erasmus MC, Department of Gastroenterology and Hepatology, Rotterdam, The Netherlands
Expert Opin Biol Ther 7:1233-43. 2007..This review presents biologics in Crohn's disease focusing on efficacy, steroid sparing, mucosal healing and safety, including immunogenicity... - Bleeding - not always a sign of relapse of long-standing colitisC J van der Woude
Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands
Endoscopy 39:E121-2. 2007 - Laparoscopic ileocolic resection versus infliximab treatment of distal ileitis in Crohn's disease: a randomized multicenter trial (LIR!C-trial)Emma J Eshuis
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
BMC Surg 8:15. 2008..The objective of this study is to compare infliximab treatment with laparoscopic ileocolic resection in patients with recurrent Crohn's disease of the distal ileum with respect to quality of life and costs... - Chromosomal and microsatellite instability of adenocarcinomas and dysplastic lesions (DALM) in ulcerative colitisJolanda M van Dieren
Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands
Diagn Mol Pathol 15:216-22. 2006..Further, we found a low percentage of MSI. Thus, DALM/UCCs display profound chromosomal instability, but this is not associated with concurrent MSI... - Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein foldingJ Jasper Deuring
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre Rotterdam, 3015 CE Rotterdam, The Netherlands
Biochem J 441:87-93. 2012.... - Local immune regulation of mucosal inflammation by tacrolimusJolanda M van Dieren
Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
Dig Dis Sci 55:2514-9. 2010..Our in vivo studies aimed at evaluating whether local tacrolimus treatment in mice would bring about local immune suppression and to compare colonic and systemic tacrolimus levels after locally and systemically applied tacrolimus... - Inflammatory bowel disease-patients are insufficiently educated about the basic characteristics of their disease and the associated risk of colorectal cancerJudith E Baars
Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, Postbus 2040, 3000 CA Rotterdam, The Netherlands
Dig Liver Dis 42:777-84. 2010..We assessed patients' knowledge of disease and its associated risks/complications, and their perspectives on current recommendations for colectomy when low-grade dysplasia is found... - Biomarker-based prediction of inflammatory bowel disease-related colorectal cancer: a case-control studyMonique M Gerrits
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Cell Oncol (Dordr) 34:107-17. 2011..Screening accuracy may increase by using a biomarker-based surveillance strategy... - A short course of corticosteroids prior to surveillance colonoscopy to decrease mucosal inflammation in inflammatory bowel disease patients: results from a randomized controlled trialJudith E Baars
Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands
J Crohns Colitis 4:661-8. 2010..This randomized controlled trial assessed the effectiveness of a low dose of corticosteroids prior to surveillance colonoscopy to decrease mucosal inflammation... - SOCS3 in immune regulation of inflammatory bowel disease and inflammatory bowel disease-related cancerYi Li
Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands
Cytokine Growth Factor Rev 23:127-38. 2012..Finally, we explore how this knowledge may open novel avenues for the rational treatment of IBD and IBD-related cancer... - Misclassification of dysplasia in patients with inflammatory bowel disease: consequences for progression rates to advanced neoplasiaFiona D M van Schaik
University Medical Center Utrecht, Department of Gastroenterology and Hepatology, Utrecht, The Netherlands
Inflamm Bowel Dis 17:1108-16. 2011..We studied the progression rate of flat LGD and IND to advanced neoplasia (high-grade dysplasia [HGD] or colorectal cancer [CRC]) before and after histopathological review by a panel of gastrointestinal expert pathologists... - Local application of tacrolimus in distal colitis: feasible and safeJolanda M van Dieren
Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
Inflamm Bowel Dis 15:193-8. 2009..However, potential toxicity and systemic (side) effects after oral intake limit its use. We investigated the local applicability and safety of tacrolimus for distal colitis... - Impeded protein folding and function in active inflammatory bowel diseaseJ Jasper Deuring
Erasmus MC University Medical Centre Rotterdam, Department of Gastroenterology and Hepatology, s Gravendijkwal 230, Room L 462, 3015 CE Rotterdam, The Netherlands
Biochem Soc Trans 39:1107-11. 2011..In the present review, we discuss the possible inflammatory pathways affecting protein folding and eventually leading to IEC malfunction in patients with active IBD... - STAT1, STAT6 and Adenosine 3',5'-Cyclic Monophosphate (cAMP) Signaling Drive SOCS3 Expression in Inactive Ulcerative ColitisYi Li
Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, Netherlands Department of Gastroenterology and Hepatology, Shanghai Jiao Tong University School of Medicine, Renji Hospital, Shanghai, China
Mol Med 18:1412-9. 2012..Our results highlight the multifactorial nature of the factors that cause exacerbation in UC... - IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancerYi Li
Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, Netherlands
Carcinogenesis 33:1889-96. 2012..Hence, DNMT1 emerges as a rational target in preventive strategies aimed at counteracting UC-CRC... - Solution focused therapy: a promising new tool in the management of fatigue in Crohn's disease patients psychological interventions for the management of fatigue in Crohn's diseaseLauran Vogelaar
Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands
J Crohns Colitis 5:585-91. 2011..Crohn's disease patients have a decreased Quality of Life (QoL) which is in part due to extreme fatigue. In a pilot study we prospectively assessed the feasibility and effect of psychological interventions in the management of fatigue... - Anti-inflammatory actions of phosphatidylinositolJolanda M van Dieren
Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Eur J Immunol 41:1047-57. 2011..These data validate PI as a pluripotent inhibitor that can be applied mucosally as well as systemically. Its compelling functions render PI a promising novel physiological immune suppressant... - Roles of CD1d-restricted NKT cells in the intestineJolanda M van Dieren
Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, and Department of Pediatric Gastroenterology, Sophia Children s Hospital, Rotterdam, The Netherlands
Inflamm Bowel Dis 13:1146-52. 2007..In this article we review the current literature on intestinal NKT cells and their roles in IBD pathogenesis. Specifically, the nomenclature, NKT antigens, and immune mechanisms of NKT cells within the intestinal mucosa are discussed... - New insights into the role of STAT3 in IBDYi Li
Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, Netherlands
Inflamm Bowel Dis 18:1177-83. 2012..As such, the action of STAT3 in IBD is highly context-dependent but always important... - Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesisYi Li
Department of Gastroenterology and Hepatology, Erasmus Medical Centre, Rotterdam, Netherlands
Gut 59:227-35. 2010..Mouse models have shown that interleukin (IL)6 stimulates survival, proliferation and progression to cancer of intestinal epithelial cells via activation of signal transducers and activators of transcription 3 (STAT3)... - Patients' preferences regarding shared decision-making in the treatment of inflammatory bowel disease: results from a patient-empowerment studyJudith E Baars
Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands j baars erasmusmc nl
Digestion 81:113-9. 2010..Because data are lacking on the preferences of patients with chronic diseases such as inflammatory bowel disease (IBD), we wanted to assess IBD patients' preferences about being involved in such decisions... - Genomic analysis of a case of multifocal adenocarcinoma in ulcerative colitisHerman van Dekken
Department of Pathology, Erasmus Medical Center, Josephine Nefkens Institute, Dr Molewaterplein 50, 3015GE Rotterdam, The Netherlands
Virchows Arch 449:716-21. 2006..We conclude that these three multifocal tumors must have originated from the same preneoplastic lineage... - Disease severity does not affect the interval between IBD diagnosis and the development of CRC: results from two large, Dutch case seriesErik Mooiweer
Department of Gastroenterology and Hepatology, University Medical Center Utrecht, The Netherlands
J Crohns Colitis 6:435-40. 2012..In the present study we aimed to identify characteristics potentially explaining these differences in two cohorts of patients with IBD-related CRC... - Predictors of dose escalation of adalimumab in a prospective cohort of Crohn's disease patientsE Bultman
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre Rotterdam, The Netherlands
Aliment Pharmacol Ther 35:335-41. 2012..Adalimumab is effective for the induction and maintenance of remission in Crohn's disease (CD)-patients... - Single-balloon enteroscopy, magnetic resonance enterography, and abdominal US useful for evaluation of small-bowel disease in children with (suspected) Crohn's diseaseLissy de Ridder
Department of Pediatric Gastroenterology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
Gastrointest Endosc 75:87-94. 2012..The usefulness of single-balloon enteroscopy (SBE) has not been evaluated in children with known or suspected Crohn's disease (CD)... - Acute CNS white matter lesions in patients with inflammatory bowel diseaseLonneke M L de Lau
Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
Inflamm Bowel Dis 15:576-80. 2009..Most previous reports involve cerebral venous thrombosis, central nervous system vasculitis, or peripheral nerve inflammation... - Patient's perspectives important for early anti-tumor necrosis factor treatment in inflammatory bowel diseaseJudith E Baars
Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands
Digestion 79:30-5. 2009..We assessed the perspectives of patients with inflammatory bowel disease (IBD) concerning the treatment-associated risks/benefits of infliximab... - Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease riskEleonora A M Festen
Department of Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
Am J Gastroenterol 105:395-402. 2010..Genetic susceptibility is known to make a major contribution to the pathogenesis of ulcerative colitis (UC). Recently, three studies, including a genome-wide association study (GWAS), reported novel UC risk loci... - Revisiting the immunomodulators tacrolimus, methotrexate, and mycophenolate mofetil: their mechanisms of action and role in the treatment of IBDJolanda M van Dieren
Department of Gastroenterology and Hepatology, Division of Gastroenterology and Nutrition, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
Inflamm Bowel Dis 12:311-27. 2006..First, this review discusses the potential targets for immunomodulating therapies in IBDs. Second, the immunomodulating mechanisms and effects of the 3 immunomodulators are discussed in relationship to these treatment targets...