Research Topics
Genomes and Genes | Arnoud H M van VlietSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
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Publications
NikR-mediated regulation of Helicobacter pylori acid adaptationArnoud H M van Vliet
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Trends Microbiol 12:489-94. 2004..Despite the paucity of regulatory proteins, this enables H. pylori to optimally adapt to conditions in the stomach, making it one of the most successful human pathogens...- Differential regulation of amidase- and formamidase-mediated ammonia production by the Helicobacter pylori fur repressorArnoud H M van Vliet
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
J Biol Chem 278:9052-7. 2003..These roles of Fur in regulation of the H. pylori amidases suggest that the H. pylori Fur regulator may have acquired extra functions to compensate for the absence of other regulatory systems... 
Metal-responsive gene regulation and metal transport in Helicobacter speciesClara Belzer
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Room L 455, s Gravendijkwal 230, 3015CE, Rotterdam, The Netherlands
Biometals 20:417-29. 2007....- Iron-responsive regulation of the Helicobacter pylori iron-cofactored superoxide dismutase SodB is mediated by FurFlorian D Ernst
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dijkzigt L 4, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
J Bacteriol 187:3687-92. 2005..In conclusion, H. pylori Fur is a versatile regulator involved in many pathways essential for gastric colonization, including superoxide stress defense... - Acid-responsive gene induction of ammonia-producing enzymes in Helicobacter pylori is mediated via a metal-responsive repressor cascadeArnoud H M van Vliet
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Infect Immun 72:766-73. 2004..5 in wild-type H. pylori. We hypothesize that H. pylori uses a repressor cascade to respond to low pH, with NikR initiating the response directly via the urease operon and indirectly via the members of the Fur regulon... - The nickel-responsive regulator NikR controls activation and repression of gene transcription in Helicobacter pyloriFlorian D Ernst
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Infect Immun 73:7252-8. 2005..In conclusion, the NikR protein is able to function both as a repressor and as an activator of gene transcription, depending on the position of the binding site... - Iron-responsive repression of urease expression in Helicobacter hepaticus is mediated by the transcriptional regulator FurClara Belzer
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, 3015 CE Rotterdam, The Netherlands
Infect Immun 75:745-52. 2007..This represents a novel type of urease regulation in ureolytic bacteria and extends the already diverse regulatory repertoire of the Fur protein... - Transcriptional profiling of Helicobacter pylori Fur- and iron-regulated gene expressionFlorian D Ernst
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Dijkzigt L 455, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Microbiology 151:533-46. 2005..pylori Fur is a versatile regulator involved in many pathways essential for gastric colonization. These findings further delineate the central role of Fur in regulating the unique capacity of H. pylori to colonize the human stomach... 
The Helicobacter hepaticus hefA gene is involved in resistance to amoxicillinClara Belzer
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Helicobacter 14:72-9. 2009..In this study we have determined the susceptibility of gastric and enterohepatic Helicobacter species to amoxicillin, and have investigated the mechanism of amoxicillin resistance in Helicobacter hepaticus...- NikR mediates nickel-responsive transcriptional repression of the Helicobacter pylori outer membrane proteins FecA3 (HP1400) and FrpB4 (HP1512)Florian D Ernst
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Room L 455, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
Infect Immun 74:6821-8. 2006..pylori to the gastric lifestyle... - UreA2B2: a second urease system in the gastric pathogen Helicobacter felisRaymond G J Pot
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
FEMS Immunol Med Microbiol 50:273-9. 2007..Although the exact function of the UreA2B2 system is still unknown, it is conceivable that UreA2B2 may contribute to pathogenesis of H. felis infection through a yet unknown mechanism... - The role of the Ferric Uptake Regulator (Fur) in regulation of Helicobacter pylori iron uptakeArnoud H M van Vliet
Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands
Helicobacter 7:237-44. 2002..Bacterial iron-responsive regulation is often mediated by Ferric Uptake Regulator (Fur) homologs, and in this study we have determined the role of H. pylori Fur in regulation of H. pylori iron uptake... - The functional status of the Helicobacter pylori sabB adhesin gene as a putative marker for disease outcomeRamon de Jonge
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands
Helicobacter 9:158-64. 2004..Assuming that SabB is involved in bacterial adhesion, this association suggests that adherent H. pylori are more prone to elimination by the host immune system... - The Helicobacter pylori plasticity region locus jhp0947-jhp0949 is associated with duodenal ulcer disease and interleukin-12 production in monocyte cellsRamon de Jonge
Department of Gastroenterology and Hepatology, Room L-459, Erasmus MC-University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
FEMS Immunol Med Microbiol 41:161-7. 2004..027). Therefore, the jhp0947-jhp0949 locus may be a novel putative H. pylori marker for disease outcome independent of the cag PAI... - Inverse nickel-responsive regulation of two urease enzymes in the gastric pathogen Helicobacter mustelaeJeroen Stoof
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
Environ Microbiol 10:2586-97. 2008..Pathogens often express colonization factors which are adapted to their host. The UreA2B2 urease could represent an example of pathogen adaptation to the specifics of the diet of their carnivorous host, rather than to the host itself... - NikR mediates nickel-responsive transcriptional induction of urease expression in Helicobacter pyloriArnoud H M van Vliet
Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands
Infect Immun 70:2846-52. 2002..In conclusion, the H. pylori NikR protein and a 19-bp operator sequence in the ureA promoter are both essential for nickel-responsive induction of urease expression in H. pylori... - Differential regulation of urease activity in Helicobacter hepaticus and Helicobacter pyloriClara Belzer
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Microbiology 151:3989-95. 2005..In conclusion, both the role of the urease enzyme and the regulation of urease activity differ between the enterohepatic pathogen H. hepaticus and the gastric pathogen H. pylori... - An ABC transporter and a TonB ortholog contribute to Helicobacter mustelae nickel and cobalt acquisitionJeroen Stoof
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, Netherlands
Infect Immun 78:4261-7. 2010.... - Pathogenesis of Helicobacter pylori infectionJohannes G Kusters
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Clin Microbiol Rev 19:449-90. 2006..This review focuses on the microbiological, clinical, immunological, and biochemical aspects of the pathogenesis of H. pylori... - COX-2 CA-haplotype is a risk factor for the development of esophageal adenocarcinomaLeon M G Moons
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
Am J Gastroenterol 102:2373-9. 2007..Neoplastic progression of BE towards EAC is associated with increased expression of COX-2. Increased COX-2 expression and enzyme activity is linked to the COX-2 CA haplotype, which consists of two gene polymorphisms in the COX-2 promoter... - Characterization of NikR-responsive promoters of urease and metal transport genes of Helicobacter mustelaeJeroen Stoof
Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
Biometals 23:145-59. 2010..The improved consensus NikR operator sequence allows the prediction of additional NikR targets in Helicobacter genomes, as demonstrated by the identification of a new nickel-repressed outer membrane protein in H. mustelae... - High-grade dysplasia in Barrett's esophagus is associated with increased expression of calgranulin A and BDorine A Bax
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
Scand J Gastroenterol 42:902-10. 2007..The aim of this study was to increase the understanding of the development of dysplastic lesions in BE through the identification of genes that are differentially transcribed in these tissue types... - Transcriptional phase variation of a type III restriction-modification system in Helicobacter pyloriNicolette de Vries
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands
J Bacteriol 184:6615-23. 2002..Moreover, the C tract was required for the occurrence of transcriptional phase variation. Our finding that translation and transcription are linked during phase variation through slipped-strand mispairing is new for H. pylori... - Multiple mutations in or adjacent to the conserved penicillin-binding protein motifs of the penicillin-binding protein 1A confer amoxicillin resistance to Helicobacter pyloriMonique M Gerrits
Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center, Rotterdam, The Netherlands
Helicobacter 11:181-7. 2006..pylori. The findings of this study currently preclude the rapid detection of amoxicillin resistance in H. pylori by molecular tests... - Role of the Helicobacter pylori outer-membrane proteins AlpA and AlpB in colonization of the guinea pig stomachRamon de Jonge
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands
J Med Microbiol 53:375-9. 2004..05). In conclusion, absence of AlpA or AlpB is a serious disadvantage for colonization of the stomach by H. pylori... - The stress-induced hsp12 gene shows genetic variation among Helicobacter pylori strainsNicolette de Vries
Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
FEMS Immunol Med Microbiol 38:45-51. 2003..The stress-regulated, strain-specific hsp12 genes may be involved in adaptation of individual H. pylori strains to their specific hosts, and contribute to long-term colonization of the gastric niche... - Helicobacter pylori and antimicrobial resistance: molecular mechanisms and clinical implicationsMonique M Gerrits
Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, Netherlands
Lancet Infect Dis 6:699-709. 2006..We focus on the treatment of H pylori infection and on the clinical relevance, mechanisms, and diagnosis of antimicrobial resistance... - The role of iron in Campylobacter gene regulation, metabolism and oxidative stress defenseArnoud H M van Vliet
Department of Gastroenterology and Hepatology, Erasmus Medical Center, Dr Molewaterplein 40, Rotterdam, The Netherlands
FEMS Microbiol Rev 26:173-86. 2002.... - Direct random insertion mutagenesis of Helicobacter pyloriRamon de Jonge
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
J Microbiol Methods 52:93-100. 2003..The isolation of two independent H. pylori mutants defective in production of urease from this library underlines the potential of this mutagenesis strategy... - Molecular alterations during development of esophageal adenocarcinomaDorine A Bax
Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands
J Surg Oncol 92:89-98; discussion 99. 2005..These novel developments will open new perspectives for diagnosis, treatment, and prevention of esophageal adenocarcinoma... - Serum- and animal tissue-free medium for transport and growth of Helicobacter pyloriCindy M Dierikx
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
FEMS Immunol Med Microbiol 50:239-43. 2007..pylori. The formulation of SATFM may allow its use in international transport of H. pylori, and may also allow certified use in immunization studies requiring growth of H. pylori and other bacterial pathogens... - Effects of 16S rRNA gene mutations on tetracycline resistance in Helicobacter pyloriMonique M Gerrits
Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands
Antimicrob Agents Chemother 47:2984-6. 2003..pylori isolates... - Barrett's oesophagus is characterized by a predominantly humoral inflammatory responseLeon M G Moons
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
J Pathol 207:269-76. 2005..It may be that this shift, which is similar to that found in other chronic inflammatory conditions, contributes to an increased cancer risk in BO...