Arnoud H M van Vliet

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi NikR-mediated regulation of Helicobacter pylori acid adaptation
    Arnoud H M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Trends Microbiol 12:489-94. 2004
  2. ncbi Differential regulation of amidase- and formamidase-mediated ammonia production by the Helicobacter pylori fur repressor
    Arnoud H M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
    J Biol Chem 278:9052-7. 2003
  3. pmc Metal-responsive gene regulation and metal transport in Helicobacter species
    Clara Belzer
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Room L 455, s Gravendijkwal 230, 3015CE, Rotterdam, The Netherlands
    Biometals 20:417-29. 2007
  4. pmc Iron-responsive regulation of the Helicobacter pylori iron-cofactored superoxide dismutase SodB is mediated by Fur
    Florian D Ernst
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dijkzigt L 4, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Bacteriol 187:3687-92. 2005
  5. pmc Acid-responsive gene induction of ammonia-producing enzymes in Helicobacter pylori is mediated via a metal-responsive repressor cascade
    Arnoud H M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Infect Immun 72:766-73. 2004
  6. pmc The nickel-responsive regulator NikR controls activation and repression of gene transcription in Helicobacter pylori
    Florian D Ernst
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Infect Immun 73:7252-8. 2005
  7. pmc Iron-responsive repression of urease expression in Helicobacter hepaticus is mediated by the transcriptional regulator Fur
    Clara Belzer
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, 3015 CE Rotterdam, The Netherlands
    Infect Immun 75:745-52. 2007
  8. ncbi Transcriptional profiling of Helicobacter pylori Fur- and iron-regulated gene expression
    Florian D Ernst
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Dijkzigt L 455, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Microbiology 151:533-46. 2005
  9. doi The Helicobacter hepaticus hefA gene is involved in resistance to amoxicillin
    Clara Belzer
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Helicobacter 14:72-9. 2009
  10. pmc NikR mediates nickel-responsive transcriptional repression of the Helicobacter pylori outer membrane proteins FecA3 (HP1400) and FrpB4 (HP1512)
    Florian D Ernst
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Room L 455, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Infect Immun 74:6821-8. 2006

Collaborators

  • Ernst J Kuipers
  • Johannes G Kusters
  • Stefan Bereswill
  • Georg Homuth
  • Christina M J E Vandenbroucke-Grauls
  • Barbara Waidner
  • Herman van Dekken
  • Ulrike Mäder
  • Hidekazu Suzuki
  • Alex Kleinjan
  • Kausilia K Krishnadath
  • Jeroen Stoof
  • Clara Belzer
  • Florian D Ernst
  • Ramon de Jonge
  • Monique M Gerrits
  • Raymond G J Pot
  • Dorine A Bax
  • Peter D Siersema
  • Leon M G Moons
  • Nicolette de Vries
  • Simone Breijer
  • Cindy M Dierikx
  • Manfred Kist
  • Ruud J L F Loffeld
  • Charles W Penn
  • Gerard Klaver
  • Daan van der Neut
  • Jaime Martodihardjo
  • Piet J M Nuijten
  • Agnieszka M Rygiel
  • Nanda de Groot
  • Willem A Bode
  • Louise A M de Haan
  • Jelle Haringsma
  • Bart A M van Schendel
  • Charles M H Hensgens
  • Han Geldof
  • Peter Loeffen
  • Jacques J G H M Bergman
  • Anthonie Z M Groothuismink
  • Arthur J M Vos
  • Sergio Mendonca
  • Anita P O Godoy
  • José Pedrazzoli
  • Wannie M Horrevoets
  • Marcelo L Ribeiro
  • Jaap Kwekkeboom
  • Angela Heijens
  • Wendy M W Tra
  • Roya Sarwari
  • Catherine S Beckwith
  • Evelien Bultman
  • Sjoerd G Rijpkema
  • Zarmina Durrani
  • Sabine C L Langeveld
  • Marco Berning
  • Dennis Bakker
  • Esther M van Ark
  • Dirk Duinsbergen
  • Patricia Wiesenekker

Detail Information

Publications33

  1. ncbi NikR-mediated regulation of Helicobacter pylori acid adaptation
    Arnoud H M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Trends Microbiol 12:489-94. 2004
    ..Despite the paucity of regulatory proteins, this enables H. pylori to optimally adapt to conditions in the stomach, making it one of the most successful human pathogens...
  2. ncbi Differential regulation of amidase- and formamidase-mediated ammonia production by the Helicobacter pylori fur repressor
    Arnoud H M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
    J Biol Chem 278:9052-7. 2003
    ..These roles of Fur in regulation of the H. pylori amidases suggest that the H. pylori Fur regulator may have acquired extra functions to compensate for the absence of other regulatory systems...
  3. pmc Metal-responsive gene regulation and metal transport in Helicobacter species
    Clara Belzer
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Room L 455, s Gravendijkwal 230, 3015CE, Rotterdam, The Netherlands
    Biometals 20:417-29. 2007
    ....
  4. pmc Iron-responsive regulation of the Helicobacter pylori iron-cofactored superoxide dismutase SodB is mediated by Fur
    Florian D Ernst
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dijkzigt L 4, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Bacteriol 187:3687-92. 2005
    ..In conclusion, H. pylori Fur is a versatile regulator involved in many pathways essential for gastric colonization, including superoxide stress defense...
  5. pmc Acid-responsive gene induction of ammonia-producing enzymes in Helicobacter pylori is mediated via a metal-responsive repressor cascade
    Arnoud H M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Infect Immun 72:766-73. 2004
    ..5 in wild-type H. pylori. We hypothesize that H. pylori uses a repressor cascade to respond to low pH, with NikR initiating the response directly via the urease operon and indirectly via the members of the Fur regulon...
  6. pmc The nickel-responsive regulator NikR controls activation and repression of gene transcription in Helicobacter pylori
    Florian D Ernst
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Infect Immun 73:7252-8. 2005
    ..In conclusion, the NikR protein is able to function both as a repressor and as an activator of gene transcription, depending on the position of the binding site...
  7. pmc Iron-responsive repression of urease expression in Helicobacter hepaticus is mediated by the transcriptional regulator Fur
    Clara Belzer
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, 3015 CE Rotterdam, The Netherlands
    Infect Immun 75:745-52. 2007
    ..This represents a novel type of urease regulation in ureolytic bacteria and extends the already diverse regulatory repertoire of the Fur protein...
  8. ncbi Transcriptional profiling of Helicobacter pylori Fur- and iron-regulated gene expression
    Florian D Ernst
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Dijkzigt L 455, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Microbiology 151:533-46. 2005
    ..pylori Fur is a versatile regulator involved in many pathways essential for gastric colonization. These findings further delineate the central role of Fur in regulating the unique capacity of H. pylori to colonize the human stomach...
  9. doi The Helicobacter hepaticus hefA gene is involved in resistance to amoxicillin
    Clara Belzer
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Helicobacter 14:72-9. 2009
    ..In this study we have determined the susceptibility of gastric and enterohepatic Helicobacter species to amoxicillin, and have investigated the mechanism of amoxicillin resistance in Helicobacter hepaticus...
  10. pmc NikR mediates nickel-responsive transcriptional repression of the Helicobacter pylori outer membrane proteins FecA3 (HP1400) and FrpB4 (HP1512)
    Florian D Ernst
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Room L 455, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Infect Immun 74:6821-8. 2006
    ..pylori to the gastric lifestyle...
  11. ncbi UreA2B2: a second urease system in the gastric pathogen Helicobacter felis
    Raymond G J Pot
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    FEMS Immunol Med Microbiol 50:273-9. 2007
    ..Although the exact function of the UreA2B2 system is still unknown, it is conceivable that UreA2B2 may contribute to pathogenesis of H. felis infection through a yet unknown mechanism...
  12. ncbi The role of the Ferric Uptake Regulator (Fur) in regulation of Helicobacter pylori iron uptake
    Arnoud H M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands
    Helicobacter 7:237-44. 2002
    ..Bacterial iron-responsive regulation is often mediated by Ferric Uptake Regulator (Fur) homologs, and in this study we have determined the role of H. pylori Fur in regulation of H. pylori iron uptake...
  13. ncbi The functional status of the Helicobacter pylori sabB adhesin gene as a putative marker for disease outcome
    Ramon de Jonge
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Helicobacter 9:158-64. 2004
    ..We have evaluated the correlation between the expression status of these four genes and disease outcome of H. pylori infection in a Dutch patient population...
  14. ncbi The Helicobacter pylori plasticity region locus jhp0947-jhp0949 is associated with duodenal ulcer disease and interleukin-12 production in monocyte cells
    Ramon de Jonge
    Department of Gastroenterology and Hepatology, Room L 459, Erasmus MC University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    FEMS Immunol Med Microbiol 41:161-7. 2004
    ..027). Therefore, the jhp0947-jhp0949 locus may be a novel putative H. pylori marker for disease outcome independent of the cag PAI...
  15. doi Inverse nickel-responsive regulation of two urease enzymes in the gastric pathogen Helicobacter mustelae
    Jeroen Stoof
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Environ Microbiol 10:2586-97. 2008
    ..Pathogens often express colonization factors which are adapted to their host. The UreA2B2 urease could represent an example of pathogen adaptation to the specifics of the diet of their carnivorous host, rather than to the host itself...
  16. pmc NikR mediates nickel-responsive transcriptional induction of urease expression in Helicobacter pylori
    Arnoud H M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands
    Infect Immun 70:2846-52. 2002
    ..In conclusion, the H. pylori NikR protein and a 19-bp operator sequence in the ureA promoter are both essential for nickel-responsive induction of urease expression in H. pylori...
  17. ncbi Differential regulation of urease activity in Helicobacter hepaticus and Helicobacter pylori
    Clara Belzer
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Microbiology 151:3989-95. 2005
    ..In conclusion, both the role of the urease enzyme and the regulation of urease activity differ between the enterohepatic pathogen H. hepaticus and the gastric pathogen H. pylori...
  18. pmc An ABC transporter and a TonB ortholog contribute to Helicobacter mustelae nickel and cobalt acquisition
    Jeroen Stoof
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, Netherlands
    Infect Immun 78:4261-7. 2010
    ....
  19. pmc Pathogenesis of Helicobacter pylori infection
    Johannes G Kusters
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Clin Microbiol Rev 19:449-90. 2006
    ..This review focuses on the microbiological, clinical, immunological, and biochemical aspects of the pathogenesis of H. pylori...
  20. ncbi COX-2 CA-haplotype is a risk factor for the development of esophageal adenocarcinoma
    Leon M G Moons
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Gastroenterol 102:2373-9. 2007
    ..Neoplastic progression of BE towards EAC is associated with increased expression of COX-2. Increased COX-2 expression and enzyme activity is linked to the COX-2 CA haplotype, which consists of two gene polymorphisms in the COX-2 promoter...
  21. doi Characterization of NikR-responsive promoters of urease and metal transport genes of Helicobacter mustelae
    Jeroen Stoof
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Biometals 23:145-59. 2010
    ..The improved consensus NikR operator sequence allows the prediction of additional NikR targets in Helicobacter genomes, as demonstrated by the identification of a new nickel-repressed outer membrane protein in H. mustelae...
  22. ncbi High-grade dysplasia in Barrett's esophagus is associated with increased expression of calgranulin A and B
    Dorine A Bax
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Scand J Gastroenterol 42:902-10. 2007
    ..The aim of this study was to increase the understanding of the development of dysplastic lesions in BE through the identification of genes that are differentially transcribed in these tissue types...
  23. pmc Transcriptional phase variation of a type III restriction-modification system in Helicobacter pylori
    Nicolette de Vries
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Bacteriol 184:6615-23. 2002
    ..Moreover, the C tract was required for the occurrence of transcriptional phase variation. Our finding that translation and transcription are linked during phase variation through slipped-strand mispairing is new for H. pylori...
  24. ncbi Multiple mutations in or adjacent to the conserved penicillin-binding protein motifs of the penicillin-binding protein 1A confer amoxicillin resistance to Helicobacter pylori
    Monique M Gerrits
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Helicobacter 11:181-7. 2006
    ..pylori isolates, and is mediated by mutations in penicillin-binding protein 1A (PBP1A). In this study the molecular mechanism underlying amoxicillin resistance of seven additional Amx H. pylori isolates has been established...
  25. ncbi Role of the Helicobacter pylori outer-membrane proteins AlpA and AlpB in colonization of the guinea pig stomach
    Ramon de Jonge
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Med Microbiol 53:375-9. 2004
    ..05). In conclusion, absence of AlpA or AlpB is a serious disadvantage for colonization of the stomach by H. pylori...
  26. ncbi The stress-induced hsp12 gene shows genetic variation among Helicobacter pylori strains
    Nicolette de Vries
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
    FEMS Immunol Med Microbiol 38:45-51. 2003
    ..The stress-regulated, strain-specific hsp12 genes may be involved in adaptation of individual H. pylori strains to their specific hosts, and contribute to long-term colonization of the gastric niche...
  27. ncbi Helicobacter pylori and antimicrobial resistance: molecular mechanisms and clinical implications
    Monique M Gerrits
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands
    Lancet Infect Dis 6:699-709. 2006
    ..We focus on the treatment of H pylori infection and on the clinical relevance, mechanisms, and diagnosis of antimicrobial resistance...
  28. ncbi The role of iron in Campylobacter gene regulation, metabolism and oxidative stress defense
    Arnoud H M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus Medical Center, Dr Molewaterplein 40, Rotterdam, The Netherlands
    FEMS Microbiol Rev 26:173-86. 2002
    ....
  29. ncbi Direct random insertion mutagenesis of Helicobacter pylori
    Ramon de Jonge
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Microbiol Methods 52:93-100. 2003
    ..The isolation of two independent H. pylori mutants defective in production of urease from this library underlines the potential of this mutagenesis strategy...
  30. ncbi Molecular alterations during development of esophageal adenocarcinoma
    Dorine A Bax
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Surg Oncol 92:89-98; discussion 99. 2005
    ..These novel developments will open new perspectives for diagnosis, treatment, and prevention of esophageal adenocarcinoma...
  31. ncbi Serum- and animal tissue-free medium for transport and growth of Helicobacter pylori
    Cindy M Dierikx
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    FEMS Immunol Med Microbiol 50:239-43. 2007
    ..pylori. The formulation of SATFM may allow its use in international transport of H. pylori, and may also allow certified use in immunization studies requiring growth of H. pylori and other bacterial pathogens...
  32. pmc Effects of 16S rRNA gene mutations on tetracycline resistance in Helicobacter pylori
    Monique M Gerrits
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 47:2984-6. 2003
    ..pylori isolates...
  33. ncbi Barrett's oesophagus is characterized by a predominantly humoral inflammatory response
    Leon M G Moons
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
    J Pathol 207:269-76. 2005
    ..It may be that this shift, which is similar to that found in other chronic inflammatory conditions, contributes to an increased cancer risk in BO...