A C J van Akkooi

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc Isolated tumor cells and long-term prognosis of patients with melanoma
    A C J van Akkooi
    Ann Surg Oncol 15:1547-8. 2008
  2. pmc Cutaneous melanoma and sentinel lymph node biopsy
    A C J van Akkooi
    Ann Surg Oncol 15:1808-9; author reply 1810-1. 2008
  3. doi request reprint Sentinel node tumor burden according to the Rotterdam criteria is the most important prognostic factor for survival in melanoma patients: a multicenter study in 388 patients with positive sentinel nodes
    Alexander C J van Akkooi
    Department of Surgical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Ann Surg 248:949-55. 2008
  4. ncbi request reprint Sentinel node biopsy for clear cell sarcoma
    A C J van Akkooi
    Department of Surgical Oncology, Erasmus University Medical Center Daniel den Hoed Cancer Center, Groene Hilledijk 301, Kamer B3 16, 3075 EA, Rotterdam, The Netherlands
    Eur J Surg Oncol 32:996-9. 2006
  5. doi request reprint Importance of tumor load in the sentinel node in melanoma: clinical dilemmas
    Alexander C J van Akkooi
    Department of Surgical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Groene Hilledijk 301, Kamer A1 41, 3075 EA Rotterdam, The Netherlands
    Nat Rev Clin Oncol 7:446-54. 2010
  6. doi request reprint Expert opinion in melanoma: the sentinel node; EORTC Melanoma Group recommendations on practical methodology of the measurement of the microanatomic location of metastases and metastatic tumour burden
    Alexander C J van Akkooi
    Erasmus University Medical Centre Daniel den Hoed Cancer Centre, Department of Surgical Oncology, Groene Hilledijk 301 Kamer A1 41, 3075 EA Rotterdam, The Netherlands
    Eur J Cancer 45:2736-42. 2009
  7. doi request reprint Phase III trial comparing adjuvant treatment with pegylated interferon Alfa-2b versus observation: prognostic significance of autoantibodies--EORTC 18991
    Marna G Bouwhuis
    Department of Surgery, Division Surgical Oncology, Erasmus University Medical Center Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Clin Oncol 28:2460-6. 2010
  8. ncbi request reprint Multivariable analysis comparing outcome after sentinel node biopsy or therapeutic lymph node dissection in patients with melanoma
    A C J van Akkooi
    Department of Surgical Oncology, Erasmus University Medical Centre Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands
    Br J Surg 94:1293-9. 2007
  9. ncbi request reprint High positive sentinel node identification rate by EORTC melanoma group protocol. Prognostic indicators of metastatic patterns after sentinel node biopsy in melanoma
    A C J van Akkooi
    Department of Surgical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, 301 Groene Hilledijk, 3075 EA, Rotterdam, The Netherlands
    Eur J Cancer 42:372-80. 2006
  10. ncbi request reprint Clinical relevance of melanoma micrometastases (<0.1 mm) in sentinel nodes: are these nodes to be considered negative?
    A C J van Akkooi
    Department of Surgical Oncology, Erasmus University Medical Center Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Ann Oncol 17:1578-85. 2006

Detail Information

Publications17

  1. pmc Isolated tumor cells and long-term prognosis of patients with melanoma
    A C J van Akkooi
    Ann Surg Oncol 15:1547-8. 2008
  2. pmc Cutaneous melanoma and sentinel lymph node biopsy
    A C J van Akkooi
    Ann Surg Oncol 15:1808-9; author reply 1810-1. 2008
  3. doi request reprint Sentinel node tumor burden according to the Rotterdam criteria is the most important prognostic factor for survival in melanoma patients: a multicenter study in 388 patients with positive sentinel nodes
    Alexander C J van Akkooi
    Department of Surgical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Ann Surg 248:949-55. 2008
    ..This is characterized by an increased detection of cases with minimal tumor burden (SUB-micrometastasis <0.1 mm), which represents different biology...
  4. ncbi request reprint Sentinel node biopsy for clear cell sarcoma
    A C J van Akkooi
    Department of Surgical Oncology, Erasmus University Medical Center Daniel den Hoed Cancer Center, Groene Hilledijk 301, Kamer B3 16, 3075 EA, Rotterdam, The Netherlands
    Eur J Surg Oncol 32:996-9. 2006
    ..SN status seems to predict additional nodal involvement and recurrent disease as well as survival. The SN procedure might be a useful and accurate staging procedure in CCS patients, comparable to the situation in melanoma...
  5. doi request reprint Importance of tumor load in the sentinel node in melanoma: clinical dilemmas
    Alexander C J van Akkooi
    Department of Surgical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Groene Hilledijk 301, Kamer A1 41, 3075 EA Rotterdam, The Netherlands
    Nat Rev Clin Oncol 7:446-54. 2010
    ..1 mm by the Rotterdam Criteria have excellent survival rates. Ultrasound-guided fine-needle aspiration cytology is emerging as a staging tool for high-risk patients, but more research is necessary before this can change clinical practice...
  6. doi request reprint Expert opinion in melanoma: the sentinel node; EORTC Melanoma Group recommendations on practical methodology of the measurement of the microanatomic location of metastases and metastatic tumour burden
    Alexander C J van Akkooi
    Erasmus University Medical Centre Daniel den Hoed Cancer Centre, Department of Surgical Oncology, Groene Hilledijk 301 Kamer A1 41, 3075 EA Rotterdam, The Netherlands
    Eur J Cancer 45:2736-42. 2009
    ..1mm or 0.1-1.0mm or >1.0mm...
  7. doi request reprint Phase III trial comparing adjuvant treatment with pegylated interferon Alfa-2b versus observation: prognostic significance of autoantibodies--EORTC 18991
    Marna G Bouwhuis
    Department of Surgery, Division Surgical Oncology, Erasmus University Medical Center Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Clin Oncol 28:2460-6. 2010
    ..We evaluated the prognostic significance of autoantibodies in the European Organisation for Research and Treatment of Cancer 18991 trial, comparing long-term administration of pegylated IFN (PEG-IFN) with observation...
  8. ncbi request reprint Multivariable analysis comparing outcome after sentinel node biopsy or therapeutic lymph node dissection in patients with melanoma
    A C J van Akkooi
    Department of Surgical Oncology, Erasmus University Medical Centre Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands
    Br J Surg 94:1293-9. 2007
    ..This study compared the outcome after completion lymph node dissection (CLND) in SN-positive tumours with elective total lymph node dissection (TLND) in patients with palpable nodes...
  9. ncbi request reprint High positive sentinel node identification rate by EORTC melanoma group protocol. Prognostic indicators of metastatic patterns after sentinel node biopsy in melanoma
    A C J van Akkooi
    Department of Surgical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, 301 Groene Hilledijk, 3075 EA, Rotterdam, The Netherlands
    Eur J Cancer 42:372-80. 2006
    ..The SN status is the most important predictive value for DFS and OS. In-transit metastasis rates correlated with SN-positivity, Breslow thickness and ulceration of the primary...
  10. ncbi request reprint Clinical relevance of melanoma micrometastases (<0.1 mm) in sentinel nodes: are these nodes to be considered negative?
    A C J van Akkooi
    Department of Surgical Oncology, Erasmus University Medical Center Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Ann Oncol 17:1578-85. 2006
    ..Therefore, our data suggest that patients with sub-micrometastases (<0.1 mm) in the SN may be judged as SN negative, as non-stage III, and are highly unlikely to benefit from CLND, which we no longer recommend...
  11. doi request reprint Prognosis in patients with sentinel node-positive melanoma without immediate completion lymph node dissection
    A P T van der Ploeg
    Erasmus University Medical Centre Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands
    Br J Surg 99:1396-405. 2012
    ..The aim of this study was to evaluate the impact of immediate CLND on the outcome of patients with SN-positive melanoma...
  12. doi request reprint Prognosis in patients with sentinel node-positive melanoma is accurately defined by the combined Rotterdam tumor load and Dewar topography criteria
    Augustinus P T van der Ploeg
    Erasmus University Medical Center Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Clin Oncol 29:2206-14. 2011
    ..These factors reflect biologic behavior and may separate out patients who may or may not need additional locoregional and/or systemic therapy...
  13. pmc Therapeutic surgical management of palpable melanoma groin metastases: superficial or combined superficial and deep groin lymph node dissection
    A P T van der Ploeg
    Department of Surgical Oncology, Erasmus University Medical Center Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Ann Surg Oncol 18:3300-8. 2011
    ..The aim of this study is to evaluate the experience in CGD versus SGD patients in our center...
  14. ncbi request reprint Morbidity and prognosis after therapeutic lymph node dissections for malignant melanoma
    A C J van Akkooi
    Department of Surgical Oncology, Erasmus University Medical Center Daniel den Hoed Cancer Center, 301 Groene Hilledijk, 3075 EA, Rotterdam, The Netherlands
    Eur J Surg Oncol 33:102-8. 2007
    ..In conclusion, TLND for stage III melanoma is accompanied with considerable short-term complications, and can achieve regional control and potential curation in approximately one in every four patients...
  15. doi request reprint Autoimmune antibodies and recurrence-free interval in melanoma patients treated with adjuvant interferon
    Marna G Bouwhuis
    Department of Surgical Oncology, Erasmus University MC Daniel den Hoed Cancer Center, 301 Groene Hilledijk, Rotterdam, The Netherlands
    J Natl Cancer Inst 101:869-77. 2009
    ....
  16. ncbi request reprint Extra-axial chordoma
    A C J van Akkooi
    Department of Surgical Oncology, Erasmus University Medical Center, Postbus 2040, 3000 CA, Rotterdam, The Netherlands
    J Bone Joint Surg Br 88:1232-4. 2006
    ..We report the case of a 56-year-old woman who developed an extra-axial chordoma of the right thoracic wall in close relationship with the tenth rib. The tumour was completely removed and the prognosis is excellent...
  17. doi request reprint Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial
    Alexander M M Eggermont
    Erasmus University Medical Center, Rotterdam, Netherlands
    Lancet 372:117-26. 2008
    ..Any benefit of adjuvant interferon alfa-2b for melanoma could depend on dose and duration of treatment. Our aim was to determine whether pegylated interferon alfa-2b can facilitate prolonged exposure while maintaining tolerability...