Arzu Umar

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi request reprint Comparative proteome analysis revealing an 11-protein signature for aggressive triple-negative breast cancer
    Ning Qing Liu
    Affiliations of authors Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands NQL, MPL, MS, RBHB, TDM, AMS, JWMM, JAF, AU Department of Neurology CS, TML and Postgraduate School of Molecular Medicine NQL, RBHB, TDM, AMS, JWMM, JAF, AU, Erasmus University Medical Center, Rotterdam, The Netherlands Department of Radiation Oncology PNS and Department of Laboratory Medicine FCGJS, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden BKL Department of Oncology Pathology, Karolinska Institute, Stockholm, Sweden BKL Clinical Experimental Oncology Laboratory, National Cancer Centre Giovanni Paolo II, Bari, Italy AM, AP Translational Cancer Research Unit, Oncology Center, GZA Hospitals St Augustinus
    J Natl Cancer Inst 106:djt376. 2014
  2. doi request reprint High-throughput proteomics of breast carcinoma cells: a focus on FTICR-MS
    Arzu Umar
    University Medical Center Rotterdam, Josephine Nefkens Institute, Laboratory of Genomics and Proteomics in Breast Cancer, Department of Medical Oncology, Dr Molewaterplein 50, Be 430c, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Expert Rev Proteomics 5:445-55. 2008
  3. pmc Identification of a putative protein profile associated with tamoxifen therapy resistance in breast cancer
    Arzu Umar
    Erasmus Medical Center Rotterdam, Josephine Nefkens Inst, Dept of Medical Oncology, Laboratory of Genomics and Proteomics of Breast Cancer, Dr Molewaterplein 50, Be 430c, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Mol Cell Proteomics 8:1278-94. 2009
  4. ncbi request reprint NanoLC-FT-ICR MS improves proteome coverage attainable for approximately 3000 laser-microdissected breast carcinoma cells
    Arzu Umar
    Department of Medical Oncology, Erasmus Medical Center Rotterdam, Josephine Nefkens Institute, The Netherlands
    Proteomics 7:323-9. 2007
  5. ncbi request reprint Method optimisation for peptide profiling of microdissected breast carcinoma tissue by matrix-assisted laser desorption/ionisation-time of flight and matrix-assisted laser desorption/ionisation-time of flight/time of flight-mass spectrometry
    Arzu Umar
    Department of Neurology and Center for Biomics, Erasmus MC, Rotterdam, The Netherlands
    Proteomics 5:2680-8. 2005
  6. ncbi request reprint Proteomic profiling of epididymis and vas deferens: identification of proteins regulated during rat genital tract development
    Arzu Umar
    Department of Reproduction and Development, Erasmus MC, P O Box 1738, Rotterdam 3000 DR, The Netherlands
    Endocrinology 144:4637-47. 2003
  7. ncbi request reprint Proteomic analysis of androgen-regulated protein expression in a mouse fetal vas deferens cell line
    Arzu Umar
    Department of Reproduction and Development, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Endocrinology 144:1147-54. 2003
  8. pmc Proteomics pipeline for biomarker discovery of laser capture microdissected breast cancer tissue
    Ning Qing Liu
    Department of Medical Oncology and Daniel Den Hoed Cancer Center, Erasmus University Medical Center, Dr Molewaterplein 50, Rotterdam, The Netherlands
    J Mammary Gland Biol Neoplasia 17:155-64. 2012
  9. doi request reprint Optimized nLC-MS workflow for laser capture microdissected breast cancer tissue
    René B H Braakman
    Department of Medical Oncology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Proteomics 75:2844-54. 2012
  10. ncbi request reprint Quantitative proteomic analysis of microdissected breast cancer tissues: comparison of label-free and SILAC-based quantification with shotgun, directed, and targeted MS approaches
    Ning Qing Liu
    Department of Medical Oncology, Erasmus MC Cancer Institute and Department of Neurology, Erasmus University Medical Center, Dr Molewaterplein 50, Be 401, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Proteome Res 12:4627-41. 2013

Detail Information

Publications15

  1. doi request reprint Comparative proteome analysis revealing an 11-protein signature for aggressive triple-negative breast cancer
    Ning Qing Liu
    Affiliations of authors Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands NQL, MPL, MS, RBHB, TDM, AMS, JWMM, JAF, AU Department of Neurology CS, TML and Postgraduate School of Molecular Medicine NQL, RBHB, TDM, AMS, JWMM, JAF, AU, Erasmus University Medical Center, Rotterdam, The Netherlands Department of Radiation Oncology PNS and Department of Laboratory Medicine FCGJS, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden BKL Department of Oncology Pathology, Karolinska Institute, Stockholm, Sweden BKL Clinical Experimental Oncology Laboratory, National Cancer Centre Giovanni Paolo II, Bari, Italy AM, AP Translational Cancer Research Unit, Oncology Center, GZA Hospitals St Augustinus
    J Natl Cancer Inst 106:djt376. 2014
    ..Clinical outcome of patients with triple-negative breast cancer (TNBC) is highly variable. This study aims to identify and validate a prognostic protein signature for TNBC patients to reduce unnecessary adjuvant systemic therapy...
  2. doi request reprint High-throughput proteomics of breast carcinoma cells: a focus on FTICR-MS
    Arzu Umar
    University Medical Center Rotterdam, Josephine Nefkens Institute, Laboratory of Genomics and Proteomics in Breast Cancer, Department of Medical Oncology, Dr Molewaterplein 50, Be 430c, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Expert Rev Proteomics 5:445-55. 2008
    ..In this review, we describe the applicability of FTICR-MS for breast cancer proteomics, particularly for the analysis of complex protein mixtures obtained from a limited number of cells typically available from clinical specimens...
  3. pmc Identification of a putative protein profile associated with tamoxifen therapy resistance in breast cancer
    Arzu Umar
    Erasmus Medical Center Rotterdam, Josephine Nefkens Inst, Dept of Medical Oncology, Laboratory of Genomics and Proteomics of Breast Cancer, Dr Molewaterplein 50, Be 430c, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Mol Cell Proteomics 8:1278-94. 2009
    ....
  4. ncbi request reprint NanoLC-FT-ICR MS improves proteome coverage attainable for approximately 3000 laser-microdissected breast carcinoma cells
    Arzu Umar
    Department of Medical Oncology, Erasmus Medical Center Rotterdam, Josephine Nefkens Institute, The Netherlands
    Proteomics 7:323-9. 2007
    ..This work demonstrates that a substantial number of proteins can be detected and identified from limited number of cells using the AMT tag approach, and opens doors for high-throughput in-depth proteomics analysis of clinical samples...
  5. ncbi request reprint Method optimisation for peptide profiling of microdissected breast carcinoma tissue by matrix-assisted laser desorption/ionisation-time of flight and matrix-assisted laser desorption/ionisation-time of flight/time of flight-mass spectrometry
    Arzu Umar
    Department of Neurology and Center for Biomics, Erasmus MC, Rotterdam, The Netherlands
    Proteomics 5:2680-8. 2005
    ..In conclusion, we describe a method that is suitable for direct peptide profiling on small amounts of microdissected cells obtained from breast cancer tissues...
  6. ncbi request reprint Proteomic profiling of epididymis and vas deferens: identification of proteins regulated during rat genital tract development
    Arzu Umar
    Department of Reproduction and Development, Erasmus MC, P O Box 1738, Rotterdam 3000 DR, The Netherlands
    Endocrinology 144:4637-47. 2003
    ....
  7. ncbi request reprint Proteomic analysis of androgen-regulated protein expression in a mouse fetal vas deferens cell line
    Arzu Umar
    Department of Reproduction and Development, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Endocrinology 144:1147-54. 2003
    ..Posttranslational modification of mElfin and CBF-A by androgens may be associated with a cytoskeletal change that is involved in androgen-regulated gene expression...
  8. pmc Proteomics pipeline for biomarker discovery of laser capture microdissected breast cancer tissue
    Ning Qing Liu
    Department of Medical Oncology and Daniel Den Hoed Cancer Center, Erasmus University Medical Center, Dr Molewaterplein 50, Rotterdam, The Netherlands
    J Mammary Gland Biol Neoplasia 17:155-64. 2012
    ..Therefore, we show that our tissue proteomics pipeline is robust and applicable for the identification of breast cancer specific protein markers...
  9. doi request reprint Optimized nLC-MS workflow for laser capture microdissected breast cancer tissue
    René B H Braakman
    Department of Medical Oncology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Proteomics 75:2844-54. 2012
    ..This article is part of a Special Issue entitled: Proteomics: The clinical link...
  10. ncbi request reprint Quantitative proteomic analysis of microdissected breast cancer tissues: comparison of label-free and SILAC-based quantification with shotgun, directed, and targeted MS approaches
    Ning Qing Liu
    Department of Medical Oncology, Erasmus MC Cancer Institute and Department of Neurology, Erasmus University Medical Center, Dr Molewaterplein 50, Be 401, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Proteome Res 12:4627-41. 2013
    ..The SILAC-based SRM method can be used for the development of clinically relevant protein assays in tumor biopsies. ..
  11. doi request reprint Laser capture microdissection applications in breast cancer proteomics
    René B H Braakman
    Department of Medical Oncology, Center for Translational Molecular Medicine, and Cancer Genomics Centre, Erasmus MC Rotterdam, Rotterdam, The Netherlands
    Methods Mol Biol 755:143-54. 2011
    ..Protocols are provided for sectioning, staining, microdissection, sample preparation, and mass spectrometric analysis of snap frozen breast cancer tissue...
  12. pmc Differential modulation of androgen receptor transcriptional activity by the nuclear receptor co-repressor (N-CoR)
    Cor A Berrevoets
    Department of Reproduction and Development, Erasmus MC, University Medical Center Rotterdam, 3000 DR Rotterdam, Netherlands
    Biochem J 379:731-8. 2004
    ..These results indicate that lack of N-CoR action allows these antiandrogens to act as strong agonists on the mutant AR...
  13. ncbi request reprint Functional analysis of a novel androgen receptor mutation, Q902K, in an individual with partial androgen insensitivity
    Arzu Umar
    Department of Reproduction and Development, Erasmus MC, University Medical Center Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:507-15. 2005
    ..These results indicate that residue Q902 is involved in TIF2 and NH2/COOH interaction and that the Q to K mutation results in a mild impairment of AR function, which can explain the partial AIS phenotype of the patient...
  14. ncbi request reprint Antiandrogens: selective androgen receptor modulators
    Cor A Berrevoets
    Department of Reproduction and Development, Erasmus University Medical Centre Rotterdam, PO Box 1738, DR 3000 Rotterdam, The Netherlands
    Mol Cell Endocrinol 198:97-103. 2002
    ..As a consequence, this might affect recruitment of co-regulators, thereby allowing CPA and OHF to act as strong agonists on the mutant AR...
  15. ncbi request reprint Use of Universal Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-Based Selected Reaction Monitoring (SRM) Approach for Verification of Breast Cancer-Related Protein Markers
    Ning Qing Liu
    Department of Medical Oncology, Laboratory of Breast Cancer Genomics and Proteomics, Erasmus University Medical Center, Erasmus MC Cancer Institute, Wytemaweg 80, Be 401, 2040, 3000, CA, Rotterdam, The Netherlands
    Methods Mol Biol 1156:307-22. 2014
    ..Here we describe a hands-on protocol of using this SILAC-SRM method for verification of breast cancer-related markers, which can also be used for verification of protein markers in other types of solid tumor tissues. ..