A G Uitterlinden

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites
    Andre G Uitterlinden
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Hum Genet 75:1032-45. 2004
  2. pmc Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
    Fernando Rivadeneira
    Department of Internal Medicine, Rotterdam, The Netherlands
    Nat Genet 41:1199-206. 2009
  3. pmc Reproductive aging-associated common genetic variants and the risk of breast cancer
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, 980 West Walnut Street, R3 C241, Indianapolis, IN 46202, USA
    Breast Cancer Res 14:R54. 2012
  4. pmc Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12 and folic acid on fracture incidence
    Janneke P van Wijngaarden
    Department of Human Nutrition, Wageningen University, P, O, Box 8129 6700 EV Wageningen, The Netherlands
    BMC Geriatr 11:80. 2011
  5. pmc Vitamin D binding protein genotype and osteoporosis
    Yue Fang
    Department of Internal Medicine, Erasmus Medical Center, Genetic Laboratory, Rotterdam, The Netherlands
    Calcif Tissue Int 85:85-93. 2009
  6. pmc The -1997 G/T and Sp1 polymorphisms in the collagen type I alpha1 (COLIA1) gene in relation to changes in femoral neck bone mineral density and the risk of fracture in the elderly: the Rotterdam study
    Nahid Yazdanpanah
    Netherlands Institute for Health Science, Rotterdam, The Netherlands
    Calcif Tissue Int 81:18-25. 2007
  7. pmc GnRH and LHR gene variants predict adverse outcome in premenopausal breast cancer patients
    Djura Piersma
    Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Breast Cancer Res 9:R51. 2007
  8. pmc Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis
    Hanneke J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:164. 2010
  9. pmc Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies
    Dennis O Mook-Kanamori
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 10:67. 2009
  10. pmc [Cost] effectiveness of withdrawal of fall-risk increasing drugs versus conservative treatment in older fallers: design of a multicenter randomized controlled trial (IMPROveFALL-study)
    Klaas A Hartholt
    Department of Internal Medicine Section Geriatric Medicine, Erasmus MC, University Medical Rotterdam, P, O, Box 2040, 3000 CA Rotterdam, The Netherlands
    BMC Geriatr 11:48. 2011

Detail Information

Publications82

  1. pmc Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites
    Andre G Uitterlinden
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Hum Genet 75:1032-45. 2004
    ..02). The molecular mechanism whereby these moderate SOST genotype effects are mediated remains to be elucidated, but it is likely to involve differences in regulation of SOST gene expression...
  2. pmc Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
    Fernando Rivadeneira
    Department of Internal Medicine, Rotterdam, The Netherlands
    Nat Genet 41:1199-206. 2009
    ..The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD...
  3. pmc Reproductive aging-associated common genetic variants and the risk of breast cancer
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, 980 West Walnut Street, R3 C241, Indianapolis, IN 46202, USA
    Breast Cancer Res 14:R54. 2012
    ..Recent genome-wide association studies have identified several novel genetic loci associated with these two traits. However, the association between these loci and breast cancer risk is unknown...
  4. pmc Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12 and folic acid on fracture incidence
    Janneke P van Wijngaarden
    Department of Human Nutrition, Wageningen University, P, O, Box 8129 6700 EV Wageningen, The Netherlands
    BMC Geriatr 11:80. 2011
    ....
  5. pmc Vitamin D binding protein genotype and osteoporosis
    Yue Fang
    Department of Internal Medicine, Erasmus Medical Center, Genetic Laboratory, Rotterdam, The Netherlands
    Calcif Tissue Int 85:85-93. 2009
    ..05). All associations were independent of age and gender. Our study demonstrated that the genetic effect of the DBP gene on fracture risk appears only in combination with other genetic and environmental risk factors for bone metabolism...
  6. pmc The -1997 G/T and Sp1 polymorphisms in the collagen type I alpha1 (COLIA1) gene in relation to changes in femoral neck bone mineral density and the risk of fracture in the elderly: the Rotterdam study
    Nahid Yazdanpanah
    Netherlands Institute for Health Science, Rotterdam, The Netherlands
    Calcif Tissue Int 81:18-25. 2007
    ..7, P = 0.001). We confirm that the COLIA1 Sp1 polymorphism influences BMD and the risk of fracture in postmenopausal Caucasian women. In contrast, we found no independent effect of the -1997 G/T promoter polymorphism on BMD or fracture...
  7. pmc GnRH and LHR gene variants predict adverse outcome in premenopausal breast cancer patients
    Djura Piersma
    Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Breast Cancer Res 9:R51. 2007
    ..Breast cancer development and progression are dependent on estrogen activity. In premenopausal women, estrogen production is mainly regulated through the hypothalamic-pituitary-gonadal (HPG) axis...
  8. pmc Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis
    Hanneke J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:164. 2010
    ..The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis...
  9. pmc Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies
    Dennis O Mook-Kanamori
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 10:67. 2009
    ..The objective of this study was to examine whether T2D gene polymorphism TCF7L2 rs7903146 is associated with growth patterns from fetal life until infancy...
  10. pmc [Cost] effectiveness of withdrawal of fall-risk increasing drugs versus conservative treatment in older fallers: design of a multicenter randomized controlled trial (IMPROveFALL-study)
    Klaas A Hartholt
    Department of Internal Medicine Section Geriatric Medicine, Erasmus MC, University Medical Rotterdam, P, O, Box 2040, 3000 CA Rotterdam, The Netherlands
    BMC Geriatr 11:48. 2011
    ....
  11. ncbi request reprint Identifying genetic risk factors for osteoporosis
    A G Uitterlinden
    Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Musculoskelet Neuronal Interact 6:16-26. 2006
    ..To accomplish this, we need large (global) collaborative studies using standardized methodology and definitions, to quantify by meta-analysis the subtle effects of the responsible gene variants...
  12. ncbi request reprint Genetics and biology of vitamin D receptor polymorphisms
    Andre G Uitterlinden
    Genetic Laboratory, Room Ee575, Department of Internal Medicine, Erasmus MC, Dr Molewaterplein 50, PO Box 1738, NL 3000 DR Rotterdam, The Netherlands
    Gene 338:143-56. 2004
    ..Substantial progress has been made that will deepen our understanding of variability in the vitamin D endocrine system and might find applications in risk assessment of disease and in predicting response-to-treatment...
  13. ncbi request reprint Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states
    Andre G Uitterlinden
    Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, P O Box 1738, Genetic Laboratory, Room Ee575, NL 3000 DR Rotterdam, The Netherlands
    J Steroid Biochem Mol Biol 89:187-93. 2004
    ..Eventually, results of this research will deepen our understanding of variability in the Vitamin D endocrine system and might find applications in risk-assessment of disease and in predicting response-to-treatment...
  14. pmc Estrogen receptor alpha polymorphisms and postmenopausal breast cancer risk
    A M González-Zuloeta Ladd
    Department of Epidemiology and Biostatistics, Erasmus MC, P O Box 2040, Rotterdam, 3000 CA, The Netherlands
    Breast Cancer Res Treat 107:415-9. 2008
    ..We evaluated whether these polymorphisms were associated with breast cancer risk by means of an association study in a population of Caucasian postmenopausal women from the Rotterdam study and a meta-analysis of published data...
  15. ncbi request reprint Evidence for auto/paracrine actions of vitamin D in bone: 1alpha-hydroxylase expression and activity in human bone cells
    M van Driel
    Department of Internal Medicine, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    FASEB J 20:2417-9. 2006
    ..This is strongly dependent on osteoclast inducer RANKL. This study showing expression, activity, and functionality of 1alpha-hydroxylase unequivocally demonstrates that vitamin D can act in an auto/paracrine manner in bone...
  16. ncbi request reprint Interaction between vitamin D receptor genotype and estrogen receptor alpha genotype influences vertebral fracture risk
    E M Colin
    Departments of Internal Medicine, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:3777-84. 2003
    ..In conclusion, interaction between ERalpha and VDR gene polymorphisms leads to increased risk of osteoporotic vertebral fractures in women, largely independent of bone mineral density...
  17. doi request reprint Genotypes associated with reduced activity of VKORC1 and CYP2C9 and their modification of acenocoumarol anticoagulation during the initial treatment period
    M Teichert
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Clin Pharmacol Ther 85:379-86. 2009
    ..8 mg/week. Our conclusion was that an initial standard dosing regimen with acenocoumarol increases the risk of severe overanticoagulation in patients with variant alleles of the VKORC1 and CYP2C9 genes...
  18. doi request reprint Genetic polymorphisms of the glucocorticoid receptor may affect the phenotype of women with anovulatory polycystic ovary syndrome
    O Valkenburg
    Division of Reproductive Medicine, Department of Gynaecology and Obstetrics, Erasmus MC University Medical Center, Room HS508, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Hum Reprod 26:2902-11. 2011
    ..This study aims to assess the influence of known functional polymorphisms in genes that are responsible for the production, metabolism and signal transduction of steroid hormones on the susceptibility to and phenotype of PCOS...
  19. ncbi request reprint Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study
    R B A Vaes
    Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    Ann Rheum Dis 68:1754-60. 2009
    ..A polymorphism (rs143383; T to C) near the GDF5 gene has been associated with height and osteoarthritis (OA), but debate exists about whether its primary biological action is directed to cartilage or bone...
  20. ncbi request reprint Variations in estrogen receptor alpha gene and risk of dementia, and brain volumes on MRI
    T den Heijer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    Mol Psychiatry 9:1129-35. 2004
    ..50 (SE 0.10) in PP genotype, 4.45 (SE 0.06) in Pp genotype, and 4.18 ml (SE 0.08) in pp genotype (P trend=0.008). Further studies are required to investigate whether this smaller amygdalar volume has functional significance...
  21. ncbi request reprint The collagen Ia1 SP1 polymorphism is associated with differences in ultrasound transmission velocity in the calcaneus in postmenopausal women
    P Kann
    Department of Internal Medicine, Erasmus University Medical School, Rotterdam, The Netherlands
    Calcif Tissue Int 70:450-6. 2002
    ..The relationship is independent of BMD and increases with age, contributing to an explanation of the increased fracture risk observed for this polymorphism...
  22. doi request reprint The effect of thiazide and loop diuretics on urinary levels of free deoxypyridinoline: an osteoclastic bone-resorption marker
    R Ruiter
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
    J Clin Pharm Ther 38:225-9. 2013
    ..Deoxypyridinoline (DP) acts as a cross-link between adjacent collagen chains to provide structural rigidity. Our aim was to investigate the association between use of thiazides and loop diuretics and urinary levels FDP...
  23. doi request reprint The association between plasma homocysteine levels, methylation capacity and incident osteoporotic fractures
    A W Enneman
    Erasmus MC, Department of Internal Medicine, Postbus 2040, 3000 CA Rotterdam, The Netherlands
    Bone 50:1401-5. 2012
    ....
  24. ncbi request reprint Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts
    J M Kerkhof
    Department of Internal Medicine Erasmus Medical Center, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 16:1141-9. 2008
    ..To examine the association of genetic variation in key players in the Wnt signaling pathway with aspects of osteoarthritis (OA) in two population-based cohort studies: the Rotterdam Study and the Chingford Study...
  25. doi request reprint Wnt signaling acts and is regulated in a human osteoblast differentiation dependent manner
    M Eijken
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    J Cell Biochem 104:568-79. 2008
    ..Moreover, osteoblast differentiation suppressed endogenous Wnt signaling and changed the expression of multiple Wnt signaling related genes...
  26. doi request reprint Association of lumbar disc degeneration with osteoporotic fractures; the Rotterdam study and meta-analysis from systematic review
    M C Castaño-Betancourt
    Department of Internal Medicine, Erasmus Medical Center, 3000 DR Rotterdam, the Netherlands The Netherlands Genomics Initiative sponsored Netherlands Consortium for Healthy Aging NGI NCHA, 2300 RC Leiden, The Netherlands Department of Epidemiology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    Bone 57:284-9. 2013
    ..To investigate the relation between lumbar disc degeneration (LDD) and all type of osteoporotic (OP) fractures including vertebral...
  27. ncbi request reprint TRPV4 deficiency causes sexual dimorphism in bone metabolism and osteoporotic fracture risk
    B C J van der Eerden
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands Electronic address
    Bone 57:443-54. 2013
    ..This identifies TRPV4 as a unique sexually dimorphic therapeutic and/or diagnostic candidate for osteoporosis. ..
  28. doi request reprint Genetic variation in the ABCC2 gene is associated with dose decreases or switches to other cholesterol-lowering drugs during simvastatin and atorvastatin therapy
    M L Becker
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
    Pharmacogenomics J 13:251-6. 2013
    ..09) were associated with these events in simvastatin users. A similar but not significant association was found in atorvastatin users. To conclude, genetic variation in the ABCC2 gene is associated with these events in simvastatin users...
  29. ncbi request reprint Protective effect of NSAIDs on cancer and influence of COX-2 C(-765G) genotype
    C Siemes
    Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Curr Cancer Drug Targets 8:753-64. 2008
    ..The aim of this study was to explore the role of cumulative NSAID use on four common non-skin related cancers and modification by COX-2 G(-765)C genotype...
  30. ncbi request reprint B-vitamin levels and genetics of hyperhomocysteinemia are not associated with arterial stiffness
    S C van Dijk
    Erasmus Medical Center, Department of Internal Medicine, Section of Geriatrics, P O Box 2040, 3000 CA Rotterdam, The Netherlands Electronic address
    Nutr Metab Cardiovasc Dis 24:760-6. 2014
    ..A potential causal effect of homocysteine was explored using a genetic risk score reflecting an individual's risk of having a long-term elevated plasma homocysteine level and also associations with B-vitamin levels were investigated...
  31. ncbi request reprint Bone mineral density and vertebral fracture history are associated with incident and progressive radiographic knee osteoarthritis in elderly men and women: the Rotterdam Study
    A P Bergink
    Department of Internal Medicine, Erasmus Medical Center, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Bone 37:446-56. 2005
    ..To study the association between baseline femoral neck and lumbar spine bone mineral density (BMD), prevalent fractures and incident and progressive radiographic osteoarthritis (ROA) of the knee in men and women...
  32. doi request reprint Vitamin K epoxide reductase complex subunit 1 (VKORC1) polymorphism and aortic calcification: the Rotterdam Study
    M Teichert
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 28:771-6. 2008
    ..We investigated the association between the VKORC1 1173C>T polymorphism and calcification of the aortic far wall in a large population-based cohort...
  33. ncbi request reprint Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study
    S C E Schuit
    Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    Bone 34:195-202. 2004
    ..5; in men, this percentage was even lower (21%). Thus, there is a clear need for the development of more sensitive risk assessment tools, using not only BMD, but also other clinical predictors of fractures...
  34. ncbi request reprint TGF-beta1 polymorphisms and arterial stiffness; the Rotterdam Study
    M P S Sie
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Hum Hypertens 21:431-7. 2007
    ..The haplotype-based analyses yielded similar results. The results of this study show that the TGF-beta1 -800 G/A, -509 C/T, codon 10 Leu/Pro and codon 25 Arg/Pro polymorphisms are not associated with arterial stiffness...
  35. ncbi request reprint Detection of sequence variability of the collagen type IIalpha 1 3' variable number of tandem repeat
    J B van Meurs
    Department of Internal Medicine, Erasmus University Rotterdam, The Netherlands
    Electrophoresis 21:3571-7. 2000
    ..HA is a sensitive genotyping method to document allelic diversity at this locus, which can distinguish more alleles compared to the SS method...
  36. ncbi request reprint Collagen Ialpha1 polymorphism is associated with bone characteristics in Caucasian children and young adults
    I M van der Sluis
    Department of Pediatrics, Sophia Children s Hospital Rotterdam, Rotterdam, The Netherlands
    Calcif Tissue Int 71:393-9. 2002
    ..In conclusion, the COLIA1 polymorphism in children and young adults is associated with several bone characteristics. However, at least a part of the COLIA1 effect on bone mass may be related to differences in frame size...
  37. doi request reprint Single nucleotide polymorphisms in genes that are associated with a modified response to statin therapy: the Rotterdam Study
    C E de Keyser
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Pharmacogenomics J 11:72-80. 2011
    ..In conclusion, we found that the CETP rs1532624 polymorphism is associated with cholesterol response to statin therapy in a cohort of elderly subjects in the general population...
  38. ncbi request reprint Interaction between the vitamin D receptor gene and collagen type Ialpha1 gene in susceptibility for fracture
    A G Uitterlinden
    Department of Internal Medicine, Erasmus University Medical School, Rotterdam, The Netherlands
    J Bone Miner Res 16:379-85. 2001
    ..Our data indicate that interlocus interaction is likely to be an important component of osteoporotic fracture risk...
  39. doi request reprint The maternal homocysteine pathway is influenced by riboflavin intake and MTHFR polymorphisms without affecting the risk of orofacial clefts in the offspring
    M Vujkovic
    Department of Obstetrics and Gynaecology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Eur J Clin Nutr 64:266-73. 2010
    ....
  40. pmc Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium
    H J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 19:254-64. 2011
    ..To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes...
  41. ncbi request reprint Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis
    H J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Osteoarthritis Cartilage 19:265-71. 2011
    ..To clarify the role of common genetic variation in the Interleukin-1β (IL1B) and Interleukin-1R antagonist (IL1RN) genes on risk of knee and hip osteoarthritis (OA) and severity of knee OA by means of large-scale meta-analyses...
  42. ncbi request reprint Evidence that both 1alpha,25-dihydroxyvitamin D3 and 24-hydroxylated D3 enhance human osteoblast differentiation and mineralization
    M van Driel
    Department of Internal Medicine, Erasmus MC, 3015 GE Rotterdam, The Netherlands
    J Cell Biochem 99:922-35. 2006
    ..The intestinal antagonist 1beta,25-(OH)2D3 acts in bone as an agonist and directly stimulates mineralization in a nuclear VDR-dependent way...
  43. doi request reprint The contribution of hip geometry to the prediction of hip osteoarthritis
    M C Castaño-Betancourt
    Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands The Netherlands Genomics Initiative sponsored Netherlands Consortium for Healthy Aging NGI NCHA, Rotterdam Leiden, The Netherlands
    Osteoarthritis Cartilage 21:1530-6. 2013
    ..To determine how well measures of hip geometry can predict radiological incident hip osteoarthritis (HOA) compared to well known clinical risk factors...
  44. doi request reprint Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study
    L Oei
    Department of Internal Medicine, Erasmus MC, P O Box 2040 ee5 79, 3000 CA, Rotterdam, The Netherlands
    Osteoporos Int 25:1247-54. 2014
    ..Serum high-sensitivity CRP was associated with fracture risk and lower femoral neck bending strength. Mendelian randomization analyses did not yield evidence for this relationship being causal...
  45. ncbi request reprint Interleukin 6 G-174 C polymorphism and breast cancer risk
    A M González-Zuloeta Ladd
    Department of Epidemiology and Biostatistics Department, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 21:373-6. 2006
    ..This increased risk was not statistically significant. Our data suggest that the IL-6 G-174 C polymorphism does not seem to play a role in breast cancer risk, although its role as a prognostic factor remains to be studied...
  46. ncbi request reprint Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus
    M L Becker
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
    Pharmacogenomics J 9:242-7. 2009
    ..09-0.47, P=0.005). After Bonferroni correction, the P-value was 0.050. To conclude, genetic variation at rs622342 in the SLC22A1 gene was associated with the glucose-lowering effect of metformin in patients with diabetes mellitus...
  47. ncbi request reprint Low prevalence of NOD2 SNPs in Behçet's disease suggests protective association in Caucasians
    Jasper H Kappen
    Department of Internal Medicine, Section of Clinical Immunology, Erasmus University Hospital, Rotterdam, The Netherlands
    Rheumatology (Oxford) 48:1375-7. 2009
    ..We studied the frequency of these variants in BD patients...
  48. pmc Genomewide association studies of stroke
    M Arfan Ikram
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 360:1718-28. 2009
    ..The genes underlying the risk of stroke in the general population remain undetermined...
  49. ncbi request reprint Recipient gene polymorphisms in the Th-1 cytokines IL-2 and IFN-gamma in relation to acute rejection and graft vascular disease after clinical heart transplantation
    C T J Holweg
    Erasmus MC, Department of Internal Medicine, Room Ee 563a, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Transpl Immunol 11:121-7. 2003
    ..63). In conclusion, we did not detect an association between the IL-2 T-330G promoter polymorphism and CA repeat polymorphism in the first intron of the IFN-gamma gene and AR or GVD after heart transplantation...
  50. pmc Genetic risk profiles for depression and anxiety in adult and elderly cohorts
    A Demirkan
    Genetic Epidemiology Unit of the Departments of Epidemiology and Clinical Genetics, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Mol Psychiatry 16:773-83. 2011
    ..Remarkably, the predictive value of these profiles was as large in the sample of elderly participants as in the middle-aged samples...
  51. doi request reprint Sex-specific genetic effects influence variation in body composition
    M C Zillikens
    Department of Internal Medicine, Erasmus Medical Centre, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Diabetologia 51:2233-41. 2008
    ..Despite well-known sex differences in body composition it is not known whether sex-specific genetic or environmental effects contribute to these differences...
  52. doi request reprint Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome
    O Valkenburg
    Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center, Room HS508, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Hum Reprod 24:2014-22. 2009
    ..The present study aims to examine the influence of genetic variants of the HPG-axis on the severity of clinical features of PCOS and disease susceptibility...
  53. doi request reprint Genetic determinants of treatment benefit of the angiotensin-converting enzyme-inhibitor perindopril in patients with stable coronary artery disease
    Jasper Jan Brugts
    Department of Cardiology, Erasmus MC, Thoraxcenter, s Gravendijkwal 230, Rotterdam, The Netherlands
    Eur Heart J 31:1854-64. 2010
    ..However, these patients cannot be identified by clinical characteristics. We developed a genetic profile to predict the treatment benefit of ACE-inhibitors exist and to optimize therapy with ACE-inhibitors...
  54. ncbi request reprint A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters
    Robin P Peeters
    Department of Internal Medicine, Rm Ee 502, Erasmus University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 289:E75-81. 2005
    ..We hypothesize that this might be explained by the decline in skeletal muscle size during aging, resulting in a relative decrease in the contribution of D2 to serum T(3) production...
  55. doi request reprint A pharmacogenetic analysis of determinants of hypertension and blood pressure response to angiotensin-converting enzyme inhibitor therapy in patients with vascular disease and healthy individuals
    Jasper J Brugts
    Department of Cardiology, Erasmus MC Thoraxcenter, Rotterdam, The Netherlands
    J Hypertens 29:509-19. 2011
    ....
  56. pmc The Generation R Study: design and cohort update 2010
    Vincent W V Jaddoe
    The Generation R Study Group AE006, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 25:823-41. 2010
    ..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
  57. ncbi request reprint A polymorphism in type I deiodinase is associated with circulating free insulin-like growth factor I levels and body composition in humans
    Robin P Peeters
    Department of Internal Medicine, Room Ee 502, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:256-63. 2005
    ..The association of D1 haplotype allele 2 with serum T(3) levels in the elderly population suggests a relative increase in its contribution to circulating T(3) in old age...
  58. pmc The Generation R Study Biobank: a resource for epidemiological studies in children and their parents
    Vincent W V Jaddoe
    The Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 22:917-23. 2007
    ....
  59. pmc Predicting human height by Victorian and genomic methods
    Yurii S Aulchenko
    Department of Epidemiology and Biostatistics and Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    Eur J Hum Genet 17:1070-5. 2009
    ....
  60. doi request reprint The Generation R Study: design and cohort update until the age of 4 years
    Vincent W V Jaddoe
    The Generation R Study Group AE006, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 23:801-11. 2008
    ..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
  61. pmc Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Am J Hum Genet 82:411-23. 2008
    ..Testing markers in the HERC2-OCA2 region may be useful in forensic applications to predict eye color phenotypes of unknown persons of European genetic origin...
  62. doi request reprint Genetic architecture of open angle glaucoma and related determinants
    Wishal D Ramdas
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Med Genet 48:190-6. 2011
    ..We evaluated whether the same genes that determine VCDR and IOP also predict OAG...
  63. ncbi request reprint The association between plasma homocysteine levels and bone quality and bone mineral density parameters in older persons
    A W Enneman
    Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Bone 63:141-6. 2014
    ..Therefore, we wanted to investigate whether plasma homocysteine levels are associated with bone quality parameters, rather than with bone mineral density...
  64. ncbi request reprint A new marker for osteoarthritis: cross-sectional and longitudinal approach
    M Reijman
    Erasmus Medical Center, Rotterdam, The Netherlands
    Arthritis Rheum 50:2471-8. 2004
    ..To investigate the association between urinary concentrations of C-telopeptide fragments of type II collagen (CTX-II) and the prevalence and progression of radiographic osteoarthritis (OA) of the knee and hip...
  65. ncbi request reprint 11beta-Hydroxysteroid dehydrogenase expression and glucocorticoid synthesis are directed by a molecular switch during osteoblast differentiation
    M Eijken
    Department Internal Medicine, Erasmus Medical Center, Room Ee526, P O Box 1738, 3000 DR, Rotterdam, The Netherlands
    Mol Endocrinol 19:621-31. 2005
    ..This efficient mechanism by which osteoblasts generate cortisol in an autocrine fashion to ensure proper differentiation will help to understand the complex effects of cortisol on bone metabolism...
  66. ncbi request reprint Genetic polymorphisms and clinical practice: the example of osteoporosis
    H A P Pols
    Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    Acta Clin Belg 57:266-70. 2002
    ..We will here discuss some developments in the field of the genetics of osteoporosis...
  67. ncbi request reprint Polymorphisms in thyroid hormone pathway genes are associated with plasma TSH and iodothyronine levels in healthy subjects
    Robin P Peeters
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3000 DR The Netherlands
    J Clin Endocrinol Metab 88:2880-8. 2003
    ..We have analyzed eight SNPs in five thyroid hormone pathway genes and found significant associations of three SNPs in two genes (D1, TSHR) with plasma TSH or iodothyronine levels in a normal population...
  68. pmc A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation
    Karol Estrada
    Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hum Mol Genet 18:3516-24. 2009
    ..1 x 10(-7)). Taken together, these results suggest that variation in the C-type natriuretic peptide signaling pathway, involving the NPPC and NPR3 genes, plays an important role in determining human body height...
  69. pmc Breast-feeding modifies the association of PPARgamma2 polymorphism Pro12Ala with growth in early life: the Generation R Study
    Dennis O Mook-Kanamori
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes 58:992-8. 2009
    ..We examined whether the PPARgamma2 Ala12 allele influences growth in early life and whether this association is modified by breast-feeding...
  70. ncbi request reprint Genetic variation, C-reactive protein levels, and incidence of diabetes
    Abbas Dehghan
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Diabetes 56:872-8. 2007
    ..45, 95% CI 1.08-1.96). These findings support the hypothesis that serum CRP enhances the development of diabetes...
  71. pmc Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM
    N Amin
    Unit of Genetic Epidemiology, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Mol Psychiatry 17:1116-29. 2012
    ..Pathway analysis of differentially expressed genes revealed significantly enriched ubiquitin proteasome (P-value=2.2 × 10(-05)) and Parkinson's disease pathways (P-value=3.6 × 10(-05))...
  72. doi request reprint Osteoarthritis year 2012 in review: genetics and genomics
    J B J van Meurs
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands The Netherlands Genomics Initiative sponsored Netherlands Consortium for Healthy Aging NGI NCHA, Leiden Rotterdam, The Netherlands
    Osteoarthritis Cartilage 20:1470-6. 2012
    ..In addition, most recent developments in genetics and genomics research and their relevance to OA are discussed in this review...
  73. doi request reprint The rationale and design of the PERindopril GENEtic association study (PERGENE): a pharmacogenetic analysis of angiotensin-converting enzyme inhibitor therapy in patients with stable coronary artery disease
    J J Brugts
    Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Cardiovasc Drugs Ther 23:171-81. 2009
    ..Until now, pharmacogenetic research of the efficacy of ACE-inhibitor therapy in CAD patients is still in a preliminary stage...
  74. ncbi request reprint The effect of catechol-O-methyltransferase Met/Val functional polymorphism on smoking cessation: retrospective and prospective analyses in a cohort study
    Maryam Omidvar
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
    Pharmacogenet Genomics 19:45-51. 2009
    ..We investigated the relationship of this COMT single nucleotide polymorphism with smoking cessation in elderly persons in retrospective and prospective analyses...
  75. ncbi request reprint Polymorphisms in the interleukin 6 and transforming growth factor beta1 gene and risk of dementia. The Rotterdam Study
    Marieke van Oijen
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Neurosci Lett 402:113-7. 2006
    ..Associations did not differ across APOE genotypes. Our findings do not suggest involvement of genetic variance in IL-6 and TGFbeta1 in the development of dementia...
  76. pmc Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Circ Cardiovasc Genet 2:125-33. 2009
    ..Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels...
  77. pmc Association of heat shock proteins with all-cause mortality
    L Broer
    Department of Epidemiology, Erasmus Medical Center, Dr Molewaterplein 50, PO Box 2040, 3000, CA, Rotterdam, The Netherlands
    Age (Dordr) 35:1367-76. 2013
    ..In the replication phase, only HSF2 (rs1416733) remained significantly associated with all-cause mortality. Rs1416733 is a known cis-eQTL for HSF2. Our findings suggest a role of HSF2 in all-cause mortality...
  78. doi request reprint A genome-wide association study of acenocoumarol maintenance dosage
    Martina Teichert
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Hum Mol Genet 18:3758-68. 2009
    ..Besides age, gender, body mass index and target INR, one polymorphism within each of the VKORC1, CYP2C9, CYP4F2 and CYP2C18 genes could explain 48.8% of acenocoumarol dosage variation...
  79. doi request reprint A study of the SORL1 gene in Alzheimer's disease and cognitive function
    Fan Liu
    Genetic Epidemiology Unit, Erasmus Medical Center, Rotterdam, The Netherlands
    J Alzheimers Dis 18:51-64. 2009
    ..In conclusion, our data do not support the hypothesis that genetic variants in SORL1 are related to the risk of AD...
  80. ncbi request reprint Complement component C3 and risk of age-related macular degeneration
    Dominiek D G Despriet
    Department of Epidemiology and Biostatistics, Rotterdam, Erasmus Medical Centre, The Netherlands
    Ophthalmology 116:474-480.e2. 2009
    ..To explore the association between polymorphisms in the complement component 3 (C3) gene and age-related macular degeneration (AMD), and to investigate the modifying effect of complement factor H (CFH) Y402H, LOC387715 A69S and smoking...
  81. ncbi request reprint A common polymorphism renders the luteinizing hormone receptor protein more active by improving signal peptide function and predicts adverse outcome in breast cancer patients
    Djura Piersma
    Department of Internal Medicine, Erasmus MC, Room Ee532, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 91:1470-6. 2006
    ..The pituitary gonadotropin LH is an important regulator of estrogen production in premenopausal women, whereas even in women after menopause, 10-25% of ovarian steroid hormone production is LH dependent...
  82. doi request reprint Glucocorticoid receptor gene and risk of cardiovascular disease
    Erica L T Van Den Akker
    Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Arch Intern Med 168:33-9. 2008
    ..Our aim was to determine the contribution of genetic glucocorticoid receptor variants, with different cortisol sensitivities, to the risk of cardiovascular disease...