Gianluca Trifiro

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi request reprint Risk of cardiac valve regurgitation with dopamine agonist use in Parkinson's disease and hyperprolactinaemia: a multi-country, nested case-control study
    Gianluca Trifiro
    Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Drug Saf 35:159-71. 2012
  2. ncbi request reprint EU-ADR healthcare database network vs. spontaneous reporting system database: preliminary comparison of signal detection
    Gianluca Trifiro
    Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Stud Health Technol Inform 166:25-30. 2011
  3. ncbi request reprint Age-related changes in pharmacodynamics: focus on drugs acting on central nervous and cardiovascular systems
    Gianluca Trifiro
    Department of Medical Informatics, Erasmus University Medical Center Dr Molewaterplein 50, 3000 DR, Rotterdam, The Netherlands
    Curr Drug Metab 12:611-20. 2011
  4. pmc Antipsychotic drug use and community-acquired pneumonia
    Gianluca Trifiro
    Department of Medical Informatics, Erasmus University Medical Center, Dr Molewaterplein 50, 3000 DR, Rotterdam, The Netherlands
    Curr Infect Dis Rep 13:262-8. 2011
  5. doi request reprint Risk of ischemic stroke associated with antidepressant drug use in elderly persons
    Gianluca Trifiro
    Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Clin Psychopharmacol 30:252-8. 2010
  6. doi request reprint Association of community-acquired pneumonia with antipsychotic drug use in elderly patients: a nested case-control study
    Gianluca Trifiro
    Erasmus University Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Ann Intern Med 152:418-25, W139-40. 2010
  7. doi request reprint Prescribing pattern of antipsychotic drugs in the Italian general population 2000-2005: a focus on elderly with dementia
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
    Int Clin Psychopharmacol 25:22-8. 2010
  8. doi request reprint Data mining on electronic health record databases for signal detection in pharmacovigilance: which events to monitor?
    Gianluca Trifiro
    Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Pharmacoepidemiol Drug Saf 18:1176-84. 2009
  9. doi request reprint Adherence to gastroprotection during cyclooxygenase 2 inhibitor treatment and the risk of upper gastrointestinal tract events: a population-based study
    Vera E Valkhoff
    Erasmus University Medical Centre, Rotterdam, The Netherlands
    Arthritis Rheum 64:2792-802. 2012
  10. doi request reprint Prescribing pattern of anti-Parkinson drugs in Southern Italy: cross-sectional analysis in the years 2003-2005
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Parkinsonism Relat Disord 14:420-5. 2008

Collaborators

Detail Information

Publications43

  1. doi request reprint Risk of cardiac valve regurgitation with dopamine agonist use in Parkinson's disease and hyperprolactinaemia: a multi-country, nested case-control study
    Gianluca Trifiro
    Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Drug Saf 35:159-71. 2012
    ..Cases were patients who developed newly diagnosed CVR. Controls were CVR-free patients from the same cohorts and were matched to cases by age, sex, database and calendar year...
  2. ncbi request reprint EU-ADR healthcare database network vs. spontaneous reporting system database: preliminary comparison of signal detection
    Gianluca Trifiro
    Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Stud Health Technol Inform 166:25-30. 2011
    ..The methodology for signal detection in EU-ADR is still under development and testing phase...
  3. ncbi request reprint Age-related changes in pharmacodynamics: focus on drugs acting on central nervous and cardiovascular systems
    Gianluca Trifiro
    Department of Medical Informatics, Erasmus University Medical Center Dr Molewaterplein 50, 3000 DR, Rotterdam, The Netherlands
    Curr Drug Metab 12:611-20. 2011
    ..Clinicians should be aware of the age-related physiologic changes affecting several organ systems and their implications on the effect of drugs that are commonly prescribed to elderly patients...
  4. pmc Antipsychotic drug use and community-acquired pneumonia
    Gianluca Trifiro
    Department of Medical Informatics, Erasmus University Medical Center, Dr Molewaterplein 50, 3000 DR, Rotterdam, The Netherlands
    Curr Infect Dis Rep 13:262-8. 2011
    ..Some general recommendations to clinicians are proposed to prevent the risk of pneumonia in patients requiring antipsychotic treatment...
  5. doi request reprint Risk of ischemic stroke associated with antidepressant drug use in elderly persons
    Gianluca Trifiro
    Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Clin Psychopharmacol 30:252-8. 2010
    ..To summarize, compared with nonuse, only SSRI use seems to be associated with an increased risk of ischemic stroke in elderly patients, particularly as a short-term effect...
  6. doi request reprint Association of community-acquired pneumonia with antipsychotic drug use in elderly patients: a nested case-control study
    Gianluca Trifiro
    Erasmus University Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Ann Intern Med 152:418-25, W139-40. 2010
    ..However, epidemiologic evidence of the association between antipsychotic drug use and pneumonia is limited...
  7. doi request reprint Prescribing pattern of antipsychotic drugs in the Italian general population 2000-2005: a focus on elderly with dementia
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
    Int Clin Psychopharmacol 25:22-8. 2010
    ..Similar trends were not observed in general population and elderly as a whole...
  8. doi request reprint Data mining on electronic health record databases for signal detection in pharmacovigilance: which events to monitor?
    Gianluca Trifiro
    Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Pharmacoepidemiol Drug Saf 18:1176-84. 2009
    ..Since mining on all possible events was considered to unduly increase the number of spurious signals, we wanted to create a ranked list of high-priority events...
  9. doi request reprint Adherence to gastroprotection during cyclooxygenase 2 inhibitor treatment and the risk of upper gastrointestinal tract events: a population-based study
    Vera E Valkhoff
    Erasmus University Medical Centre, Rotterdam, The Netherlands
    Arthritis Rheum 64:2792-802. 2012
    ..We undertook this study to determine the association between GPA adherence and UGI tract events among patients receiving coxibs...
  10. doi request reprint Prescribing pattern of anti-Parkinson drugs in Southern Italy: cross-sectional analysis in the years 2003-2005
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Parkinsonism Relat Disord 14:420-5. 2008
    ..A high proportion of APD users (15-20%) received only one prescription during the study period...
  11. doi request reprint The risk of new onset heart failure associated with dopamine agonist use in Parkinson's disease
    M Mostafa Mokhles
    Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands
    Pharmacol Res 65:358-64. 2012
    ..Among non-ergot dopamine agonists, we observed a statistically significant association between pramipexole use and heart failure, especially during the first months of therapy and in very old patients...
  12. doi request reprint Combining electronic healthcare databases in Europe to allow for large-scale drug safety monitoring: the EU-ADR Project
    Preciosa M Coloma
    Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Pharmacoepidemiol Drug Saf 20:1-11. 2011
    ..In this proof-of-concept paper we describe the framework, process, and preliminary results of combining data from European electronic healthcare record (EHR) databases for large-scale monitoring of drug safety...
  13. doi request reprint Electronic healthcare databases for active drug safety surveillance: is there enough leverage?
    Preciosa M Coloma
    Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands
    Pharmacoepidemiol Drug Saf 21:611-21. 2012
    ..To provide estimates of the number and types of drugs that can be monitored for safety surveillance using electronic healthcare databases...
  14. ncbi request reprint Use and tolerability of newer antipsychotics and antidepressants: a chart review in a paediatric setting
    Marianna Alacqua
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Pharm World Sci 30:44-50. 2008
    ..To analyse the prescribing pattern and the safety profile of different atypical antipsychotics and selective serotonin reuptake inhibitors (SSRIs) during the years 2002-2003 in paediatric setting...
  15. ncbi request reprint Antidepressant drugs: prevalence, incidence and indication of use in general practice of Southern Italy during the years 2003-2004
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Messina, Italy
    Pharmacoepidemiol Drug Saf 16:552-9. 2007
    ..To estimate 1-year prevalence, 1-year incidence and indication of use of antidepressant (AD) drug treatment in general practice of Southern Italy during the years 2003-2004...
  16. ncbi request reprint Statin-macrolide interaction risk: a population-based study throughout a general practice database
    Nadia Piacentini
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Eur J Clin Pharmacol 61:615-20. 2005
    ..e., macrolides). The aim of this study was to assess whether concurrent statin/macrolide prescriptions at high interaction risk are commonly written in a general practice setting...
  17. doi request reprint Epidemiology of gout and hyperuricaemia in Italy during the years 2005-2009: a nationwide population-based study
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Ann Rheum Dis 72:694-700. 2013
    ..To assess the epidemiology of gout and hyperuricaemia in the Italian general population during the years 2005-2009...
  18. doi request reprint A reference standard for evaluation of methods for drug safety signal detection using electronic healthcare record databases
    Preciosa M Coloma
    Department of Medical Informatics, Erasmus Medical Center, Postbus 2040, 3000, CA, Rotterdam, The Netherlands
    Drug Saf 36:13-23. 2013
    ..e. list of all known adverse reactions and which drugs can cause them). As there is no true gold standard, prospective evaluation of signal detection methods remains a challenge...
  19. doi request reprint Prescribing pattern of drugs in the treatment of osteoarthritis in Italian general practice: the effect of rofecoxib withdrawal
    Marianna Alacqua
    University of Messina, Messina, Italy
    Arthritis Rheum 59:568-74. 2008
    ..The aim of the present study was to compare the trend of nonsteroidal antiinflammatory drug (NSAID) use and other analgesics in osteoarthritis (OA) treatment before and after rofecoxib withdrawal in Italian general practice...
  20. doi request reprint Signal detection of potentially drug-induced acute liver injury in children using a multi-country healthcare database network
    Carmen Ferrajolo
    Department of Medical Informatics, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Drug Saf 37:99-108. 2014
    ..Data mining in spontaneous reporting databases has shown that drug-induced liver injury is infrequently reported in children...
  21. doi request reprint A nationwide prospective study on prescribing pattern of antidepressant drugs in Italian primary care
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Eur J Clin Pharmacol 69:227-36. 2013
    ..Our purpose was to explore antidepressant drug (AD) prescribing patterns in Italian primary care...
  22. ncbi request reprint All-cause mortality associated with atypical and typical antipsychotics in demented outpatients
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Italy
    Pharmacoepidemiol Drug Saf 16:538-44. 2007
    ..To estimate the association between use of typical and atypical antipsychotics and all-cause mortality in a population of demented outpatients...
  23. pmc Prescribing pattern of anti-epileptic drugs in an Italian setting of elderly outpatients: a population-based study during 2004-07
    Alessandro Oteri
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria, 98125 Messina, Italy
    Br J Clin Pharmacol 70:514-22. 2010
    ....
  24. ncbi request reprint Antipsychotic prescribing pattern among Italian general practitioners: a population-based study during the years 1999-2002
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98100 Messina, Italy
    Eur J Clin Pharmacol 61:47-53. 2005
    ..To assess the antipsychotic use and the prevalence/incidence of antipsychotic drug users in Italy during the years 1999-2002. To estimate the persistence with antipsychotic medications, and to measure their off-label use...
  25. doi request reprint Use of antipsychotics in elderly patients with dementia: do atypical and conventional agents have a similar safety profile?
    Gianluca Trifiro
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
    Pharmacol Res 59:1-12. 2009
    ..More effective interventions are necessary to improve postmarket drug safety in vulnerable populations...
  26. pmc Prescribing pattern of glucose lowering drugs in the United Kingdom in the last decade: a focus on the effects of safety warnings about rosiglitazone
    Ingrid Leal
    Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Br J Clin Pharmacol 75:861-8. 2013
    ..We analyzed the prescription pattern of GLDs from 2000 to November 2009 in the United Kingdom (UK) using the THIN database with special focus on the effects of the safety warnings about rosiglitazone issued in May 2007 and January 2008...
  27. doi request reprint Postmarketing safety surveillance : where does signal detection using electronic healthcare records fit into the big picture?
    Preciosa M Coloma
    Ee 2116, Department of Medical Informatics, Erasmus Medical Centre, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Drug Saf 36:183-97. 2013
    ..Proper evaluation and communication of potential signals identified remains an imperative and should accompany any signal detection activity...
  28. ncbi request reprint [ADR-related hospitalization in persons aged 55 years and older in the Netherlands]
    R Ruiter
    Erasmus Medisch Centrum, Rotterdam
    Ned Tijdschr Geneeskd 157:A5182. 2013
    ....
  29. doi request reprint The EU-ADR corpus: annotated drugs, diseases, targets, and their relationships
    Erik M van Mulligen
    Dept of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Biomed Inform 45:879-84. 2012
    ..These annotated relationships will be used to train and evaluate text-mining software to capture these relationships in texts...
  30. ncbi request reprint Using electronic health care records for drug safety signal detection: a comparative evaluation of statistical methods
    Martijn J Schuemie
    Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Med Care 50:890-7. 2012
    ..Drug safety monitoring relies primarily on spontaneous reporting, but electronic health care record databases offer a possible alternative for the detection of adverse drug reactions (ADRs)...
  31. ncbi request reprint Adverse drug events in emergency department population: a prospective Italian study
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Messina, Messina, Italy
    Pharmacoepidemiol Drug Saf 14:333-40. 2005
    ..We therefore carried out a study to determine ADE incidence and ADE-related hospital admissions among emergency department (ED) visits, and to identify the risk factors for serious ADE leading to ED visit...
  32. doi request reprint Suboptimal gastroprotective coverage of NSAID use and the risk of upper gastrointestinal bleeding and ulcers: an observational study using three European databases
    Eva M van Soest
    Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Gut 60:1650-9. 2011
    ..It is unknown to what extent the protective effect is influenced by therapy adherence...
  33. doi request reprint Additional risk minimisation measures in the EU - are they eligible for assessment?
    Inge M Zomerdijk
    Departments of Medical Informatics, Erasmus University Medical Centre, Rotterdam, The Netherlands Dutch Medicines Evaluations Board, Utrecht, The Netherlands
    Pharmacoepidemiol Drug Saf 22:1046-53. 2013
    ..The aim of this study was to classify the aRMMs in the EU with a special emphasis on the possibilities to analyse the effectiveness of these aRMMs in existing electronic healthcare databases (EHDs)...
  34. doi request reprint Clinically significant drug interactions with newer antidepressants
    Edoardo Spina
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
    CNS Drugs 26:39-67. 2012
    ..Knowledge of the interaction potential of individual antidepressants is essential for safe prescribing and may help clinicians to predict and eventually avoid certain drug combinations...
  35. doi request reprint Adverse drug reaction-related hospitalizations in persons aged 55 years and over: a population-based study in the Netherlands
    Rikje Ruiter
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
    Drugs Aging 29:225-32. 2012
    ..However, a recent study conducted in the Netherlands found that ADR-related hospitalizations had stabilized during the years 1997-2007. Nonetheless, this study did not take into account the number of medicines used...
  36. doi request reprint Acute cerebellar ataxia following meningococcal group C conjugate vaccination
    Paola Maria Cutroneo
    1Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
    J Child Neurol 29:128-30. 2014
    ..Progressive clinical improvement was obtained after corticosteroid treatment. This case increases the small number of postvaccinal ataxias and contributes to further clarifying the complex pathogenesis of this disorder. ..
  37. doi request reprint Effects of L'Aquila earthquake on the prescribing pattern of antidepressant and antipsychotic drugs
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
    Int J Clin Pharm 35:1053-62. 2013
    ..Moreover, it could be useful to both identify risk categories that require special assistance and assess possible drug abuse or misuse...
  38. pmc Drug-induced acute myocardial infarction: identifying 'prime suspects' from electronic healthcare records-based surveillance system
    Preciosa M Coloma
    Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 8:e72148. 2013
    ..Routinely collected electronic healthcare data give a good snapshot of how drugs are being used in 'real-world' settings...
  39. doi request reprint How much are biosimilars used in southern Italy?: a retrospective analysis of epoetin utilization in the local health unit of Messina in the years 2010-2011
    Chiara Loiacono
    Department of Clinical and Experimental Medicine and Pharmacology, Unit of Pharmacology, University of Messina, Messina, Italy
    BioDrugs 26:113-20. 2012
    ..Epoetins are one of the three biologics for which biosimilars are available in Italy. So far, there is a lack of Italian national/regional longitudinal data about epoetin use...
  40. doi request reprint Risk minimization activities of centrally authorized products in the EU: a descriptive study
    Inge M Zomerdijk
    Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Drug Saf 35:299-314. 2012
    ..This study describes the additional RMAs of centrally authorized medicinal products authorized between 1 January 1995 and 1 January 2010...
  41. pmc Interaction risk with proton pump inhibitors in general practice: significant disagreement between different drug-related information sources
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Messina, Italy
    Br J Clin Pharmacol 62:582-90. 2006
    ....
  42. ncbi request reprint The EU-ADR project: preliminary results and perspective
    Gianluca Trifiro
    Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Stud Health Technol Inform 148:43-9. 2009
    ..The EU-ADR project aims to exploit different European electronic healthcare records (EHR) databases for drug safety signal detection. In this paper we describe the project framework and the preliminary results...
  43. doi request reprint The burden of nephrotoxic drug prescriptions in patients with chronic kidney disease: a retrospective population-based study in southern Italy
    Ylenia Ingrasciotta
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
    PLoS ONE 9:e89072. 2014
    ..The use of nephrotoxic drugs can further worsening renal function in chronic kidney disease (CKD) patients. It is therefore imperative to explore prescribing practices that can negatively affect CKD patients...