Gianluca Trifiro

..Cases were patients who developed newly diagnosed CVR. Controls were CVR-free patients from the same cohorts and were matched to cases by age, sex, database and calendar year...

..The methodology for signal detection in EU-ADR is still under development and testing phase...

..Clinicians should be aware of the age-related physiologic changes affecting several organ systems and their implications on the effect of drugs that are commonly prescribed to elderly patients...

..Some general recommendations to clinicians are proposed to prevent the risk of pneumonia in patients requiring antipsychotic treatment...

..To summarize, compared with nonuse, only SSRI use seems to be associated with an increased risk of ischemic stroke in elderly patients, particularly as a short-term effect...

..However, epidemiologic evidence of the association between antipsychotic drug use and pneumonia is limited...

..Similar trends were not observed in general population and elderly as a whole...

..Since mining on all possible events was considered to unduly increase the number of spurious signals, we wanted to create a ranked list of high-priority events...

..We undertook this study to determine the association between GPA adherence and UGI tract events among patients receiving coxibs...

..A high proportion of APD users (15-20%) received only one prescription during the study period...

..Among non-ergot dopamine agonists, we observed a statistically significant association between pramipexole use and heart failure, especially during the first months of therapy and in very old patients...

..In this proof-of-concept paper we describe the framework, process, and preliminary results of combining data from European electronic healthcare record (EHR) databases for large-scale monitoring of drug safety...

..To provide estimates of the number and types of drugs that can be monitored for safety surveillance using electronic healthcare databases...

..To analyse the prescribing pattern and the safety profile of different atypical antipsychotics and selective serotonin reuptake inhibitors (SSRIs) during the years 2002-2003 in paediatric setting...

..To estimate 1-year prevalence, 1-year incidence and indication of use of antidepressant (AD) drug treatment in general practice of Southern Italy during the years 2003-2004...

..The aim of the present study was to compare the trend of nonsteroidal antiinflammatory drug (NSAID) use and other analgesics in osteoarthritis (OA) treatment before and after rofecoxib withdrawal in Italian general practice...

..To estimate the association between use of typical and atypical antipsychotics and all-cause mortality in a population of demented outpatients...

..e. list of all known adverse reactions and which drugs can cause them). As there is no true gold standard, prospective evaluation of signal detection methods remains a challenge...

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..Our purpose was to explore antidepressant drug (AD) prescribing patterns in Italian primary care...

..More effective interventions are necessary to improve postmarket drug safety in vulnerable populations...

..To assess the antipsychotic use and the prevalence/incidence of antipsychotic drug users in Italy during the years 1999-2002. To estimate the persistence with antipsychotic medications, and to measure their off-label use...

..These annotated relationships will be used to train and evaluate text-mining software to capture these relationships in texts...

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..Drug safety monitoring relies primarily on spontaneous reporting, but electronic health care record databases offer a possible alternative for the detection of adverse drug reactions (ADRs)...

..We therefore carried out a study to determine ADE incidence and ADE-related hospital admissions among emergency department (ED) visits, and to identify the risk factors for serious ADE leading to ED visit...

..It is unknown to what extent the protective effect is influenced by therapy adherence...

..To assess the epidemiology of gout and hyperuricaemia in the Italian general population during the years 2005-2009...

..Knowledge of the interaction potential of individual antidepressants is essential for safe prescribing and may help clinicians to predict and eventually avoid certain drug combinations...

..However, a recent study conducted in the Netherlands found that ADR-related hospitalizations had stabilized during the years 1997-2007. Nonetheless, this study did not take into account the number of medicines used...

..Proper evaluation and communication of potential signals identified remains an imperative and should accompany any signal detection activity...

..Epoetins are one of the three biologics for which biosimilars are available in Italy. So far, there is a lack of Italian national/regional longitudinal data about epoetin use...

..This study describes the additional RMAs of centrally authorized medicinal products authorized between 1 January 1995 and 1 January 2010...

..The EU-ADR project aims to exploit different European electronic healthcare records (EHR) databases for drug safety signal detection. In this paper we describe the project framework and the preliminary results...

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..We analyzed the prescription pattern of GLDs from 2000 to November 2009 in the United Kingdom (UK) using the THIN database with special focus on the effects of the safety warnings about rosiglitazone issued in May 2007 and January 2008...