Research Topics
Genomes and Genes
| Ivo P TouwSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
| Collaborators
|
Detail Information
Publications
Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disordersIvo P Touw
Department of Hematology, Erasmus University Medical Center, P O Box 1738, 3000 DR, Rotterdam, The Netherlands
Front Biosci 12:800-15. 2007..Here we review how these mechanisms are thought to act in concert to meet with these demands and how perturbations in the function of the G-CSF receptor are implicated in various types of myeloid disease...- Retroviral insertion mutagenesis in mice as a comparative oncogenomics tool to identify disease genes in human leukemiaIvo P Touw
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Mol Ther 15:13-9. 2007..We will specifically focus on the value of employing retroviral insertion mutagenesis in mice and gene expression profiling in man in the context of acute myeloid leukemia... 
Granulocyte colony-stimulating factor receptor signaling: implications for G-CSF responses and leukemic progression in severe congenital neutropeniaIvo P Touw
Department of Hematology, Erasmus University Medical Center, Dr Molewaterplein 50 3015 GE, Rotterdam, The Netherlands
Hematol Oncol Clin North Am 27:61-73, viii. 2013....- Janus kinases promote cell-surface expression and provoke autonomous signalling from routing-defective G-CSF receptorsAnnemarie Meenhuis
Department of Hematology, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Biochem J 417:737-46. 2009.... 
Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptorMahban I Irandoust
Department of Hematology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
EMBO J 26:1782-93. 2007..This is the first demonstration of SOCS-mediated ubiquitination and routing of a cytokine receptor and its impact on maintaining an appropriate signaling output...- G-CSF receptor truncations found in SCN/AML relieve SOCS3-controlled inhibition of STAT5 but leave suppression of STAT3 intactGert Jan M van de Geijn
Institute of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
Blood 104:667-74. 2004.... - Distinct activities of suppressor of cytokine signaling (SOCS) proteins and involvement of the SOCS box in controlling G-CSF signalingGert-Jan M van de Geijn
Institute of Hematology, Erasmus University Medical Center, Room Ee 1330c, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
J Leukoc Biol 76:237-44. 2004.... - Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum-early endosome interfaceKarishma Palande
Department of Hematology, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands
J Cell Sci 124:3695-705. 2011..Conversely, Ptp1b might keep Prdx4 active by reducing its phosphorylation. These findings unveil a new signal transduction regulatory circuitry involving redox-controlled processes in the ER and activated cytokine receptors in endosomes... - Dicer1 deletion in myeloid-committed progenitors causes neutrophil dysplasia and blocks macrophage/dendritic cell development in miceMir Farshid Alemdehy
Department of Hematology, Erasmus University Medical Center, Dr Molewaterplein 50, Rotterdam, The Netherlands
Blood 119:4723-30. 2012..These results provide evidence for a miRNA-controlled switch for a cellular program of self-renewal and expansion toward myeloid differentiation in GMPs... - Lineage-instructive function of C/EBPα in multipotent hematopoietic cells and early thymic progenitorsAlbert Wölfler
Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
Blood 116:4116-25. 2010..These findings support an instructive but argue against a lineage-restrictive role of C/EBPα in multipotent hematopoietic and thymic progenitors... - Site-specific ubiquitination determines lysosomal sorting and signal attenuation of the granulocyte colony-stimulating factor receptorAlbert Wölfler
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Traffic 10:1168-79. 2009.... - Large-scale identification of disease genes involved in acute myeloid leukemiaStefan J Erkeland
Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
J Virol 78:1971-80. 2004.... - The gene encoding thioredoxin-interacting protein (TXNIP) is a frequent virus integration site in virus-induced mouse leukemia and is overexpressed in a subset of AML patientsStefan J Erkeland
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Leuk Res 33:1367-71. 2009..Nucleotide sequencing revealed no abnormalities in the TXNIP coding region in AML. These findings suggest that deregulated TXNIP expression contributes to MLV-induced murine leukemia as well as human AML... - Retroviral integration mutagenesis in mice and comparative analysis in human AML identify reduced PTP4A3 expression as a prognostic indicatorRenee Beekman
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
PLoS ONE 6:e26537. 2011..In conclusion, our novel strategy has identified PTP4A3 to potentially have a role in AML, on one hand as a candidate HIG contributing to leukemogenesis in mice and on the other hand as a prognostic indicator in human AML... - G-CSF and its receptor in myeloid malignancyRenee Beekman
Department of Hematology, Erasmus MC, Rotterdam, The Netherlands
Blood 115:5131-6. 2010.... - Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemiaRenee Beekman
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Blood 119:5071-7. 2012..The sequential gain of 2 CSF3R mutations implicates abnormal G-CSF signaling as a driver of leukemic transformation in this case of SCN... - MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1-regulated pathways in miceAnnemarie Meenhuis
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Blood 118:916-25. 2011..We demonstrate that AAAGUGC seed-containing miRNAs promote cell expansion, replating capacity and signaling in hematopoietic cells by interference with SQSTM1-regulated pathways... - Significance of murine retroviral mutagenesis for identification of disease genes in human acute myeloid leukemiaStefan J Erkeland
Department of Hematology, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
Cancer Res 66:622-6. 2006.... - Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblastsRastislav Horos
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Blood 119:262-72. 2012..Our data suggest that impaired internal ribosomal entry site-mediated translation of mRNAs expressed at increased levels in erythroblasts contributes to the erythroid phenotype of DBA... - Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- miceJoanna M Prasher
Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
EMBO J 24:861-71. 2005..These data support the hypothesis that spontaneous interstrand crosslink damage contributes to the functional decline of the hematopoietic system associated with aging... - The antioxidant protein peroxiredoxin 4 is epigenetically down regulated in acute promyelocytic leukemiaKarishma K Palande
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
PLoS ONE 6:e16340. 2011..These findings suggest that the control of G-CSF responses by the antioxidant protein PRDX4 may be perturbed in APL... - The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptorAnnemarie Meenhuis
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Biochem J 434:343-51. 2011..These results support a model in which CSF3R ubiquitination is dynamically controlled at the early endosome by feedback mechanisms involving CSF3-induced E3 ligase (SOCS3) and deubiquitinase (DUB2A) activities... - The gene encoding the transcriptional regulator Yin Yang 1 (YY1) is a myeloid transforming gene interfering with neutrophilic differentiationStefan J Erkeland
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Blood 101:1111-7. 2003..Collectively, these data imply a possible role of perturbed expression of YY1 in the development of AML through interference with the myeloid differentiation program in the leukemic progenitor cells... - HAT: hypergeometric analysis of tiling-arrays with application to promoter-GeneChip dataErdogan Taskesen
Department of Hematology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands
BMC Bioinformatics 11:275. 2010..Furthermore, the chromosomal distance between neighboring probes can vary across the genome among different arrays... - Scratching the surface: signaling and routing dynamics of the CSF3 receptorKarishma Palande
Department of Hematology, Erasmus University Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
Front Biosci 18:91-105. 2013..Here, we review the mechanisms of intracellular routing of CSF3R, their consequences for myeloid blood cell development and their implications for myeloid diseases... - Loss of ercc1 results in a time- and dose-dependent reduction of proliferating early hematopoietic progenitorsJudith H E Verhagen-Oldenampsen
Department of Hematology, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Anemia 2012:783068. 2012..In conclusion, lack of Ercc1 results in a severe competitive disadvantage of HSPCs and is most deleterious in proliferating progenitor cells... - Receptor activation and 2 distinct COOH-terminal motifs control G-CSF receptor distribution and internalization kineticsLambertus H J Aarts
Institute of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Blood 103:571-9. 2004..As a result, these mutants showed constitutively high cell-surface expression... - Analysis of Jak2 catalytic function by peptide microarrays: the role of the JH2 domain and V617F mutationArturo Sanz
Department of Hematology, Erasmus MC, Rotterdam, The Netherlands
PLoS ONE 6:e18522. 2011..Additionally, this method can be used to identify new regulatory mechanisms for protein kinases that provide a better platform for designing specific strategies for therapeutic approaches... - A functional single-nucleotide polymorphism of the G-CSF receptor gene predisposes individuals to high-risk myelodysplastic syndromeAlbert Wölfler
Division of Hematology, Medical University of Graz, Auenbruggerplatz 38, A 8036 Graz, Austria
Blood 105:3731-6. 2005..These results suggest that lifelong altered G-CSF response by the G-CSF-R_785Lys may render individuals susceptible to development of high-risk MDS... - Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytesEwa Sicinska
Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Mol Cell Biol 26:8052-60. 2006..Collectively, these results demonstrate that cyclin D3 is an essential cell cycle recipient of G-CSF signaling, and they provide a molecular link of how G-CSF-dependent signaling triggers cell proliferation... - Granulocyte colony-stimulating factor: key (f)actor or innocent bystander in the development of secondary myeloid malignancy?Ivo P Touw
J Natl Cancer Inst 99:183-6. 2007 - Myeloid maturation block by AML1-MTG16 is associated with Csf1r epigenetic downregulationStefano Rossetti
Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Oncogene 24:5325-32. 2005..Thus, there seems to be an association between AML1-MTG16-induced myeloid maturation block and epigenetic changes of a myeloid master gene... - G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growthQuan Sheng Zhu
Division of Pediatrics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Blood 107:1847-56. 2006..These data suggest that the G-CSF-induced Lyn-PI3K-Akt pathway drives ROS production. One beneficial effect of therapeutic targeting of Lyn-PI3K-kinase-Akt cascade is abrogating ROS production... - GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivoAnne Vroon
Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, The Netherlands
J Leukoc Biol 75:698-704. 2004..In view of these data, we suggest that the impaired G-CSF-induced neutrophil mobilization in the absence of GRK6 may be a result of enhanced CXCR4-mediated retention of PMN in the bone marrow... - Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF-induced expansion of myeloid progenitor cellsMirjam H A Hermans
Institute of Hematology, Erasmus University of Rotterdam, The Netherlands
Blood 101:2584-90. 2003..These findings suggest that tyrosines in the cytoplasmic domain of G-CSF-R, although dispensable for G-CSF-induced colony growth, recruit signaling mechanisms that regulate the maintenance and outgrowth of myeloid progenitor cells...