Ivo P Touw

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders
    Ivo P Touw
    Department of Hematology, Erasmus University Medical Center, P O Box 1738, 3000 DR, Rotterdam, The Netherlands
    Front Biosci 12:800-15. 2007
  2. pmc Large-scale identification of disease genes involved in acute myeloid leukemia
    Stefan J Erkeland
    Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Virol 78:1971-80. 2004
  3. ncbi request reprint Retroviral insertion mutagenesis in mice as a comparative oncogenomics tool to identify disease genes in human leukemia
    Ivo P Touw
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Mol Ther 15:13-9. 2007
  4. pmc Retroviral integration mutagenesis in mice and comparative analysis in human AML identify reduced PTP4A3 expression as a prognostic indicator
    Renee Beekman
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 6:e26537. 2011
  5. pmc The antioxidant protein peroxiredoxin 4 is epigenetically down regulated in acute promyelocytic leukemia
    Karishma K Palande
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 6:e16340. 2011
  6. doi request reprint Granulocyte colony-stimulating factor receptor signaling: implications for G-CSF responses and leukemic progression in severe congenital neutropenia
    Ivo P Touw
    Department of Hematology, Erasmus University Medical Center, Dr Molewaterplein 50 3015 GE, Rotterdam, The Netherlands
    Hematol Oncol Clin North Am 27:61-73, viii. 2013
  7. pmc Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor
    Mahban I Irandoust
    Department of Hematology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    EMBO J 26:1782-93. 2007
  8. doi request reprint The gene encoding thioredoxin-interacting protein (TXNIP) is a frequent virus integration site in virus-induced mouse leukemia and is overexpressed in a subset of AML patients
    Stefan J Erkeland
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Leuk Res 33:1367-71. 2009
  9. doi request reprint Janus kinases promote cell-surface expression and provoke autonomous signalling from routing-defective G-CSF receptors
    Annemarie Meenhuis
    Department of Hematology, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Biochem J 417:737-46. 2009
  10. doi request reprint Site-specific ubiquitination determines lysosomal sorting and signal attenuation of the granulocyte colony-stimulating factor receptor
    Albert Wölfler
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Traffic 10:1168-79. 2009

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders
    Ivo P Touw
    Department of Hematology, Erasmus University Medical Center, P O Box 1738, 3000 DR, Rotterdam, The Netherlands
    Front Biosci 12:800-15. 2007
    ..Here we review how these mechanisms are thought to act in concert to meet with these demands and how perturbations in the function of the G-CSF receptor are implicated in various types of myeloid disease...
  2. pmc Large-scale identification of disease genes involved in acute myeloid leukemia
    Stefan J Erkeland
    Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Virol 78:1971-80. 2004
    ....
  3. ncbi request reprint Retroviral insertion mutagenesis in mice as a comparative oncogenomics tool to identify disease genes in human leukemia
    Ivo P Touw
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Mol Ther 15:13-9. 2007
    ..We will specifically focus on the value of employing retroviral insertion mutagenesis in mice and gene expression profiling in man in the context of acute myeloid leukemia...
  4. pmc Retroviral integration mutagenesis in mice and comparative analysis in human AML identify reduced PTP4A3 expression as a prognostic indicator
    Renee Beekman
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 6:e26537. 2011
    ..In conclusion, our novel strategy has identified PTP4A3 to potentially have a role in AML, on one hand as a candidate HIG contributing to leukemogenesis in mice and on the other hand as a prognostic indicator in human AML...
  5. pmc The antioxidant protein peroxiredoxin 4 is epigenetically down regulated in acute promyelocytic leukemia
    Karishma K Palande
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 6:e16340. 2011
    ..These findings suggest that the control of G-CSF responses by the antioxidant protein PRDX4 may be perturbed in APL...
  6. doi request reprint Granulocyte colony-stimulating factor receptor signaling: implications for G-CSF responses and leukemic progression in severe congenital neutropenia
    Ivo P Touw
    Department of Hematology, Erasmus University Medical Center, Dr Molewaterplein 50 3015 GE, Rotterdam, The Netherlands
    Hematol Oncol Clin North Am 27:61-73, viii. 2013
    ....
  7. pmc Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor
    Mahban I Irandoust
    Department of Hematology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    EMBO J 26:1782-93. 2007
    ..This is the first demonstration of SOCS-mediated ubiquitination and routing of a cytokine receptor and its impact on maintaining an appropriate signaling output...
  8. doi request reprint The gene encoding thioredoxin-interacting protein (TXNIP) is a frequent virus integration site in virus-induced mouse leukemia and is overexpressed in a subset of AML patients
    Stefan J Erkeland
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Leuk Res 33:1367-71. 2009
    ..Nucleotide sequencing revealed no abnormalities in the TXNIP coding region in AML. These findings suggest that deregulated TXNIP expression contributes to MLV-induced murine leukemia as well as human AML...
  9. doi request reprint Janus kinases promote cell-surface expression and provoke autonomous signalling from routing-defective G-CSF receptors
    Annemarie Meenhuis
    Department of Hematology, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Biochem J 417:737-46. 2009
    ....
  10. doi request reprint Site-specific ubiquitination determines lysosomal sorting and signal attenuation of the granulocyte colony-stimulating factor receptor
    Albert Wölfler
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Traffic 10:1168-79. 2009
    ....
  11. ncbi request reprint G-CSF receptor truncations found in SCN/AML relieve SOCS3-controlled inhibition of STAT5 but leave suppression of STAT3 intact
    Gert Jan M van de Geijn
    Institute of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    Blood 104:667-74. 2004
    ....
  12. pmc Peroxiredoxin-controlled G-CSF signalling at the endoplasmic reticulum-early endosome interface
    Karishma Palande
    Department of Hematology, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands
    J Cell Sci 124:3695-705. 2011
    ..Conversely, Ptp1b might keep Prdx4 active by reducing its phosphorylation. These findings unveil a new signal transduction regulatory circuitry involving redox-controlled processes in the ER and activated cytokine receptors in endosomes...
  13. ncbi request reprint Distinct activities of suppressor of cytokine signaling (SOCS) proteins and involvement of the SOCS box in controlling G-CSF signaling
    Gert Jan M van de Geijn
    Institute of Hematology, Erasmus University Medical Center, Room Ee 1330c, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Leukoc Biol 76:237-44. 2004
    ....
  14. doi request reprint Dicer1 deletion in myeloid-committed progenitors causes neutrophil dysplasia and blocks macrophage/dendritic cell development in mice
    Mir Farshid Alemdehy
    Department of Hematology, Erasmus University Medical Center, Dr Molewaterplein 50, Rotterdam, The Netherlands
    Blood 119:4723-30. 2012
    ..These results provide evidence for a miRNA-controlled switch for a cellular program of self-renewal and expansion toward myeloid differentiation in GMPs...
  15. doi request reprint Lineage-instructive function of C/EBPα in multipotent hematopoietic cells and early thymic progenitors
    Albert Wölfler
    Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    Blood 116:4116-25. 2010
    ..These findings support an instructive but argue against a lineage-restrictive role of C/EBPα in multipotent hematopoietic and thymic progenitors...
  16. ncbi request reprint Significance of murine retroviral mutagenesis for identification of disease genes in human acute myeloid leukemia
    Stefan J Erkeland
    Department of Hematology, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Cancer Res 66:622-6. 2006
    ....
  17. ncbi request reprint Scratching the surface: signaling and routing dynamics of the CSF3 receptor
    Karishma Palande
    Department of Hematology, Erasmus University Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Front Biosci (Landmark Ed) 18:91-105. 2013
    ..Here, we review the mechanisms of intracellular routing of CSF3R, their consequences for myeloid blood cell development and their implications for myeloid diseases...
  18. ncbi request reprint The gene encoding the transcriptional regulator Yin Yang 1 (YY1) is a myeloid transforming gene interfering with neutrophilic differentiation
    Stefan J Erkeland
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 101:1111-7. 2003
    ..Collectively, these data imply a possible role of perturbed expression of YY1 in the development of AML through interference with the myeloid differentiation program in the leukemic progenitor cells...
  19. doi request reprint G-CSF and its receptor in myeloid malignancy
    Renee Beekman
    Department of Hematology, Erasmus MC, Rotterdam, The Netherlands
    Blood 115:5131-6. 2010
    ....
  20. doi request reprint Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia
    Renee Beekman
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 119:5071-7. 2012
    ..The sequential gain of 2 CSF3R mutations implicates abnormal G-CSF signaling as a driver of leukemic transformation in this case of SCN...
  21. pmc MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1-regulated pathways in mice
    Annemarie Meenhuis
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 118:916-25. 2011
    ..We demonstrate that AAAGUGC seed-containing miRNAs promote cell expansion, replating capacity and signaling in hematopoietic cells by interference with SQSTM1-regulated pathways...
  22. doi request reprint Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts
    Rastislav Horos
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 119:262-72. 2012
    ..Our data suggest that impaired internal ribosomal entry site-mediated translation of mRNAs expressed at increased levels in erythroblasts contributes to the erythroid phenotype of DBA...
  23. pmc HAT: hypergeometric analysis of tiling-arrays with application to promoter-GeneChip data
    Erdogan Taskesen
    Department of Hematology, Erasmus University Medical Center, Rotterdam, 3015 GE, The Netherlands
    BMC Bioinformatics 11:275. 2010
    ..Furthermore, the chromosomal distance between neighboring probes can vary across the genome among different arrays...
  24. pmc Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice
    Joanna M Prasher
    Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    EMBO J 24:861-71. 2005
    ..These data support the hypothesis that spontaneous interstrand crosslink damage contributes to the functional decline of the hematopoietic system associated with aging...
  25. doi request reprint The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor
    Annemarie Meenhuis
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Biochem J 434:343-51. 2011
    ..These results support a model in which CSF3R ubiquitination is dynamically controlled at the early endosome by feedback mechanisms involving CSF3-induced E3 ligase (SOCS3) and deubiquitinase (DUB2A) activities...
  26. pmc Loss of ercc1 results in a time- and dose-dependent reduction of proliferating early hematopoietic progenitors
    Judith H E Verhagen-Oldenampsen
    Department of Hematology, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Anemia 2012:783068. 2012
    ..In conclusion, lack of Ercc1 results in a severe competitive disadvantage of HSPCs and is most deleterious in proliferating progenitor cells...
  27. ncbi request reprint Receptor activation and 2 distinct COOH-terminal motifs control G-CSF receptor distribution and internalization kinetics
    Lambertus H J Aarts
    Institute of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 103:571-9. 2004
    ..As a result, these mutants showed constitutively high cell-surface expression...
  28. pmc Analysis of Jak2 catalytic function by peptide microarrays: the role of the JH2 domain and V617F mutation
    Arturo Sanz
    Department of Hematology, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 6:e18522. 2011
    ..Additionally, this method can be used to identify new regulatory mechanisms for protein kinases that provide a better platform for designing specific strategies for therapeutic approaches...
  29. pmc Essential role for cyclin D3 in granulocyte colony-stimulating factor-driven expansion of neutrophil granulocytes
    Ewa Sicinska
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 26:8052-60. 2006
    ..Collectively, these results demonstrate that cyclin D3 is an essential cell cycle recipient of G-CSF signaling, and they provide a molecular link of how G-CSF-dependent signaling triggers cell proliferation...
  30. ncbi request reprint A functional single-nucleotide polymorphism of the G-CSF receptor gene predisposes individuals to high-risk myelodysplastic syndrome
    Albert Wölfler
    Division of Hematology, Medical University of Graz, Auenbruggerplatz 38, A 8036 Graz, Austria
    Blood 105:3731-6. 2005
    ..These results suggest that lifelong altered G-CSF response by the G-CSF-R_785Lys may render individuals susceptible to development of high-risk MDS...
  31. ncbi request reprint Granulocyte colony-stimulating factor: key (f)actor or innocent bystander in the development of secondary myeloid malignancy?
    Ivo P Touw
    J Natl Cancer Inst 99:183-6. 2007
  32. ncbi request reprint Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF-induced expansion of myeloid progenitor cells
    Mirjam H A Hermans
    Institute of Hematology, Erasmus University of Rotterdam, The Netherlands
    Blood 101:2584-90. 2003
    ..These findings suggest that tyrosines in the cytoplasmic domain of G-CSF-R, although dispensable for G-CSF-induced colony growth, recruit signaling mechanisms that regulate the maintenance and outgrowth of myeloid progenitor cells...
  33. pmc G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth
    Quan Sheng Zhu
    Division of Pediatrics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 107:1847-56. 2006
    ..These data suggest that the G-CSF-induced Lyn-PI3K-Akt pathway drives ROS production. One beneficial effect of therapeutic targeting of Lyn-PI3K-kinase-Akt cascade is abrogating ROS production...
  34. ncbi request reprint GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo
    Anne Vroon
    Laboratory of Psychoneuroimmunology, University Medical Center Utrecht, The Netherlands
    J Leukoc Biol 75:698-704. 2004
    ..In view of these data, we suggest that the impaired G-CSF-induced neutrophil mobilization in the absence of GRK6 may be a result of enhanced CXCR4-mediated retention of PMN in the bone marrow...
  35. ncbi request reprint Myeloid maturation block by AML1-MTG16 is associated with Csf1r epigenetic downregulation
    Stefano Rossetti
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Oncogene 24:5325-32. 2005
    ..Thus, there seems to be an association between AML1-MTG16-induced myeloid maturation block and epigenetic changes of a myeloid master gene...