H A Tiddens

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Detecting early structural lung damage in cystic fibrosis
    Harm A W M Tiddens
    Department of Pediatric Pulmonology, Erasmus MC University Medical Center Rotterdam, Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Pulmonol 34:228-31. 2002
  2. ncbi request reprint Extra-fine particles improve lung delivery of inhaled steroids in infants: a study in an upper airway model
    Hettie M Janssens
    Department of Pediatrics, Division of Respiratory Medicine, Sophia Childrens Hospital Erasmus Medical Center, Rotterdam, The Netherlands
    Chest 123:2083-8. 2003
  3. ncbi request reprint Tracheomalacia and bronchomalacia in children: incidence and patient characteristics
    Ruben Boogaard
    Erasmus MC Sophia Children s Hospital, Erasmus University Medical Centre, Department of Pediatrics, Division of Pediatric Pulmonology, Rotterdam, The Netherlands
    Chest 128:3391-7. 2005
  4. ncbi request reprint Effect of dry powder inhaler resistance on the inspiratory flow rates and volumes of cystic fibrosis patients of six years and older
    H A Tiddens
    Department of Pediatric Pulmonology, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    J Aerosol Med 19:456-65. 2006
  5. doi request reprint Multi-modality monitoring of cystic fibrosis lung disease: the role of chest computed tomography
    Harm A W M Tiddens
    Erasmus MC Sophia Children s Hospital, University Medical Center, Department of Pediatric Pulmonology and Allergology, Department of Radiology, Rotterdam, The Netherlands Electronic address
    Paediatr Respir Rev 15:92-7. 2014
  6. pmc Experimental designs for small randomised clinical trials: an algorithm for choice
    Catherine Cornu
    Hopital Louis Pradel, centre d investigation clinique, INSERM CIC201 UMR5558, 28, avenue du doyen Lepine, Bron 69677 Cedex, France
    Orphanet J Rare Dis 8:48. 2013
  7. ncbi request reprint Inhaled antibiotics
    Harm Tiddens
    Dept of Paediatrics, Erasmus MC University Medical Center Rotterdam, Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Pulmonol Suppl 26:92-4. 2004
  8. ncbi request reprint Imaging and clinical trials in cystic fibrosis
    Harm A W M Tiddens
    Department of Pediatric Pulmonology and Allergology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Proc Am Thorac Soc 4:343-6. 2007
  9. ncbi request reprint Update on the application of chest computed tomography scanning to cystic fibrosis
    Harm A W M Tiddens
    Erasmus Medical Centre Rotterdam Sophia Children s Hospital, Department of Pediatric Pulmonology and Allergology, Rotterdam, The Netherlands
    Curr Opin Pulm Med 12:433-9. 2006
  10. doi request reprint Cystic fibrosis lung disease starts in the small airways: can we treat it more effectively?
    Harm A W M Tiddens
    Department of Pediatric Pulmonology and Allergology, Erasmus MC Sophia, Rotterdam, The Netherlands
    Pediatr Pulmonol 45:107-17. 2010

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Detecting early structural lung damage in cystic fibrosis
    Harm A W M Tiddens
    Department of Pediatric Pulmonology, Erasmus MC University Medical Center Rotterdam, Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Pulmonol 34:228-31. 2002
    ....
  2. ncbi request reprint Extra-fine particles improve lung delivery of inhaled steroids in infants: a study in an upper airway model
    Hettie M Janssens
    Department of Pediatrics, Division of Respiratory Medicine, Sophia Childrens Hospital Erasmus Medical Center, Rotterdam, The Netherlands
    Chest 123:2083-8. 2003
    ..Aim: To compare the dose delivered to the lungs of HFA-BDP and CFC-BDP at different breathing patterns using an upper airway model of an infant...
  3. ncbi request reprint Tracheomalacia and bronchomalacia in children: incidence and patient characteristics
    Ruben Boogaard
    Erasmus MC Sophia Children s Hospital, Erasmus University Medical Centre, Department of Pediatrics, Division of Pediatric Pulmonology, Rotterdam, The Netherlands
    Chest 128:3391-7. 2005
    ....
  4. ncbi request reprint Effect of dry powder inhaler resistance on the inspiratory flow rates and volumes of cystic fibrosis patients of six years and older
    H A Tiddens
    Department of Pediatric Pulmonology, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    J Aerosol Med 19:456-65. 2006
    ..The recorded inspiratory patterns can be used on the bench to design and test new dry powder formulations and devices to target the largest proportion of the CF population...
  5. doi request reprint Multi-modality monitoring of cystic fibrosis lung disease: the role of chest computed tomography
    Harm A W M Tiddens
    Erasmus MC Sophia Children s Hospital, University Medical Center, Department of Pediatric Pulmonology and Allergology, Department of Radiology, Rotterdam, The Netherlands Electronic address
    Paediatr Respir Rev 15:92-7. 2014
    ..In between chest CT imaging, physiologic measures are important to obtain for monitoring. Stratification of monitoring protocols based on the risk profile of the patient can help us in the future to better care for people with CF. ..
  6. pmc Experimental designs for small randomised clinical trials: an algorithm for choice
    Catherine Cornu
    Hopital Louis Pradel, centre d investigation clinique, INSERM CIC201 UMR5558, 28, avenue du doyen Lepine, Bron 69677 Cedex, France
    Orphanet J Rare Dis 8:48. 2013
    ..There are a number of alternative trial designs to the usual parallel group design, each of which offers specific advantages, but they also have specific limitations. Thus the choice of the most appropriate design is not simple...
  7. ncbi request reprint Inhaled antibiotics
    Harm Tiddens
    Dept of Paediatrics, Erasmus MC University Medical Center Rotterdam, Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Pulmonol Suppl 26:92-4. 2004
  8. ncbi request reprint Imaging and clinical trials in cystic fibrosis
    Harm A W M Tiddens
    Department of Pediatric Pulmonology and Allergology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Proc Am Thorac Soc 4:343-6. 2007
    ..CT measurement of airway wall thickening is possible. Airway wall thickening is related to inflammation; thus, this endpoint is of significance for interventional studies that include antiinflammatory drugs...
  9. ncbi request reprint Update on the application of chest computed tomography scanning to cystic fibrosis
    Harm A W M Tiddens
    Erasmus Medical Centre Rotterdam Sophia Children s Hospital, Department of Pediatric Pulmonology and Allergology, Rotterdam, The Netherlands
    Curr Opin Pulm Med 12:433-9. 2006
    ....
  10. doi request reprint Cystic fibrosis lung disease starts in the small airways: can we treat it more effectively?
    Harm A W M Tiddens
    Department of Pediatric Pulmonology and Allergology, Erasmus MC Sophia, Rotterdam, The Netherlands
    Pediatr Pulmonol 45:107-17. 2010
    ..Therapy should be aimed to target the small airways more efficiently, especially with drugs that can correct the basic defect at an early stage of disease...
  11. doi request reprint Improved treatment response to dornase alfa in cystic fibrosis patients using controlled inhalation
    E M Bakker
    Dept of Paediatric Pulmonology and Allergology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Eur Respir J 38:1328-35. 2011
    ..Adherent children showed a larger treatment response for small airway deposition...
  12. ncbi request reprint Chest computed tomography scans should be considered as a routine investigation in cystic fibrosis
    Harm A W M Tiddens
    Erasmus MC Sophia, Department of Pediatric Pulmonology and Allergology, Dr Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands
    Paediatr Respir Rev 7:202-8. 2006
    ....
  13. doi request reprint Airway dimensions in bronchopulmonary dysplasia: implications for airflow obstruction
    Harm A W M Tiddens
    Division of Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Pulmonol 43:1206-13. 2008
    ..001) in BPD than in SIDS patients. It is likely that the increased thickness of the airway wall components contributes to airflow obstruction in BPD patients...
  14. doi request reprint Quality improvement in your CF centre: taking care of care
    Harm A W M Tiddens
    Department of Pediatric Respiratory Medicine and Allergology, Erasmus Medical Centre Sophia Children s Hospital, 3015 GJ Rotterdam, The Netherlands
    J Cyst Fibros 8:S2-5. 2009
    ..This may imply changes to routine centre practice as well as to treatment strategies...
  15. ncbi request reprint Physiological and morphological determinants of maximal expiratory flow in chronic obstructive lung disease
    H A Tiddens
    Dept of Pediatrics, Erasmus University, Rotterdam, The Netherlands
    Eur Respir J 9:1785-94. 1996
    ..We conclude that the maximal flow-static recoil model does not adequately reflect the collapsibility of the flow-limiting segment...
  16. ncbi request reprint Computed tomographic estimation of lung dimensions throughout the growth period
    P A de Jong
    Erasmus MC Sophia, Dept of Paediatric Pulmonology and Allergology, Rotterdam, The Netherlands
    Eur Respir J 27:261-7. 2006
    ..The data from the current study provide normative computed tomography estimates of airway wall and lumen, and arterial and parenchyma dimensions throughout the growth period that may be useful for the study of alterations in disease...
  17. ncbi request reprint DNase in stable cystic fibrosis infants: a pilot study
    Maartje Ten Berge
    Department of Pediatrics, Division of Respiratory Medicine, Erasmus MC University Medical Center Rotterdam Sophia Children s Hospital, P O Box 2060, 3000, CB, Rotterdam, Netherlands
    J Cyst Fibros 2:183-8. 2003
    ..To assess the feasibility of measuring short-term effects of inhaled recombinant human deoxyribonuclease (rhDNase, Pulmozyme on lung function, pulse oximetry and symptom scores in infants and toddlers with stable cystic fibrosis...
  18. doi request reprint The spectrum of structural abnormalities on CT scans from patients with CF with severe advanced lung disease
    M Loeve
    Department of Pediatric Pulmonology and Allergology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Thorax 64:876-82. 2009
    ..Little is known about the spectrum of structural abnormalities on CT scans from patients with CF with severe advanced lung disease (SALD). No specific CT scoring system for SALD is available...
  19. ncbi request reprint Compliance, hysteresis, and collapsibility of human small airways
    H A Tiddens
    Department of Pediatrics, Division of Respiratory Medicine, Sophia Children s Hospital, Rotterdam, The Netherlands
    Am J Respir Crit Care Med 160:1110-8. 1999
    ..5, p = 0.05). We conclude that, in this study, smooth muscle area and smooth muscle tone, but not total wall area, are determinants for compliance, hysteresis, and collapsibility of isolated airways obtained from smokers...
  20. doi request reprint New antimicrobial strategies in cystic fibrosis
    Mireille van Westreenen
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Paediatr Drugs 12:343-52. 2010
    ..These developments will be of great importance in improving effective treatment and reducing the treatment burden for CF patients in the near future...
  21. ncbi request reprint RhDNase before airway clearance therapy improves airway patency in children with CF
    Lianne J van der Giessen
    Department of Paediatric Physiotherapy, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Pediatr Pulmonol 42:624-30. 2007
    ..Little is known about the optimal timing of rhDNase nebulization in relation to airway clearance therapy (ACT)...
  22. ncbi request reprint Preserved diffusion capacity in children with cystic fibrosis
    Peter J F M Merkus
    Department of Pediatrics, Subdivision of Respiratory Medicine, Erasmus University Medical Center Rotterdam, The Netherlands
    Pediatr Pulmonol 37:56-60. 2004
    ..Diffusion capacity at rest does not appear to be a suitable early marker of progressive deterioration of CF lung disease...
  23. ncbi request reprint Aerosol therapy: the special needs of young children
    Hettie M Janssens
    Department of Paediatric Pulmonology, Erasmus MC Sophia, University Medical Center Rotterdam, Sophia Children s Hospital, Rotterdam, The Netherlands
    Paediatr Respir Rev 7:S83-5. 2006
    ..During crying the dose to the lungs is minimal. Optimal aerosol delivery to the lungs of young children can be achieved with a good facemask seal, good cooperation of the child, with quiet breathing and an aerosol with small particles...
  24. ncbi request reprint Predictive value of infant lung function testing for airway malacia
    Els C van der Wiel
    Department of Pediatrics, Division of Respiratory Medicine, Erasmus Medical Center Sophia Children s Hospital University Medical Center Rotterdam, Rotterdam, The Netherlands
    Pediatr Pulmonol 40:431-6. 2005
    ..In this selected group of infants, routine lung function testing could not discriminate between infants with and without airway malacia. However, the presence of tidal flow limitation was 100% predictive and specific for airway malacia...
  25. ncbi request reprint The Sophia Anatomical Infant Nose-Throat (Saint) model: a valuable tool to study aerosol deposition in infants
    H M Janssens
    Department of Pediatric Pulmonology, Sophia Children's Hospital/Erasmus Medical Centre Rotterdam, The Netherlands
    J Aerosol Med 14:433-41. 2001
    ..This model will be used to obtain insight in aerosol treatment that cannot be obtained in vivo...
  26. ncbi request reprint The micro-plethysmograph: a new device to measure small volume displacements by isolated human airway segments
    H A Tiddens
    Department of Pediatrics, Erasmus University, and University Hospital Sophia Children s Hospital, Rotterdam, The Netherlands
    J Pharmacol Toxicol Methods 40:13-20. 1998
    ..In addition, this device can be used to measure leak or diffusion at any transmural pressure...
  27. ncbi request reprint Estimation of cancer mortality associated with repetitive computed tomography scanning
    Pim A de Jong
    Department of Pediatric Pulmonology and Allergology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Am J Respir Crit Care Med 173:199-203. 2006
    ..Low-dose radiation from computed tomography (CT) may increase the risk of certain cancers, especially in children...
  28. ncbi request reprint Cystic fibrosis specific computed tomography scoring
    Pim A de Jong
    Department of Pediatric Pulmonology and Allergology, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Proc Am Thorac Soc 4:338-42. 2007
    ..Development of reference images for the components of this system will be important in reducing the variability between observers and to train new readers...
  29. ncbi request reprint Dose reduction for CT in children with cystic fibrosis: is it feasible to reduce the number of images per scan?
    Pim A de Jong
    Department of Paediatric Pulmonology and Allergology, Erasmus MC, Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Pediatr Radiol 36:50-3. 2006
    ..Reducing the dose for each CT scan is important for children with cystic fibrosis (CF)...
  30. doi request reprint Cystic fibrosis: are volumetric ultra-low-dose expiratory CT scans sufficient for monitoring related lung disease?
    Martine Loeve
    Department of Pediatric Pulmonology and Allergology, Erasmus Medical Center Sophia Children s Hospital, 3015 GJ Rotterdam, The Netherlands
    Radiology 253:223-9. 2009
    ..To assess whether chest computed tomography (CT) scores from ultra-low-dose end-expiratory scans alone could suffice for assessment of all cystic fibrosis (CF)-related structural lung abnormalities...
  31. ncbi request reprint Estimation of lung growth using computed tomography
    P A de Jong
    Dept of Paediatric Pulmonology, Sophia Children s Hospital, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands
    Eur Respir J 22:235-8. 2003
    ..The increase in the lung expansion after the age of 2 yrs suggests progressive alveolar expansion with increasing lung volume...
  32. doi request reprint Lung morphology assessment using MRI: a robust ultra-short TR/TE 2D steady state free precession sequence used in cystic fibrosis patients
    Riccarda Failo
    Pediatric Radiology and Pulmonology Department, Erasmus Medical Center, Sophia Children s Hospital, Rotterdam, The Netherlands
    Magn Reson Med 61:299-306. 2009
    ..Most importantly, the SNR of the expiratory scans enables to visualize air trapping. The preliminary results of this study suggest MRI as a noteworthy additional imaging tool for routine monitoring of CF patients...
  33. ncbi request reprint Aerosol therapy and the fighting toddler: is administration during sleep an alternative?
    Hettie M Janssens
    Department of Pediatrics, Erasmus Medical Center Rotterdam Sophia Children s Hospital, Rotterdam, The Netherlands
    J Aerosol Med 16:395-400. 2003
    ..Administration of aerosols during sleep might, therefore, be an efficient alternative for uncooperative toddlers...
  34. ncbi request reprint Determining factors of aerosol deposition for four pMDI-spacer combinations in an infant upper airway model
    Hettie M Janssens
    Department of Pediatrics, Division of Respiratory Medicine, Erasmus MC Sophia Children s Hospital, 3000 CB Rotterdam, The Netherlands
    J Aerosol Med 17:51-61. 2004
    ..Deposition of particles <2.1 microm is relatively flow independent. When electrostatic charge of spacers is reduced, lung dose is pMDI dependent and spacer independent...
  35. doi request reprint Bronchiectasis and pulmonary exacerbations in children and young adults with cystic fibrosis
    Martine Loeve
    Department of Pediatric Pulmonology and Allergology, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Chest 140:178-85. 2011
    ..The objective of this study was to investigate the association between CT scan scores and RTE-R in a cohort of pediatric patients with CF...
  36. ncbi request reprint Monitoring cystic fibrosis lung disease in clinical trials: is it time for a change?
    Harm A W M Tiddens
    Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Proc Am Thorac Soc 4:297-8. 2007
  37. ncbi request reprint Macrolide resistance of Staphylococcus aureus and Haemophilus species associated with long-term azithromycin use in cystic fibrosis
    Sonja J Phaff
    Department of Pediatric Pulmonology and Allergology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    J Antimicrob Chemother 57:741-6. 2006
    ..The purpose of this study was to determine the association between long-term use of azithromycin in CF patients and change over time in macrolide susceptibility of Staphylococcus aureus and Haemophilus spp...
  38. ncbi request reprint Pulmonary disease assessment in cystic fibrosis: comparison of CT scoring systems and value of bronchial and arterial dimension measurements
    Pim A de Jong
    Department of Paediatric Pulmonology, Erasmus Medical Center Rotterdam, The Netherlands
    Radiology 231:434-9. 2004
    ....
  39. ncbi request reprint Computed tomography in the evaluation of cystic fibrosis lung disease
    Alan S Brody
    Department of Radiology, MLC 5031, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
    Am J Respir Crit Care Med 172:1246-52. 2005
    ..Second is the need for more sensitive outcome measures to assess new therapies. This had led to new interest and a series of important publications. The goal of this article is to present the current status of CT scanning in CF...
  40. doi request reprint Structural and functional lung disease in primary ciliary dyskinesia
    Francesca Santamaria
    Department of Pediatrics, Federico II University, Naples, Italy
    Chest 134:351-7. 2008
    ..High-resolution CT (HRCT) scan data on primary ciliary dyskinesia (PCD) related lung disease are scarce...
  41. ncbi request reprint In vitro determination of the optimal particle size for nebulized aerosol delivery to infants
    Karen G Schüepp
    Swiss Paediatric Respiratory Research Group, Division of Respiratory Medicine, University Children s Hospital, Zurich, Switzerland
    J Aerosol Med 18:225-35. 2005
    ..4 microm and a geometric standard deviation (GSD) of 1.56. From our in vitro study, we conclude that the optimal particle size for nebulized aerosols for inhalation therapy for infants should have a MMAD of <2.4 microm...