Research Topics
| H A TiddensSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
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Detail Information
Publications
Detecting early structural lung damage in cystic fibrosisHarm A W M Tiddens
Department of Pediatric Pulmonology, Erasmus MC University Medical Center Rotterdam, Sophia Children s Hospital, Rotterdam, The Netherlands
Pediatr Pulmonol 34:228-31. 2002....- Extra-fine particles improve lung delivery of inhaled steroids in infants: a study in an upper airway modelHettie M Janssens
Department of Pediatrics, Division of Respiratory Medicine, Sophia Childrens Hospital/Erasmus Medical Center, Rotterdam, The Netherlands
Chest 123:2083-8. 2003..1 microm improves the dose delivered to the lungs substantially. Furthermore, the large proportion of extra-fine particles in HFA-BDP results in lung doses less dependent on breathing pattern compared with CFC-BDP... - Tracheomalacia and bronchomalacia in children: incidence and patient characteristicsRuben Boogaard
Erasmus MC Sophia Children s Hospital, Erasmus University Medical Centre, Department of Pediatrics, Division of Pediatric Pulmonology, Rotterdam, The Netherlands
Chest 128:3391-7. 2005.... - Effect of dry powder inhaler resistance on the inspiratory flow rates and volumes of cystic fibrosis patients of six years and olderH A Tiddens
Department of Pediatric Pulmonology, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
J Aerosol Med 19:456-65. 2006..The recorded inspiratory patterns can be used on the bench to design and test new dry powder formulations and devices to target the largest proportion of the CF population... 
Improved treatment response to dornase alfa in cystic fibrosis patients using controlled inhalationE M Bakker
Dept of Paediatric Pulmonology and Allergology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
Eur Respir J 38:1328-35. 2011..Adherent children showed a larger treatment response for small airway deposition...- Chest computed tomography scans should be considered as a routine investigation in cystic fibrosisHarm A W M Tiddens
Erasmus MC Sophia, Department of Pediatric Pulmonology and Allergology, Dr Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands
Paediatr Respir Rev 7:202-8. 2006.... - Update on the application of chest computed tomography scanning to cystic fibrosisHarm A W M Tiddens
Erasmus Medical Centre Rotterdam Sophia Children s Hospital, Department of Pediatric Pulmonology and Allergology, Rotterdam, The Netherlands
Curr Opin Pulm Med 12:433-9. 2006.... - Imaging and clinical trials in cystic fibrosisHarm A W M Tiddens
Department of Pediatric Pulmonology and Allergology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
Proc Am Thorac Soc 4:343-6. 2007..CT measurement of airway wall thickening is possible. Airway wall thickening is related to inflammation; thus, this endpoint is of significance for interventional studies that include antiinflammatory drugs... - Airway dimensions in bronchopulmonary dysplasia: implications for airflow obstructionHarm A W M Tiddens
Division of Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
Pediatr Pulmonol 43:1206-13. 2008..001) in BPD than in SIDS patients. It is likely that the increased thickness of the airway wall components contributes to airflow obstruction in BPD patients... - Quality improvement in your CF centre: taking care of careHarm A W M Tiddens
Department of Pediatric Respiratory Medicine and Allergology, Erasmus Medical Centre Sophia Children s Hospital, 3015 GJ Rotterdam, The Netherlands
J Cyst Fibros 8:S2-5. 2009..This may imply changes to routine centre practice as well as to treatment strategies... - Cystic fibrosis lung disease starts in the small airways: can we treat it more effectively?Harm A W M Tiddens
Department of Pediatric Pulmonology and Allergology, Erasmus MC Sophia, Rotterdam, The Netherlands
Pediatr Pulmonol 45:107-17. 2010..Therapy should be aimed to target the small airways more efficiently, especially with drugs that can correct the basic defect at an early stage of disease... - Inhaled antibioticsHarm Tiddens
Dept. of Paediatrics, Erasmus MC-University Medical Center Rotterdam, Sophia Children's Hospital, Rotterdam, The Netherlands
Pediatr Pulmonol Suppl 26:92-4. 2004 - Physiological and morphological determinants of maximal expiratory flow in chronic obstructive lung diseaseH A Tiddens
Dept of Pediatrics, Erasmus University, Rotterdam, The Netherlands
Eur Respir J 9:1785-94. 1996..We conclude that the maximal flow-static recoil model does not adequately reflect the collapsibility of the flow-limiting segment... - Computed tomographic estimation of lung dimensions throughout the growth periodP A de Jong
Erasmus MC-Sophia, Dept of Paediatric Pulmonology and Allergology, Rotterdam, The Netherlands
Eur Respir J 27:261-7. 2006..The data from the current study provide normative computed tomography estimates of airway wall and lumen, and arterial and parenchyma dimensions throughout the growth period that may be useful for the study of alterations in disease... - DNase in stable cystic fibrosis infants: a pilot studyMaartje Ten Berge
Department of Pediatrics, Division of Respiratory Medicine, Erasmus MC--University Medical Center Rotterdam/Sophia Children's Hospital, P.O. Box 2060, 3000, CB, Rotterdam, Netherlands
J Cyst Fibros 2:183-8. 2003..CONCLUSIONS: This pilot study indicates that objective assessment of the effects of rhDNase is feasible in infants with CF who have little or no respiratory symptoms. Our results warrant a larger randomized placebo-controlled trial... - Compliance, hysteresis, and collapsibility of human small airwaysH A Tiddens
Department of Pediatrics, Division of Respiratory Medicine, Sophia Children s Hospital, Rotterdam, The Netherlands
Am J Respir Crit Care Med 160:1110-8. 1999..5, p = 0.05). We conclude that, in this study, smooth muscle area and smooth muscle tone, but not total wall area, are determinants for compliance, hysteresis, and collapsibility of isolated airways obtained from smokers... - The spectrum of structural abnormalities on CT scans from patients with CF with severe advanced lung diseaseM Loeve
Department of Pediatric Pulmonology and Allergology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
Thorax 64:876-82. 2009..Little is known about the spectrum of structural abnormalities on CT scans from patients with CF with severe advanced lung disease (SALD). No specific CT scoring system for SALD is available... - Aerosol therapy: the special needs of young childrenHettie M Janssens
Department of Paediatric Pulmonology, Erasmus MC Sophia, University Medical Center Rotterdam, Sophia Children s Hospital, Rotterdam, The Netherlands
Paediatr Respir Rev 7:S83-5. 2006..During crying the dose to the lungs is minimal. Optimal aerosol delivery to the lungs of young children can be achieved with a good facemask seal, good cooperation of the child, with quiet breathing and an aerosol with small particles... - RhDNase before airway clearance therapy improves airway patency in children with CFLianne J van der Giessen
Department of Paediatric Physiotherapy, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
Pediatr Pulmonol 42:624-30. 2007..Little is known about the optimal timing of rhDNase nebulization in relation to airway clearance therapy (ACT)... - Preserved diffusion capacity in children with cystic fibrosisPeter J F M Merkus
Department of Pediatrics, Subdivision of Respiratory Medicine, Erasmus University Medical Center Rotterdam, The Netherlands
Pediatr Pulmonol 37:56-60. 2004..Diffusion capacity at rest does not appear to be a suitable early marker of progressive deterioration of CF lung disease... - New antimicrobial strategies in cystic fibrosisMireille van Westreenen
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
Paediatr Drugs 12:343-52. 2010..These developments will be of great importance in improving effective treatment and reducing the treatment burden for CF patients in the near future... - Predictive value of infant lung function testing for airway malaciaEls C van der Wiel
Department of Pediatrics, Division of Respiratory Medicine, Erasmus Medical Center-Sophia Children's Hospital/University Medical Center Rotterdam, Rotterdam, The Netherlands
Pediatr Pulmonol 40:431-6. 2005..In this selected group of infants, routine lung function testing could not discriminate between infants with and without airway malacia. However, the presence of tidal flow limitation was 100% predictive and specific for airway malacia... - The micro-plethysmograph: a new device to measure small volume displacements by isolated human airway segmentsH A Tiddens
Department of Pediatrics, Erasmus University, and University Hospital Sophia Children s Hospital, Rotterdam, The Netherlands
J Pharmacol Toxicol Methods 40:13-20. 1998..In addition, this device can be used to measure leak or diffusion at any transmural pressure... - The Sophia Anatomical Infant Nose-Throat (Saint) model: a valuable tool to study aerosol deposition in infantsH M Janssens
Department of Pediatric Pulmonology, Sophia Children's Hospital/Erasmus Medical Centre Rotterdam, The Netherlands
J Aerosol Med 14:433-41. 2001..This model will be used to obtain insight in aerosol treatment that cannot be obtained in vivo... - Estimation of cancer mortality associated with repetitive computed tomography scanningPim A de Jong
Department of Pediatric Pulmonology and Allergology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
Am J Respir Crit Care Med 173:199-203. 2006..Low-dose radiation from computed tomography (CT) may increase the risk of certain cancers, especially in children... - Dose reduction for CT in children with cystic fibrosis: is it feasible to reduce the number of images per scan?Pim A de Jong
Department of Paediatric Pulmonology and Allergology, Erasmus MC, Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
Pediatr Radiol 36:50-3. 2006..Reducing the dose for each CT scan is important for children with cystic fibrosis (CF)... - Cystic fibrosis specific computed tomography scoringPim A de Jong
Department of Pediatric Pulmonology and Allergology, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
Proc Am Thorac Soc 4:338-42. 2007..Development of reference images for the components of this system will be important in reducing the variability between observers and to train new readers... - Cystic fibrosis: are volumetric ultra-low-dose expiratory CT scans sufficient for monitoring related lung disease?Martine Loeve
Department of Pediatric Pulmonology and Allergology, Erasmus Medical Center Sophia Children s Hospital, 3015 GJ Rotterdam, The Netherlands
Radiology 253:223-9. 2009..To assess whether chest computed tomography (CT) scores from ultra-low-dose end-expiratory scans alone could suffice for assessment of all cystic fibrosis (CF)-related structural lung abnormalities... - Estimation of lung growth using computed tomographyP A de Jong
Dept of Paediatric Pulmonology, Sophia Children's Hospital, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands
Eur Respir J 22:235-8. 2003..The increase in the lung expansion after the age of 2 yrs suggests progressive alveolar expansion with increasing lung volume... - Lung morphology assessment using MRI: a robust ultra-short TR/TE 2D steady state free precession sequence used in cystic fibrosis patientsRiccarda Failo
Pediatric Radiology and Pulmonology Department, Erasmus Medical Center, Sophia Children s Hospital, Rotterdam, The Netherlands
Magn Reson Med 61:299-306. 2009..Most importantly, the SNR of the expiratory scans enables to visualize air trapping. The preliminary results of this study suggest MRI as a noteworthy additional imaging tool for routine monitoring of CF patients... - Aerosol therapy and the fighting toddler: is administration during sleep an alternative?Hettie M Janssens
Department of Pediatrics, Erasmus Medical Center Rotterdam Sophia Children s Hospital, Rotterdam, The Netherlands
J Aerosol Med 16:395-400. 2003..Administration of aerosols during sleep might, therefore, be an efficient alternative for uncooperative toddlers... - Determining factors of aerosol deposition for four pMDI-spacer combinations in an infant upper airway modelHettie M Janssens
Department of Pediatrics, Division of Respiratory Medicine, Erasmus MC-Sophia Children's Hospital, 3000 CB Rotterdam, The Netherlands
J Aerosol Med 17:51-61. 2004..Deposition of particles <2.1 microm is relatively flow independent. When electrostatic charge of spacers is reduced, lung dose is pMDI dependent and spacer independent... - Bronchiectasis and pulmonary exacerbations in children and young adults with cystic fibrosisMartine Loeve
Department of Pediatric Pulmonology and Allergology, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
Chest 140:178-85. 2011..The objective of this study was to investigate the association between CT scan scores and RTE-R in a cohort of pediatric patients with CF... - Monitoring cystic fibrosis lung disease in clinical trials: is it time for a change?Harm A W M Tiddens
Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
Proc Am Thorac Soc 4:297-8. 2007 - Macrolide resistance of Staphylococcus aureus and Haemophilus species associated with long-term azithromycin use in cystic fibrosisSonja J Phaff
Department of Pediatric Pulmonology and Allergology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands
J Antimicrob Chemother 57:741-6. 2006..CONCLUSIONS: Over a 4 year period, azithromycin maintenance therapy in our CF population was associated with an increase in macrolide resistance in S. aureus and Haemophilus spp... - Structural and functional lung disease in primary ciliary dyskinesiaFrancesca Santamaria
Department of Pediatrics, Federico II University, Naples, Italy
Chest 134:351-7. 2008..High-resolution CT (HRCT) scan data on primary ciliary dyskinesia (PCD) related lung disease are scarce... - Computed tomography in the evaluation of cystic fibrosis lung diseaseAlan S Brody
Department of Radiology, MLC 5031, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
Am J Respir Crit Care Med 172:1246-52. 2005..Second is the need for more sensitive outcome measures to assess new therapies. This had led to new interest and a series of important publications. The goal of this article is to present the current status of CT scanning in CF... - Pulmonary disease assessment in cystic fibrosis: comparison of CT scoring systems and value of bronchial and arterial dimension measurementsPim A de Jong
Department of Paediatric Pulmonology, Erasmus Medical Center Rotterdam, The Netherlands
Radiology 231:434-9. 2004..CONCLUSION: Thin-section CT scores were reproducible and were correlated with PFT results. Measurements of bronchial dimensions were not significantly related to scores or PFT results... - In vitro determination of the optimal particle size for nebulized aerosol delivery to infantsKaren G Schüepp
Swiss Paediatric Respiratory Research Group, Division of Respiratory Medicine, University Children s Hospital, Zurich, Switzerland
J Aerosol Med 18:225-35. 2005..4 microm and a geometric standard deviation (GSD) of 1.56. From our in vitro study, we conclude that the optimal particle size for nebulized aerosols for inhalation therapy for infants should have a MMAD of <2.4 microm...