Eric A P Steegers

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi request reprint Pre-eclampsia
    Eric A P Steegers
    Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands
    Lancet 376:631-44. 2010
  2. pmc Tissue-specific DNA methylation profiles in newborns
    Emilie Herzog
    Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Centre Rotterdam, Dr, Molewaterplein 50, Rotterdam, GE 3015, The Netherlands
    Clin Epigenetics 5:8. 2013
  3. pmc Pregnancy and liver adenoma management: PALM-study
    Susanna M van Aalten
    Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Gastroenterol 12:82. 2012
  4. pmc Quantitative cardiovascular magnetic resonance in pregnant women: cross-sectional analysis of physiological parameters throughout pregnancy and the impact of the supine position
    Alexia Rossi
    Department of Cardiology, Erasmus University Medical Center s, Gravendijkwal 230, 3015CE Rotterdam, The Netherlands
    J Cardiovasc Magn Reson 13:31. 2011
  5. pmc Study protocol: Cost effectiveness of two strategies to implement the NVOG guidelines on hypertension in pregnancy: An innovative strategy including a computerised decision support system compared to a common strategy of professional audit and feedback, a
    Susanne He Luitjes
    Department of Obstetrics and Gynaecology, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, Netherlands
    Implement Sci 5:68. 2010
  6. pmc Residential traffic exposure and pregnancy-related outcomes: a prospective birth cohort study
    Edith H van den Hooven
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health 8:59. 2009
  7. pmc Well being of obstetric patients on minimal blood transfusions (WOMB trial)
    Babette W Prick
    Department of Obstetrics and Gynaecology, Erasmus Medical Centre, Rotterdam, The Netherlands
    BMC Pregnancy Childbirth 10:83. 2010
  8. pmc Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies
    Dennis O Mook-Kanamori
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 10:67. 2009
  9. pmc Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study
    Miranda J J Geelhoed
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:39. 2010
  10. doi request reprint Shared constitutional risks for maternal vascular-related pregnancy complications and future cardiovascular disease
    Anne L Berends
    Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynecology, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hypertension 51:1034-41. 2008

Detail Information

Publications79

  1. doi request reprint Pre-eclampsia
    Eric A P Steegers
    Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands
    Lancet 376:631-44. 2010
    ..Pre-eclampsia foretells raised rates of cardiovascular and metabolic disease in later life, which could be reason for subsequent lifestyle education and intervention...
  2. pmc Tissue-specific DNA methylation profiles in newborns
    Emilie Herzog
    Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Centre Rotterdam, Dr, Molewaterplein 50, Rotterdam, GE 3015, The Netherlands
    Clin Epigenetics 5:8. 2013
    ....
  3. pmc Pregnancy and liver adenoma management: PALM-study
    Susanna M van Aalten
    Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Gastroenterol 12:82. 2012
    ..We aim to investigate the management and outcome of HCA during pregnancy and labor based on a prospectively acquired online database in the Netherlands...
  4. pmc Quantitative cardiovascular magnetic resonance in pregnant women: cross-sectional analysis of physiological parameters throughout pregnancy and the impact of the supine position
    Alexia Rossi
    Department of Cardiology, Erasmus University Medical Center s, Gravendijkwal 230, 3015CE Rotterdam, The Netherlands
    J Cardiovasc Magn Reson 13:31. 2011
    ..The purpose of this study was to investigate the effect of postural changes on cardiac dimensions and function during mid and late pregnancy using cardiovascular magnetic resonance (CMR)...
  5. pmc Study protocol: Cost effectiveness of two strategies to implement the NVOG guidelines on hypertension in pregnancy: An innovative strategy including a computerised decision support system compared to a common strategy of professional audit and feedback, a
    Susanne He Luitjes
    Department of Obstetrics and Gynaecology, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, Netherlands
    Implement Sci 5:68. 2010
    ..A cost effectiveness and cost utility analysis will be performed according to the intention-to-treat principle and from a societal perspective. Cost effectiveness ratios will be calculated using bootstrapping techniques...
  6. pmc Residential traffic exposure and pregnancy-related outcomes: a prospective birth cohort study
    Edith H van den Hooven
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health 8:59. 2009
    ..The considerable traffic-related intra-urban spatial variation needs to be considered in exposure assessment. Residential proximity to traffic is a proxy for traffic-related exposures that takes into account within-city contrasts...
  7. pmc Well being of obstetric patients on minimal blood transfusions (WOMB trial)
    Babette W Prick
    Department of Obstetrics and Gynaecology, Erasmus Medical Centre, Rotterdam, The Netherlands
    BMC Pregnancy Childbirth 10:83. 2010
    ..At present, there are no strict transfusion criteria for this specific indication, resulting in a wide variation in postpartum policy of RBC transfusion in the Netherlands...
  8. pmc Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies
    Dennis O Mook-Kanamori
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 10:67. 2009
    ..The objective of this study was to examine whether T2D gene polymorphism TCF7L2 rs7903146 is associated with growth patterns from fetal life until infancy...
  9. pmc Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study
    Miranda J J Geelhoed
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:39. 2010
    ..We examined whether these glucocorticoid receptor gene polymorphisms are associated with growth in fetal and early postnatal life...
  10. doi request reprint Shared constitutional risks for maternal vascular-related pregnancy complications and future cardiovascular disease
    Anne L Berends
    Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynecology, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hypertension 51:1034-41. 2008
    ..These findings suggest shared constitutional risks for vascular-related pregnancy complications and future cardiovascular disease...
  11. doi request reprint Maternal caffeine intake from coffee and tea, fetal growth, and the risks of adverse birth outcomes: the Generation R Study
    Rachel Bakker
    Departments of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands
    Am J Clin Nutr 91:1691-8. 2010
    ..Caffeine is a widely used and accepted pharmacologically active substance. The effect of caffeine intake during pregnancy on fetal growth and development is still unclear...
  12. doi request reprint Estimating the effect of gestational age on test performance of combined first-trimester screening for Down syndrome: a preliminary study
    Peter N van Heesch
    Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Perinat Med 38:305-9. 2010
    ..To establish how different methods of estimating gestational age (GA) affect reliability of first-trimester screening for Down syndrome...
  13. doi request reprint Symptoms of post-traumatic stress after preeclampsia
    Meeke Hoedjes
    Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands
    J Psychosom Obstet Gynaecol 32:126-34. 2011
    ..There was a relatively high prevalence of postpartum symptoms of PTSD among women after preeclampsia. The prevalence was highest among younger women who experienced more adverse pregnancy outcomes...
  14. doi request reprint Employment status and the risk of pregnancy complications: the Generation R Study
    Pauline W Jansen
    The Generation R Study Group, Erasmus MC University Medical Centre Rotterdam, PO Box 2040 Room Ae 029, 3000 CA Rotterdam, The Netherlands
    Occup Environ Med 67:387-94. 2010
    ..This study explored the relationships of employment status, type of unemployment and number of weekly working hours, with a wide range of pregnancy outcomes...
  15. doi request reprint Resolution of hypertension and proteinuria after preeclampsia
    Durk Berks
    Department of Obstetrics and Gynecology, Division of Obstetric and Prenatal Medicine, Erasmus MC Medical Centre, Rotterdam, The Netherlands
    Obstet Gynecol 114:1307-14. 2009
    ....
  16. doi request reprint Association of higher rheumatoid arthritis disease activity during pregnancy with lower birth weight: results of a national prospective study
    Yaël A de Man
    Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Arthritis Rheum 60:3196-206. 2009
    ..To determine the outcome of pregnancy in women with rheumatoid arthritis (RA) in relation to disease activity and medication use during the pregnancy...
  17. doi request reprint Intrauterine cannabis exposure affects fetal growth trajectories: the Generation R Study
    Hanan El Marroun
    Department of Child and Adolescent Psychiatry and the Generation R Study Group, Rotterdam, The Netherlands
    J Am Acad Child Adolesc Psychiatry 48:1173-81. 2009
    ..This study examined the relation between maternal cannabis use and fetal growth until birth in a population-based sample...
  18. doi request reprint Ethnic differences in considerations whether or not to participate in prenatal screening for Down syndrome
    Mirjam P Fransen
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Prenat Diagn 29:1262-9. 2009
    ..To evaluate ethnic differences in considerations whether or not to participate in prenatal screening for Down syndrome and to relate these to differences in participation...
  19. doi request reprint Body mass index is an important determinant of methylation biomarkers in women of reproductive ages
    Lydi M J W van Driel
    Department of Obstetrics and Gynecology, Division of Obstetrics and Prenatal Medicine, Erasmus Medical Center, University Medical Centre, Rotterdam, The Netherlands
    J Nutr 139:2315-21. 2009
    ..Thus, the determinants of SAM and SAH differ from those of tHcy concentrations. Given that BMI was a strong determinant of SAM concentrations, it should be included in future studies on cellular methylation...
  20. doi request reprint Medical record validation of maternally reported history of preeclampsia
    Marianne Coolman
    The Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Clin Epidemiol 63:932-7. 2010
    ..In this study, we assessed the validity of maternally self-reported history of preeclampsia...
  21. doi request reprint Explaining educational inequalities in birthweight: the Generation R Study
    Pauline W Jansen
    The Generation R Study Group, Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Paediatr Perinat Epidemiol 23:216-28. 2009
    ..In order to tackle inequalities in birthweight, it is important that interventions are accessible for pregnant women in lower socio-economic strata...
  22. doi request reprint Fetal growth retardation and risk of febrile seizures
    Annemarie M Visser
    Generation R Study Group, Erasmus University Medical Center, Department of Neurology, PO Box 2040, 3000 CA Rotterdam, Netherlands
    Pediatrics 126:e919-25. 2010
    ..The goal was to examine the associations between fetal growth characteristics in different trimesters of pregnancy and the occurrence of febrile seizures in early childhood...
  23. doi request reprint Mother's educational level and fetal growth: the genesis of health inequalities
    Lindsay M Silva
    The Generation R Study Group, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Int J Epidemiol 39:1250-61. 2010
    ....
  24. doi request reprint Ethnic and socio-economic differences in uptake of prenatal diagnostic tests for Down's syndrome
    Mirjam P Fransen
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 151:158-62. 2010
    ..The objective of this study was to assess ethnic and socio-economic differences in the uptake of maternal age-based prenatal diagnostic testing for Down's syndrome by amniocentesis or chorionic villus sampling...
  25. doi request reprint Air pollution, blood pressure, and the risk of hypertensive complications during pregnancy: the generation R study
    Edith H van den Hooven
    The Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Hypertension 57:406-12. 2011
    ..72 [95% CI 1.12 to 2.63] per 10-μg/m(3) increase). In conclusion, our results suggest that air pollution may affect maternal cardiovascular health during pregnancy. The effects might be small but relevant on a population level...
  26. pmc Individual accumulation of heterogeneous risks explains perinatal inequalities within deprived neighbourhoods
    Sarah Timmermans
    The Generation R Study Group, Erasmus MC Rotterdam, POB 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Epidemiol 26:165-80. 2011
    ..To conclude, women from a socioeconomically deprived neighbourhood are at an increased risk for adverse pregnancy outcomes. Differences regarding possibly avoidable risk factors imply that preventive strategies may prove effective...
  27. doi request reprint Effect of postpartum lifestyle interventions on weight loss, smoking cessation, and prevention of smoking relapse: a systematic review
    Meeke Hoedjes
    Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands
    Obstet Gynecol Surv 65:631-52. 2010
    ..While awaiting their development, it seems reasonable to utilize existing lifestyle interventions shown to be effective in unselected postpartum women...
  28. doi request reprint Electroencephalography during normotensive and hypertensive pregnancy: a systematic review
    Ingrid A Brussé
    Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynecology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Obstet Gynecol Surv 65:794-803. 2010
    ..Further research is needed to establish the clinical value of implementing EEGs in the assessment of the preeclamptic/eclamptic patient...
  29. pmc The Generation R Study: design and cohort update 2010
    Vincent W V Jaddoe
    The Generation R Study Group AE006, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 25:823-41. 2010
    ..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
  30. ncbi request reprint [Rheumatic diseases need more attention in case of the desire to have children and during pregnancy]
    Yaël A de Man
    Erasmus MC, afd Reumatologie, Rotterdam, The Netherlands
    Ned Tijdschr Geneeskd 155:A2622. 2011
    ..The newer agents such as tumour necrosis factor (TNF) alpha blocking agents can also be of use. Specific preconception care should be offered to women with rheumatic diseases to optimize and increase chances of a successful pregnancy...
  31. doi request reprint Urban perinatal health inequalities
    Jashvant Poeran
    Erasmus University Rotterdam, Institute of Health Policy and Management, PO Box 1738, Rotterdam 3000 DR, The Netherlands
    J Matern Fetal Neonatal Med 24:643-6. 2011
    ..Large urban areas have higher perinatal mortality rates. In attaining a better understanding, we conducted an analysis on a neighborhood level in Rotterdam, the second largest city of The Netherlands...
  32. doi request reprint Intrauterine cannabis exposure leads to more aggressive behavior and attention problems in 18-month-old girls
    Hanan El Marroun
    The Department of Child and Adolescent Psychiatry, Erasmus MC, Sophia Children s Hospital, Rotterdam 3000 CB, The Netherlands
    Drug Alcohol Depend 118:470-4. 2011
    ..In this study, we aimed to determine the relationship between gestational cannabis use and childhood attention problems and aggressive behavior...
  33. doi request reprint Preferences for postpartum lifestyle counseling among women sharing an increased cardiovascular and metabolic risk: a focus group study
    Meeke Hoedjes
    Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands
    Hypertens Pregnancy 30:83-92. 2011
    ..To describe women's preferences for postpartum lifestyle counseling after a pregnancy complicated by preeclampsia, intrauterine growth restriction, and/or gestational diabetes...
  34. doi request reprint Postpartum depression after mild and severe preeclampsia
    Meeke Hoedjes
    Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Womens Health (Larchmt) 20:1535-42. 2011
    ....
  35. ncbi request reprint [Innovative three-dimensional imaging: opportunities for virtual embryoscopy]
    Melek Rousian
    Erasmus Medisch Centrum, afd Verloskunde en Vrouwenziekten, Rotterdam, The Netherlands
    Ned Tijdschr Geneeskd 154:A1606. 2010
    ..This may contribute to prenatal diagnostics being brought forward from the second and third trimesters to the first trimester of pregnancy...
  36. doi request reprint Ethnic differences in participation in prenatal screening for Down syndrome: a register-based study
    Mirjam P Fransen
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Prenat Diagn 30:988-94. 2010
    ..To assess ethnic differences in participation in prenatal screening for Down syndrome in the Netherlands...
  37. doi request reprint Ethnic differences in informed decision-making about prenatal screening for Down's syndrome
    Mirjam P Fransen
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Epidemiol Community Health 64:262-8. 2010
    ..The aim of this study was to assess ethnic variations in informed decision-making about prenatal screening for Down's syndrome and to examine the contribution of background and decision-making variables...
  38. ncbi request reprint Growth, development and health from early fetal life until young adulthood: the Generation R Study
    Albert Hofman
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Sophia Children s Hospital, Rotterdam, The Netherlands
    Paediatr Perinat Epidemiol 18:61-72. 2004
    ..The study entered its pilot phase to test the logistics in December 2001. Full participant recruitment and complete data collection started in 2002...
  39. doi request reprint Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide
    Lydi M J W van Driel
    Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology, Erasmus University Medical Centre, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Eur Heart J 29:1424-31. 2008
    ....
  40. doi request reprint Active and passive maternal smoking during pregnancy and the risks of low birthweight and preterm birth: the Generation R Study
    Vincent W V Jaddoe
    The Generation R Study Group, and Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Paediatr Perinat Epidemiol 22:162-71. 2008
    ..Smoking in early pregnancy only, seems not to affect fetal growth adversely. Health care strategies for pregnant women should be aimed at quitting smoking completely rather than reducing the number of cigarettes...
  41. pmc The Generation R Study Biobank: a resource for epidemiological studies in children and their parents
    Vincent W V Jaddoe
    The Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 22:917-23. 2007
    ....
  42. ncbi request reprint The outcome of gastroschisis after a prenatal diagnosis or a diagnosis only at birth. Recommendations for prenatal surveillance
    Titia E Cohen-Overbeek
    Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 139:21-7. 2008
    ..Intestinal atresia established after birth and preterm versus term delivery were studied as risk factors...
  43. ncbi request reprint Moderate alcohol consumption during pregnancy and the risk of low birth weight and preterm birth. The generation R study
    Vincent W V Jaddoe
    Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands
    Ann Epidemiol 17:834-40. 2007
    ..To examine the associations of alcohol consumption in different periods of pregnancy with the risks of low birth weight and preterm birth...
  44. ncbi request reprint Ethnic differences in determinants of participation and non-participation in prenatal screening for Down syndrome: a theoretical framework
    Mirjam P Fransen
    Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    Prenat Diagn 27:938-50. 2007
    ..To develop a theoretical framework for analysing ethnic differences in determinants of participation and non-participation in prenatal screening for Down syndrome...
  45. ncbi request reprint Risk of complications during pregnancy in women with congenital aortic stenosis
    Sing Chien Yap
    Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands
    Int J Cardiol 126:240-6. 2008
    ..Data on non-cardiac complications are limited, and this information is crucial for prenatal counselling and perinatal care. The aim of this study was to present the maternal and perinatal outcome of pregnancy in women with congenital AS...
  46. ncbi request reprint Application of the magnitude-squared coherence function between uterine and umbilical flow velocity waveforms for predicting placental dysfunction: a preliminary study
    Pieter C Struijk
    Department of Obstetrics and Gynecology, Erasmus MC, Division Obstetrics and Prenatal Medicine, Rotterdam, The Netherlands
    Ultrasound Med Biol 33:1057-63. 2007
    ..The inclusion of magnitude-squared coherence as one of the prediction parameters may improve the early identification of pregnancies subsequently complicated by preeclampsia...
  47. ncbi request reprint Maternal smoking and fetal growth characteristics in different periods of pregnancy: the generation R study
    Vincent W V Jaddoe
    The Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Epidemiol 165:1207-15. 2007
    ..The larger effect on femur length suggests that smoking during pregnancy affects primarily peripheral tissues...
  48. ncbi request reprint The Generation R Study: Design and cohort profile
    Vincent W V Jaddoe
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 21:475-84. 2006
    ..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
  49. ncbi request reprint Insufficient efficacy of intravenous ketanserin in severe early-onset pre-eclampsia
    Lidwien M Hanff
    Department of Hospital Pharmacy, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 128:199-203. 2006
    ..To analyze the efficacy of intravenous ketanserin in controlling blood pressure of severe early-onset pre-eclamptic patients...
  50. ncbi request reprint Maternal and perinatal outcome of preeclampsia with an onset before 24 weeks' gestation. Audit in a tertiary referral center
    Ingrid P M Gaugler-Senden
    Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Hospital Rotterdam, SKZ 4130, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 128:216-21. 2006
    ..We therefore, evaluated pregnancy outcome in these women at our department where temporising management was introduced as the standard policy in early onset preeclampsia...
  51. ncbi request reprint Increased expression of vascular endothelial growth factor in cardiac structures of fetus with hydrops as compared to nonhydropic controls
    Helen Brandenburg
    Department of Obstetrics and Gynecology, Erasmus Medical Center, University of Rotterdam, Rotterdam, The Netherlands
    Fetal Diagn Ther 21:84-91. 2006
    ..The hypothesis that severe fetal hydrops is caused by an excess of vascular endothelial growth factor (VEGF), mainly produced in the fetal heart, is tested...
  52. ncbi request reprint Intravenous use of the calcium-channel blocker nicardipine as second-line treatment in severe, early-onset pre-eclamptic patients
    Lidwien M Hanff
    Department of Hospital Pharmacy, Rotterdam, The Netherlands
    J Hypertens 23:2319-26. 2005
    ..To evaluate the efficacy of intravenous administration of nicardipine as a second-line temporizing treatment in severe, early-onset, pre-eclamptic patients...
  53. doi request reprint Two MTHFR polymorphisms, maternal B-vitamin intake, and CHDs
    Lydi M J W van Driel
    Department of Obstetrics and Gynecology Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Birth Defects Res A Clin Mol Teratol 82:474-81. 2008
    ..Whether these polymorphisms are associated with CHDs is not clear. We studied both MTHFR polymorphisms, folate and vitamin B2 by maternal food intake and supplements, and CHD risk...
  54. doi request reprint Severe, very early onset preeclampsia: subsequent pregnancies and future parental cardiovascular health
    Ingrid P M Gaugler-Senden
    Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center Rotterdam, SKZ 4130, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 140:171-7. 2008
    ..To study subsequent pregnancy outcome in women with severe, very early onset preeclampsia (onset before 24 weeks' gestation) and to analyze cardiovascular risk profiles of these women and their partners...
  55. doi request reprint The Generation R Study: design and cohort update until the age of 4 years
    Vincent W V Jaddoe
    The Generation R Study Group AE006, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 23:801-11. 2008
    ..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
  56. doi request reprint Fetal and postnatal growth and body composition at 6 months of age
    Lamise Ay
    The Generation R Study Group AE006, Department of Pediatrics, Erasmus Medical Center, P O Box 2040, Rotterdam 3000 CA, The Netherlands
    J Clin Endocrinol Metab 94:2023-30. 2009
    ....
  57. doi request reprint Periconception folic acid supplementation, fetal growth and the risks of low birth weight and preterm birth: the Generation R Study
    Sarah Timmermans
    The Generation R Study Group, Erasmus MC, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Br J Nutr 102:777-85. 2009
    ..28, 0.69 and OR 0.40, 95 % CI 0.22, 0.72). In conclusion, periconception folic acid supplementation is associated with increased fetal growth resulting in higher placental and birth weight, and decreased risks of low birth weight and SGA...
  58. ncbi request reprint V-scope: design and implementation of an immersive and desktop virtual reality volume visualization system
    Anton H J Koning
    Department of Bioinformatics, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Stud Health Technol Inform 142:136-8. 2009
    ..This greatly improves the understanding of the data, and allows the efficient measurement of volumes and distances in a way that was previously not possible...
  59. doi request reprint No midpregnancy fall in diastolic blood pressure in women with a low educational level: the Generation R Study
    Lindsay M Silva
    The Generation R Study Group, Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hypertension 52:645-51. 2008
    ..This might partly explain these women's susceptibility to preeclampsia...
  60. doi request reprint Are starting and continuing breastfeeding related to educational background? The generation R study
    Lenie van Rossem
    Generation R Study Group, Department of Public Health, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands
    Pediatrics 123:e1017-27. 2009
    ..To assess the effect of a woman's educational level on starting and continuing breastfeeding and to assess the role of sociodemographic, lifestyle-related, psychosocial, and birth characteristics in this association...
  61. doi request reprint Smoking during pregnancy in ethnic populations: the Generation R study
    Ernst Jan W M Troe
    The Generation R Study Group, Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
    Nicotine Tob Res 10:1373-84. 2008
    ..Smoking rates and correlates of smoking during pregnancy varied by ethnic background. These observations should be considered when designing maternal smoking prevention and intervention strategies...
  62. doi request reprint Determinants of folic acid use in early pregnancy in a multi-ethnic urban population in The Netherlands: the Generation R study
    Sarah Timmermans
    Department of Obstetrics and Gynecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC Rotterdam, The Netherlands
    Prev Med 47:427-32. 2008
    ..Recommendations on folic acid use to prevent neural tube defects have been launched in several countries. Adequate folic acid use seems to be low. This study assesses the prevalence of folic acid use and identifies its determinants...
  63. doi request reprint Maternal intake of fat, riboflavin and nicotinamide and the risk of having offspring with congenital heart defects
    Huberdina P M Smedts
    Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Centre, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    Eur J Nutr 47:357-65. 2008
    ..Fatty acids play a central role in embryonic development, and the B-vitamins riboflavin and nicotinamide are co-enzymes in lipid metabolism...
  64. doi request reprint Embryonic delay in growth and development related to confined placental trisomy 16 mosaicism, diagnosed by I-Space Virtual Reality
    Christine M Verwoerd-Dikkeboom
    Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Fertil Steril 90:2017.e19-22. 2008
    ..To demonstrate the use of a novel three-dimensional (3D) virtual reality (VR) system in the visualization of first trimester growth and development in a case of confined placental trisomy 16 mosaicism (CPM+16)...
  65. doi request reprint Growth, obesity, and cardiac structures in early childhood: the Generation R Study
    Layla L de Jonge
    Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Hypertension 57:934-40. 2011
    ..Overweight and obese children show cardiac adaptations already at the age of 2 years. Further studies are needed to assess whether these structural adaptations influence the risk of cardiovascular disease in later life...
  66. doi request reprint Virtual reality for embryonic measurements requiring depth perception
    Melek Rousian
    Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Fertil Steril 95:773-4. 2011
    ..Inherently three-dimensional structures, like the umbilical cord and limbs, can be efficiently and accurately measured using VR...
  67. doi request reprint Glucocorticoid receptor-9beta polymorphism is associated with systolic blood pressure and heart growth during early childhood. The Generation R Study
    J J Miranda Geelhoed
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Early Hum Dev 87:97-102. 2011
    ..glucocorticoid receptor-9β polymorphism (rs6198) is associated with the susceptibility for cardiovascular disease...
  68. doi request reprint First trimester umbilical cord and vitelline duct measurements using virtual reality
    Melek Rousian
    Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Early Hum Dev 87:77-82. 2011
    ..Virtual reality (VR) allows efficient visualisation and measurement of complex structures like the umbilical cord and vitelline duct...
  69. doi request reprint Foetal and postnatal growth and bone mass at 6 months: the Generation R Study
    Lamise Ay
    The Generation R Study Group, Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 74:181-90. 2011
    ..To examine whether parental, foetal and postnatal characteristics and growth patterns in foetal life and infancy are associated with bone mass at 6 months, as bone acquisition seems to be associated with genetic and environmental factors...
  70. doi request reprint Pregnancy-induced fluctuations in functional T-cell subsets in multiple sclerosis patients
    Rinze F Neuteboom
    Department of Neurology, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands
    Mult Scler 16:1073-8. 2010
    ..During pregnancy, especially during the third trimester, multiple sclerosis (MS) disease activity is reduced. It is not known which factors mediate this disease amelioration...
  71. doi request reprint Genetic and lifestyle factors related to the periconception vitamin B12 status and congenital heart defects: a Dutch case-control study
    Anna C Verkleij-Hagoort
    Department of Obstetrics, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Mol Genet Metab 94:112-9. 2008
    ..The future enlargement of our sample size might demonstrate significant associations...
  72. doi request reprint First trimester interleukin 8 levels are associated with postpartum relapse in multiple sclerosis
    Rinze F Neuteboom
    Department of Neurology, Erasmus MC, Rotterdam, The Netherlands
    Mult Scler 15:1356-8. 2009
    ..03). High first trimester serum levels of interleukin 8 were associated with a high risk of postpartum relapse (p = 0.007). These results help us to further understand the altered disease course during pregnancy...
  73. ncbi request reprint Human fetal albumin synthesis rates during different periods of gestation
    Chris H P van den Akker
    Department of Pediatrics, Division of Neonatology, Erasmus MC Sophia Children s Hospital, Rotterdam, Netherlands
    Am J Clin Nutr 88:997-1003. 2008
    ..Despite nutritional intervention, albumin concentrations are often low in critically ill premature neonates...
  74. doi request reprint Human fetal amino acid metabolism at term gestation
    Chris H P van den Akker
    Department of Pediatrics, Division of Neonatology, Erasmus MC Sophia Children s Hospital, Rotterdam, Netherlands
    Am J Clin Nutr 89:153-60. 2009
    ..Phenylalanine kinetics is of special interest as is debate as to whether neonates will adequately hydroxylate phenylalanine to the semiessential AA tyrosine...
  75. doi request reprint Maternal medication use, carriership of the ABCB1 3435C > T polymorphism and the risk of a child with cleft lip with or without cleft palate
    Bart J B Bliek
    Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Am J Med Genet A 149:2088-92. 2009
    ..2, 95% CI = 1.0-369.2). These data suggest that mothers who carry the ABCB1 3435C > T polymorphism are at significantly increased risk for having offspring with CL/P, especially mothers using medication in the periconceptional period...
  76. pmc The influence of labour on the pharmacokinetics of intravenously administered amoxicillin in pregnant women
    Anouk E Muller
    Erasmus MC, University Medical Centre Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    Br J Clin Pharmacol 66:866-74. 2008
    ..These might change the pharmacokinetics of amoxicillin, necessitating adjustment of the dose for prevention of neonatal infections. We investigated the influence of labour on the pharmacokinetics of amoxicillin...
  77. ncbi request reprint Preconception folic acid treatment affects the microenvironment of the maturing oocyte in humans
    Jolanda C Boxmeer
    Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Fertil Steril 89:1766-70. 2008
    ..To investigate the influence of folic acid supplementation on the follicular fluid concentrations of folate and total homocysteine and their relationship to the diameter of the follicle...
  78. ncbi request reprint A longitudinal study of antioxidant status during uncomplicated and hypertensive pregnancies
    Eva Maria Roes
    Department of Obstetrics and Gynaecology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Acta Obstet Gynecol Scand 85:148-55. 2006
    ....
  79. ncbi request reprint Dutch community midwives' views on preconception care
    Peter N A C M van Heesch
    Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Midwifery 22:120-4. 2006
    ....