L E Stearne

Summary

Affiliation: Erasmus University
Country: The Netherlands

Publications

  1. pmc In vivo efficacy of trovafloxacin against Bacteroides fragilis in mixed infection with either Escherichia coli or a vancomycin-resistant strain of Enterococcus faecium in an established-abscess murine model
    L E Stearne
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 45:1394-401. 2001
  2. ncbi request reprint Biodistribution of long-circulating PEG-liposomes in a murine model of established subcutaneous abscesses
    Lorna E T Stearne
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, P O Box 1738, 3000 DR, Netherlands
    Biochim Biophys Acta 1561:91-7. 2002
  3. pmc Effect of a single percutaneous abscess drainage puncture and imipenem therapy, alone or in combination, in treatment of mixed-infection abscesses in mice
    Lorna E T Stearne
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, The Netherlands
    Antimicrob Agents Chemother 46:3712-8. 2002
  4. pmc Effect of recombinant murine granulocyte colony-stimulating factor with or without fluoroquinolone therapy on mixed-infection abscesses in mice
    Lorna E T Stearne
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Antimicrob Agents Chemother 49:3668-75. 2005
  5. pmc Effect of dosing and dosing frequency on the efficacy of ceftizoxime and the emergence of ceftizoxime resistance during the early development of murine abscesses caused by Bacteroides fragilis and Enterobacter cloacae mixed infection
    Lorna E T Stearne
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, 6500 GS, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 51:3605-11. 2007
  6. pmc Comparative study of the effects of ceftizoxime, piperacillin, and piperacillin-tazobactam concentrations on antibacterial activity and selection of antibiotic-resistant mutants of Enterobacter cloacae and Bacteroides fragilis in vitro and in vivo in mixe
    Lorna E T Stearne
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 48:1688-98. 2004

Detail Information

Publications6

  1. pmc In vivo efficacy of trovafloxacin against Bacteroides fragilis in mixed infection with either Escherichia coli or a vancomycin-resistant strain of Enterococcus faecium in an established-abscess murine model
    L E Stearne
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 45:1394-401. 2001
    ..In addition, we have shown for the first time that a decrease in bacterial numbers also leads to a reduction in both abscess weight and inflammation...
  2. ncbi request reprint Biodistribution of long-circulating PEG-liposomes in a murine model of established subcutaneous abscesses
    Lorna E T Stearne
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, P O Box 1738, 3000 DR, Netherlands
    Biochim Biophys Acta 1561:91-7. 2002
    ..We conclude that PEG-liposomes localise to a significant degree at the infection focus in our mouse model and may provide a new approach to the antimicrobial treatment of intra-abdominal abscesses...
  3. pmc Effect of a single percutaneous abscess drainage puncture and imipenem therapy, alone or in combination, in treatment of mixed-infection abscesses in mice
    Lorna E T Stearne
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, The Netherlands
    Antimicrob Agents Chemother 46:3712-8. 2002
    ..Possible reasons for the reduced activity of imipenem in vivo are discussed, and we conclude that standard susceptibility tests overestimate the efficacy of this antibiotic against the organisms present in these abscesses...
  4. pmc Effect of recombinant murine granulocyte colony-stimulating factor with or without fluoroquinolone therapy on mixed-infection abscesses in mice
    Lorna E T Stearne
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Antimicrob Agents Chemother 49:3668-75. 2005
    ..In conclusion, the addition of G-CSF to a fluoroquinolone is not advisable since, depending on the virulence of the E. coli strains, this might detrimentally influence the outcome of therapy...
  5. pmc Effect of dosing and dosing frequency on the efficacy of ceftizoxime and the emergence of ceftizoxime resistance during the early development of murine abscesses caused by Bacteroides fragilis and Enterobacter cloacae mixed infection
    Lorna E T Stearne
    Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, 6500 GS, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 51:3605-11. 2007
    ..cloacae mutants. An fAUC-to-MIC ratio of 1,000 was needed to prevent the emergence of this resistance...
  6. pmc Comparative study of the effects of ceftizoxime, piperacillin, and piperacillin-tazobactam concentrations on antibacterial activity and selection of antibiotic-resistant mutants of Enterobacter cloacae and Bacteroides fragilis in vitro and in vivo in mixe
    Lorna E T Stearne
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Antimicrob Agents Chemother 48:1688-98. 2004
    ..cloacae and B. fragilis. Results demonstrate the adverse microbiological outcome of choosing an expanded-spectrum cephalosporin like CZX for empirical treatment of mixed infections involving a susceptible Enterobacter strain...