Affiliation: Erasmus University
Country: The Netherlands
- Transcriptional control of t lymphocyte differentiationF J Staal
Department of Immunology, Erasmus University Rotterdam, Rotterdam, Netherlands
Stem Cells 19:165-79. 2001..Here we will review the TF families that play an important role in differentiation of thymocytes, particularly focusing on recent new information with respect to the Tcf, bHLH, GATA, and CBF/HES TF families...
- A novel germline mutation of PTEN associated with brain tumours of multiple lineagesF J T Staal
Department of Immunology, Erasmus University Rotterdam, Rotterdam, The Netherlands
Br J Cancer 86:1586-91. 2002..Together, these findings suggest that the Arg234Gln missense mutation in PTEN has oncogenic properties and predisposes to brain tumours of multiple lineages...
- Tcf/Lef transcription factors during T-cell development: unique and overlapping functionsF J Staal
Department of Immunology, Utrecht Medical Center, Utrecht, The Netherlands
Hematol J 1:3-6. 2000..In the absence of Wnt signaling, Tcf factors associate with proteins of the Groucho family of transcriptional repressors to strongly repress target gene transcription...
- Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcriptionF J Staal
Department of Immunology and Center for Biomedical Genetics, Utrecht Medical Center, Utrecht, The Netherlands
Eur J Immunol 31:285-93. 2001..Retroviral expression of soluble Wnt receptor mutants that block Wnt signaling inhibits thymocyte development. These results imply an important role for the Wnt cascade in thymocyte development...