P D Siersema

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Therapeutic esophageal interventions for dysphagia and bleeding
    Peter D Siersema
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Curr Opin Gastroenterol 22:442-7. 2006
  2. ncbi request reprint [Guideline 'Diagnosis and treatment of oesophageal carcinoma']
    P D Siersema
    Erasmus MC Centrum, Rotterdam
    Ned Tijdschr Geneeskd 150:1877-82. 2006
  3. pmc Colonic stenting as bridge to surgery versus emergency surgery for management of acute left-sided malignant colonic obstruction: a multicenter randomized trial (Stent-in 2 study)
    Jeanin E van Hooft
    Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
    BMC Surg 7:12. 2007
  4. pmc Stent versus gastrojejunostomy for the palliation of gastric outlet obstruction: a systematic review
    Suzanne M Jeurnink
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, The Netherlands
    BMC Gastroenterol 7:18. 2007
  5. ncbi request reprint New developments in palliative therapy
    Peter D Siersema
    Chief of Endoscopy, Head of the Gastrointestinal Oncology Program Department of Gastroenterology and Hepatology, Room Hs 512, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Best Pract Res Clin Gastroenterol 20:959-78. 2006
  6. ncbi request reprint [Palliative treatment in patients with oesophagus carcinoma]
    P D Siersema
    Erasmus MC, afd Maag, Darm en Leverziekten, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 149:2775-82. 2005
  7. ncbi request reprint Endoscopic therapeutic esophageal interventions: what is new? What needs further study? What can we forget?
    Peter D Siersema
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Curr Opin Gastroenterol 21:490-7. 2005
  8. ncbi request reprint Phase II study of neo-adjuvant chemotherapy with paclitaxel and cisplatin given every 2 weeks for patients with a resectable squamous cell carcinoma of the esophagus
    M B Polee
    Department of Medical Oncology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Ann Oncol 14:1253-7. 2003
  9. pmc Nurse-led follow-up of patients after oesophageal or gastric cardia cancer surgery: a randomised trial
    E M L Verschuur
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Br J Cancer 100:70-6. 2009
  10. ncbi request reprint Self-expanding metal stents for complicated and recurrent esophagogastric cancer
    P D Siersema
    Department of Gastroenterology and Hepatology, University Hospital Rotterdam-Dijkzigt, Rotterdam, The Netherlands
    Gastrointest Endosc 54:579-86. 2001

Detail Information

Publications152 found, 100 shown here

  1. ncbi request reprint Therapeutic esophageal interventions for dysphagia and bleeding
    Peter D Siersema
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Curr Opin Gastroenterol 22:442-7. 2006
    ..This article reviews the most notable results of esophageal interventions for dysphagia and bleeding published in 2005...
  2. ncbi request reprint [Guideline 'Diagnosis and treatment of oesophageal carcinoma']
    P D Siersema
    Erasmus MC Centrum, Rotterdam
    Ned Tijdschr Geneeskd 150:1877-82. 2006
    ..Psychosocial support is an important element in the follow-up of patients with oesophageal carcinoma...
  3. pmc Colonic stenting as bridge to surgery versus emergency surgery for management of acute left-sided malignant colonic obstruction: a multicenter randomized trial (Stent-in 2 study)
    Jeanin E van Hooft
    Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
    BMC Surg 7:12. 2007
    ....
  4. pmc Stent versus gastrojejunostomy for the palliation of gastric outlet obstruction: a systematic review
    Suzanne M Jeurnink
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, The Netherlands
    BMC Gastroenterol 7:18. 2007
    ..Recently, stent placement has been introduced as an alternative treatment. We reviewed the available literature on stent placement and GJJ for gastric outlet obstruction, with regard to medical effects and costs...
  5. ncbi request reprint New developments in palliative therapy
    Peter D Siersema
    Chief of Endoscopy, Head of the Gastrointestinal Oncology Program Department of Gastroenterology and Hepatology, Room Hs 512, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Best Pract Res Clin Gastroenterol 20:959-78. 2006
    ..In the future, a multimodal approach--for example by combining stent placement with chemotherapy or radiotherapy--may improve the prognosis of patients without jeopardizing their quality of life...
  6. ncbi request reprint [Palliative treatment in patients with oesophagus carcinoma]
    P D Siersema
    Erasmus MC, afd Maag, Darm en Leverziekten, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 149:2775-82. 2005
    ..Quality of life is an important endpoint to consider in the palliative treatment of patients with oesophageal cancer. Well-established standardized and validated questionnaires are available for this purpose...
  7. ncbi request reprint Endoscopic therapeutic esophageal interventions: what is new? What needs further study? What can we forget?
    Peter D Siersema
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Curr Opin Gastroenterol 21:490-7. 2005
    ..Endoscopic esophageal interventions form an important part of gastrointestinal endoscopy. This article reviews the most notable results of esophageal endoscopy and interventions published in 2004...
  8. ncbi request reprint Phase II study of neo-adjuvant chemotherapy with paclitaxel and cisplatin given every 2 weeks for patients with a resectable squamous cell carcinoma of the esophagus
    M B Polee
    Department of Medical Oncology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Ann Oncol 14:1253-7. 2003
    ..In this study we investigate the feasibility and efficacy of this regimen in a neo-adjuvant setting...
  9. pmc Nurse-led follow-up of patients after oesophageal or gastric cardia cancer surgery: a randomised trial
    E M L Verschuur
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Br J Cancer 100:70-6. 2009
    ..This type of care is very likely to be more cost effective than physician-led follow-up...
  10. ncbi request reprint Self-expanding metal stents for complicated and recurrent esophagogastric cancer
    P D Siersema
    Department of Gastroenterology and Hepatology, University Hospital Rotterdam-Dijkzigt, Rotterdam, The Netherlands
    Gastrointest Endosc 54:579-86. 2001
    ..Placement should be considered at an early stage in these conditions...
  11. ncbi request reprint Phase I study of a weekly schedule of a fixed dose of cisplatin and escalating doses of paclitaxel in patients with advanced oesophageal cancer
    M B Polee
    Department of Medical Oncology, University Hospital Rotterdam, Dijkzigt, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    Eur J Cancer 38:1495-500. 2002
    ..Occurring diarrhoea should be handled with caution because it may be a sign of neutropenic enterocolitis. The response rate of this dose-dense schedule seems encouraging...
  12. pmc Porphyrin biosynthesis in human Barrett's oesophagus and adenocarcinoma after ingestion of 5-aminolaevulinic acid
    P Hinnen
    Department of Gastroenterology and Internal Medicine II, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    Br J Cancer 83:539-43. 2000
    ..e. PBG-D) and lower PPIX precursor concentrations were found in BE and AC compared to SQ. It is therefore possible that PPIX levels will peak at earlier time intervals in BE and AC compared to SQ...
  13. doi request reprint Cost comparison of gastrojejunostomy versus duodenal stent placement for malignant gastric outlet obstruction
    S M Jeurnink
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, s Gravendijkwal 230, Rotterdam, The Netherlands
    J Gastroenterol 45:537-43. 2010
    ..As health economic aspects have only been studied in general terms, we estimated the cost of GJJ and that of stent placement in such patients...
  14. doi request reprint Single and sequential biodegradable stent placement for refractory benign esophageal strictures: a prospective follow-up study
    M M C Hirdes
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Endoscopy 44:649-54. 2012
    ..The aim of this study was to evaluate the safety and long term efficacy of single and sequential biodegradable stent placement in patients with RBES...
  15. ncbi request reprint Does CDX2 expression predict Barrett's metaplasia in oesophageal columnar epithelium without goblet cells?
    M Kerkhof
    Department of Gastroenterology and Hepatology, Erasus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Aliment Pharmacol Ther 24:1613-21. 2006
    ..As intestinal metaplasia and cardiac-type mucosa are endoscopically indiscernible, it is difficult to take targeted samples from columnar-lined oesophagus with consequently a risk of having undetected intestinal metaplasia...
  16. doi request reprint Surgical gastrojejunostomy or endoscopic stent placement for the palliation of malignant gastric outlet obstruction (SUSTENT study): a multicenter randomized trial
    Suzanne M Jeurnink
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Gastrointest Endosc 71:490-9. 2010
    ..Both gastrojejunostomy (GJJ) and stent placement are commonly used palliative treatments of obstructive symptoms caused by malignant gastric outlet obstruction (GOO)...
  17. ncbi request reprint A comparison of 3 types of covered metal stents for the palliation of patients with dysphagia caused by esophagogastric carcinoma: a prospective, randomized study
    P D Siersema
    Departments of Gastroenterology and Hepatology and Epidemiology and Biostatistics, University Hospital Rotterdam-Dijkzigt, Rotterdam, The Netherlands
    Gastrointest Endosc 54:145-53. 2001
    ..Although stent migration is reduced by increasing stent diameter, tumor overgrowth remains an intractable problem that requires a new approach...
  18. ncbi request reprint Stent placement or brachytherapy for palliation of dysphagia from esophageal cancer: a prognostic model to guide treatment selection
    Ewout W Steyerberg
    Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, The Netherlands
    Gastrointest Endosc 62:333-40. 2005
    ..The benefit of brachytherapy, however, only occurred after a relatively long survival. The objective is to develop a model that distinguishes patients with a poor prognosis from those with a relatively good prognosis...
  19. pmc Prognostic factors for survival in patients with advanced oesophageal cancer treated with cisplatin-based combination chemotherapy
    M B Polee
    Department of Medical Oncology, Erasmus Medical Center, Rotterdam, The Netherlands
    Br J Cancer 89:2045-50. 2003
    ..The performance status, extent of disease, LDH and the addition of paclitaxel to cisplatin are independent prognostic factors in patients with advanced oesophageal cancer, who are treated with cisplatin-based combination chemotherapy...
  20. pmc Predictors of complications after endoscopic retrograde cholangiopancreatography: a prognostic model for early discharge
    S M Jeurnink
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Surg Endosc 25:2892-900. 2011
    ....
  21. pmc The role of socio-economic status in the decision making on diagnosis and treatment of oesophageal cancer in The Netherlands
    E P M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Br J Cancer 95:1180-5. 2006
    ..Moreover, the correlations between SES and different treatment modalities suggest that both patient and doctor determinants contribute to the decision on the most optimal treatment modality in patients with oesophageal cancer...
  22. ncbi request reprint Gastrojejunostomy versus stent placement in patients with malignant gastric outlet obstruction: a comparison in 95 patients
    S M Jeurnink
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, The Netherlands
    J Surg Oncol 96:389-96. 2007
    ..In this retrospective study, we compared GJJ and stent placement with regard to medical effects...
  23. ncbi request reprint Kinetics, localization, and mechanism of 5-aminolevulinic acid-induced porphyrin accumulation in normal and Barrett's-like rat esophagus
    J van den Boogert
    Department of Surgery, Erasmus University Medical Faculty, Rotterdam, The Netherlands
    Lasers Surg Med 24:3-13. 1999
    ..To optimize photosensitizer administration, the kinetics of 5-aminolevulinic acid (ALA)-induced porphyrin accumulation in the normal and Barrett's-like esophagus were studied in the rat...
  24. doi request reprint Predictors for neoplastic progression in patients with Barrett's Esophagus: a prospective cohort study
    M Sikkema
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Gastroenterol 106:1231-8. 2011
    ..The aim of this study was to identify such predictors of progression to high-grade dysplasia (HGD) and EAC in patients with BE after 4 years of surveillance and to develop a prediction model based on these factors...
  25. doi request reprint Gastro-oesophageal reflux, medical resource utilization and upper gastrointestinal endoscopy in patients at risk of oesophageal adenocarcinoma
    E M van Soest
    Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Aliment Pharmacol Ther 28:137-43. 2008
    ..Early identification of patients at risk of oesophageal adenocarcinoma (OAC) might improve survival...
  26. ncbi request reprint [Palliative treatment of esophageal cancer with dysphagia: more favourable outcome from single-dose internal brachytherapy than from the placement of a self-expanding stent; a multicenter randomised study]
    M Y V Homs
    afd Maag, Darm en Leverziekten, Erasmus MC, locatie Dijkzigt, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 149:2800-6. 2005
    ..To compare the results of single-dose internal irradiation (brachytherapy) and self-expanding metal stent placement in the palliation of oesophageal obstruction due to cancer of the oesophagus...
  27. doi request reprint First data on the Evolution duodenal stent for palliation of malignant gastric outlet obstruction (DUOLUTION study): a prospective multicenter study
    M W van den Berg
    Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Endoscopy 45:174-81. 2013
    ..This study is the first to describe the results regarding technical success, clinical success, complication rate, and stent dysfunction of the Evolution duodenal stent (Cook Medical, Limerick, Ireland)...
  28. pmc MUC4 is increased in high grade intraepithelial neoplasia in Barrett's oesophagus and is associated with a proapoptotic Bax to Bcl-2 ratio
    D A Bax
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, 3015 GD Rotterdam, The Netherlands
    J Clin Pathol 57:1267-72. 2004
    ..Patients with Barrett's oesophagus (BO) are at risk of oesophageal adenocarcinoma. Because the pattern of mucosal mucins changes during neoplastic progression, it may serve as a marker of intraepithelial neoplasia...
  29. pmc Timing of illumination is essential for effective and safe photodynamic therapy: a study in the normal rat oesophagus
    J van den Boogert
    Laboratory for Experimental Surgery, Erasmus University, Rotterdam, The Netherlands
    Br J Cancer 79:825-30. 1999
    ..A short interval of 2-3 h seems to be most appropriate...
  30. pmc Phase I study of a biweekly schedule of a fixed dose of cisplatin with increasing doses of paclitaxel in patients with advanced oesophageal cancer
    A van der Gaast
    Department of Medical Oncology, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    Br J Cancer 80:1052-7. 1999
    ..At higher dose levels, neurotoxicity becomes the dose-limiting toxicity. The observed response rate warrants further investigation of this schedule...
  31. ncbi request reprint Predicting presence of intestinal metaplasia and dysplasia in columnar-lined esophagus: a multivariate analysis
    M Kerkhof
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Endoscopy 39:772-8. 2007
    ..In patients with presumed Barrett esophagus we evaluated clinical risk factors that could predict the presence of intestinal metaplasia and dysplasia in biopsies of columnar-lined esophagus (CLE), independently of histological results...
  32. doi request reprint Expression of p53 as predictor for the development of esophageal cancer in achalasia patients
    I Leeuwenburgh
    Department of Gastroenterology and Hepatology, Erasmus University Medical Centre Rotterdam, The Netherlands
    Dis Esophagus 23:506-11. 2010
    ..Further study is needed to determine if patients with p53 overexpression would benefit from intensive surveillance to detect esophageal neoplasia at a potential curable stage...
  33. ncbi request reprint Palliative therapy
    Marjolein Y V Homs
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    J Surg Oncol 92:246-56. 2005
    ..For the future, a multimodality approach with stent placement or brachytherapy in combination with chemotherapy may be indicated...
  34. ncbi request reprint [Gastrojejunostomy versus endoscopic stent placement as palliative treatment of malignant stenosis of the duodenum: overview of advantages and disadvantages on the basis of a literature study]
    S M Jeurnink
    Erasmus MC Centrum, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 151:536-42. 2007
    ..To compare the results of stent placement and gastrojejunostomy in patients with malignant gastric outlet obstruction. Design. Systematic review...
  35. ncbi request reprint Experiences and expectations of patients after oesophageal cancer surgery: an explorative study
    E M L Verschuur
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Eur J Cancer Care (Engl) 15:324-32. 2006
    ..Psychosocial problems are also present, but care is less commonly expected. Nurses' involvement during follow-up could be a way to optimize patients' management after oesophageal cancer surgery...
  36. ncbi request reprint Publication bias does not play a role in the reporting of the results of endoscopic ultrasound staging of upper gastrointestinal cancers
    E P M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Endoscopy 39:325-32. 2007
    ..In this study, we assessed whether publication bias was also present in the reporting of EUS staging results in upper gastrointestinal cancer...
  37. ncbi request reprint Environmental risk factors in the development of adenocarcinoma of the oesophagus or gastric cardia: a cross-sectional study in a Dutch cohort
    P J F DE Jonge
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Aliment Pharmacol Ther 26:31-9. 2007
    ..Risk factors for adenocarcinoma of the oesophagus (OAC) and gastric cardia (GCA) are not yet established...
  38. ncbi request reprint High-resolution array comparative genomic hybridization of chromosome 8q: evaluation of putative progression markers for gastroesophageal junction adenocarcinomas
    M van Duin
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    Cytogenet Genome Res 118:130-7. 2007
    ..We conclude that, firstly, there are other genes than MYC involved in the 8q amplification in GEJ cancer. Secondly, the differential expression of these genes contributes to unravel the biology of GEJ adenocarcinomas...
  39. pmc Detection of distant metastases in patients with oesophageal or gastric cardia cancer: a diagnostic decision analysis
    E P M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Br J Cancer 97:868-76. 2007
    ..It remains to be determined whether the application of positron emission tomography will further increase sensitivities and specificities of metastases detection without jeopardising costs and QALYs...
  40. ncbi request reprint Low impact of staging EUS for determining surgical resectability in esophageal cancer
    M Van Zoonen
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    Surg Endosc 26:2828-34. 2012
    ..This study was designed to assess the diagnostic value of EUS for determining resectability of esophageal cancer...
  41. doi request reprint Relationship between esophageal contraction patterns and clearance of swallowed liquid and solid boluses in healthy controls and patients with dysphagia
    A Bogte
    Gastrointestinal Research Unit, Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands
    Neurogastroenterol Motil 24:e364-72. 2012
    ..Esophageal high-resolution manometry (HRM) is a novel method, used to analyze dysphagia. However, it is not yet clear how findings on HRM relate to bolus transport through the esophagus...
  42. ncbi request reprint Oesophagitis is common in patients with achalasia after pneumatic dilatation
    I Leeuwenburgh
    Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Aliment Pharmacol Ther 23:1197-203. 2006
    ..Treatment aims at lowering of the lower oesophageal sphincter pressure, enhancing the risk of gastro-oesophageal reflux. Nevertheless, the incidence of oesophagitis after achalasia treatment is unknown...
  43. doi request reprint Overview of the clinical problem: facts and current issues of mucinous cystic neoplasms of the pancreas
    S M Jeurnink
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre Rotterdam, The Netherlands
    Dig Liver Dis 40:837-46. 2008
    ..Further research may lead to a definitive guideline for the diagnosis and treatment of mucinous cystic neoplasms, intraductal papillary mucinous neoplasms and serous cystic neoplasms...
  44. ncbi request reprint Adherence to gastroprotection and the risk of NSAID-related upper gastrointestinal ulcers and haemorrhage
    E M van Soest
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Aliment Pharmacol Ther 26:265-75. 2007
    ..Upper gastrointestinal (UGI) complications are a well-recognized risk of NSAID treatment, requiring preventive measures in high-risk patients. Adherence to gastroprotective agents (GPAs) in NSAID users has been suggested to be suboptimal...
  45. ncbi request reprint Down syndrome and esophageal cancer
    T G Moreels
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Dis Esophagus 20:183-6. 2007
    ..The second had a short circular adenocarcinoma of the distal esophagus with peritoneal and liver metastases. The cases are discussed with regard to the current literature on Down syndrome and esophageal cancer...
  46. pmc Staging investigations for oesophageal cancer: a meta-analysis
    E P M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Br J Cancer 98:547-57. 2008
    ..Its combined use could however be of clinical value, with FDG-PET detecting possible metastases and CT confirming or excluding their presence and precisely determining the location(s)...
  47. doi request reprint The prevalence of premalignant gastric lesions in asymptomatic patients: predicting the future incidence of gastric cancer
    C M den Hoed
    Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Eur J Cancer 47:1211-8. 2011
    ..The presence of these lesions in the general population predicts the gastric cancer incidence in the coming decades. Prevalence data are mostly obtained from serological studies and endoscopy data in symptomatic patients...
  48. doi request reprint Proton pump inhibitor therapy in gastro-oesophageal reflux disease decreases the oesophageal immune response but does not reduce the formation of DNA adducts
    P J F DE Jonge
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Aliment Pharmacol Ther 28:127-36. 2008
    ..Chronic oesophageal inflammation and related oxidative stress are important in the pathogenesis of erosive oesophagitis (EO) and its malignant progression...
  49. ncbi request reprint Grading of dysplasia in Barrett's oesophagus: substantial interobserver variation between general and gastrointestinal pathologists
    M Kerkhof
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Histopathology 50:920-7. 2007
    ..To determine interobserver variation in grading of dysplasia in Barrett's oesophagus (BO) between non-expert general pathologists and expert gastrointestinal pathologists on the one hand and between expert pathologists on the other hand...
  50. ncbi request reprint Molecular evaluation of ablative therapy of Barrett's oesophagus
    Mariska Hage
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Pathol 205:57-64. 2005
    ..Persistent Barrett's oesophagus may still harbour molecular aberrations and must therefore be considered still to be at risk of progression to adenocarcinoma...
  51. pmc 5-aminolevulinic acid photodynamic therapy versus argon plasma coagulation for ablation of Barrett's oesophagus: a randomised trial
    M Hage
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre Rotterdam, The Netherlands
    Gut 53:785-90. 2004
    ..The aim of this study was to compare 5-aminolevulinic acid induced photodynamic therapy (ALA-PDT) with argon plasma coagulation (APC) with respect to complete reversal of BO...
  52. ncbi request reprint The burden of upper gastrointestinal endoscopy in patients with Barrett's esophagus
    M E Kruijshaar
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Endoscopy 38:873-8. 2006
    ..We assessed to what extent patients perceived this procedure as burdensome...
  53. pmc Cost study of metal stent placement vs single-dose brachytherapy in the palliative treatment of oesophageal cancer
    S Polinder
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, PO Box 1738, 3000 CA Rotterdam, The Netherlands
    Br J Cancer 90:2067-72. 2004
    ..Therefore, cost considerations should not play an important role in decision making on the appropriate palliative treatment strategy for patients with malignant dysphagia...
  54. doi request reprint Stent-in-stent technique for removal of embedded esophageal self-expanding metal stents
    M M C Hirdes
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Gastroenterol 106:286-93. 2011
    ..Our aim is to report the results of removal of embedded, partially covered SEMSs by induction of pressure necrosis using the stent-in-stent technique...
  55. doi request reprint The effects of guideline implementation for proton pump inhibitor prescription on two pulmonary medicine wards
    E P M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Aliment Pharmacol Ther 29:213-21. 2009
    ..It has been demonstrated that 40% of patients admitted to pulmonary medicine wards use proton pump inhibitors (PPIs) without a registered indication...
  56. pmc The homeodomain protein CDX2 is an early marker of Barrett's oesophagus
    L M G Moons
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands
    J Clin Pathol 57:1063-8. 2004
    ..In Barrett's oesophagus (BO), squamous epithelium is replaced by specialised intestinal epithelium (SIE). Transcription factors associated with intestinal differentiation, such as CDX2, may be involved in BO development...
  57. ncbi request reprint [Current surveillance policy for Barrett's oesophagus in the Netherlands]
    W L Curvers
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Maag, Darm en Leverziekten, Meibergdreef9, 1105 AZ Amsterdam
    Ned Tijdschr Geneeskd 151:1879-84. 2007
    ..To gain more insight into current surveillance and treatment of patients with Barrett's oesophagus with the aim of developing new guidelines...
  58. doi request reprint Radiologist experience and CT examination quality determine metastasis detection in patients with esophageal or gastric cardia cancer
    E P M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Eur Radiol 18:2475-84. 2008
    ..Therefore, we suggest that staging procedures for esophageal and gastric cardia cancer should preferably be performed in centers with technically advanced equipment and experienced radiologists...
  59. ncbi request reprint [Acute dysphasia: often there is a readily treatable cause]
    L M Moons
    Erasmus Medisch Centrum, locatie Dijkzigt, afd Maag, Darm en Leverziekten, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 147:1713-7. 2003
    ..The detection of early-stage oesophageal malignancies may improve the prognosis of patients with this disorder...
  60. pmc Trends in the incidence of adenocarcinoma of the oesophagus and cardia in the Netherlands 1989-2003
    M van Blankenstein
    Department of Gastroenterology and Hepatology, Erasmus MC, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Br J Cancer 96:1767-71. 2007
    ..Proposed underlying factors for the rise in ACO incidence appear to have little effect on AGC incidence. This and the secular decline in smoking among males may have led to the decline in AGC incidence...
  61. ncbi request reprint Metal stents for tumors of the distal esophagus and gastric cardia
    P D Siersema
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Endoscopy 35:79-85. 2003
  62. doi request reprint Safety and efficacy of a new non-foreshortening nitinol stent in malignant gastric outlet obstruction (DUONITI study): a prospective, multicenter study
    J E van Hooft
    Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Endoscopy 43:671-5. 2011
    ..Self-expandable metal stents have emerged as a promising treatment option. Our aim was to investigate the safety and efficacy of a new non-foreshortening nitinol duodenal stent...
  63. ncbi request reprint Oesophageal cancer incidence and mortality in patients with long-segment Barrett's oesophagus after a mean follow-up of 12.7 years
    M Hage
    Depts of Gastroenterology and Hepatology, Pathology and Public Health, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
    Scand J Gastroenterol 39:1175-9. 2004
    ..In addition, it was determined which patient factors present at index endoscopy were associated with neoplastic progression in BO...
  64. pmc Increasing incidence of Barrett's oesophagus in the general population
    E M van Soest
    Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Postbus 2040, 3000 CA Rotterdam, Netherlands
    Gut 54:1062-6. 2005
    ..This study aimed to examine the changes in BO incidence relative to the number of upper gastrointestinal endoscopies performed in the general population...
  65. doi request reprint Admission time is associated with outcome of upper gastrointestinal bleeding: results of a multicentre prospective cohort study
    N L De Groot
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Aliment Pharmacol Ther 36:477-84. 2012
    ..It has been suggested that patients presenting with upper gastrointestinal bleeding (UGIB) during the weekend have a worse outcome compared with weekdays, with an increased risk of recurrent bleeding and mortality...
  66. doi request reprint Duodenal lipid-induced symptom generation in gastroesophageal reflux disease: role of apolipoprotein A-IV and cholecystokinin
    O S van Boxel
    Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands
    Neurogastroenterol Motil 24:350-e168. 2012
    ..ApoA-IV may stimulate release of cholecystokinin (CCK), an activator of vagal afferents. This study evaluated putative involvement of abnormal apoA-IV and CCK responses to lipid in GERD...
  67. doi request reprint Expandable stents for malignant esophageal disease
    F P Vleggaar
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Gastrointest Endosc Clin N Am 21:377-88, vii. 2011
    ..Although many different palliative options for malignant dysphagia are available, expandable stent placement is the most commonly performed treatment modality...
  68. ncbi request reprint [Diagnosis and treatment of esophageal cancer in the Netherlands: wide variation in the second line]
    M Y Homs
    afd Maag, Darm en Leverziekten, Erasmus Medisch Centrum Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam
    Ned Tijdschr Geneeskd 147:2128-33. 2003
    ..To survey the diagnostic procedures and treatment strategies currently employed in hospitals for patients with oesophageal cancer...
  69. doi request reprint IBD-related carcinoma and lymphoma
    M M H Claessen
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Best Pract Res Clin Gastroenterol 25:S27-38. 2011
    ....
  70. doi request reprint A new fully covered stent with antimigration properties for the palliation of malignant dysphagia: a prospective cohort study
    Madeleen J Uitdehaag
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Gastrointest Endosc 71:600-5. 2010
    ..Fully covered stents are designed to resist tissue ingrowth that is often seen with partially covered stents. An issue with fully covered stents is the risk of migration...
  71. ncbi request reprint Patients with Barrett's esophagus perceive their risk of developing esophageal adenocarcinoma as low
    Michelle E Kruijshaar
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Gastrointest Endosc 65:26-30. 2007
    ..The risk of developing esophageal adenocarcinoma (EAC) for patients with Barrett's esophagus (BE) is approximately 0.5% per year...
  72. ncbi request reprint Single-dose brachytherapy versus metal stent placement for the palliation of dysphagia from oesophageal cancer: multicentre randomised trial
    Marjolein Y V Homs
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands
    Lancet 364:1497-504. 2004
    ..We undertook a randomised trial to compare the outcomes of brachytherapy and stent placement in patients with oesophageal cancer...
  73. doi request reprint A new metal stent with a controlled-release system for palliation of malignant dysphagia: a prospective, multicenter study
    Petra G A van Boeckel
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Gastrointest Endosc 71:455-60. 2010
    ..The stent has an internal and external silicone coating to resist tissue ingrowth and uncoated dual flanges on both ends to prevent migration. Its controlled-release system may allow full control and precise positioning of the stent...
  74. ncbi request reprint COX-2 CA-haplotype is a risk factor for the development of esophageal adenocarcinoma
    Leon M G Moons
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Gastroenterol 102:2373-9. 2007
    ..Neoplastic progression of BE towards EAC is associated with increased expression of COX-2. Increased COX-2 expression and enzyme activity is linked to the COX-2 CA haplotype, which consists of two gene polymorphisms in the COX-2 promoter...
  75. pmc Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease
    M W M D Lutgens
    Department of Gastroenterology and Hepatology, University Medical Center, 3584 CX Utrecht, The Netherlands
    Br J Cancer 101:1671-5. 2009
    ..Colonoscopic surveillance provides the best practical means for preventing colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients. Strong evidence for improved survival from surveillance programmes is sparse...
  76. ncbi request reprint Follow-up after surgical treatment for cancer of the gastrointestinal tract
    E M L Verschuur
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Dig Liver Dis 38:479-84. 2006
    ..As a consequence, follow-up strategies may differ between hospitals depending on preference of physicians. We investigated which follow-up procedures are currently employed after surgery for gastrointestinal cancer in the Netherlands...
  77. doi request reprint Esophageal perforation due to removal of partially covered self-expanding metal stents placed for a benign perforation or leak
    M M C Hirdes
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, The Netherlands
    Endoscopy 43:156-9. 2011
    ..It is therefore recommended to remove embedded partially covered SEMS only after first placing a fully covered SEMS or self-expanding plastic stent inside this stent to necrotize the ingrown tissue at the uncovered stent ends...
  78. ncbi request reprint Persistence and adherence to proton pump inhibitors in daily clinical practice
    E M van Soest
    Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Aliment Pharmacol Ther 24:377-85. 2006
    ..Proton pump inhibitors are widely used, but little is known about the usage pattern in different indications...
  79. ncbi request reprint Single-dose brachytherapy for the palliative treatment of esophageal cancer
    M Y Homs
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Endoscopy 37:1143-8. 2005
  80. ncbi request reprint Genomic analysis of Barrett's esophagus after ablative therapy: persistence of genetic alterations at tumor suppressor loci
    Mariska Hage
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    Int J Cancer 118:155-60. 2006
    ..Therefore, the goal of treatment should be the complete elimination of Barrett's mucosa...
  81. ncbi request reprint New design esophageal stents for the palliation of dysphagia from esophageal or gastric cardia cancer: a randomized trial
    Els M L Verschuur
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Gastroenterol 103:304-12. 2008
    ..New stents have been designed to overcome this unwanted sequela of stent placement. In the present study, we investigated whether results of stent placement could be improved with newer stent designs...
  82. ncbi request reprint Prior radiation and/or chemotherapy has no effect on the outcome of metal stent placement for oesophagogastric carcinoma
    Marjolein Y V Homs
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre Rotterdam, The Netherlands
    Eur J Gastroenterol Hepatol 16:163-70. 2004
    ..We evaluated the influence of prior RTCT on the outcome of stent placement in a large group of patients...
  83. ncbi request reprint Effect of stent size on complications and recurrent dysphagia in patients with esophageal or gastric cardia cancer
    Els M L Verschuur
    Department of Gastroenterology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Gastrointest Endosc 65:592-601. 2007
    ..A major drawback of stents is the occurrence of recurrent dysphagia. Large-diameter stents were introduced for the prevention of migration but may be associated with more complications...
  84. doi request reprint Treatment options for esophageal strictures
    Peter D Siersema
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Nat Clin Pract Gastroenterol Hepatol 5:142-52. 2008
    ..These complex strictures are considered refractory when they cannot be dilated to an adequate diameter. Novel treatment modalities for refractory strictures include temporary stent placement and incisional therapy...
  85. doi request reprint A pro-inflammatory genotype predisposes to Barrett's esophagus
    L M G Moons
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Postbus 2040, 3000 CA Rotterdam, The Netherlands
    Carcinogenesis 29:926-31. 2008
    ..Severity of mucosal inflammation is shown to be associated with Barrett's esophagus (BE) development in animals. It has therefore been postulated that a strong pro-inflammatory host response predisposes to BE...
  86. doi request reprint Socio-demographic factors influence chronic proton pump inhibitor use by a large population in the Netherlands
    O S van Boxel
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Aliment Pharmacol Ther 29:571-9. 2009
    ..Socio-economic status and socio-demographic factors have been shown to influence decisions related to prescribing of various drugs, but the influence of these factors on chronic PPI use is uncertain...
  87. doi request reprint Role of chemical stimulation of the duodenum in dyspeptic symptom generation
    O S van Boxel
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Gastroenterol 105:803-11; quiz 802, 812. 2010
    ..Elucidation of the abnormalities involved will provide a basis for rational treatment of dyspeptic symptoms...
  88. doi request reprint Disease burden of post-infectious irritable bowel syndrome in The Netherlands
    J A Haagsma
    Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Epidemiol Infect 138:1650-6. 2010
    ..PI-IBS is a frequent sequel of IID, resulting in a considerable disease burden compared to other outcomes. If this relationship is not considered, this will result in an underestimation of the disease burden of IID...
  89. ncbi request reprint The aetiology and clinical relevance of gastric intestinal metaplasia
    E J Kuipers
    Dig Liver Dis 36:501-4. 2004
  90. ncbi request reprint Pathogenesis, diagnosis and therapeutic possibilities of esophageal cancer
    Peter D Siersema
    Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands
    Curr Opin Gastroenterol 23:456-61. 2007
    ..This article reviews developments in pathogenesis, diagnosis and therapy of esophageal cancer published in 2006...
  91. ncbi request reprint Aneuploidy and high expression of p53 and Ki67 is associated with neoplastic progression in Barrett esophagus
    Marjon Kerkhof
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Cancer Biomark 4:1-10. 2008
    ..Accumulation of p53 was seen several years before development of HGD/EAC, and may therefore be an early marker in BE at a stage when dysplasia is not yet detected. A prospective follow-up study is needed to confirm these findings...
  92. ncbi request reprint Genomic analysis of early adenocarcinoma of the esophagus or gastroesophageal junction: tumor progression is associated with alteration of 1q and 8p sequences
    Herman van Dekken
    Department of Pathology, Erasmus MC University Medical Center, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Genes Chromosomes Cancer 45:516-25. 2006
    ..005 and 0.003, respectively). These DNA clones can be considered genomic markers for the aggressive behavior of early esophageal and gastroesophageal junction adenocarcinoma...
  93. ncbi request reprint Risk factors for the development of esophageal adenocarcinoma in Barrett's esophagus
    Pieter J F de Jonge
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Am J Gastroenterol 101:1421-9. 2006
    ..To identify risk factors for esophageal adenocarcinoma (EAC) in patients with Barrett's esophagus (BE)...
  94. doi request reprint Use of a colonoscope for distal duodenal stent placement in patients with malignant obstruction
    Suzanne M Jeurnink
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Surg Endosc 23:562-7. 2009
    ..The use of a colonoscope may overcome these problems...
  95. ncbi request reprint Esophageal stents with antireflux valve for tumors of the distal esophagus and gastric cardia: a randomized trial
    Marjolein Y V Homs
    Department of Gastroenterology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Gastrointest Endosc 60:695-702. 2004
    ..Self-expandable metal stents deployed across the gastroesophageal junction predispose to gastroesophageal reflux. The efficacy of a stent with an antireflux mechanism in preventing gastroesophageal reflux was assessed...
  96. doi request reprint Users and utilization patterns of over-the-counter acid inhibitors and antacids in The Netherlands
    Evelyn P M van Vliet
    Department of Gastroenterology, Rotterdam, The Netherlands
    Scand J Gastroenterol 43:662-8. 2008
    ..We also studied factors that were associated with the substitution of OTC acid inhibitors or antacid use for consultation with a GP...
  97. ncbi request reprint Biomarkers for risk stratification of neoplastic progression in Barrett esophagus
    Marjon Kerkhof
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Cell Oncol 29:507-17. 2007
    ..e. proliferation/cell cycle proteins, tumor suppressor genes, adhesion molecules, DNA ploidy status and inflammation associated markers, that can be used for risk stratification in BE, and discuss their respective clinical application...
  98. ncbi request reprint High dose rate brachytherapy for the palliation of malignant dysphagia
    Marjolein Y V Homs
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, P O Box 2040, Rotterdam 3000 CA, Rotterdam, The Netherlands
    Radiother Oncol 66:327-32. 2003
    ..High dose rate (HDR) brachytherapy is a commonly used palliative treatment for esophageal carcinoma. We evaluated the outcome of HDR brachytherapy in patients with malignant dysphagia...
  99. ncbi request reprint Quality of life after palliative treatment for oesophageal carcinoma -- a prospective comparison between stent placement and single dose brachytherapy
    Marjolein Y V Homs
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, P O Box 2040, 3000CA Rotterdam, The Netherlands
    Eur J Cancer 40:1862-71. 2004
    ....
  100. pmc Different perceptions of the burden of upper GI endoscopy: an empirical study in three patient groups
    Marie Louise Essink-Bot
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Qual Life Res 16:1309-18. 2007
    ..We investigated the determinants of patients' reported burden of upper gastrointestinal (GI) endoscopy by comparing data from three patient groups...
  101. ncbi request reprint CT and MR colonography: scanning techniques, postprocessing, and emphasis on polyp detection
    Remy W F Geenen
    Department of Radiology, Erasmus Medical Center, Dr Molenwaterplein 40, 3015 GD Rotterdam, The Netherlands
    Radiographics 24:e18. 2004
    ..Before CT and MR colonography can be implemented in daily practice, they must show approximately the same accuracy as colonoscopy for polyp detection in both symptomatic and screening patients...