Johannes A Schaar

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Incidence of high-strain patterns in human coronary arteries: assessment with three-dimensional intravascular palpography and correlation with clinical presentation
    Johannes A Schaar
    Erasmus Medical Center, Thoraxcenter Rotterdam, Kamer Ee 23 32, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Circulation 109:2716-9. 2004
  2. ncbi request reprint Three-dimensional palpography of human coronary arteries. Ex vivo validation and in-patient evaluation
    Johannes A Schaar
    Erasmus University, Rotterdam, The Netherlands
    Herz 30:125-33. 2005
  3. ncbi request reprint Intravascular palpography for vulnerable plaque assessment
    Johannes A Schaar
    Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 47:C86-91. 2006
  4. ncbi request reprint Current diagnostic modalities for vulnerable plaque detection
    Johannes A Schaar
    Erasmus MC Rotterdam, Thoraxcenter, Dr Molewaterplein 50, Room Ee 23 32, NL 3000 DR Rotterdam, Rotterdam, The Netherlands
    Curr Pharm Des 13:995-1001. 2007
  5. ncbi request reprint Intravascular palpography for high-risk vulnerable plaque assessment
    Johannes A Schaar
    Thorax Center, Erasmus Medical Center, Rotterdam, The Netherlands
    Herz 28:488-95. 2003
  6. ncbi request reprint Characterizing vulnerable plaque features with intravascular elastography
    Johannes A Schaar
    Thoraxcenter Erasmus MC Rotterdam, Kamer Ee 23 32, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Circulation 108:2636-41. 2003
  7. ncbi request reprint Terminology for high-risk and vulnerable coronary artery plaques. Report of a meeting on the vulnerable plaque, June 17 and 18, 2003, Santorini, Greece
    Johannes A Schaar
    Department of Experimental Echocardiography, Erasmus Medical Center Rotterdam, Dr Molewaterplein 50, P O Box, 1738 Room Ee 23 32, 3000 DR Rotterdam, The Netherlands
    Eur Heart J 25:1077-82. 2004
  8. ncbi request reprint Identification of atherosclerotic plaque components with intravascular ultrasound elastography in vivo: a Yucatan pig study
    Chris L de Korte
    Experimental Echocardiography, Erasmus University, Rotterdam, The Netherlands
    Circulation 105:1627-30. 2002
  9. ncbi request reprint Young's modulus reconstruction of vulnerable atherosclerotic plaque components using deformable curves
    Radj A Baldewsing
    Biomedical Engineering, Thorax Centre, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands
    Ultrasound Med Biol 32:201-10. 2006
  10. doi request reprint Strain distribution over plaques in human coronary arteries relates to shear stress
    Frank J H Gijsen
    Department of Biomedical Engineering, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 295:H1608-14. 2008

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Incidence of high-strain patterns in human coronary arteries: assessment with three-dimensional intravascular palpography and correlation with clinical presentation
    Johannes A Schaar
    Erasmus Medical Center, Thoraxcenter Rotterdam, Kamer Ee 23 32, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Circulation 109:2716-9. 2004
    ..We further explored the relation of such regions to clinical presentation and to C-reactive protein levels...
  2. ncbi request reprint Three-dimensional palpography of human coronary arteries. Ex vivo validation and in-patient evaluation
    Johannes A Schaar
    Erasmus University, Rotterdam, The Netherlands
    Herz 30:125-33. 2005
    ..At present, techniques with sufficient sensitivity and specificity to identify these unstable plaques are not clinically available. This paper describes a new technique to identify these plaques...
  3. ncbi request reprint Intravascular palpography for vulnerable plaque assessment
    Johannes A Schaar
    Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 47:C86-91. 2006
    ..The clinical utility of this technique is yet to be determined, and more investigation is needed...
  4. ncbi request reprint Current diagnostic modalities for vulnerable plaque detection
    Johannes A Schaar
    Erasmus MC Rotterdam, Thoraxcenter, Dr Molewaterplein 50, Room Ee 23 32, NL 3000 DR Rotterdam, Rotterdam, The Netherlands
    Curr Pharm Des 13:995-1001. 2007
    ..Most of the techniques show exiting features, but none have proven their value in an extensive in vivo validation and all have a lack of prospective data...
  5. ncbi request reprint Intravascular palpography for high-risk vulnerable plaque assessment
    Johannes A Schaar
    Thorax Center, Erasmus Medical Center, Rotterdam, The Netherlands
    Herz 28:488-95. 2003
    ..The stress in the cap increases with decreasing cap thickness and increasing macrophage infiltration. Intravascular ultrasound (IVUS) palpography might be an ideal technique to assess the mechanical properties of high-risk plaques...
  6. ncbi request reprint Characterizing vulnerable plaque features with intravascular elastography
    Johannes A Schaar
    Thoraxcenter Erasmus MC Rotterdam, Kamer Ee 23 32, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Circulation 108:2636-41. 2003
    ..However, the predictive value of intravascular elastography to detect vulnerable plaques had not been studied...
  7. ncbi request reprint Terminology for high-risk and vulnerable coronary artery plaques. Report of a meeting on the vulnerable plaque, June 17 and 18, 2003, Santorini, Greece
    Johannes A Schaar
    Department of Experimental Echocardiography, Erasmus Medical Center Rotterdam, Dr Molewaterplein 50, P O Box, 1738 Room Ee 23 32, 3000 DR Rotterdam, The Netherlands
    Eur Heart J 25:1077-82. 2004
    ..It is the hope that this usage might be of value to the larger community of scientists working in this field, and that widespread adoption of a common nomenclature would accelerate progress in the prevention of acute coronary events...
  8. ncbi request reprint Identification of atherosclerotic plaque components with intravascular ultrasound elastography in vivo: a Yucatan pig study
    Chris L de Korte
    Experimental Echocardiography, Erasmus University, Rotterdam, The Netherlands
    Circulation 105:1627-30. 2002
    ..Intravascular ultrasound elastography assesses the local strain of the atherosclerotic vessel wall. In the present study, the potential to identify different plaque components in vivo was investigated...
  9. ncbi request reprint Young's modulus reconstruction of vulnerable atherosclerotic plaque components using deformable curves
    Radj A Baldewsing
    Biomedical Engineering, Thorax Centre, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands
    Ultrasound Med Biol 32:201-10. 2006
    ..Consequently, this method may become a valuable tool for the quantification of both the morphology and stiffness of vulnerable atherosclerotic plaque components...
  10. doi request reprint Strain distribution over plaques in human coronary arteries relates to shear stress
    Frank J H Gijsen
    Department of Biomedical Engineering, Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 295:H1608-14. 2008
    ..Higher strain can be found in all other plaque regions, with the highest strain found in regions exposed to the highest shear stresses. This indicates that high shear stress might destabilize plaques, which could lead to plaque rupture...
  11. ncbi request reprint In vivo relationship between compositional and mechanical imaging of coronary arteries. Insights from intravascular ultrasound radiofrequency data analysis
    Gaston A Rodriguez-Granillo
    Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    Am Heart J 151:1025.e1-6. 2006
    ..We sought to explore in vivo the relation between mechanical and compositional properties of matched cross sections (CSs) using novel catheter-based techniques...
  12. ncbi request reprint An inverse method for imaging the local elasticity of atherosclerotic coronary plaques
    Radjkumarsing A Baldewsing
    Department of Biomedical Engineering, Erasmus Medical Center, Rotterdam, The Netherlands
    IEEE Trans Inf Technol Biomed 12:277-89. 2008
    ....
  13. ncbi request reprint Local elasticity imaging of vulnerable atherosclerotic coronary plaques
    Radj A Baldewsing
    Biomedical Engineering, Thorax Center, Erasmus Medical Center, Rotterdam, The Netherlands
    Adv Cardiol 44:35-61. 2007
    ..This chapter describes the terminology and pathophysiology of vulnerable plaques and discusses the techniques behind, the methods for and the validations of the elasticity imaging techniques...
  14. ncbi request reprint A finite element model for performing intravascular ultrasound elastography of human atherosclerotic coronary arteries
    Radj A Baldewsing
    Biomedical Engineering, Thoraxcenter, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Ultrasound Med Biol 30:803-13. 2004
    ..As such, the FEM may help in quantifying strain-dependencies and assist in tissue characterization by reconstructing a Young's modulus image from a measured elastogram...
  15. ncbi request reprint Robustness of reconstructing the Young's modulus distribution of vulnerable atherosclerotic plaques using a parametric plaque model
    Radj A Baldewsing
    Biomedical Engineering, Thorax Centre, Erasmus Medical Centre Rotterdam, Rotterdam, The Netherlands
    Ultrasound Med Biol 31:1631-45. 2005
    ..Furthermore, reconstructions were 1. independent of catheter position and 2. independent of strain noise. As such, this method has potential to monitor robustly and quantitatively atherosclerosis in vivo...
  16. doi request reprint High shear stress induces a strain increase in human coronary plaques over a 6-month period
    Frank J H Gijsen
    Department of Biomedical Engineering, Thoraxcenter, ErasmusMC, Rotterdam, The Netherlands
    EuroIntervention 7:121-7. 2011
    ..We investigated changes in plaque composition in human coronary arteries over a 6-month period and how these changes are related to shear stress...
  17. ncbi request reprint Assessment of vulnerable plaque composition by matching the deformation of a parametric plaque model to measured plaque deformation
    Radj A Baldewsing
    Biomedical Engineering, room Ee 23 02, Thoraxcenter, Erasmus Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    IEEE Trans Med Imaging 24:514-28. 2005
    ..2/4 kPa, EM = 16.8/16, for the in vitro plaque EL = n.a./29, EM = n.a./647, EC = n.a./1784 kPa and for the in vivo plaque EL = n.a./2, EM = n.a./188, Ec = n.a./188 kPa...
  18. ncbi request reprint Noninvasive detection of subclinical coronary atherosclerosis coupled with assessment of changes in plaque characteristics using novel invasive imaging modalities: the Integrated Biomarker and Imaging Study (IBIS)
    Carlos A G van Mieghem
    Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 47:1134-42. 2006
    ..Our purpose was to assess noninvasive imaging in detection of subclinical atherosclerosis and to examine novel invasive modalities to describe prevalence and temporal changes in putative characteristics of "high-risk" plaques...
  19. ncbi request reprint Intravascular elastography: from bench to bedside
    Chris L de Korte
    Thoraxcenter, Erasmus Medical Center, Rotterdam, Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands
    J Interv Cardiol 16:253-9. 2003
    ..The development of three-dimensional elastography provides a technique that may develop into a clinical available tool for identifying the rupture-prone plaque...
  20. ncbi request reprint Finite element modeling and intravascular ultrasound elastography of vulnerable plaques: parameter variation
    Radj A Baldewsing
    Biomedical Engineering, room Ee 23 02, Thoraxcenter, Erasmus Medical Center Rotterdam, P O Box 1738, Rotterdam 3000 DR, The Netherlands
    Ultrasonics 42:723-9. 2004
    ..To understand and quantify the influence of these parameters upon measured IVUS elastograms, they were varied in a finite element model (FEM) that simulates IVUS elastograms of vulnerable plaques...
  21. ncbi request reprint Rationale and methods of the integrated biomarker and imaging study (IBIS): combining invasive and non-invasive imaging with biomarkers to detect subclinical atherosclerosis and assess coronary lesion biology
    Carlos A G van Mieghem
    Erasmus Medical Center, Thoraxcenter, Rotterdam, The Netherlands
    Int J Cardiovasc Imaging 21:425-41. 2005
    ..It outlines the analyses that will be performed to compare invasive and non-invasive imaging techniques in conjunction with multiple biomarkers to characterize non-flow limiting subclinical coronary lesions...
  22. ncbi request reprint Contrast harmonic intravascular ultrasound: a feasibility study for vasa vasorum imaging
    David E Goertz
    Biomedical Engineering Dept, Thoraxcenter, Erasmus Medical Centre, Rotterdam, The Netherlands
    Invest Radiol 41:631-8. 2006
    ..We sought to investigate feasibility of vasa vasorum imaging using the novel technique of contrast harmonic intravascular ultrasound...
  23. ncbi request reprint [New insights towards catheter-based identification of vulnerable plaque]
    Gaston A Rodriguez-Granillo
    Interventional Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    Rev Esp Cardiol 58:1197-206. 2005
    ..These new modalities have the potential to provide insights into the pathophysiology of the natural history of coronary plaque by means of prospective studies...
  24. ncbi request reprint Imaging of atherosclerosis. Elastography
    Stephane G Carlier
    Cardiovascular Centre, OLV Hospital, Aalst, Belgium
    J Cardiovasc Risk 9:237-45. 2002
    ..In this paper, the approaches of the different research groups will be discussed and the focus will be on our approach to the application of intravascular elastography...
  25. ncbi request reprint Images in cardiovascular medicine. Detection of a vulnerable coronary plaque: a treatment dilemma
    Chourmouzios A Arampatzis
    Catheterisation Laboratory, Thoraxcenter BD 410, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Circulation 108:e34-5. 2003