Research Topics
Genomes and GenesSpecies | Henk RusscherSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
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Detail Information
Publications
[Approaches to vitamin B12 deficiency]Henk Russcher
Erasmus Medisch Centrum, afd Klinische Chemie, Rotterdam, The Netherlands
Ned Tijdschr Geneeskd 156:A3595. 2012..A new approach to diagnosing vitamin B12 deficiency is presented, based upon these 2 case descriptions...- Increased expression of the glucocorticoid receptor-A translational isoform as a result of the ER22/23EK polymorphismHenk Russcher
Department of Internal Medicine, Room Ee 593, Erasmus MC, University Medical Center Rotterdam, Molewaterplein 40, P O Box 2040, 3000 CA Rotterdam, The Netherlands
Mol Endocrinol 19:1687-96. 2005..These results show that the transcriptional activity in GR(ER22/23EK) carriers is decreased because more of the less transcriptionally active GR-A isoform is formed. This is probably caused by altered secondary mRNA structure... - Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expressionHenk Russcher
Erasmus Medical Center, Department of Internal Medicine, Room Ee593, Dr Molewaterplein 40, P O Box 2040, 3000 CA Rotterdam, The Netherlands
J Clin Endocrinol Metab 90:5804-10. 2005..The ER22/23EK and N363S polymorphisms have been described to be associated with lower and higher GC sensitivity, respectively... - Glucocorticoid receptor polymorphism affects transrepression but not transactivationErica L T Van Den Akker
Erasmus Medical Center, Department of Internal Medicine, Room Ee 585, P O Box 2040, 3000 CA Rotterdam, The Netherlands
J Clin Endocrinol Metab 91:2800-3. 2006..Their beneficial effects are thought to be mediated by GC transrepression on gene expression. However, their use is limited by serious adverse effects, presumably mediated by GC transactivation of gene expression... 
The Mediterranean diet and fetal size parameters: the Generation R StudySarah Timmermans
Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000CA Rotterdam, The Netherlands
Br J Nutr 108:1399-409. 2012..To conclude, low adherence to a Mediterranean diet in early pregnancy seems associated with decreased intra-uterine size with a lower placental and a lower birth weight...- Strategies for the characterization of disorders in cortisol sensitivityHenk Russcher
Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands
J Clin Endocrinol Metab 91:694-701. 2006..CONCLUSION: This study illustrates several strategies to define abnormalities in GC sensitivity by describing nine patients with affected GC sensitivity, all with a unique clinical course and background... - Associations between promoter usage and alternative splicing of the glucocorticoid receptor geneHenk Russcher
Department of Internal Medicine, Erasmus MC, University Medical Center Dr Molewaterplein 40, Rotterdam, The Netherlands
J Mol Endocrinol 38:91-8. 2007..This indicates that regulation of GR splice variants could partly occur through selective use of the multiple promoters, and that this is another way to sensitize cells and tissues to the different activities of the GR isoforms... 
Air pollution exposure and markers of placental growth and function: the generation R studyEdith H van den Hooven
The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
Environ Health Perspect 120:1753-9. 2012..Air pollution exposure during pregnancy might affect placental growth and function, perhaps leading to pregnancy complications...- Glucocorticoid receptor gene and risk of cardiovascular diseaseErica L T Van Den Akker
Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
Arch Intern Med 168:33-9. 2008..Our aim was to determine the contribution of genetic glucocorticoid receptor variants, with different cortisol sensitivities, to the risk of cardiovascular disease... - Differential regulation of synthetic glucocorticoids on gene expression levels of glucocorticoid-induced leucine zipper and interleukin-2Pauline Smit
Department of Internal Medicine, Room Ee 585, Erasmus Medical Center, Dr. Molewaterplein 40, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands
J Clin Endocrinol Metab 90:2994-3000. 2005.... - C-reactive protein levels in early pregnancy, fetal growth patterns, and the risk for neonatal complications: the Generation R StudyGesina D S Ernst
Generation R Study Group, Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
Am J Obstet Gynecol 205:132.e1-12. 2011..We sought to examine the associations of maternal C-reactive protein (CRP) levels with fetal growth and the risks of neonatal complications... - Angiogenic and fibrinolytic factors in blood during the first half of pregnancy and adverse pregnancy outcomesMarianne Coolman
Department of Obstetrics and Gynaecology, Erasmus Medical Centre, Rotterdam, The Netherlands
Obstet Gynecol 119:1190-200. 2012..To estimate whether the imbalance of angiogenic factors (soluble fms-like tyrosine kinase-1, placental growth factor) and fibrinolytic factors (plasminogen activator inhibitor-2 [PAI-2]) might affect placentation in early pregnancy... - C-reactive protein levels, blood pressure and the risks of gestational hypertensive complications: the Generation R StudyLayla L de Jonge
The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
J Hypertens 29:2413-21. 2011..We also explored the role of maternal BMI in these associations... - Chronic air pollution exposure during pregnancy and maternal and fetal C-reactive protein levels: the Generation R StudyEdith H van den Hooven
Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
Environ Health Perspect 120:746-51. 2012..Exposure to air pollution has been associated with higher C-reactive protein (CRP) levels, suggesting an inflammatory response. Not much is known about this association in pregnancy... - Genetic polymorphisms and multifactorial diseases: facts and fallacies revealed by the glucocorticoid receptor geneElisabeth F C van Rossum
Department of Internal Medicine, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Trends Endocrinol Metab 16:445-50. 2005..In this review we describe a number of the limitations related to this type of research; from both our own experience with studies on polymorphisms in the glucocorticoid receptor gene, and shortcomings and solutions from the literature... - Ficoll-separated mononuclear cells from sepsis patients are contaminated with granulocytesErica L T Van Den Akker
Department of Pediatric Endocrinology, Office sp 1536, Erasmus MC, PO Box 2060, 3000 CB Rotterdam, The Netherlands
Intensive Care Med 34:912-6. 2008..To determine the cell content and purity of Ficoll-separated peripheral blood mononuclear cells and granulocyte isolates in sepsis patients compared to healthy controls... - Major dietary patterns and blood pressure patterns during pregnancy: the Generation R StudySarah Timmermans
Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
Am J Obstet Gynecol 205:337.e1-12. 2011..We sought to evaluate associations between dietary patterns and systolic blood pressure (SBP) and diastolic blood pressure during pregnancy... - Identification and characterization of two unusual cGMP-stimulated phoshodiesterases in dictyosteliumLeonard Bosgraaf
Department of Biochemistry, University of Groningen, 9747 AG Groningen, The Netherlands
Mol Biol Cell 13:3878-89. 2002..The human cGMP-stimulated cAMP/cGMP phosphodiesterase has similar biochemical properties, but a completely different topology: hydrolysis takes place by a class I catalytic domain and GAF domains mediate cGMP activation...