Henk Russcher

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint [Approaches to vitamin B12 deficiency]
    Henk Russcher
    Erasmus Medisch Centrum, afd Klinische Chemie, Rotterdam, The Netherlands
    Ned Tijdschr Geneeskd 156:A3595. 2012
  2. ncbi request reprint Increased expression of the glucocorticoid receptor-A translational isoform as a result of the ER22/23EK polymorphism
    Henk Russcher
    Department of Internal Medicine, Room Ee 593, Erasmus MC, University Medical Center Rotterdam, Molewaterplein 40, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Mol Endocrinol 19:1687-96. 2005
  3. ncbi request reprint Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression
    Henk Russcher
    Erasmus Medical Center, Department of Internal Medicine, Room Ee593, Dr Molewaterplein 40, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:5804-10. 2005
  4. pmc Air pollution exposure and markers of placental growth and function: the generation R study
    Edith H van den Hooven
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health Perspect 120:1753-9. 2012
  5. ncbi request reprint Glucocorticoid receptor polymorphism affects transrepression but not transactivation
    Erica L T Van Den Akker
    Erasmus Medical Center, Department of Internal Medicine, Room Ee 585, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 91:2800-3. 2006
  6. doi request reprint The Mediterranean diet and fetal size parameters: the Generation R Study
    Sarah Timmermans
    Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Br J Nutr 108:1399-409. 2012
  7. ncbi request reprint Associations between promoter usage and alternative splicing of the glucocorticoid receptor gene
    Henk Russcher
    Department of Internal Medicine, Erasmus MC, University Medical Center Dr Molewaterplein 40, Rotterdam, The Netherlands
    J Mol Endocrinol 38:91-8. 2007
  8. ncbi request reprint Strategies for the characterization of disorders in cortisol sensitivity
    Henk Russcher
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 91:694-701. 2006
  9. ncbi request reprint Differential regulation of synthetic glucocorticoids on gene expression levels of glucocorticoid-induced leucine zipper and interleukin-2
    Pauline Smit
    Department of Internal Medicine, Room Ee 585, Erasmus Medical Center, Dr Molewaterplein 40, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:2994-3000. 2005
  10. doi request reprint Glucocorticoid receptor gene and risk of cardiovascular disease
    Erica L T Van Den Akker
    Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Arch Intern Med 168:33-9. 2008

Collaborators

Detail Information

Publications20

  1. ncbi request reprint [Approaches to vitamin B12 deficiency]
    Henk Russcher
    Erasmus Medisch Centrum, afd Klinische Chemie, Rotterdam, The Netherlands
    Ned Tijdschr Geneeskd 156:A3595. 2012
    ..A new approach to diagnosing vitamin B12 deficiency is presented, based upon these 2 case descriptions...
  2. ncbi request reprint Increased expression of the glucocorticoid receptor-A translational isoform as a result of the ER22/23EK polymorphism
    Henk Russcher
    Department of Internal Medicine, Room Ee 593, Erasmus MC, University Medical Center Rotterdam, Molewaterplein 40, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Mol Endocrinol 19:1687-96. 2005
    ..These results show that the transcriptional activity in GR(ER22/23EK) carriers is decreased because more of the less transcriptionally active GR-A isoform is formed. This is probably caused by altered secondary mRNA structure...
  3. ncbi request reprint Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression
    Henk Russcher
    Erasmus Medical Center, Department of Internal Medicine, Room Ee593, Dr Molewaterplein 40, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:5804-10. 2005
    ..The ER22/23EK and N363S polymorphisms have been described to be associated with lower and higher GC sensitivity, respectively...
  4. pmc Air pollution exposure and markers of placental growth and function: the generation R study
    Edith H van den Hooven
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health Perspect 120:1753-9. 2012
    ..Air pollution exposure during pregnancy might affect placental growth and function, perhaps leading to pregnancy complications...
  5. ncbi request reprint Glucocorticoid receptor polymorphism affects transrepression but not transactivation
    Erica L T Van Den Akker
    Erasmus Medical Center, Department of Internal Medicine, Room Ee 585, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 91:2800-3. 2006
    ..Their beneficial effects are thought to be mediated by GC transrepression on gene expression. However, their use is limited by serious adverse effects, presumably mediated by GC transactivation of gene expression...
  6. doi request reprint The Mediterranean diet and fetal size parameters: the Generation R Study
    Sarah Timmermans
    Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Br J Nutr 108:1399-409. 2012
    ..To conclude, low adherence to a Mediterranean diet in early pregnancy seems associated with decreased intra-uterine size with a lower placental and a lower birth weight...
  7. ncbi request reprint Associations between promoter usage and alternative splicing of the glucocorticoid receptor gene
    Henk Russcher
    Department of Internal Medicine, Erasmus MC, University Medical Center Dr Molewaterplein 40, Rotterdam, The Netherlands
    J Mol Endocrinol 38:91-8. 2007
    ..This indicates that regulation of GR splice variants could partly occur through selective use of the multiple promoters, and that this is another way to sensitize cells and tissues to the different activities of the GR isoforms...
  8. ncbi request reprint Strategies for the characterization of disorders in cortisol sensitivity
    Henk Russcher
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 91:694-701. 2006
    ..The clinical presentation of abnormalities in glucocorticoid (GC) sensitivity is diverse, and therefore it is difficult to diagnose this condition...
  9. ncbi request reprint Differential regulation of synthetic glucocorticoids on gene expression levels of glucocorticoid-induced leucine zipper and interleukin-2
    Pauline Smit
    Department of Internal Medicine, Room Ee 585, Erasmus Medical Center, Dr Molewaterplein 40, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:2994-3000. 2005
    ....
  10. doi request reprint Glucocorticoid receptor gene and risk of cardiovascular disease
    Erica L T Van Den Akker
    Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Arch Intern Med 168:33-9. 2008
    ..Our aim was to determine the contribution of genetic glucocorticoid receptor variants, with different cortisol sensitivities, to the risk of cardiovascular disease...
  11. doi request reprint C-reactive protein levels in early pregnancy, fetal growth patterns, and the risk for neonatal complications: the Generation R Study
    Gesina D S Ernst
    Generation R Study Group, Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Obstet Gynecol 205:132.e1-12. 2011
    ..We sought to examine the associations of maternal C-reactive protein (CRP) levels with fetal growth and the risks of neonatal complications...
  12. doi request reprint Maternal soluble fms-like tyrosine kinase-1, placental growth factor, plasminogen activator inhibitor-2, and folate concentrations and early fetal size: the Generation R study
    Marieke I Bouwland-Both
    Generation R study, Erasmus Medical Center, Rotterdam, The Netherlands Department of Obstetrics and Gynecology, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Obstet Gynecol 209:121.e1-121.e11. 2013
    ..This study aims to identify associations between these maternal biomarkers and early fetal size...
  13. doi request reprint Angiogenic and fibrinolytic factors in blood during the first half of pregnancy and adverse pregnancy outcomes
    Marianne Coolman
    Department of Obstetrics and Gynaecology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Obstet Gynecol 119:1190-200. 2012
    ..To estimate whether the imbalance of angiogenic factors (soluble fms-like tyrosine kinase-1, placental growth factor) and fibrinolytic factors (plasminogen activator inhibitor-2 [PAI-2]) might affect placentation in early pregnancy...
  14. doi request reprint C-reactive protein levels, blood pressure and the risks of gestational hypertensive complications: the Generation R Study
    Layla L de Jonge
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    J Hypertens 29:2413-21. 2011
    ..We also explored the role of maternal BMI in these associations...
  15. pmc Chronic air pollution exposure during pregnancy and maternal and fetal C-reactive protein levels: the Generation R Study
    Edith H van den Hooven
    Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health Perspect 120:746-51. 2012
    ..Exposure to air pollution has been associated with higher C-reactive protein (CRP) levels, suggesting an inflammatory response. Not much is known about this association in pregnancy...
  16. ncbi request reprint Genetic polymorphisms and multifactorial diseases: facts and fallacies revealed by the glucocorticoid receptor gene
    Elisabeth F C van Rossum
    Department of Internal Medicine, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Trends Endocrinol Metab 16:445-50. 2005
    ..In this review we describe a number of the limitations related to this type of research; from both our own experience with studies on polymorphisms in the glucocorticoid receptor gene, and shortcomings and solutions from the literature...
  17. doi request reprint Ficoll-separated mononuclear cells from sepsis patients are contaminated with granulocytes
    Erica L T Van Den Akker
    Department of Pediatric Endocrinology, Office sp 1536, Erasmus MC, PO Box 2060, 3000 CB Rotterdam, The Netherlands
    Intensive Care Med 34:912-6. 2008
    ..To determine the cell content and purity of Ficoll-separated peripheral blood mononuclear cells and granulocyte isolates in sepsis patients compared to healthy controls...
  18. doi request reprint Major dietary patterns and blood pressure patterns during pregnancy: the Generation R Study
    Sarah Timmermans
    Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Obstet Gynecol 205:337.e1-12. 2011
    ..We sought to evaluate associations between dietary patterns and systolic blood pressure (SBP) and diastolic blood pressure during pregnancy...
  19. doi request reprint Interference of ethylene glycol with (L)-lactate measurement is assay-dependent
    Andrei Tintu
    Department of Clinical Chemistry, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Ann Clin Biochem 50:70-2. 2013
    ..In this study, we evaluated the effects of EG and its metabolites on routinely used lactate measuring methods...
  20. pmc Identification and characterization of two unusual cGMP-stimulated phoshodiesterases in dictyostelium
    Leonard Bosgraaf
    Department of Biochemistry, University of Groningen, 9747 AG Groningen, The Netherlands
    Mol Biol Cell 13:3878-89. 2002
    ..The human cGMP-stimulated cAMP/cGMP phosphodiesterase has similar biochemical properties, but a completely different topology: hydrolysis takes place by a class I catalytic domain and GAF domains mediate cGMP activation...