Research Topics
| Bob RoozenbeekSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
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Detail Information
Publications
Predicting 14-day mortality after severe traumatic brain injury: application of the IMPACT models in the brain trauma foundation TBI-tracĀ® New York State databaseBob Roozenbeek
Department of Public Health, Center for Medical Decision Making, Erasmus MC, Rotterdam, The Netherlands
J Neurotrauma 29:1306-12. 2012..79 (Core) and 0.83 (Extended). We conclude that the IMPACT models validly predict 14-day mortality in the BTF database, confirming generalizability of these models for outcome prediction in TBI patients...
Prediction of outcome after moderate and severe traumatic brain injury: external validation of the International Mission on Prognosis and Analysis of Clinical Trials (IMPACT) and Corticoid Randomisation After Significant Head injury (CRASH) prognostic modBob Roozenbeek
Department of Public Health, Center for Medical Decision Making, Erasmus MC, Rotterdam, The Netherlands
Crit Care Med 40:1609-17. 2012....
The added value of ordinal analysis in clinical trials: an example in traumatic brain injuryBob Roozenbeek
Department of Neurosurgery, Antwerp University Hospital, Wilrijkstraat 10, Edegem, Belgium
Crit Care 15:R127. 2011..The objective of this study is to quantify the benefits of ordinal analysis in the real-life situation of a large TBI trial...
Baseline characteristics and statistical power in randomized controlled trials: selection, prognostic targeting, or covariate adjustment?Bob Roozenbeek
Department of Public Health, Center for Medical Decision Making, Erasmus MC, Rotterdam, The Netherlands
Crit Care Med 37:2683-90. 2009..We aimed to investigate the potential benefits of different approaches for dealing with heterogeneity in a case study on traumatic brain injury (TBI)...
Between-centre differences and treatment effects in randomized controlled trials: a case study in traumatic brain injuryHester F Lingsma
Department of Public Health, Erasmus MC, P, O, Box 2040, 3000 CA Rotterdam, The Netherlands
Trials 12:201. 2011..The aim of this study was to assess the influence of between-centre differences in outcome on the estimated treatment effect in a large RCT in TBI...
Large between-center differences in outcome after moderate and severe traumatic brain injury in the international mission on prognosis and clinical trial design in traumatic brain injury (IMPACT) studyHester F Lingsma
Erasmus Medical Center, Department of Public Health, Rotterdam, The Netherlands
Neurosurgery 68:601-7; discussion 607-8. 2011..Differences between centers in patient outcome after traumatic brain injury are of importance for multicenter studies and have seldom been studied...
IMPACT recommendations for improving the design and analysis of clinical trials in moderate to severe traumatic brain injuryAndrew I R Maas
Department of Neurosurgery, University Hospital Antwerp, 2650 Edegem, Belgium
Neurotherapeutics 7:127-34. 2010..This corresponds to being able to detect a 7% treatment effect with the same number of patients needed to demonstrate a 10% difference with an unadjusted analysis based on the dichotomized Glasgow outcome scale...
Prognostic value of major extracranial injury in traumatic brain injury: an individual patient data meta-analysis in 39,274 patientsNikki van Leeuwen
Center for Medical Decision Making, Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
Neurosurgery 70:811-8; discussion 818. 2012..Major extracranial injury (MEI) is common in traumatic brain injury (TBI) patients, but the effect on outcome is controversial...
The influence of enrollment criteria on recruitment and outcome distribution in traumatic brain injury studies: results from the impact studyBob Roozenbeek
Department of Public Health, Center for Medical Decision Making, Rotterdam, The Netherlands
J Neurotrauma 26:1069-75. 2009..The use of strict enrollment criteria leads to substantial reductions in the recruitment of RCTs in TBI. The outcome in TBI studies depends strongly on the enrollment criteria...
Early prognosis in traumatic brain injury: from prophecies to predictionsHester F Lingsma
Centre for Medical Decision Making, Department of Public Health, Erasmus University Medical Centre, Rotterdam, The Netherlands
Lancet Neurol 9:543-54. 2010..Continued development, refinement, and validation is advocated, together with assessment of the clinical impact of prediction models, including treatment response...
Clinical trials in traumatic brain injury: past experience and current developmentsAndrew I R Maas
Department of Neurosurgery, University Hospital 2650 Antwerp, Belgium
Neurotherapeutics 7:115-26. 2010....
