Guus F Rimmelzwaan

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi request reprint Developing vaccines against virus infections: between hope and fear
    Guus F Rimmelzwaan
    Professor Immuno virology, Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Hum Vaccin Immunother 8:286-8. 2012
  2. ncbi request reprint [The 2005-2006 influenza season in the Netherlands and the vaccine composition for the 2006-2007 season]
    G F Rimmelzwaan
    Erasmus MC, afd Virologie, Rotterdam
    Ned Tijdschr Geneeskd 150:2209-14. 2006
  3. doi request reprint Candidate influenza vaccines based on recombinant modified vaccinia virus Ankara
    Guus F Rimmelzwaan
    Erasmus Medical Center, Department of Virology, Rotterdam, The Netherlands
    Expert Rev Vaccines 8:447-54. 2009
  4. ncbi request reprint Correlates of protection: novel generations of influenza vaccines
    Guus F Rimmelzwaan
    Department of Virology Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Vaccine 26:D41-4. 2008
  5. ncbi request reprint [The 2003/2004 influenza season in the Netherlands with a limited epidemic of the virus variant A/Fujian, and the vaccine composition for the 2004/2005 season]
    G F Rimmelzwaan
    Erasmus Medisch Centrum, afd Virologie, Postbus 1738, 3000 DR Rotterdam
    Ned Tijdschr Geneeskd 148:1984-8. 2004
  6. ncbi request reprint [Influenza season 2007/'08 in the Netherlands: antigenic variation, oseltamivir resistance and vaccine composition for the 2008/'09 season]
    G F Rimmelzwaan
    Erasmus MC Centrum, afd Virologie, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 152:2138-44. 2008
  7. doi request reprint Influenza virus CTL epitopes, remarkably conserved and remarkably variable
    Guus F Rimmelzwaan
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Vaccine 27:6363-5. 2009
  8. ncbi request reprint Sequence variation in the influenza A virus nucleoprotein associated with escape from cytotoxic T lymphocytes
    G F Rimmelzwaan
    Institute for Virology, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Virus Res 103:97-100. 2004
  9. doi request reprint Use of GFP-expressing influenza viruses for the detection of influenza virus A/H5N1 neutralizing antibodies
    Guus F Rimmelzwaan
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Vaccine 29:3424-30. 2011
  10. ncbi request reprint Attachment of infectious influenza A viruses of various subtypes to live mammalian and avian cells as measured by flow cytometry
    Guus F Rimmelzwaan
    Department of Virology, Postgraduate School Molecular Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Virus Res 129:175-81. 2007

Detail Information

Publications140 found, 100 shown here

  1. doi request reprint Developing vaccines against virus infections: between hope and fear
    Guus F Rimmelzwaan
    Professor Immuno virology, Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Hum Vaccin Immunother 8:286-8. 2012
    ..After two years I chose to become a medical biologist. Especially the mandatory internships at various research departments were of great interest and made me pursuing a career as biomedical researcher...
  2. ncbi request reprint [The 2005-2006 influenza season in the Netherlands and the vaccine composition for the 2006-2007 season]
    G F Rimmelzwaan
    Erasmus MC, afd Virologie, Rotterdam
    Ned Tijdschr Geneeskd 150:2209-14. 2006
    ..For the 2006-2007 influenza season, the World Health Organization has recommended the following vaccine composition: A/Wisconsin/67/05 (H3N2), A/New Caledonia/20/99 (H1N1) and B/Malaysia/2506/05...
  3. doi request reprint Candidate influenza vaccines based on recombinant modified vaccinia virus Ankara
    Guus F Rimmelzwaan
    Erasmus Medical Center, Department of Virology, Rotterdam, The Netherlands
    Expert Rev Vaccines 8:447-54. 2009
    ..Specifically, we will focus on the preclinical evaluation of recombinant MVA vector as pandemic influenza A/H5N1 vaccine candidates and discuss the possible future approaches for the use of these novel MVA-based vaccines...
  4. ncbi request reprint Correlates of protection: novel generations of influenza vaccines
    Guus F Rimmelzwaan
    Department of Virology Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Vaccine 26:D41-4. 2008
    ..Here we reviewed potential correlates of protection against influenza and discussed some of the vaccination strategies that could result in optimal protection against epidemic and pandemic influenza...
  5. ncbi request reprint [The 2003/2004 influenza season in the Netherlands with a limited epidemic of the virus variant A/Fujian, and the vaccine composition for the 2004/2005 season]
    G F Rimmelzwaan
    Erasmus Medisch Centrum, afd Virologie, Postbus 1738, 3000 DR Rotterdam
    Ned Tijdschr Geneeskd 148:1984-8. 2004
    ....
  6. ncbi request reprint [Influenza season 2007/'08 in the Netherlands: antigenic variation, oseltamivir resistance and vaccine composition for the 2008/'09 season]
    G F Rimmelzwaan
    Erasmus MC Centrum, afd Virologie, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 152:2138-44. 2008
    ..For the 2008/'09 influenza season, the World Health Organization has recommended the following vaccine composition: A/Brisbane/59/07 (H1N1), A/Brisbane/10/07 (H3N2) and B/Florida/4/06...
  7. doi request reprint Influenza virus CTL epitopes, remarkably conserved and remarkably variable
    Guus F Rimmelzwaan
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Vaccine 27:6363-5. 2009
    ..A mutational analysis of this epitope indicated that it is under functional constraints. Also in influenza A viruses of other subtypes, including H5N1, the M1(58-66) is highly conserved...
  8. ncbi request reprint Sequence variation in the influenza A virus nucleoprotein associated with escape from cytotoxic T lymphocytes
    G F Rimmelzwaan
    Institute for Virology, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Virus Res 103:97-100. 2004
    ....
  9. doi request reprint Use of GFP-expressing influenza viruses for the detection of influenza virus A/H5N1 neutralizing antibodies
    Guus F Rimmelzwaan
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Vaccine 29:3424-30. 2011
    ....
  10. ncbi request reprint Attachment of infectious influenza A viruses of various subtypes to live mammalian and avian cells as measured by flow cytometry
    Guus F Rimmelzwaan
    Department of Virology, Postgraduate School Molecular Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Virus Res 129:175-81. 2007
    ..Virus attachment was not always predictive for efficient infection of the cells...
  11. doi request reprint Vaccination strategies to protect children against seasonal and pandemic influenza
    Guus F Rimmelzwaan
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Vaccine 29:7551-3. 2011
    ..This would afford protection through maternally derived antibodies. In addition, vaccination of close family members of young infants is recommended, to prevent transmission within the household...
  12. pmc Functional compensation of a detrimental amino acid substitution in a cytotoxic-T-lymphocyte epitope of influenza a viruses by comutations
    G F Rimmelzwaan
    Erasmus MC, Department of Virology, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Virol 78:8946-9. 2004
    ..We hypothesized that influenza A viruses need to overcome functional constraints to accumulate mutations in CTL epitopes and escape from CTLs...
  13. ncbi request reprint Human airway epithelial cells present antigen to influenza virus-specific CD8+ CTL inefficiently after incubation with viral protein together with ISCOMATRIX
    G F Rimmelzwaan
    Institute of Virology, National Influenza Center, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Vaccine 22:2769-75. 2004
    ....
  14. doi request reprint Airborne transmission of influenza A/H5N1 virus between ferrets
    Sander Herfst
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Science 336:1534-41. 2012
    ..Thus, avian A/H5N1 influenza viruses can acquire the capacity for airborne transmission between mammals without recombination in an intermediate host and therefore constitute a risk for human pandemic influenza...
  15. pmc Insertion of a multibasic cleavage motif into the hemagglutinin of a low-pathogenic avian influenza H6N1 virus induces a highly pathogenic phenotype
    Vincent J Munster
    Department of Virology, Erasmus Medical Center, PO Box 2040, Rotterdam, Netherlands
    J Virol 84:7953-60. 2010
    ....
  16. doi request reprint Evaluation of ISCOM-adjuvanted subunit vaccines containing recombinant feline immunodeficiency virus Rev, OrfA and envelope protein in cats
    Willem Huisman
    Erasmus MC, Institute of Virology, Rotterdam, The Netherlands
    Vaccine 26:2553-61. 2008
    ..Although the vaccines proved to be immunogenic, vaccinated cats were not protected from infection with FIV...
  17. doi request reprint Evaluation of a modified vaccinia virus Ankara (MVA)-based candidate pandemic influenza A/H1N1 vaccine in the ferret model
    Joost H C M Kreijtz
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Gen Virol 91:2745-52. 2010
    ..In contrast, two immunizations induced robust antibody responses and protected ferrets from developing severe disease, confirming that MVA is an attractive influenza vaccine production platform...
  18. pmc Efficacy of vaccination with different combinations of MF59-adjuvanted and nonadjuvanted seasonal and pandemic influenza vaccines against pandemic H1N1 (2009) influenza virus infection in ferrets
    Judith M A van den Brand
    Department of Virology, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, Netherlands
    J Virol 85:2851-8. 2011
    ....
  19. pmc Protection of mice against lethal infection with highly pathogenic H7N7 influenza A virus by using a recombinant low-pathogenicity vaccine strain
    Emmie de Wit
    Department of Virology, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Virol 79:12401-7. 2005
    ..The data presented suggest that vaccine candidates based on low-pathogenicity avian influenza A viruses, which can be prepared ahead of pandemic threats, can be efficacious if an effective adjuvant is used...
  20. ncbi request reprint Fluorescent antigen-transfected target cell cytotoxic T lymphocyte assay for ex vivo detection of antigen-specific cell-mediated cytotoxicity
    Carel A van Baalen
    Department of Virology, Erasmus MC, University Medical Center and Postgraduate School of Molecular Medicine, Rotterdam, The Netherlands
    J Infect Dis 192:1183-90. 2005
    ..The FATT-CTL assay provides a versatile tool that will advance our understanding of cell-mediated immunity...
  21. pmc Binding of DC-SIGN to the hemagglutinin of influenza A viruses supports virus replication in DC-SIGN expressing cells
    Marine L B Hillaire
    Erasmus Medical Centre, Rotterdam, The Netherlands
    PLoS ONE 8:e56164. 2013
    ..Furthermore, the efficiency of DC-SIGN mediated infection is dependent on the extent of glycosylation of the viral hemagglutinin...
  22. pmc Mallards and highly pathogenic avian influenza ancestral viruses, northern Europe
    Vincent J Munster
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Emerg Infect Dis 11:1545-51. 2005
    ....
  23. ncbi request reprint Preferential HLA usage in the influenza virus-specific CTL response
    Adrianus C M Boon
    Department of Virology and World Health Organization National Influenza Center, Erasmus Medical Center, Rotterdam, The Netherlands
    J Immunol 172:4435-43. 2004
    ..In contrast, the CTL response to influenza B virus was mainly directed toward HLA-B*0801-restricted epitopes. Thus, the preferential use of HLA alleles depended on the virus studied...
  24. pmc Vaccination against human influenza A/H3N2 virus prevents the induction of heterosubtypic immunity against lethal infection with avian influenza A/H5N1 virus
    Rogier Bodewes
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 4:e5538. 2009
    ..These findings may have implications for the general recommendation to vaccinate all healthy children against seasonal influenza in the light of the current pandemic threat caused by highly pathogenic avian A/H5N1 influenza viruses...
  25. pmc MVA-based H5N1 vaccine affords cross-clade protection in mice against influenza A/H5N1 viruses at low doses and after single immunization
    Joost H C M Kreijtz
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 4:e7790. 2009
    ..It was concluded that MVA-based vaccines allowed significant dose-sparing and afford cross-clade protection, also after a single immunization, which are favorable properties for an H5N1 vaccine candidate...
  26. pmc Introduction of virulence markers in PB2 of pandemic swine-origin influenza virus does not result in enhanced virulence or transmission
    Sander Herfst
    Department of Virology, Erasmus Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, Netherlands
    J Virol 84:3752-8. 2010
    ....
  27. doi request reprint Vaccination with whole inactivated virus vaccine affects the induction of heterosubtypic immunity against influenza virus A/H5N1 and immunodominance of virus-specific CD8+ T-cell responses in mice
    Rogier Bodewes
    Department of Virology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Gen Virol 91:1743-53. 2010
    ..These findings may have implications for vaccination strategies aimed at the induction of protective immunity to seasonal and/or pandemic influenza...
  28. pmc Limited airborne transmission of H7N9 influenza A virus between ferrets
    Mathilde Richard
    Department of Viroscience, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands
    Nature 501:560-3. 2013
    ..This A(H7N9) virus outbreak highlights the need for increased understanding of the determinants of efficient airborne transmission of avian influenza viruses between mammals. ..
  29. pmc A recombinant influenza A virus expressing domain III of West Nile virus induces protective immune responses against influenza and West Nile virus
    Byron E E Martina
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 6:e18995. 2011
    ..Furthermore, mice vaccinated with FLU-NA-DIII developed protective influenza virus-specific antibody titers. It was concluded that this vector system might be an attractive platform for the development of bivalent WNV-influenza vaccines...
  30. doi request reprint Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets
    Vincent J Munster
    National Influenza Center and Department of Virology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands
    Science 325:481-3. 2009
    ..These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences...
  31. ncbi request reprint The molecular basis of the pathogenicity of the Dutch highly pathogenic human influenza A H7N7 viruses
    Vincent J Munster
    Department of Virology and National Influenza Center, Erasmus Medical Center, Rotterdam, The Netherlands
    J Infect Dis 196:258-65. 2007
    ..We conclude that the influenza virus HA and PB2 genes should be the prime targets for molecular surveillance during outbreaks of zoonotic HPAI viruses...
  32. ncbi request reprint H5N1 Virus Attachment to Lower Respiratory Tract
    Debby van Riel
    Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
    Science 312:399. 2006
    ..These findings may explain, at least in part, the localization and severity of H5N1 viral pneumonia in humans. They also identify the cat and the ferret as suitable experimental animals based on this criterion...
  33. pmc Spatial, temporal, and species variation in prevalence of influenza A viruses in wild migratory birds
    Vincent J Munster
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Pathog 3:e61. 2007
    ..These data are useful for designing new surveillance programs and are particularly relevant due to increased interest in avian influenza in wild birds...
  34. pmc Reassortment between Avian H5N1 and human influenza viruses is mainly restricted to the matrix and neuraminidase gene segments
    Eefje J A Schrauwen
    Viroscience Lab, Postgraduate School Molecular Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 8:e59889. 2013
    ..The neuraminidase and matrix gene segments of human influenza viruses showed the highest genetic compatibility with HPAI H5N1 virus...
  35. doi request reprint DC-SIGN enhances infection of cells with glycosylated West Nile virus in vitro and virus replication in human dendritic cells induces production of IFN-alpha and TNF-alpha
    Byron E E Martina
    Department of Virology, Erasmus Medical Center Rotterdam, Institute of Virology, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Virus Res 135:64-71. 2008
    ..Together, these results indicate that DC-SIGN enhances infection of cells by WNV glycosylated strains, which may at least in part explain the higher pathogenicity of glycosylated L1 strains versus most non-glycosylated L2 strains...
  36. pmc Possible increased pathogenicity of pandemic (H1N1) 2009 influenza virus upon reassortment
    Eefje J A Schrauwen
    National Influenza Centre and Erasmus Medical Center Department of Virology, Rotterdam, The Netherlands
    Emerg Infect Dis 17:200-8. 2011
    ....
  37. pmc Virulence-associated substitution D222G in the hemagglutinin of 2009 pandemic influenza A(H1N1) virus affects receptor binding
    Salin Chutinimitkul
    Department of Virology, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands
    J Virol 84:11802-13. 2010
    ..Altered receptor specificity of the virus with D222G thus affected interaction with cells of the human lower respiratory tract, possibly explaining the observed association with enhanced disease in humans...
  38. ncbi request reprint A reverse-genetics system for Influenza A virus using T7 RNA polymerase
    Emmie de Wit
    National Influenza Center, Department of Virology and Postgraduate School of Molecular Medicine, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Gen Virol 88:1281-7. 2007
    ..Thus, a reverse-genetics system for the rescue of Influenza A virus has been developed, which will be useful for fundamental research and vaccine seed strain production in a variety of cell lines...
  39. ncbi request reprint Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques
    Bart L Haagmans
    Department of Virology, Erasmus Medical Centre, PO Box 1738, 3000 DR, Rotterdam, Netherlands
    Nat Med 10:290-3. 2004
    ..Postexposure treatment with pegylated IFN-alpha yielded intermediate results. We therefore suggest that pegylated IFN-alpha protects type 1 pneumocytes from SCV infection, and should be considered a candidate drug for SARS therapy...
  40. pmc Infection of the upper respiratory tract with seasonal influenza A(H3N2) virus induces protective immunity in ferrets against infection with A(H1N1)pdm09 virus after intranasal, but not intratracheal, inoculation
    Rogier Bodewes
    Viroscience Lab, Erasmus MC, Rotterdam, Netherlands
    J Virol 87:4293-301. 2013
    ..These findings are of interest in light of the development of so-called universal influenza vaccines that aim at the induction of cross-reactive T cell responses...
  41. ncbi request reprint Recombinant modified vaccinia virus Ankara-based vaccine induces protective immunity in mice against infection with influenza virus H5N1
    Joost H C M Kreijtz
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Infect Dis 195:1598-606. 2007
    ..Our data suggest that recombinant MVA expressing the HA of influenza virus A/Vietnam/1194/04 is a promising alternative vaccine candidate that could be used for the induction of protective immunity against various H5N1 influenza strains...
  42. doi request reprint Evaluation of vaccination strategies against infection with feline immunodeficiency virus (FIV) based on recombinant viral vectors expressing FIV Rev and OrfA
    Willem Huisman
    Erasmus MC, Institute of Virology, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Vet Immunol Immunopathol 126:332-8. 2008
    ..These recombinant viral vectors were used to immunize cats using a prime-boost regimen and the protective efficacy of this vaccination strategy was assessed after challenge infection of immunized cats with FIV...
  43. doi request reprint Severity of pneumonia due to new H1N1 influenza virus in ferrets is intermediate between that due to seasonal H1N1 virus and highly pathogenic avian influenza H5N1 virus
    Judith M A van den Brand
    Department of Virology, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Infect Dis 201:993-9. 2010
    ..Three influenza pandemics of the previous century caused variable mortality, which largely depended on the development of severe pneumonia. However, the ability of the new H1N1 virus to cause pneumonia is poorly understood...
  44. pmc Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals
    Debby van Riel
    Department of Virology, Erasmus MC, P O Box 2040, 3015 CA, Rotterdam, The Netherlands
    Am J Pathol 171:1215-23. 2007
    ..The PVA in human respiratory tract most closely mirrored that in ferrets and pigs for human influenza viruses and that in ferrets, pigs, and cats for avian influenza viruses...
  45. pmc Assessment of the antiviral properties of recombinant porcine SP-D against various influenza A viruses in vitro
    Marine L B Hillaire
    Erasmus Medical Centre, Rotterdam, The Netherlands
    PLoS ONE 6:e25005. 2011
    ..It was concluded that recombinant porcine SP-D holds promise as a novel antiviral agent against influenza and further development and evaluation in vivo seems warranted...
  46. pmc Pathogenesis of Influenza A/H5N1 virus infection in ferrets differs between intranasal and intratracheal routes of inoculation
    Rogier Bodewes
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Pathol 179:30-6. 2011
    ..The method of virus inoculation requires careful consideration in the design of ferret experiments as a model for influenza A/H5N1 in humans...
  47. pmc Molecular determinants of adaptation of highly pathogenic avian influenza H7N7 viruses to efficient replication in the human host
    Emmie de Wit
    National Influenza Center and Department of Virology, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Virol 84:1597-606. 2010
    ....
  48. pmc Seasonal and pandemic human influenza viruses attach better to human upper respiratory tract epithelium than avian influenza viruses
    Debby van Riel
    Erasmus Medical Center, Department of Virology, CA Rotterdam, The Netherlands
    Am J Pathol 176:1614-8. 2010
    ..These results suggest that the ability of an influenza virus to attach to human upper respiratory tract is a critical factor for efficient transmission in the human population...
  49. pmc Insertion of a multibasic cleavage site in the haemagglutinin of human influenza H3N2 virus does not increase pathogenicity in ferrets
    Eefje J A Schrauwen
    National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Gen Virol 92:1410-5. 2011
    ..This study indicates that acquisition of an MBCS alone is insufficient to increase pathogenicity of a prototypical seasonal human H3N2 virus...
  50. ncbi request reprint Does influenza vaccination exacerbate asthma in children?
    Herman J Bueving
    Department of General Practice, Room FF 305, Erasmus MC University Medical Center Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Vaccine 23:91-6. 2004
    ..The risks of influenza vaccination in asthmatic children are still being discussed. Especially, the risk that influenza vaccination may exacerbate asthma is an issue in this debate...
  51. pmc The multibasic cleavage site in H5N1 virus is critical for systemic spread along the olfactory and hematogenous routes in ferrets
    Eefje J A Schrauwen
    National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Virol 86:3975-84. 2012
    ..In conclusion, HPAI H5N1 virus can spread systemically via two different routes, olfactory and hematogenous, in ferrets. This systemic spread was dependent on the presence of the MBCS in HA...
  52. doi request reprint Characterization of recombinant influenza A virus as a vector for HIV-1 p17Gag
    Anna L de Goede
    Department of Virology, Erasmus Medical Center, P O Box 1738, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Vaccine 27:5735-9. 2009
    ..This study shows that replication-deficient rFlu-p17 is antigenic in vitro and immunogenic in vivo and warrants further development as a candidate vaccine vector...
  53. pmc Practical considerations for high-throughput influenza A virus surveillance studies of wild birds by use of molecular diagnostic tests
    Vincent J Munster
    National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Clin Microbiol 47:666-73. 2009
    ..Moreover, the lessons learned from current large-scale influenza A virus surveillance activities could be valuable for other pathogen surveillance programs in the future...
  54. ncbi request reprint Recognition of homo- and heterosubtypic variants of influenza A viruses by human CD8+ T lymphocytes
    Adrianus C M Boon
    Department of Virology and WHO National Influenza Center, Erasmus MC, Rotterdam, The Netherlands
    J Immunol 172:2453-60. 2004
    ....
  55. ncbi request reprint An amino acid substitution in the influenza A virus hemagglutinin associated with escape from recognition by human virus-specific CD4+ T-cells
    Eufemia G M Berkhoff
    Department of Virology and Postgraduate School Molecular Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Virus Res 126:282-7. 2007
    ..It was speculated that influenza viruses could evade recognition by virus-specific CD4+ T-cells, at least temporarily...
  56. pmc The hypervariable immunodominant NP418-426 epitope from the influenza A virus nucleoprotein is recognized by cytotoxic T lymphocytes with high functional avidity
    Adrianus C M Boon
    Department of Virology, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Virol 80:6024-32. 2006
    ..01). It was speculated that the high functional avidity of NP(418-426)-specific CTL was responsible for the diversification of this influenza A virus CTL epitope...
  57. doi request reprint Cross-protective immunity against influenza pH1N1 2009 viruses induced by seasonal influenza A (H3N2) virus is mediated by virus-specific T-cells
    Marine L B Hillaire
    Erasmus Medical Centre, Rotterdam, The Netherlands
    J Gen Virol 92:2339-49. 2011
    ....
  58. doi request reprint Intrahost evolution of envelope glycoprotein and OrfA sequences after experimental infection of cats with a molecular clone and a biological isolate of feline immunodeficiency virus
    Willem Huisman
    Erasmus MC, Institute of Virology, Rotterdam, The Netherlands
    Virus Res 137:24-32. 2008
    ..Although the extent of variation was higher after infection with biological isolate AM19, a large portion of these variant sequences was already present in the inoculum...
  59. ncbi request reprint Virology: SARS virus infection of cats and ferrets
    Byron E E Martina
    Institute of Virology, Erasmus Medical Centre, 3015 GE Rotterdam, The Netherlands
    Nature 425:915. 2003
  60. doi request reprint Annual influenza vaccination affects the development of heterosubtypic immunity
    Rogier Bodewes
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    Vaccine 30:7407-10. 2012
    ..These findings highlight the importance of the development of vaccines that provide protection against influenza A viruses of all subtypes...
  61. doi request reprint Human T-cells directed to seasonal influenza A virus cross-react with 2009 pandemic influenza A (H1N1) and swine-origin triple-reassortant H3N2 influenza viruses
    Marine L B Hillaire
    Department of Viroscience, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    J Gen Virol 94:583-92. 2013
    ..It was concluded that cross-reacting T-cells had the potential to afford protective immunity against A(H1N1)pdm09 viruses during the pandemic and offer some degree of protection against infection with A(H3N2)v viruses...
  62. pmc Annual vaccination against influenza virus hampers development of virus-specific CD8⁺ T cell immunity in children
    Rogier Bodewes
    Department of Virology, Erasmus Medical Center, Dr Molewaterplein 50, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Virol 85:11995-2000. 2011
    ..The consequences of these findings are discussed in the light of the development of protective immunity to seasonal and future pandemic influenza viruses...
  63. ncbi request reprint Host species barriers to influenza virus infections
    Thijs Kuiken
    Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
    Science 312:394-7. 2006
    ....
  64. doi request reprint Yearly influenza vaccinations: a double-edged sword?
    Rogier Bodewes
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Lancet Infect Dis 9:784-8. 2009
    ..Preventing infection with seasonal influenza viruses by vaccination might prevent the induction of heterosubtypic immunity to pandemic strains, which might be a disadvantage to immunologically naive people-eg, infants...
  65. doi request reprint The number and position of N-linked glycosylation sites in the hemagglutinin determine differential recognition of seasonal and 2009 pandemic H1N1 influenza virus by porcine surfactant protein D
    Marine L B Hillaire
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Virus Res 169:301-5. 2012
    ..However, predicting the effect remains difficult as it was shown to be dependent on the strain and the position of the glycosylation sites...
  66. ncbi request reprint Immunization with West Nile virus envelope domain III protects mice against lethal infection with homologous and heterologous virus
    Byron E Martina
    Erasmus Medical Center, Institute of Virology, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Vaccine 26:153-7. 2008
    ..It induces high neutralizing antibody titers, as well as, protection against lethal WNV infection in C57BL/6 mice. This vaccine preparation also afforded partial protection against lethal JEV infection...
  67. pmc Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome
    Ron A M Fouchier
    Department of Virology and National Influenza Center, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 101:1356-61. 2004
    ..Because H7N7 viruses have caused disease in mammals, including horses, seals, and humans, on several occasions in the past, they may be unusual in their zoonotic potential and, thus, form a pandemic threat to humans...
  68. pmc Influenza A virus (H5N1) infection in cats causes systemic disease with potential novel routes of virus spread within and between hosts
    Guus F Rimmelzwaan
    Department of Virology, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Am J Pathol 168:176-83; quiz 364. 2006
    ..This study in cats demonstrates that H5N1 virus infection causes systemic disease and spreads by potentially novel routes within and between mammalian hosts...
  69. doi request reprint FATT-CTL assay for detection of antigen-specific cell-mediated cytotoxicity
    Carel A van Baalen
    Department of Virology, Erasmus MC University Medical Center and Postgraduate School of Molecular Medicine, Rotterdam, The Netherlands
    Cytometry A 73:1058-65. 2008
    ..By measuring their defining function, the FATT-CTL assay contributes to a more complete assessment of antigen-specific CTL responses to infection and vaccination...
  70. doi request reprint The ins and outs of universal childhood influenza vaccination
    Pieter L A Fraaij
    Department of Virology, Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Future Microbiol 6:1171-84. 2011
    ....
  71. pmc Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls
    Ron A M Fouchier
    Dept of Virology, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Virol 79:2814-22. 2005
    ..We propose that sequence analyses of HA and NA genes of influenza A viruses be used for the rapid identification of existing and novel HA and NA subtypes...
  72. pmc A single immunization with CoVaccine HT-adjuvanted H5N1 influenza virus vaccine induces protective cellular and humoral immune responses in ferrets
    R Bodewes
    Department of Virology, Erasmus Medical Center, Dr Molewaterplein 50, PO Box 2040, 3000 CA Rotterdam, Netherlands
    J Virol 84:7943-52. 2010
    ..1 of H5N1 influenza viruses. Thus, the use of the novel adjuvant CoVaccine HT with cell culture-derived inactivated influenza A/H5N1 virus antigen is a promising and dose-sparing vaccine approach warranting further clinical evaluation...
  73. pmc Highly pathogenic avian influenza virus H7N7 isolated from a fatal human case causes respiratory disease in cats but does not spread systemically
    Debby van Riel
    Department of Virology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Am J Pathol 177:2185-90. 2010
    ..These findings suggest that HPAIV H5N1 possesses other characteristics that allow it to cause systemic disease in both humans and cats...
  74. ncbi request reprint Efficient generation and growth of influenza virus A/PR/8/34 from eight cDNA fragments
    Emmie de Wit
    National Influenza Center and Department of Virology, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Virus Res 103:155-61. 2004
    ..In conclusion, high-titer virus stocks of recombinant influenza A/PR/8/34 virus can be produced as well as virus stocks with much lower titers, but without the requirement of virus amplification through replication...
  75. ncbi request reprint Rapid sequencing of the non-coding regions of influenza A virus
    Emmie de Wit
    National Influenza Center and Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    J Virol Methods 139:85-9. 2007
    ..These PCR fragments can be sequenced directly without the need for cloning PCR fragments first. This method was used to sequence the NCRs of A/Bilthoven/16190/68 (H3N2) and A/Turkey/Turkey/1/05 (H5N1)...
  76. pmc Both conventional and interferon killer dendritic cells have antigen-presenting capacity during influenza virus infection
    Corine H GeurtsvanKessel
    Department of Pulmonary Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands
    PLoS ONE 4:e7187. 2009
    ..In conclusion, we found evidence for APC function of lung NK cells during influenza infection, but this is a feature not exclusive to the IKDC subset...
  77. doi request reprint Animal models for the preclinical evaluation of candidate influenza vaccines
    Rogier Bodewes
    Department of Virology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Expert Rev Vaccines 9:59-72. 2010
    ..Commonly, vaccines are tested for safety and efficacy in mice, ferrets and/or macaques. The use of each of these species has its advantages and limitations, which are addressed here...
  78. ncbi request reprint Assessment of the extent of variation in influenza A virus cytotoxic T-lymphocyte epitopes by using virus-specific CD8+ T-cell clones
    E G M Berkhoff
    Department of Virology and Postgraduate School of Molecular Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Gen Virol 88:530-5. 2007
    ..6 % of all CTL clones. For some of these CTL clones, the minimal epitope and the residues responsible for abrogation of T-cell recognition were identified...
  79. pmc Functional constraints of influenza A virus epitopes limit escape from cytotoxic T lymphocytes
    E G M Berkhoff
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Virol 79:11239-46. 2005
    ..It was speculated that functional constraints limit variation in certain epitopes, especially at anchor residues, explaining the conserved nature of these epitopes...
  80. ncbi request reprint Influenza virus-specific cytotoxic T lymphocytes: a correlate of protection and a basis for vaccine development
    Guus F Rimmelzwaan
    Erasmus Medical Center, Department of Virology, Rotterdam, The Netherlands
    Curr Opin Biotechnol 18:529-36. 2007
    ..In the present paper, the possibility to develop (cross-reactive) CTL-inducing vaccines is discussed...
  81. ncbi request reprint [The 2002/2003 influenza season in the Netherlands and the vaccine composition for the 2003/2004 season]
    J C de Jong
    Erasmus Medisch Centrum, afd Virologie, Postbus 1738, 3000 DR Rotterdam
    Ned Tijdschr Geneeskd 147:1971-5. 2003
    ..One of these later died as a result of this. None of the avian and human H7N7-virus isolates examined contained human or porcine influenza-A virus genes...
  82. doi request reprint The novel adjuvant CoVaccineHT increases the immunogenicity of cell-culture derived influenza A/H5N1 vaccine and induces the maturation of murine and human dendritic cells in vitro
    R Bodewes
    Department of Virology, Erasmus Medical Center, Dr Molewaterplein 50, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Vaccine 27:6833-9. 2009
    ..Inhibition experiments indicated that the effect of CoVaccineHT is mediated through TLR4 signaling. These data suggest that CoVaccineHT also will increase the immunogenicity of an influenza A/H5N1 vaccine in humans...
  83. ncbi request reprint [The 2006/'07 influenza season in the Netherlands and the vaccine composition for the 2007/'08 season]
    J C de Jong
    Erasmus MC Centrum, afd Virologie, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 151:2158-65. 2007
    ..For the 2007/'08 influenza season the World Health Organization has recommended the following vaccine composition: A/Solomon Islands/3/06 (H1N1) (new), A/Wisconsin/67/05 (H3N2), and B/Malaysia/2506/04...
  84. pmc Functional profile of human influenza virus-specific cytotoxic T lymphocyte activity is influenced by interleukin-2 concentration and epitope specificity
    A C M Boon
    Department of Virology and WHO National Influenza Center, Erasmus Medical Center, Rotterdam, The Netherlands
    Clin Exp Immunol 142:45-52. 2005
    ..05). The IL-2 concentration during expansion of virus-specific cells had a profound effect on the functionality of both M1-Tm(+) and NP-Tm(+) cells...
  85. ncbi request reprint Influenza A virus specific T cell immunity in humans during aging
    A C M Boon
    Erasmus University Rotterdam, Institute of Virology, Rotterdam, Netherlands
    Virology 299:100-8. 2002
    ....
  86. pmc The magnitude and specificity of influenza A virus-specific cytotoxic T-lymphocyte responses in humans is related to HLA-A and -B phenotype
    A C M Boon
    Institute of Virology, Erasmus University Rotterdam, 3015 GE Rotterdam, The Netherlands
    J Virol 76:582-90. 2002
    ..Furthermore, the magnitude of the influenza virus-specific CTL response seems dependent on the HLA-A and -B phenotypes...
  87. ncbi request reprint [The influenza season 2004/'05 in the Netherlands with the largest epidemic of the last 5 years caused by the virus variant A/California and the composition of the vaccine for the season 2005/'06]
    J C de Jong
    Erasmus MC, afd Virologie, Postbus 1738, 3000 DR Rotterdam
    Ned Tijdschr Geneeskd 149:2355-61. 2005
    ..For the 2005/'06 season, the World Health Organization has recommended the following vaccine composition: A/California/7/04 (H3N2), A/New Caledonia/20/99 (HiNI), and B/Shanghai/361/02...
  88. ncbi request reprint Full restoration of viral fitness by multiple compensatory co-mutations in the nucleoprotein of influenza A virus cytotoxic T-lymphocyte escape mutants
    G F Rimmelzwaan
    Department of Virology and WHO National Influenza Center, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Gen Virol 86:1801-5. 2005
    ..The nucleoprotein displays unexpected flexibility to overcome functional constraints imposed by CTL epitope sequences, allowing influenza viruses to escape from specific CTLs...
  89. doi request reprint Recombinant modified vaccinia virus Ankara expressing the hemagglutinin gene confers protection against homologous and heterologous H5N1 influenza virus infections in macaques
    J H C M Kreijtz
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Infect Dis 199:405-13. 2009
    ....
  90. pmc A mutation in the HLA-B*2705-restricted NP383-391 epitope affects the human influenza A virus-specific cytotoxic T-lymphocyte response in vitro
    E G M Berkhoff
    Institute of Virology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    J Virol 78:5216-22. 2004
    ....
  91. ncbi request reprint [2000/01 influenza season and the vaccine composition for the season 2001/'02]
    J C de Jong
    Erasmus Universiteit, afd Virologie, Postbus 1738, 3000, DR Rotterdam
    Ned Tijdschr Geneeskd 145:1945-50. 2001
    ....
  92. pmc The loss of immunodominant epitopes affects interferon-gamma production and lytic activity of the human influenza virus-specific cytotoxic T lymphocyte response in vitro
    E G M Berkhoff
    Department of Virology and Postgraduate School of Molecular Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Clin Exp Immunol 148:296-306. 2007
    ..These findings indicate that the loss of single immunodominant epitopes affects the functionality of the virus-specific CTL response significantly...
  93. ncbi request reprint A single dose of an ISCOM influenza vaccine induces long-lasting protective immunity against homologous challenge infection but fails to protect Cynomolgus macaques against distant drift variants of influenza A (H3N2) viruses
    G F Rimmelzwaan
    National Influenza Centre, Institute of Virology, Erasmus Medical Centre Rotterdam, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands
    Vaccine 20:158-63. 2001
    ....
  94. ncbi request reprint [The 2001/2002 influenza season and the vaccine composition for the 2002/2003 season]
    G F Rimmelzwaan
    Erasmus Medisch Centrum, afd Virologie, Postbus 1738, 3000 DR Rotterdam
    Ned Tijdschr Geneeskd 146:1846-50. 2002
    ....
  95. ncbi request reprint Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome
    Thijs Kuiken
    Department of Virology, Erasmus Medical Centre, PO Box 1738, 3000 DR, Rotterdam, Netherlands
    Lancet 362:263-70. 2003
    ..We did clinical and experimental studies to assess the role of this virus in the cause of SARS...
  96. pmc In vitro assessment of attachment pattern and replication efficiency of H5N1 influenza A viruses with altered receptor specificity
    Salin Chutinimitkul
    Department of Virology and National Influenza Center, Erasmus MC, P O Box 2040, 3000CA Rotterdam, Netherlands
    J Virol 84:6825-33. 2010
    ....
  97. pmc Targets for the induction of protective immunity against influenza a viruses
    Rogier Bodewes
    Department of Virology, ErasmusMC, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands E Mails R B A D M E O
    Viruses 2:166-88. 2010
    ....
  98. ncbi request reprint Antibodies specific for hypervariable regions 3 to 5 of the feline immunodeficiency virus envelope glycoprotein are not solely responsible for vaccine-induced acceleration of challenge infection in cats
    Willem Huisman
    Erasmus MC, Institute of Virology, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Gen Virol 85:1833-41. 2004
    ....
  99. ncbi request reprint Newer respiratory virus infections: human metapneumovirus, avian influenza virus, and human coronaviruses
    Ron Am Fouchier
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Curr Opin Infect Dis 18:141-6. 2005
    ..Here we review the recent literature on these respiratory viruses...
  100. ncbi request reprint In vitro effect of bioactive compounds on influenza virus specific B- and T-cell responses
    A C M Boon
    Erasmus University Rotterdam, Institute of Virology, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Scand J Immunol 55:24-32. 2002
    ..Neither of the two compounds exhibited a positive effect on the production of influenza virus specific antibodies by human peripheral blood mononuclear cells in vitro...
  101. ncbi request reprint Pathology of human influenza A (H5N1) virus infection in cynomolgus macaques (Macaca fascicularis)
    T Kuiken
    Institute of Virology, National Influenza Center, Erasmus Medical Center, Rotterdam, The Netherlands
    Vet Pathol 40:304-10. 2003
    ....