G F Rimmelzwaan

Summary

Affiliation: Erasmus University
Country: The Netherlands

Publications

  1. ncbi request reprint Antigenic and genetic characterization of swine influenza A (H1N1) viruses isolated from pneumonia patients in The Netherlands
    G F Rimmelzwaan
    Institute of Virology, Erasmus Medical Center Rotterdam, Rotterdam, 3000 DR, The Netherlands
    Virology 282:301-6. 2001
  2. ncbi request reprint Influenza vaccines: new developments
    G F Rimmelzwaan
    Institute of Virology, National Influenza Center, Erasmus University Rotterdam, The Netherlands
    Curr Opin Pharmacol 1:491-6. 2001
  3. ncbi request reprint Comparison of RNA hybridization, hemagglutination assay, titration of infectious virus and immunofluorescence as methods for monitoring influenza virus replication in vitro
    G F Rimmelzwaan
    National Influenza Centre and Department of Virology, Erasmus University Rotterdam, The Netherlands
    J Virol Methods 74:57-66. 1998
  4. ncbi request reprint [The 2001/2002 influenza season and the vaccine composition for the 2002/2003 season]
    G F Rimmelzwaan
    Erasmus Medisch Centrum, afd Virologie, Postbus 1738, 3000 DR Rotterdam
    Ned Tijdschr Geneeskd 146:1846-50. 2002
  5. pmc Inhibition of influenza virus replication by nitric oxide
    G F Rimmelzwaan
    National Influenza Center, Department of Virology, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Virol 73:8880-3. 1999
  6. ncbi request reprint Preclinical evaluation of a modified vaccinia virus Ankara (MVA)-based vaccine against influenza A/H5N1 viruses
    J H C M Kreijtz
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Vaccine 27:6296-9. 2009
  7. ncbi request reprint Influenza virus subtype cross-reactivities of haemagglutination inhibiting and virus neutralising serum antibodies induced by infection or vaccination with an ISCOM-based vaccine
    G F Rimmelzwaan
    National Influenza Centre and Department of Virology, Erasmus University Rotterdam, The Netherlands
    Vaccine 17:2512-6. 1999
  8. pmc The loss of immunodominant epitopes affects interferon-gamma production and lytic activity of the human influenza virus-specific cytotoxic T lymphocyte response in vitro
    E G M Berkhoff
    Department of Virology and Postgraduate School of Molecular Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Clin Exp Immunol 148:296-306. 2007
  9. doi request reprint The novel adjuvant CoVaccineHT increases the immunogenicity of cell-culture derived influenza A/H5N1 vaccine and induces the maturation of murine and human dendritic cells in vitro
    R Bodewes
    Department of Virology, Erasmus Medical Center, Dr Molewaterplein 50, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Vaccine 27:6833-9. 2009
  10. ncbi request reprint Assessment of the extent of variation in influenza A virus cytotoxic T-lymphocyte epitopes by using virus-specific CD8+ T-cell clones
    E G M Berkhoff
    Department of Virology and Postgraduate School of Molecular Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Gen Virol 88:530-5. 2007

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Antigenic and genetic characterization of swine influenza A (H1N1) viruses isolated from pneumonia patients in The Netherlands
    G F Rimmelzwaan
    Institute of Virology, Erasmus Medical Center Rotterdam, Rotterdam, 3000 DR, The Netherlands
    Virology 282:301-6. 2001
    ..It is concluded that European swine H1N1 viruses can infect humans directly, causing serious disease without the need for any reassortment event...
  2. ncbi request reprint Influenza vaccines: new developments
    G F Rimmelzwaan
    Institute of Virology, National Influenza Center, Erasmus University Rotterdam, The Netherlands
    Curr Opin Pharmacol 1:491-6. 2001
    ....
  3. ncbi request reprint Comparison of RNA hybridization, hemagglutination assay, titration of infectious virus and immunofluorescence as methods for monitoring influenza virus replication in vitro
    G F Rimmelzwaan
    National Influenza Centre and Department of Virology, Erasmus University Rotterdam, The Netherlands
    J Virol Methods 74:57-66. 1998
    ..Thus, besides direct measurement of infectious virus and immunofluorescence, RNA hybridization proved to be a sensitive assay for monitoring influenza virus replication in vitro...
  4. ncbi request reprint [The 2001/2002 influenza season and the vaccine composition for the 2002/2003 season]
    G F Rimmelzwaan
    Erasmus Medisch Centrum, afd Virologie, Postbus 1738, 3000 DR Rotterdam
    Ned Tijdschr Geneeskd 146:1846-50. 2002
    ....
  5. pmc Inhibition of influenza virus replication by nitric oxide
    G F Rimmelzwaan
    National Influenza Center, Department of Virology, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Virol 73:8880-3. 1999
    ..Reduction of productively infected cells and virus production proved to correlate with inhibition of viral RNA synthesis, indicating that NO affects an early step in the replication cycle of influenza viruses...
  6. ncbi request reprint Preclinical evaluation of a modified vaccinia virus Ankara (MVA)-based vaccine against influenza A/H5N1 viruses
    J H C M Kreijtz
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Vaccine 27:6296-9. 2009
    ..Therefore MVA-HA-VN/04 is a promising vaccine candidate for the induction of protective immunity against highly pathogenic avian influenza A/H5N1 viruses...
  7. ncbi request reprint Influenza virus subtype cross-reactivities of haemagglutination inhibiting and virus neutralising serum antibodies induced by infection or vaccination with an ISCOM-based vaccine
    G F Rimmelzwaan
    National Influenza Centre and Department of Virology, Erasmus University Rotterdam, The Netherlands
    Vaccine 17:2512-6. 1999
    ..The strong antibody response induced by vaccination with the A/Netherlands/18/94-ISCOM preparation was shown to be cross-reactive with recent influenza virus strains, which were isolated since 1992, but not with older strains...
  8. pmc The loss of immunodominant epitopes affects interferon-gamma production and lytic activity of the human influenza virus-specific cytotoxic T lymphocyte response in vitro
    E G M Berkhoff
    Department of Virology and Postgraduate School of Molecular Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Clin Exp Immunol 148:296-306. 2007
    ..These findings indicate that the loss of single immunodominant epitopes affects the functionality of the virus-specific CTL response significantly...
  9. doi request reprint The novel adjuvant CoVaccineHT increases the immunogenicity of cell-culture derived influenza A/H5N1 vaccine and induces the maturation of murine and human dendritic cells in vitro
    R Bodewes
    Department of Virology, Erasmus Medical Center, Dr Molewaterplein 50, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Vaccine 27:6833-9. 2009
    ..Inhibition experiments indicated that the effect of CoVaccineHT is mediated through TLR4 signaling. These data suggest that CoVaccineHT also will increase the immunogenicity of an influenza A/H5N1 vaccine in humans...
  10. ncbi request reprint Assessment of the extent of variation in influenza A virus cytotoxic T-lymphocyte epitopes by using virus-specific CD8+ T-cell clones
    E G M Berkhoff
    Department of Virology and Postgraduate School of Molecular Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Gen Virol 88:530-5. 2007
    ..6 % of all CTL clones. For some of these CTL clones, the minimal epitope and the residues responsible for abrogation of T-cell recognition were identified...
  11. ncbi request reprint Full restoration of viral fitness by multiple compensatory co-mutations in the nucleoprotein of influenza A virus cytotoxic T-lymphocyte escape mutants
    G F Rimmelzwaan
    Department of Virology and WHO National Influenza Center, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Gen Virol 86:1801-5. 2005
    ..The nucleoprotein displays unexpected flexibility to overcome functional constraints imposed by CTL epitope sequences, allowing influenza viruses to escape from specific CTLs...
  12. pmc Functional constraints of influenza A virus epitopes limit escape from cytotoxic T lymphocytes
    E G M Berkhoff
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Virol 79:11239-46. 2005
    ..It was speculated that functional constraints limit variation in certain epitopes, especially at anchor residues, explaining the conserved nature of these epitopes...
  13. pmc A mutation in the HLA-B*2705-restricted NP383-391 epitope affects the human influenza A virus-specific cytotoxic T-lymphocyte response in vitro
    E G M Berkhoff
    Institute of Virology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    J Virol 78:5216-22. 2004
    ....
  14. pmc Repository of Eurasian influenza A virus hemagglutinin and neuraminidase reverse genetics vectors and recombinant viruses
    J Keawcharoen
    National Influenza Centre and Department of Virology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Vaccine 28:5803-9. 2010
    ..These plasmids and viruses may be useful for numerous purposes, including influenza virus research projects, vaccination studies, and to serve as reference reagents in diagnostic settings...
  15. ncbi request reprint [The 2003/2004 influenza season in the Netherlands with a limited epidemic of the virus variant A/Fujian, and the vaccine composition for the 2004/2005 season]
    G F Rimmelzwaan
    Erasmus Medisch Centrum, afd Virologie, Postbus 1738, 3000 DR Rotterdam
    Ned Tijdschr Geneeskd 148:1984-8. 2004
    ....
  16. ncbi request reprint Sequence variation in the influenza A virus nucleoprotein associated with escape from cytotoxic T lymphocytes
    G F Rimmelzwaan
    Institute for Virology, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Virus Res 103:97-100. 2004
    ....
  17. doi request reprint Recombinant modified vaccinia virus Ankara expressing the hemagglutinin gene confers protection against homologous and heterologous H5N1 influenza virus infections in macaques
    J H C M Kreijtz
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Infect Dis 199:405-13. 2009
    ....
  18. ncbi request reprint Influenza A virus specific T cell immunity in humans during aging
    A C M Boon
    Erasmus University Rotterdam, Institute of Virology, Rotterdam, Netherlands
    Virology 299:100-8. 2002
    ....
  19. ncbi request reprint Fitness costs limit escape from cytotoxic T lymphocytes by influenza A viruses
    E G M Berkhoff
    Department of Virology and WHO National Influenza Center, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Vaccine 24:6594-6. 2006
    ..Our findings indicated that fitness costs limited variation in functionally constrained epitopes, especially at anchor residues...
  20. ncbi request reprint Human airway epithelial cells present antigen to influenza virus-specific CD8+ CTL inefficiently after incubation with viral protein together with ISCOMATRIX
    G F Rimmelzwaan
    Institute of Virology, National Influenza Center, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Vaccine 22:2769-75. 2004
    ....
  21. ncbi request reprint [2000/01 influenza season and the vaccine composition for the season 2001/'02]
    J C de Jong
    Erasmus Universiteit, afd Virologie, Postbus 1738, 3000, DR Rotterdam
    Ned Tijdschr Geneeskd 145:1945-50. 2001
    ....
  22. ncbi request reprint Characterization of high-growth reassortant influenza A viruses generated in MDCK cells cultured in serum-free medium
    J T Voeten
    Institute of Virology and WHO National Influenza Centre, Erasmus University Rotterdam, The Netherlands
    Vaccine 17:1942-50. 1999
    ..The use of MDCK-SF1 cells together with these reassortants for generating influenza virus antigens can significantly speed up the vaccine production procedure...
  23. doi request reprint Pandemic 2009 H1N1 influenza virus causes diffuse alveolar damage in cynomolgus macaques
    S Herfst
    Department of Virology, Erasmus Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Vet Pathol 47:1040-7. 2010
    ..Its higher pathogenicity compared with a seasonal H1N1 virus may be explained in part by higher replication in the lower respiratory tract...
  24. pmc Functional compensation of a detrimental amino acid substitution in a cytotoxic-T-lymphocyte epitope of influenza a viruses by comutations
    G F Rimmelzwaan
    Erasmus MC, Department of Virology, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Virol 78:8946-9. 2004
    ..We hypothesized that influenza A viruses need to overcome functional constraints to accumulate mutations in CTL epitopes and escape from CTLs...
  25. pmc Antigenic and genetic evolution of swine influenza A (H3N2) viruses in Europe
    J C de Jong
    National Influenza Center, Department of Virology, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Virol 81:4315-22. 2007
    ..Our data suggest that humoral immunity in the population plays a smaller role in the evolutionary selection processes of swine H3N2 viruses than in human H3N2 viruses...
  26. pmc Use of recombinant nucleoproteins in enzyme-linked immunosorbent assays for detection of virus-specific immunoglobulin A (IgA) and IgG antibodies in influenza virus A- or B-infected patients
    J T Voeten
    WHO National Influenza Centre and Institute of Virology, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Clin Microbiol 36:3527-31. 1998
    ....
  27. pmc Pathogenesis of influenza A (H5N1) virus infection in a primate model
    G F Rimmelzwaan
    Institute of Virology, National Influenza Center, Erasmus University Medical Center Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Virol 75:6687-91. 2001
    ..Reverse transcription PCR, virus isolation, and immunohistochemistry showed that the respiratory tract is the major target of the virus...
  28. pmc Functional profile of human influenza virus-specific cytotoxic T lymphocyte activity is influenced by interleukin-2 concentration and epitope specificity
    A C M Boon
    Department of Virology and WHO National Influenza Center, Erasmus Medical Center, Rotterdam, The Netherlands
    Clin Exp Immunol 142:45-52. 2005
    ..05). The IL-2 concentration during expansion of virus-specific cells had a profound effect on the functionality of both M1-Tm(+) and NP-Tm(+) cells...
  29. ncbi request reprint [The influenza season 2004/'05 in the Netherlands with the largest epidemic of the last 5 years caused by the virus variant A/California and the composition of the vaccine for the season 2005/'06]
    J C de Jong
    Erasmus MC, afd Virologie, Postbus 1738, 3000 DR Rotterdam
    Ned Tijdschr Geneeskd 149:2355-61. 2005
    ..For the 2005/'06 season, the World Health Organization has recommended the following vaccine composition: A/California/7/04 (H3N2), A/New Caledonia/20/99 (HiNI), and B/Shanghai/361/02...
  30. ncbi request reprint [The 2005-2006 influenza season in the Netherlands and the vaccine composition for the 2006-2007 season]
    G F Rimmelzwaan
    Erasmus MC, afd Virologie, Rotterdam
    Ned Tijdschr Geneeskd 150:2209-14. 2006
    ..For the 2006-2007 influenza season, the World Health Organization has recommended the following vaccine composition: A/Wisconsin/67/05 (H3N2), A/New Caledonia/20/99 (H1N1) and B/Malaysia/2506/05...
  31. ncbi request reprint [The 2002/2003 influenza season in the Netherlands and the vaccine composition for the 2003/2004 season]
    J C de Jong
    Erasmus Medisch Centrum, afd Virologie, Postbus 1738, 3000 DR Rotterdam
    Ned Tijdschr Geneeskd 147:1971-5. 2003
    ..One of these later died as a result of this. None of the avian and human H7N7-virus isolates examined contained human or porcine influenza-A virus genes...
  32. pmc Cross-recognition of avian H5N1 influenza virus by human cytotoxic T-lymphocyte populations directed to human influenza A virus
    J H C M Kreijtz
    Department of Virology, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Virol 82:5161-6. 2008
    ..This preexisting cross-reactive T-cell immunity in the human population may dampen the impact of a next pandemic...
  33. doi request reprint Redundancy of the influenza A virus-specific cytotoxic T lymphocyte response in HLA-B*2705 transgenic mice limits the impact of a mutation in the immunodominant NP(383-391) epitope on influenza pathogenesis
    R Bodewes
    Department of Virology, Erasmus MC, Dr Molewaterplein 50, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Virus Res 155:123-30. 2011
    ....
  34. doi request reprint Infection of mice with a human influenza A/H3N2 virus induces protective immunity against lethal infection with influenza A/H5N1 virus
    J H C M Kreijtz
    Department of Virology, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Vaccine 27:4983-9. 2009
    ..Furthermore the existence of pre-existing heterosubtypic immunity may dampen the impact a future influenza pandemic may have...
  35. ncbi request reprint Mismatch between the 1997/1998 influenza vaccine and the major epidemic A(H3N2) virus strain as the cause of an inadequate vaccine-induced antibody response to this strain in the elderly
    J C de Jong
    Department of Virology, WHO National Influenza Centre, Erasmus University, Rotterdam, The Netherlands
    J Med Virol 61:94-9. 2000
    ..If an antigenic mismatch is observed, the protective efficacy of the vaccine, especially for the elderly, may be insufficient. The observations also support the current policy to include the elderly in serologic efficacy trials...
  36. ncbi request reprint A single dose of an ISCOM influenza vaccine induces long-lasting protective immunity against homologous challenge infection but fails to protect Cynomolgus macaques against distant drift variants of influenza A (H3N2) viruses
    G F Rimmelzwaan
    National Influenza Centre, Institute of Virology, Erasmus Medical Centre Rotterdam, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands
    Vaccine 20:158-63. 2001
    ....
  37. ncbi request reprint Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus
    E C Claas
    Department of Virology and WHO National Influenza Centre, Erasmus University, Rotterdam, The Netherlands
    Lancet 351:472-7. 1998
    ..Preceding this incident, avian influenza outbreaks of high mortality were reported from three chicken farms in Hong Kong, and the virus involved was also found to be of the H5 subtype...
  38. pmc Sequence variation in a newly identified HLA-B35-restricted epitope in the influenza A virus nucleoprotein associated with escape from cytotoxic T lymphocytes
    A C M Boon
    Institute of Virology, Erasmus University Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Virol 76:2567-72. 2002
    ..The influenza virus variants emerged in chronological order, and CTLs directed against old variants failed to recognize more recent strains of influenza A virus, indicating an escape from CTL immunity...
  39. ncbi request reprint Low pathogenic avian influenza A(H7N9) virus causes high mortality in ferrets upon intratracheal challenge: a model to study intervention strategies
    J H C M Kreijtz
    Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands
    Vaccine 31:4995-9. 2013
    ..This model will facilitate the development and assessment of clinical intervention strategies for LPAI-H7N9 virus infection in humans, such as preventive vaccination and the use of antivirals. ..
  40. doi request reprint Immune responses to influenza virus infection
    J H C M Kreijtz
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    Virus Res 162:19-30. 2011
    ..The development of such novel vaccines would imply that also new immune correlates of protection need to be established in order to facilitate assessment of vaccine efficacy...
  41. ncbi request reprint A primate model to study the pathogenesis of influenza A (H5N1) virus infection
    G F Rimmelzwaan
    Institute of Virology, National Influenza Center, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Avian Dis 47:931-3. 2003
    ..The data indicate that ARDS and multiple organ dysfunction syndrome (MODS), observed in both humans and monkeys infected with this virus, are caused by diffuse alveolar damage from virus replication in the lungs alone...
  42. ncbi request reprint Primary influenza A virus infection induces cross-protective immunity against a lethal infection with a heterosubtypic virus strain in mice
    J H C M Kreijtz
    Department of Virology, Erasmus Medical Centre, P O Box 1738, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Vaccine 25:612-20. 2007
    ..The implications of these observations are discussed in the light of the current pandemic threat and development of vaccines that aim at the induction of virus-specific CTL...
  43. ncbi request reprint Haemagglutination-inhibiting antibody to influenza virus
    J C de Jong
    National Influenza Centre, Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Dev Biol (Basel) 115:63-73. 2003
    ..However, even in completely healthy elderly individuals the response to vaccination with an antigenically new virus may be strongly reduced compared with younger vaccinees...
  44. doi request reprint Pathogenesis of influenza virus infections: the good, the bad and the ugly
    T Kuiken
    Erasmus Medical Center, Department of Virology, Rotterdam, The Netherlands
    Curr Opin Virol 2:276-86. 2012
    ..By interdisciplinary efforts to better understand the intricate interaction between virus, tissue, and immune response, we may be able to find new ways to improve the outcome of influenza virus infections...
  45. pmc Detection of influenza A viruses from different species by PCR amplification of conserved sequences in the matrix gene
    R A Fouchier
    National Influenza Center and Department of Virology, Erasmus University, Rotterdam, The Netherlands
    J Clin Microbiol 38:4096-101. 2000
    ..Comparative tests with throat swab samples from humans and fecal and cloacal swab samples from birds confirmed that the new PCR is faster and up to 100-fold more sensitive than classical virus isolation procedures...
  46. doi request reprint Clearance of influenza virus infections by T cells: risk of collateral damage?
    M L B Hillaire
    Viroscience Lab, Erasmus MC, Rotterdam, The Netherlands
    Curr Opin Virol 3:430-7. 2013
    ..Here we discuss the recent findings on the balance between the beneficial and detrimental effects of T cell responses in influenza virus infections. ..
  47. pmc Characterization of the human CD8⁺ T cell response following infection with 2009 pandemic influenza H1N1 virus
    M L B Hillaire
    Department of Virology, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Virol 85:12057-61. 2011
    ..In particular, effector cell frequencies declined rapidly postinfection in favor of relatively larger proportions of central memory cells...
  48. ncbi request reprint In vitro effect of bioactive compounds on influenza virus specific B- and T-cell responses
    A C M Boon
    Erasmus University Rotterdam, Institute of Virology, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Scand J Immunol 55:24-32. 2002
    ..Neither of the two compounds exhibited a positive effect on the production of influenza virus specific antibodies by human peripheral blood mononuclear cells in vitro...
  49. doi request reprint Vaccine-induced enhancement of viral infections
    W Huisman
    Erasmus MC, Institute of Virology, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Vaccine 27:505-12. 2009
    ..The present paper reviews the currently known mechanisms of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis...
  50. ncbi request reprint Viral vaccine meeting held in Barcelona, October 25-28, 2003
    A C M Boon
    Institute of Virology, Erasmus MC, Rotterdam, The Netherlands
    Vaccine 22:1327-34. 2004
  51. pmc Detection of nonhemagglutinating influenza a(h3) viruses by enzyme-linked immunosorbent assay in quantitative influenza virus culture
    C A van Baalen
    ViroClinics Biosciences B V, Rotterdam, The Netherlands
    J Clin Microbiol 52:1672-7. 2014
    ..The virus culture ELISA described here will enable efficacy testing of new antiviral compounds in clinical trials during seasons in which nonhemagglutinating influenza A viruses circulate. ..
  52. ncbi request reprint Pathology of human influenza A (H5N1) virus infection in cynomolgus macaques (Macaca fascicularis)
    T Kuiken
    Institute of Virology, National Influenza Center, Erasmus Medical Center, Rotterdam, The Netherlands
    Vet Pathol 40:304-10. 2003
    ....
  53. ncbi request reprint [Neuraminidase inhibitors oseltamivir and zanamivir: new means of defence against influenza]
    J C de Jong
    Erasmus Medisch Centrum, afd Virologie, Postbus 1738, 3000 DR Rotterdam
    Ned Tijdschr Geneeskd 148:73-9. 2004
    ....
  54. ncbi request reprint H5N1 influenza in Hong Kong: virus characterizations
    A D M E Osterhaus
    National Influenza Centre of the Netherlands, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Vaccine 20:S82-3. 2002
    ..Characteristics of the strains involved are discussed in relation to the question why, on the one hand, these strains were able to infect humans but on the other hand were not able to start an epidemic...
  55. ncbi request reprint Modulation of primary human immunodeficiency virus type 1 envelope glycoprotein-mediated entry by human antibodies
    M Schutten
    Erasmus University Hospital Rotterdam, Institute of Virology, The Netherlands
    J Gen Virol 78:999-1006. 1997
    ..One human monoclonal antibody directed against gp41 (IAM 2F5) inhibited entry of all the viruses studied, irrespective of their phenotype, and directly proportional to its affinity to monomeric HIV-1 gp 160...
  56. pmc The magnitude and specificity of influenza A virus-specific cytotoxic T-lymphocyte responses in humans is related to HLA-A and -B phenotype
    A C M Boon
    Institute of Virology, Erasmus University Rotterdam, 3015 GE Rotterdam, The Netherlands
    J Virol 76:582-90. 2002
    ..Furthermore, the magnitude of the influenza virus-specific CTL response seems dependent on the HLA-A and -B phenotypes...
  57. ncbi request reprint Flu in the limelight
    G F Rimmelzwaan
    Vaccine 20:2153-4. 2002
  58. ncbi request reprint Nosocomial influenza infection among post-influenza-vaccinated patients with severe pulmonary diseases
    H F Berg
    Department of Clinical Microbiology, St Elisabeth Hospital, Tilburg, The Netherlands
    J Infect 46:129-32. 2003
    ..To report an outbreak of nosocomial influenza in thirteen out of twenty-two admitted patients suffering from severe lung emphysema...
  59. ncbi request reprint [The 2006/'07 influenza season in the Netherlands and the vaccine composition for the 2007/'08 season]
    J C de Jong
    Erasmus MC Centrum, afd Virologie, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 151:2158-65. 2007
    ..For the 2007/'08 influenza season the World Health Organization has recommended the following vaccine composition: A/Solomon Islands/3/06 (H1N1) (new), A/Wisconsin/67/05 (H3N2), and B/Malaysia/2506/04...
  60. ncbi request reprint [Influenza season 2007/'08 in the Netherlands: antigenic variation, oseltamivir resistance and vaccine composition for the 2008/'09 season]
    G F Rimmelzwaan
    Erasmus MC Centrum, afd Virologie, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 152:2138-44. 2008
    ..For the 2008/'09 influenza season, the World Health Organization has recommended the following vaccine composition: A/Brisbane/59/07 (H1N1), A/Brisbane/10/07 (H3N2) and B/Florida/4/06...
  61. ncbi request reprint Impaired response rates, but satisfying protection rates to influenza vaccination in dialysis patients
    N P J Vogtländer
    Department of Internal Medicine, Red Cross Hospital, The Hague, The Netherlands
    Vaccine 22:2199-201. 2004
    ..Protective titres were reached in 53-93% of the patients. Since protective antibody titers can be induced, it is recommended to vaccinate dialysis patients annually against influenza...
  62. pmc Antigen processing for MHC class I restricted presentation of exogenous influenza A virus nucleoprotein by B-lymphoblastoid cells
    J T Voeten
    Institute of Virology and WHO National Influenza Centre, Erasmus Medical Centre Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Clin Exp Immunol 125:423-31. 2001
    ..HLA-B27-associated presentation was also observed using cells lacking a functional transporter associated with antigen processing, suggesting that alternative pathways may be exploited for processing of rNP...
  63. ncbi request reprint Influenza A virus surveillance in wild birds in Northern Europe in 1999 and 2000
    R A M Fouchier
    National Influenza Center and Department of Virology, Erasmus University, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Avian Dis 47:857-60. 2003
    ..A wide variety of isolates was obtained representing hemagglutinin (HA) subtypes 1 through 7, 10, 11, 13, an unidentifiable HA, and neuraminidase (NA) subtypes 1 through 8...
  64. ncbi request reprint The effect of anti-tumour necrosis factor alpha treatment on the antibody response to influenza vaccination
    L B S Gelinck
    Department of Infectious Diseases, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Ann Rheum Dis 67:713-6. 2008
    ..Therefore, we investigated the effect of the three currently available anti-TNF agents on influenza vaccination outcomes in a patient population with long-standing disease...
  65. pmc Poor serological responses upon influenza vaccination in patients with rheumatoid arthritis treated with rituximab
    L B S Gelinck
    Ann Rheum Dis 66:1402-3. 2007
  66. ncbi request reprint Influenza vaccination in asthmatic children: effects on quality of life and symptoms
    H J Bueving
    Dept of General Practice, room Ff305, Erasmus MC University Medical Center Rotterdam, PO Box, 1738, The Netherlands
    Eur Respir J 24:925-31. 2004
    ..Influenza vaccination was found to have a moderately beneficial effect on quality of life in influenza-positive weeks of illness in children with asthma...
  67. ncbi request reprint Cellular and humoral responses to influenza in gabonese children living in rural and semi-urban areas
    E van Riet
    Department of Parasitology, Leiden University Medical Center, Leiden, Leiden, 2300 RC, The Netherlands
    J Infect Dis 196:1671-8. 2007
    ..In addition, the effects of influenza vaccination in African countries could be very different from the effects in regions with less exposure to microorganisms and parasites...