Ingrid B Renes

Summary

Affiliation: Erasmus University
Country: The Netherlands

Publications

  1. ncbi request reprint Alterations in Muc2 biosynthesis and secretion during dextran sulfate sodium-induced colitis
    Ingrid B Renes
    Department of Pediatrics, Pediatric Gastroenterology and Nutrition, Erasmus Medical Center, Dr Molewaterplein 30, 3015 GE Rotterdam, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 282:G382-9. 2002
  2. ncbi request reprint Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection
    Maria Van Der Sluis
    Division of Neonatology, Department of Pediatrics, Erasmus MC and Sophia Children s Hospital, Rotterdam, The Netherlands
    Gastroenterology 131:117-29. 2006
  3. ncbi request reprint Methotrexate-induced mucositis in mucin 2-deficient mice
    Barbara A E de Koning
    Division of Pediatric Oncology, Laboratory of Pediatrics, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    J Cell Physiol 210:144-52. 2007
  4. ncbi request reprint Distinct epithelial responses in experimental colitis: implications for ion uptake and mucosal protection
    Ingrid B Renes
    Laboratory of Pediatrics, Pediatric Gastroenterology and Nutrition, Erasmus Medical Center, Rotterdam, and Sophia Children s Hospital, Rotterdam 3015GE, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 283:G169-79. 2002
  5. doi request reprint Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice
    Maria Van Der Sluis
    Division of Neonatology, Department of Pediatrics, Erasmus MC and Sophia Children s Hospital, Rotterdam, The Netherlands
    Lab Invest 88:634-42. 2008
  6. pmc Mucin Muc2 deficiency and weaning influences the expression of the innate defense genes Reg3β, Reg3γ and angiogenin-4
    Nanda Burger-Van Paassen
    Laboratory of Pediatrics, Division of Neonatology, Erasmus MC Sophia, Rotterdam, The Netherlands
    PLoS ONE 7:e38798. 2012
  7. doi request reprint Epithelial functions of the residual bowel after surgery for necrotising enterocolitis in human infants
    Maaike W Schaart
    Department of Pediatrics, Erasmus MC Sophia Children s Hospital, The Netherlands
    J Pediatr Gastroenterol Nutr 49:31-41. 2009
  8. ncbi request reprint Epithelial proliferation, cell death, and gene expression in experimental colitis: alterations in carbonic anhydrase I, mucin MUC2, and trefoil factor 3 expression
    Ingrid B Renes
    Department of Pediatrics, Erasmus Medical Center, Dr Molewaterplein 50, and Sophia Children s Hospital, 3015 GE Rotterdam, The Netherlands
    Int J Colorectal Dis 17:317-26. 2002
  9. doi request reprint Colitis development during the suckling-weaning transition in mucin Muc2-deficient mice
    Nanda Burger-Van Paassen
    Laboratory of Pediatrics, Rotterdam, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 301:G667-78. 2011
  10. ncbi request reprint Specific responses in rat small intestinal epithelial mRNA expression and protein levels during chemotherapeutic damage and regeneration
    Melissa Verburg
    Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Erasmus University, Rotterdam, The Netherlands
    J Histochem Cytochem 50:1525-36. 2002

Collaborators

  • Alexandra W C Einerhand
  • Barbara A E de Koning
  • Ronald R de Krijger
  • Sacha Ferdinandusse
  • Gunther Boehm
  • Marie Chantal Struijs
  • Michael Mahler
  • Jerry M Wells
  • Jules P P Meijerink
  • A Velcich
  • Jan Dekker
  • KERMIT CARRAWAY
  • Johannes B van Goudoever
  • Maria Van Der Sluis
  • Peng Lu
  • Isabelle Van Seuningen
  • Maaike W Schaart
  • Nanda Burger-Van Paassen
  • Adrianus C J M De Bruijn
  • Anita M Korteland-Van Male
  • Janneke Witte-Bouma
  • Janneke Bouma
  • Audrey Vincent
  • Hans A Büller
  • Dick Tibboel
  • Melissa Verburg
  • Henk Schierbeek
  • Kiyoshi Yamaguchi
  • Nicolas Jonckheere
  • Danielle J P M Van Nispen
  • Mireille K Makkink
  • Liora Levi
  • Jiaping Mei
  • Yael Lifshitz
  • Fabiana Bar-Yoseph
  • Linda M P Loonen
  • Jean Pierre Kerckaert
  • Patrycja J Puiman
  • Deirdre M Bouwman
  • Michael F McEntee
  • Anita Korteland-Van Male
  • Joo Heon Yoon
  • Maria Cekanova
  • Seung Joon Baek
  • Susan M Fischer
  • Jean Pierre Aubert
  • Pascal Pigny
  • Marie Paule Ducourouble
  • Anita Korteland van Male
  • Jean Noel Freund
  • Michael Perrais
  • Rolien H C Raatgeep
  • Takeshi Yamanouchi
  • Nicole M J Schwerbrock
  • Marie Luise Enss
  • Markus Cornberg
  • Hans J Hedrich
  • Marieke Jorritsma
  • Jos A Boshuizen
  • Siegfried Wagner

Detail Information

Publications27

  1. ncbi request reprint Alterations in Muc2 biosynthesis and secretion during dextran sulfate sodium-induced colitis
    Ingrid B Renes
    Department of Pediatrics, Pediatric Gastroenterology and Nutrition, Erasmus Medical Center, Dr Molewaterplein 30, 3015 GE Rotterdam, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 282:G382-9. 2002
    ..Collectively, these data suggest specific adaptations of the mucus layer to maintain the protective capacities during DSS-induced colitis...
  2. ncbi request reprint Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection
    Maria Van Der Sluis
    Division of Neonatology, Department of Pediatrics, Erasmus MC and Sophia Children s Hospital, Rotterdam, The Netherlands
    Gastroenterology 131:117-29. 2006
    ..Expression of mucin MUC2, the structural component of the colonic mucus layer, is lowered in inflammatory bowel disease. Our aim was to obtain insight in the role of Muc2 in epithelial protection...
  3. ncbi request reprint Methotrexate-induced mucositis in mucin 2-deficient mice
    Barbara A E de Koning
    Division of Pediatric Oncology, Laboratory of Pediatrics, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    J Cell Physiol 210:144-52. 2007
    ..A possible explanation is the mechanism by which Muc2 deficiency may trigger the immune system to release interleukin-10, an anti-inflammatory cytokine before MTX-treatment...
  4. ncbi request reprint Distinct epithelial responses in experimental colitis: implications for ion uptake and mucosal protection
    Ingrid B Renes
    Laboratory of Pediatrics, Pediatric Gastroenterology and Nutrition, Erasmus Medical Center, Rotterdam, and Sophia Children s Hospital, Rotterdam 3015GE, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 283:G169-79. 2002
    ..The maintenance or upregulation of Muc2 and TFF3 synthesis and secretion levels implies that goblet cells at least maintain their epithelial defense and repair capacity during acute inflammation induced by DSS...
  5. doi request reprint Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice
    Maria Van Der Sluis
    Division of Neonatology, Department of Pediatrics, Erasmus MC and Sophia Children s Hospital, Rotterdam, The Netherlands
    Lab Invest 88:634-42. 2008
    ..These data indicate that (i) in case of Muc2 deficiency, the anti-inflammatory cytokine IL-10 can control epithelial damage, though to a limited extent and (ii) the mucus layer is most likely a key factor determining colitis...
  6. pmc Mucin Muc2 deficiency and weaning influences the expression of the innate defense genes Reg3β, Reg3γ and angiogenin-4
    Nanda Burger-Van Paassen
    Laboratory of Pediatrics, Division of Neonatology, Erasmus MC Sophia, Rotterdam, The Netherlands
    PLoS ONE 7:e38798. 2012
    ....
  7. doi request reprint Epithelial functions of the residual bowel after surgery for necrotising enterocolitis in human infants
    Maaike W Schaart
    Department of Pediatrics, Erasmus MC Sophia Children s Hospital, The Netherlands
    J Pediatr Gastroenterol Nutr 49:31-41. 2009
    ..Our aim is to evaluate epithelial functions in the intestinal resection margins of tissue obtained at bowel resection for acute NEC and consecutive stoma closure...
  8. ncbi request reprint Epithelial proliferation, cell death, and gene expression in experimental colitis: alterations in carbonic anhydrase I, mucin MUC2, and trefoil factor 3 expression
    Ingrid B Renes
    Department of Pediatrics, Erasmus Medical Center, Dr Molewaterplein 50, and Sophia Children s Hospital, 3015 GE Rotterdam, The Netherlands
    Int J Colorectal Dis 17:317-26. 2002
    ..To gain insight in intestinal epithelial proliferation, cell death, and gene expression during experimental colitis rats were treated with dextran sulfate sodium (DSS) for 7 days...
  9. doi request reprint Colitis development during the suckling-weaning transition in mucin Muc2-deficient mice
    Nanda Burger-Van Paassen
    Laboratory of Pediatrics, Rotterdam, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 301:G667-78. 2011
    ..Colitis in Muc2(-/-) mice is limited before weaning by immune suppressive responses and exacerbates in the distal colon after weaning because of the decline in the immune suppressive response...
  10. ncbi request reprint Specific responses in rat small intestinal epithelial mRNA expression and protein levels during chemotherapeutic damage and regeneration
    Melissa Verburg
    Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Erasmus University, Rotterdam, The Netherlands
    J Histochem Cytochem 50:1525-36. 2002
    ..Decreased expression of enterocyte-specific markers represents decreased enterocyte function, of which fatty acid transporters were least affected...
  11. doi request reprint Small intestinal MUC2 synthesis in human preterm infants
    Maaike W Schaart
    Erasmus Medical Center, Sophia Children s Hospital, Department of Pediatrics, Division of Neonatology, Rotterdam, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 296:G1085-90. 2009
    ..Median FSR of small intestinal MUC2 was 67.2 (44.3-103.9)% per day. Systemic threonine is rapidly incorporated into MUC2 in the small intestine of preterm infants, and thereby MUC2 has a very high synthesis rate...
  12. ncbi request reprint Fate of goblet cells in experimental colitis
    Mireille K Makkink
    Department of Pediatrics, Erasmus University and Sophia Children Hospital, Rotterdam, The Netherlands
    Dig Dis Sci 47:2286-97. 2002
    ..Quantitatively, the Muc2 and TFF3 levels remained relatively stabile in IL10-/- mice. Muc2 in distal IL10-/- colon contained significantly less sulfate residues than in controls, which may compromise its protective properties...
  13. ncbi request reprint Isolation-stress increases small intestinal sensitivity to chemotherapy in rats
    Melissa Verburg
    Pediatric Gastroenterology and Nutrition, Laboratory of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
    Gastroenterology 124:660-71. 2003
    ..Psychologic stress is known to be detrimental to normal intestinal physiology. We set out to determine if psychologic stress adds to the intestinal damage provoked by chemotherapy...
  14. ncbi request reprint Protection of the Peyer's patch-associated crypt and villus epithelium against methotrexate-induced damage is based on its distinct regulation of proliferation
    Ingrid B Renes
    Laboratory of Paediatrics, Department of Gastroenterology and Nutrition, Erasmus University and Sophia Children s Hospital, Rotterdam, The Netherlands
    J Pathol 198:60-8. 2002
    ..Enterocyte function in the PP epithelium was unaffected by MTX treatment. Goblet and Paneth cell function was maintained in both NP and PP epithelium...
  15. pmc Alterations in epithelial and mesenchymal intestinal gene expression during doxorubicin-induced mucositis in mice
    Barbara A E de Koning
    Department of Pediatrics, Divisions of Pediatric Oncology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Dig Dis Sci 52:1814-25. 2007
    ..These data suggest that in response to DOX-induced damage, BMP4 and TCF4 are modulated in such a way that homeostasis of the progenitor compartment is partly preserved...
  16. doi request reprint Colonic gene expression patterns of mucin Muc2 knockout mice reveal various phases in colitis development
    Peng Lu
    Laboratory of Pediatrics, Division Neonatology, Erasmus MC Sophia, Rotterdam, The Netherlands
    Inflamm Bowel Dis 17:2047-57. 2011
    ..Mucin Muc2 knockout (Muc2(-/-)) mice spontaneously develop colitis...
  17. doi request reprint The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection
    Nanda Burger-Van Paassen
    Department of Pediatrics, Erasmus MC Sophia, Rotterdam, The Netherlands
    Biochem J 420:211-9. 2009
    ..In conclusion, 1 mM butyrate and 1-15 mM propionate increase MUC2 expression. The effects of butyrate on MUC2 mRNA are mediated via AP-1 and acetylation/methylation of histones at the MUC2 promoter...
  18. pmc High beta-palmitate fat controls the intestinal inflammatory response and limits intestinal damage in mucin Muc2 deficient mice
    Peng Lu
    Division of Neonatology, Department of Pediatrics, Erasmus MC Sophia, Rotterdam, The Netherlands
    PLoS ONE 8:e65878. 2013
    ....
  19. doi request reprint Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells
    Maria Van Der Sluis
    Department of Paediatrics, Division of Neonatology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Biochem Biophys Res Commun 369:1108-13. 2008
    ..In conclusion, this work identifies Foxa1 and Foxa2 as important regulators of Muc2 expression in the intestine...
  20. doi request reprint Threonine metabolism in the intestine of mice: loss of mucin 2 induces the threonine catabolic pathway
    Maria Van Der Sluis
    Department of Pediatrics, Division of Neonatology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    J Pediatr Gastroenterol Nutr 49:99-107. 2009
    ....
  21. ncbi request reprint Does small intestinal atresia affect epithelial protein expression in human newborns?
    Maaike W Schaart
    Division of Neonatology, Department of Pediatrics, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    J Pediatr Gastroenterol Nutr 43:576-83. 2006
    ..We investigated cell-type-specific protein expression proximal and distal to jejunal and ileal atresias in human newborns...
  22. ncbi request reprint The effect of cytostatic drug treatment on intestine-specific transcription factors Cdx2, GATA-4 and HNF-1alpha in mice
    Barbara A E de Koning
    Laboratory of Pediatrics, Division of Pediatric Gastro enterology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Cancer Chemother Pharmacol 57:801-10. 2006
    ....
  23. pmc Endoplasmic reticulum stress, unfolded protein response and altered T cell differentiation in necrotizing enterocolitis
    Peng Lu
    Division of Neonatology, Department of Pediatrics, Erasmus MC Sophia, Rotterdam, The Netherlands Department of Pediatrics, Emma Children s Hospital AMC, Amsterdam, The Netherlands
    PLoS ONE 8:e78491. 2013
    ..The objective of the study is to investigate the role of ER stress and the UPR in NEC patients...
  24. ncbi request reprint Dietary protein absorption of the small intestine in human neonates
    Maaike W Schaart
    Department of Pediatrics, Division of Neonatology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    JPEN J Parenter Enteral Nutr 31:482-6. 2007
    ..We therefore evaluated dietary feeding tolerance and quantified net dietary protein absorption capacity of the small intestine in human neonates in whom a temporary jejunostomy or ileostomy was created...
  25. ncbi request reprint Role of mucins in inflammatory bowel disease: important lessons from experimental models
    Alexandra W C Einerhand
    Laboratory of Paediatrics, Section Paediatric Gastroenterology and Nutrition, Room Ee 1571a, Erasmus Medical Centre and Sophia Children s Hospital, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Eur J Gastroenterol Hepatol 14:757-65. 2002
    ....
  26. pmc Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways
    Kiyoshi Yamaguchi
    Department of Pathobiology, College of Veterinary Medicine, The University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Mol Cancer Ther 7:2779-87. 2008
    ..Overall, these results indicate that MCC-555 has a potent tumor suppressor activity in intestinal tumorigenesis, likely involving MUC2 up-regulation by ERK and PPARgamma pathways...
  27. ncbi request reprint The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells
    Nicolas Jonckheere
    INSERM, U560, Place de Verdun, Lille, F 59045, France
    J Biol Chem 282:22638-50. 2007
    ..Altogether, these results demonstrate that MUC4 is a target gene of endodermal TFs and thus point out an important role for these TFs in regulating MUC4 expression during epithelial differentiation during development, cancer, and repair...