Research Topics
Genomes and Genes | Ingrid B RenesSummaryAffiliation: Erasmus University Country: The Netherlands Publications
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Publications
Alterations in Muc2 biosynthesis and secretion during dextran sulfate sodium-induced colitisIngrid B Renes
Department of Pediatrics, Pediatric Gastroenterology and Nutrition, Erasmus Medical Center, Dr Molewaterplein 30, 3015 GE Rotterdam, The Netherlands
Am J Physiol Gastrointest Liver Physiol 282:G382-9. 2002..Collectively, these data suggest specific adaptations of the mucus layer to maintain the protective capacities during DSS-induced colitis...- Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protectionMaria Van Der Sluis
Division of Neonatology, Department of Pediatrics, Erasmus MC and Sophia Children s Hospital, Rotterdam, The Netherlands
Gastroenterology 131:117-29. 2006..Expression of mucin MUC2, the structural component of the colonic mucus layer, is lowered in inflammatory bowel disease. Our aim was to obtain insight in the role of Muc2 in epithelial protection... - Methotrexate-induced mucositis in mucin 2-deficient miceBarbara A E de Koning
Division of Pediatric Oncology, Laboratory of Pediatrics, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
J Cell Physiol 210:144-52. 2007..A possible explanation is the mechanism by which Muc2 deficiency may trigger the immune system to release interleukin-10, an anti-inflammatory cytokine before MTX-treatment... - Distinct epithelial responses in experimental colitis: implications for ion uptake and mucosal protectionIngrid B Renes
Laboratory of Pediatrics, Pediatric Gastroenterology and Nutrition, Erasmus Medical Center, Rotterdam, and Sophia Children s Hospital, Rotterdam 3015GE, The Netherlands
Am J Physiol Gastrointest Liver Physiol 283:G169-79. 2002..The maintenance or upregulation of Muc2 and TFF3 synthesis and secretion levels implies that goblet cells at least maintain their epithelial defense and repair capacity during acute inflammation induced by DSS... 
Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient miceMaria Van Der Sluis
Division of Neonatology, Department of Pediatrics, Erasmus MC and Sophia Children s Hospital, Rotterdam, The Netherlands
Lab Invest 88:634-42. 2008..These data indicate that (i) in case of Muc2 deficiency, the anti-inflammatory cytokine IL-10 can control epithelial damage, though to a limited extent and (ii) the mucus layer is most likely a key factor determining colitis...
Mucin Muc2 deficiency and weaning influences the expression of the innate defense genes Reg3β, Reg3γ and angiogenin-4Nanda Burger-Van Paassen
Laboratory of Pediatrics, Division of Neonatology, Erasmus MC Sophia, Rotterdam, The Netherlands
PLoS ONE 7:e38798. 2012....- Epithelial functions of the residual bowel after surgery for necrotising enterocolitis in human infantsMaaike W Schaart
Department of Pediatrics, Erasmus MC Sophia Children s Hospital, The Netherlands
J Pediatr Gastroenterol Nutr 49:31-41. 2009..Our aim is to evaluate epithelial functions in the intestinal resection margins of tissue obtained at bowel resection for acute NEC and consecutive stoma closure... - Colitis development during the suckling-weaning transition in mucin Muc2-deficient miceNanda Burger-Van Paassen
Laboratory of Pediatrics, Rotterdam, The Netherlands
Am J Physiol Gastrointest Liver Physiol 301:G667-78. 2011..Colitis in Muc2(-/-) mice is limited before weaning by immune suppressive responses and exacerbates in the distal colon after weaning because of the decline in the immune suppressive response... - Fate of goblet cells in experimental colitisMireille K Makkink
Department of Pediatrics, Erasmus University and Sophia Children Hospital, Rotterdam, The Netherlands
Dig Dis Sci 47:2286-97. 2002..Quantitatively, the Muc2 and TFF3 levels remained relatively stabile in IL10-/- mice. Muc2 in distal IL10-/- colon contained significantly less sulfate residues than in controls, which may compromise its protective properties... - Specific responses in rat small intestinal epithelial mRNA expression and protein levels during chemotherapeutic damage and regenerationMelissa Verburg
Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Erasmus University, Rotterdam, The Netherlands
J Histochem Cytochem 50:1525-36. 2002..Decreased expression of enterocyte-specific markers represents decreased enterocyte function, of which fatty acid transporters were least affected... - Small intestinal MUC2 synthesis in human preterm infantsMaaike W Schaart
Erasmus Medical Center, Sophia Children s Hospital, Department of Pediatrics, Division of Neonatology, Rotterdam, The Netherlands
Am J Physiol Gastrointest Liver Physiol 296:G1085-90. 2009..Median FSR of small intestinal MUC2 was 67.2 (44.3-103.9)% per day. Systemic threonine is rapidly incorporated into MUC2 in the small intestine of preterm infants, and thereby MUC2 has a very high synthesis rate... - Epithelial proliferation, cell death, and gene expression in experimental colitis: alterations in carbonic anhydrase I, mucin MUC2, and trefoil factor 3 expressionIngrid B Renes
Department of Pediatrics, Erasmus Medical Center, Dr Molewaterplein 50, and Sophia Children's Hospital, 3015 GE Rotterdam, The Netherlands
Int J Colorectal Dis 17:317-26. 2002..Accumulation of goblet cells in the surface epithelium and up-regulation of MUC2 and TFF3 expression in the proximal colon underline the importance of goblet cells in epithelial protection and repair, respectively... - Protection of the Peyer's patch-associated crypt and villus epithelium against methotrexate-induced damage is based on its distinct regulation of proliferationIngrid B Renes
Laboratory of Paediatrics, Department of Gastroenterology and Nutrition, Erasmus University and Sophia Children's Hospital, Rotterdam, The Netherlands
J Pathol 198:60-8. 2002..Enterocyte function in the PP epithelium was unaffected by MTX treatment. Goblet and Paneth cell function was maintained in both NP and PP epithelium... - Isolation-stress increases small intestinal sensitivity to chemotherapy in ratsMelissa Verburg
Pediatric Gastroenterology and Nutrition, Laboratory of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
Gastroenterology 124:660-71. 2003..CONCLUSIONS: The clear beneficial effects of avoiding mental stress on the protection of the intestinal epithelium during cytostatic drug-treatment may be an important element for the treatment of cancer patients... - Colonic gene expression patterns of mucin Muc2 knockout mice reveal various phases in colitis developmentPeng Lu
Laboratory of Pediatrics, Division Neonatology, Erasmus MC Sophia, Rotterdam, The Netherlands
Inflamm Bowel Dis 17:2047-57. 2011..Mucin Muc2 knockout (Muc2(-/-)) mice spontaneously develop colitis... - The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protectionNanda Burger-Van Paassen
Department of Pediatrics, Erasmus MC Sophia, Rotterdam, The Netherlands
Biochem J 420:211-9. 2009..In conclusion, 1 mM butyrate and 1-15 mM propionate increase MUC2 expression. The effects of butyrate on MUC2 mRNA are mediated via AP-1 and acetylation/methylation of histones at the MUC2 promoter... - Alterations in epithelial and mesenchymal intestinal gene expression during doxorubicin-induced mucositis in miceBarbara A E de Koning
Department of Pediatrics, Divisions of Pediatric Oncology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
Dig Dis Sci 52:1814-25. 2007..These data suggest that in response to DOX-induced damage, BMP4 and TCF4 are modulated in such a way that homeostasis of the progenitor compartment is partly preserved... - Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cellsMaria Van Der Sluis
Department of Paediatrics, Division of Neonatology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
Biochem Biophys Res Commun 369:1108-13. 2008..In conclusion, this work identifies Foxa1 and Foxa2 as important regulators of Muc2 expression in the intestine... - Threonine metabolism in the intestine of mice: loss of mucin 2 induces the threonine catabolic pathwayMaria Van Der Sluis
Department of Pediatrics, Division of Neonatology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
J Pediatr Gastroenterol Nutr 49:99-107. 2009.... - Does small intestinal atresia affect epithelial protein expression in human newborns?Maaike W Schaart
Division of Neonatology, Department of Pediatrics, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
J Pediatr Gastroenterol Nutr 43:576-83. 2006..We investigated cell-type-specific protein expression proximal and distal to jejunal and ileal atresias in human newborns... - The effect of cytostatic drug treatment on intestine-specific transcription factors Cdx2, GATA-4 and HNF-1alpha in miceBarbara A E de Koning
Laboratory of Pediatrics, Division of Pediatric Gastro enterology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
Cancer Chemother Pharmacol 57:801-10. 2006.... - Dietary protein absorption of the small intestine in human neonatesMaaike W Schaart
Department of Pediatrics, Division of Neonatology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
JPEN J Parenter Enteral Nutr 31:482-6. 2007..We therefore evaluated dietary feeding tolerance and quantified net dietary protein absorption capacity of the small intestine in human neonates in whom a temporary jejunostomy or ileostomy was created... - Role of mucins in inflammatory bowel disease: important lessons from experimental modelsAlexandra W C Einerhand
Laboratory of Paediatrics, Section Paediatric Gastroenterology and Nutrition, Room Ee 1571a, Erasmus Medical Centre and Sophia Children s Hospital, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Eur J Gastroenterol Hepatol 14:757-65. 2002.... - Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathwaysKiyoshi Yamaguchi
Department of Pathobiology, College of Veterinary Medicine, The University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
Mol Cancer Ther 7:2779-87. 2008..Overall, these results indicate that MCC-555 has a potent tumor suppressor activity in intestinal tumorigenesis, likely involving MUC2 up-regulation by ERK and PPARgamma pathways... - The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cellsNicolas Jonckheere
INSERM, U560, Place de Verdun, Lille, F 59045, France
J Biol Chem 282:22638-50. 2007..Altogether, these results demonstrate that MUC4 is a target gene of endodermal TFs and thus point out an important role for these TFs in regulating MUC4 expression during epithelial differentiation during development, cancer, and repair...