Huibert A P Pols

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Endogenous sex hormones, sex hormone-binding globulin, and the risk of incident vertebral fractures in elderly men and women: the Rotterdam Study
    Hermien W Goderie-Plomp
    Department of Internal Medicine, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:3261-9. 2004
  2. ncbi request reprint Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women
    Fernando Rivadeneira
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 21:1443-56. 2006
  3. ncbi request reprint The catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men
    Lisette Stolk
    Department of Internal Medicine, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:3206-12. 2007
  4. ncbi request reprint Height in pre- and postmenopausal women is influenced by estrogen receptor alpha gene polymorphisms
    Stephanie C E Schuit
    Department of Internal Medicine, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:303-9. 2004
  5. ncbi request reprint A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity
    Marlies E Kevenaar
    Department of Internal Medicine, Room Ee532, PO Box 2040, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Hum Reprod 22:2382-8. 2007
  6. ncbi request reprint The influence of an insulin-like growth factor I gene promoter polymorphism on hip bone geometry and the risk of nonvertebral fracture in the elderly: the Rotterdam Study
    Fernando Rivadeneira
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 19:1280-90. 2004
  7. pmc The role of body mass index, insulin, and adiponectin in the relation between fat distribution and bone mineral density
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Calcif Tissue Int 86:116-25. 2010
  8. pmc Vitamin D binding protein genotype and osteoporosis
    Yue Fang
    Department of Internal Medicine, Erasmus Medical Center, Genetic Laboratory, Rotterdam, The Netherlands
    Calcif Tissue Int 85:85-93. 2009
  9. ncbi request reprint Polymorphic variations in exon 10 of the luteinizing hormone receptor: functional consequences and associations with breast cancer
    Djura Piersma
    Department of Internal Medicine, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Mol Cell Endocrinol 276:63-70. 2007
  10. ncbi request reprint Glucocorticoid receptor polymorphism affects transrepression but not transactivation
    Erica L T Van Den Akker
    Erasmus Medical Center, Department of Internal Medicine, Room Ee 585, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 91:2800-3. 2006

Detail Information

Publications87

  1. ncbi request reprint Endogenous sex hormones, sex hormone-binding globulin, and the risk of incident vertebral fractures in elderly men and women: the Rotterdam Study
    Hermien W Goderie-Plomp
    Department of Internal Medicine, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:3261-9. 2004
    ..For men, no clear association was found, possibly due to insufficient power. No clear association between testosterone and incident vertebral fractures was observed in either men or women...
  2. ncbi request reprint Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women
    Fernando Rivadeneira
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 21:1443-56. 2006
    ..Interaction of ESR2 with ESR1 and IGF1 was determined and revealed a deleterious genetic combination that enhances the risk of osteoporotic fracture...
  3. ncbi request reprint The catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men
    Lisette Stolk
    Department of Internal Medicine, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:3206-12. 2007
    ..An example is catechol-O-methyltransferase (COMT), an estrogen-degrading enzyme involved in inactivation of catechol-estrogens. Its gene contains a functional valine to methionine substitution at codon 158...
  4. ncbi request reprint Height in pre- and postmenopausal women is influenced by estrogen receptor alpha gene polymorphisms
    Stephanie C E Schuit
    Department of Internal Medicine, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:303-9. 2004
    ..5 cm shorter per allele copy of the ESR1 haplotype 1 (P for trend = 0.03). In conclusion, we demonstrate a role for genetic variations in the estrogen receptor alpha gene in determining adult stature in women...
  5. ncbi request reprint A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity
    Marlies E Kevenaar
    Department of Internal Medicine, Room Ee532, PO Box 2040, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Hum Reprod 22:2382-8. 2007
    ..Since age at menopause has a strong genetic component, we investigated the role of AMH signaling using a candidate gene approach...
  6. ncbi request reprint The influence of an insulin-like growth factor I gene promoter polymorphism on hip bone geometry and the risk of nonvertebral fracture in the elderly: the Rotterdam Study
    Fernando Rivadeneira
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 19:1280-90. 2004
    ..5; 95% CI, 1.1-2.0) of fragility fracture in women (n = 4212) but not in men (n = 2799). An approximation of hip bone geometry (from DXA) suggested the polymorphism is associated with bone strength and stability in gender-specific ways...
  7. pmc The role of body mass index, insulin, and adiponectin in the relation between fat distribution and bone mineral density
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Calcif Tissue Int 86:116-25. 2010
    ..Inverse associations after adjustment for BMI suggest that android fat deposition as measured by the WHR, WTR, and DXA-based android-to-gynoid fat ratio is not beneficial and possibly even deleterious for bone...
  8. pmc Vitamin D binding protein genotype and osteoporosis
    Yue Fang
    Department of Internal Medicine, Erasmus Medical Center, Genetic Laboratory, Rotterdam, The Netherlands
    Calcif Tissue Int 85:85-93. 2009
    ..05). All associations were independent of age and gender. Our study demonstrated that the genetic effect of the DBP gene on fracture risk appears only in combination with other genetic and environmental risk factors for bone metabolism...
  9. ncbi request reprint Polymorphic variations in exon 10 of the luteinizing hormone receptor: functional consequences and associations with breast cancer
    Djura Piersma
    Department of Internal Medicine, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Mol Cell Endocrinol 276:63-70. 2007
    ..In conclusion, although functional changes of the LHR 291Ser candidate allele were observed, no associations with breast cancer were found, while the LHR 312Asn allele can be regarded as a weak breast cancer risk allele...
  10. ncbi request reprint Glucocorticoid receptor polymorphism affects transrepression but not transactivation
    Erica L T Van Den Akker
    Erasmus Medical Center, Department of Internal Medicine, Room Ee 585, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 91:2800-3. 2006
    ..Their beneficial effects are thought to be mediated by GC transrepression on gene expression. However, their use is limited by serious adverse effects, presumably mediated by GC transactivation of gene expression...
  11. ncbi request reprint ApoE gene polymorphisms, BMD, and fracture risk in elderly men and women: the Rotterdam study
    Mariette W C J Schoofs
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam 300 DR, The Netherlands
    J Bone Miner Res 19:1490-6. 2004
    ..We did not observe an association between the ApoE polymorphism and osteoporosis in this study, which is thus far the largest study on ApoE and osteoporosis...
  12. pmc Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites
    Andre G Uitterlinden
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Hum Genet 75:1032-45. 2004
    ..02). The molecular mechanism whereby these moderate SOST genotype effects are mediated remains to be elucidated, but it is likely to involve differences in regulation of SOST gene expression...
  13. pmc SIRT1 genetic variation is related to BMI and risk of obesity
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes 58:2828-34. 2009
    ..SIRT1 has pleiotropic metabolic functions. We investigated whether SIRT1 genetic variation is associated with obesity...
  14. ncbi request reprint A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels
    Pauline Smit
    Department of Internal Medicine, Room Ee585, Erasmus Medical Center, Dr Molewaterplein 40, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:5313-6. 2005
    ..Due to a replacement of part of the CYP3A7 promoter with a sequence identical with the same region in the CYP3A4 promoter (referred to as CYP3A7*1C), some individuals still express a variant of the CYP3A7 gene later in life...
  15. ncbi request reprint Estrogen receptor alpha gene polymorphisms associated with incident aging macula disorder
    Sharmila S Boekhoorn
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 48:1012-7. 2007
    ..This study was undertaken to investigate whether genetic variations in the estrogen receptor alpha (ESR1) gene are associated with incident AMD...
  16. ncbi request reprint SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Free Radic Biol Med 46:836-41. 2009
    ..Correction of niacin deficiency and SIRT1 modulators may prolong the life span of patients with diabetes...
  17. ncbi request reprint Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women
    Stephanie C E Schuit
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Endocrinol 153:327-34. 2005
    ..It has been suggested that the estrogen receptor alpha (ESR1) gene may influence peripheral E(2) levels, but the role of common sequence variations in the ESR1 gene is unclear...
  18. pmc The interleukin-6-174 G/C promoter polymorphism and arterial stiffness; the Rotterdam Study
    Mark P S Sie
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Vasc Health Risk Manag 4:863-9. 2008
    ..CRP levels were associated with pulse wave velocity (p = 0.007). In conclusion, the interleukin-6-174 G/C polymorphism is associated with increased arterial stiffness and pulse pressure...
  19. ncbi request reprint Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 21:141-50. 2006
    ..LRP5 variation was associated to both BMD and frame size, whereas both LRP5 and 6 variations were associated with an increased fracture risk in males...
  20. ncbi request reprint Estrogen receptor alpha gene polymorphisms and risk of myocardial infarction
    Stephanie C E Schuit
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    JAMA 291:2969-77. 2004
    ..Evidence suggests that genetic variations in the estrogen receptor alpha (ESR1) gene may influence IHD risk, but the role of common sequence variations in the ESR1 gene is unclear...
  21. ncbi request reprint Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index
    Elisabeth F C van Rossum
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam The Netherlands
    Clin Endocrinol (Oxf) 59:585-92. 2003
    ....
  22. ncbi request reprint An igf-I gene polymorphism modifies the risk of diabetic retinopathy
    Ingrid Rietveld
    Department of Internal Medicine, Erasmus Medical Center, Room D 436, Dr Molewaterplein 40, 3015 GD, Rotterdam, Netherlands
    Diabetes 55:2387-91. 2006
    ..04) in the risk of retinopathy was observed compared with participants with the wild-type genotype. In conclusion, our findings suggest that this IGF-I gene polymorphism is associated with an increased risk of diabetic retinopathy...
  23. ncbi request reprint Vitamin D receptor gene haplotype is associated with body height and bone size
    Yue Fang
    Genetic Laboratory, Room Ee575, Department of Internal Medicine, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:1491-501. 2007
    ..We recently identified promoter and 3'-untranslated region (UTR) haplotype alleles that influence vitamin D receptor (VDR) mRNA expression...
  24. ncbi request reprint Lack of Association of the 11beta-hydroxysteroid dehydrogenase type 1 gene 83,557insA and hexose-6-phosphate dehydrogenase gene R453Q polymorphisms with body composition, adrenal androgen production, blood pressure, glucose metabolism, and dementia
    Pauline Smit
    Department of Internal Medicine, Room Ee530C, Erasmus Medical Center, Dr Molewaterplein 40, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:359-62. 2007
    ....
  25. doi request reprint Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index
    M Carola Zillikens
    Department of Internal Medicine, Room D428, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Am J Clin Nutr 91:1387-93. 2010
    ..Genetic variation in SIRT1 has been associated with body mass index (BMI) and risk of obesity. SIRT1 may be influenced by diet...
  26. pmc Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
    Karol Estrada
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 44:491-501. 2012
    ..3 (SLC25A13), 11q13.2 (LRP5), 4q22.1 (MEPE), 2p16.2 (SPTBN1) and 10q21.1 (DKK1). These findings shed light on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility...
  27. pmc Loci at chromosomes 13, 19 and 20 influence age at natural menopause
    Lisette Stolk
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Nat Genet 41:645-7. 2009
    ..5 year per A allele (12%); P = 2.5 × 10(-8)). These common genetic variants regulate timing of ovarian aging, an important risk factor for breast cancer, osteoporosis and cardiovascular disease...
  28. ncbi request reprint TGF-beta 1 polymorphisms and risk of myocardial infarction and stroke: the Rotterdam Study
    Mark P S Sie
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Stroke 37:2667-71. 2006
    ..We therefore investigated 5 polymorphisms in the TGF-beta1 gene (-800 G/A, -509 C/T, codon 10 Leu/Pro, codon 25 Arg/Pro, and codon 263 Thr/Ile) in relation to the risk of myocardial infarction and stroke in a population-based study...
  29. pmc Promoter and 3'-untranslated-region haplotypes in the vitamin d receptor gene predispose to osteoporotic fracture: the rotterdam study
    Yue Fang
    Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Hum Genet 77:807-23. 2005
    ..This could impact the vitamin D signaling efficiency and might contribute to the increased fracture risk we observed for these risk haplotype alleles...
  30. ncbi request reprint The RIZ Pro704 insertion-deletion polymorphism, bone mineral density and fracture risk: the Rotterdam study
    Lisette Stolk
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Bone 42:286-93. 2008
    ..This suggests this polymorphism to play a minor role, if any, as a genetic determinant of osteoporosis in elderly subjects...
  31. ncbi request reprint Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men
    Elisabeth F C van Rossum
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Med 117:158-62. 2004
    ..In the present study, we investigated whether the ER22/23EK polymorphism is associated with survival, cholesterol levels, and two predictors of mortality: serum C-reactive protein and interleukin 6 levels...
  32. ncbi request reprint Cdx-2 polymorphism in the promoter region of the human vitamin D receptor gene determines susceptibility to fracture in the elderly
    Yue Fang
    Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Bone Miner Res 18:1632-41. 2003
    ..Our findings expand previous similar findings in a Japanese study to whites and show a relationship with fracture risk of this functional polymorphism...
  33. pmc GnRH and LHR gene variants predict adverse outcome in premenopausal breast cancer patients
    Djura Piersma
    Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Breast Cancer Res 9:R51. 2007
    ..Breast cancer development and progression are dependent on estrogen activity. In premenopausal women, estrogen production is mainly regulated through the hypothalamic-pituitary-gonadal (HPG) axis...
  34. doi request reprint Estrogen receptors alpha and beta and the risk of open-angle glaucoma: the Rotterdam Study
    Simone de Voogd
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arch Ophthalmol 126:110-4. 2008
    ..To investigate whether polymorphisms in the estrogen receptor alpha (ESR1) and beta (ESR2) genes were a risk factor for open-angle glaucoma (OAG)...
  35. ncbi request reprint Association between an insulin-like growth factor I gene promoter polymorphism and bone mineral density in the elderly: the Rotterdam Study
    Fernando Rivadeneira
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:3878-84. 2003
    ..Our findings suggest that this promoter polymorphism or another functional polymorphism in linkage disequilibrium may be a genetic determinant of BMD levels and rate of bone loss in postmenopausal women...
  36. pmc Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    JAMA 299:1277-90. 2008
    ..Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population...
  37. ncbi request reprint Serum levels of sex hormone-binding globulin (SHBG) are not associated with lower levels of non-SHBG-bound testosterone in male newborns and healthy adult men
    Willem de Ronde
    Department of Internal Medicine, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 62:498-503. 2005
    ..In in vitro experiments increased levels of SHBG will be associated with decreased levels of non-SHBG bound testosterone (non-SHBG-T). However, in vivo SHBG can alter both production and clearance rates and thus plasma levels of T...
  38. ncbi request reprint The increase in cholesterol with menopause is associated with the apolipoprotein E genotype. A population-based longitudinal study
    A Elisabeth Hak
    Department of Internal Medicine, Room D429, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Atherosclerosis 175:169-76. 2004
    ....
  39. ncbi request reprint Endogenous oestrogens are related to cognition in healthy elderly women
    Corinne E I Lebrun
    Department of Internal Medicine, Erasmus University Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 63:50-5. 2005
    ..To investigate whether levels of endogenous hormones, in particular circulating oestrogens and SHBG, are associated with cognition in healthy postmenopausal women...
  40. pmc High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam Study
    Ling Oei
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes Care 36:1619-28. 2013
    ..Individuals with type 2 diabetes have increased fracture risk despite higher bone mineral density (BMD). Our aim was to examine the influence of glucose control on skeletal complications...
  41. ncbi request reprint Endogenous estradiol and risk of dementia in women and men: the Rotterdam Study
    Mirjam I Geerlings
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Ann Neurol 53:607-15. 2003
    ..The findings do not support the hypothesis that higher levels of endogenous estradiol reduce risk of dementia, neither in women nor in men...
  42. ncbi request reprint Risk factors for incident vertebral fractures in men and women: the Rotterdam Study
    Marjolein van der Klift
    Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Bone Miner Res 19:1172-80. 2004
    ..In 3001 men and women from the Rotterdam Study, prevalent nonvertebral fractures, early menopause, current smoking, and walking aid use were also strong risk factors for incident vertebral fractures...
  43. ncbi request reprint Genetics and biology of vitamin D receptor polymorphisms
    Andre G Uitterlinden
    Genetic Laboratory, Room Ee575, Department of Internal Medicine, Erasmus MC, Dr Molewaterplein 50, PO Box 1738, NL 3000 DR Rotterdam, The Netherlands
    Gene 338:143-56. 2004
    ..Substantial progress has been made that will deepen our understanding of variability in the vitamin D endocrine system and might find applications in risk assessment of disease and in predicting response-to-treatment...
  44. doi request reprint Mild hyponatremia as a risk factor for fractures: the Rotterdam Study
    Ewout J Hoorn
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 26:1822-8. 2011
    ..Increased fracture risk in hyponatremia also was independent of recent falls, pointing toward a possible effect on bone quality...
  45. ncbi request reprint Effects of the renin-angiotensin system genes and salt sensitivity genes on blood pressure and atherosclerosis in the total population and patients with type 2 diabetes
    Mojgan Yazdanpanah
    Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Diabetes 56:1905-12. 2007
    ..04 mm, P = 0.02). We found that among type 2 diabetic patients, mean systolic blood pressure, pulse pressure, and risk of hypertension increased with the number of risk genotypes for the RAS genes and the salt sensitivity genes...
  46. ncbi request reprint HMG-CoA reductase inhibitors and the risk of vertebral fracture
    Mariette W C J Schoofs
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam 3000 DR, The Netherlands
    J Bone Miner Res 19:1525-30. 2004
    ..Randomized trials on statins and fractures, carried out in populations at risk for fractures, are needed...
  47. ncbi request reprint A direct approach to the estimation of the origin of oestrogens and androgens in elderly men by comparison with hormone levels in postmenopausal women
    Willem de Ronde
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Endocrinol 152:261-8. 2005
    ..From infusion studies with radioactively labelled hormones, we know that oestradiol (E2) and oestrone (E1) are either directly secreted by the testes and adrenal glands or peripherally produced from testicular or adrenal androgens...
  48. pmc Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
    Fernando Rivadeneira
    Department of Internal Medicine, Rotterdam, The Netherlands
    Nat Genet 41:1199-206. 2009
    ..The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD...
  49. ncbi request reprint Vitamin D status, bone mineral density, and the development of radiographic osteoarthritis of the knee: The Rotterdam Study
    Arjan P Bergink
    Departments of Internal Medicine, Erasmus Medical Center, Rotterdam 3000 DR, The Netherlands
    J Clin Rheumatol 15:230-7. 2009
    ..To study the association between baseline vitamin D status, bone mineral density (BMD), and the development of radiographic osteoarthritis (ROA) of the knee in a large population-based cohort of men and women...
  50. ncbi request reprint Homocysteine levels and the risk of osteoporotic fracture
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    N Engl J Med 350:2033-41. 2004
    ..We therefore hypothesized that mildly elevated homocysteine levels might be related to age-related osteoporotic fractures...
  51. ncbi request reprint Association of 5' estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus Medical Centre, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Hum Mol Genet 12:1745-54. 2003
    ..The molecular mechanism underlying this association needs further study...
  52. ncbi request reprint Anti-Müllerian hormone and anti-Müllerian hormone type II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory women
    Marlies E Kevenaar
    Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Hum Reprod 22:1547-54. 2007
    ..Little is known about the role of AMH in human ovarian physiology. We hypothesize that in women AMH has a similar role in ovarian function as in mice and investigated this using a genetic approach...
  53. ncbi request reprint Effect of dietary B vitamins on BMD and risk of fracture in elderly men and women: the Rotterdam study
    Nahid Yazdanpanah
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Bone 41:987-94. 2007
    ..These findings highlight the importance of considering nutritional factors in epidemiological studies of osteoporosis and fractures...
  54. ncbi request reprint Withdrawal of fall-risk-increasing drugs in older persons: effect on mobility test outcomes
    Nathalie van der Velde
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Drugs Aging 24:691-9. 2007
    ..Improvement of mobility may be an important factor in this finding and we therefore tested whether mobility tests improved after FRID withdrawal...
  55. ncbi request reprint Associations of sex-hormone-binding globulin (SHBG) with non-SHBG-bound levels of testosterone and estradiol in independently living men
    Willem de Ronde
    Department of Internal Medicine, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:157-62. 2005
    ..Therefore, we conclude that in eugonadal men, higher SHBG levels are associated with lower levels of non-SHBG-E2 but slightly higher levels of non-SHBG-T. This means that SHBG cannot be regarded as an estrogen amplifier in eugonadal men...
  56. ncbi request reprint Angiotensin converting enzyme insertion/deletion polymorphism and the risk of heart failure in hypertensive subjects
    Anna F C Schut
    Genetic Epidemiology Unit, Department of Epidemiology, Eramus Medical Centre Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Eur Heart J 25:2143-8. 2004
    ..We assessed the relation between the ACE I/D polymorphism and the risk of incident heart failure in normotensive and hypertensive subjects...
  57. ncbi request reprint The importance of oestrogens in males
    Willem de Ronde
    Department of Internal Medicine, University Hospital Dijkzigt, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 58:529-42. 2003
  58. ncbi request reprint Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states
    Andre G Uitterlinden
    Department of Internal Medicine, Erasmus University Rotterdam Medical Centre, P O Box 1738, Genetic Laboratory, Room Ee575, NL 3000 DR Rotterdam, The Netherlands
    J Steroid Biochem Mol Biol 89:187-93. 2004
    ..Eventually, results of this research will deepen our understanding of variability in the Vitamin D endocrine system and might find applications in risk-assessment of disease and in predicting response-to-treatment...
  59. ncbi request reprint Effects of serum TSH and FT4 levels and the TSHR-Asp727Glu polymorphism on bone: the Rotterdam Study
    Wendy M van der Deure
    Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 68:175-81. 2008
    ..The TSHR-Asp727Glu polymorphism is associated with lower TSH levels. We therefore examined the association of this polymorphism with bone parameters...
  60. pmc Heritabilities, apolipoprotein E, and effects of inbreeding on plasma lipids in a genetically isolated population: the Erasmus Rucphen Family Study
    Aaron Isaacs
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Postbus 1738, 3000 DR Rotterdam, The Netherlands
    Eur J Epidemiol 22:99-105. 2007
    ..02 and p (trend) = 0.05, respectively). These data provide estimates of lipid heritability unbiased due to selection and suggest that this population represents a good opportunity to localize novel genes influencing plasma lipid levels...
  61. ncbi request reprint A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels
    Elisabeth F C van Rossum
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes 51:3128-34. 2002
    ..Our data suggest that carriers of the 22/23EK allele are relatively more resistant to the effects of GCs with respect to the sensitivity of the adrenal feedback mechanism than noncarriers, resulting in a better metabolic health profile...
  62. pmc Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis
    Hanneke J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:164. 2010
    ..The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis...
  63. ncbi request reprint High-dose testosterone is associated with atherosclerosis in postmenopausal women
    A Elisabeth Hak
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Maturitas 56:153-60. 2007
    ..To study the long-term effects of androgen treatment on atherosclerosis in postmenopausal women...
  64. ncbi request reprint Osteoporosis in men and women: a story about bone mineral density thresholds and hip fracture risk
    Chris E D H de Laet
    Institute for Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 17:2231-6. 2002
    ..Taken together, the average hip fracture risk in men is much lower than in women but appeared to be similar at the same BMD. Therefore, we propose the use of the same absolute BMD thresholds for decisions about interventions...
  65. ncbi request reprint A polymorphism in the IGF-I gene influences the age-related decline in circulating total IGF-I levels
    Ingrid Rietveld
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Endocrinol 148:171-5. 2003
    ..This IGF-I gene polymorphism in the promoter region of the IGF-I gene may directly influence the expression of IGF-I. In the present study we evaluated the role of this polymorphism in the age-related decline in serum IGF-I levels...
  66. ncbi request reprint Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study
    A Elisabeth Hak
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 87:3632-9. 2002
    ..In women, positive associations between levels of testosterone and aortic atherosclerosis were largely due to adverse cardiovascular disease risk factors...
  67. ncbi request reprint Serum insulin-like growth factor binding protein-2 levels as an indicator of functional ability in elderly men
    Annewieke W van den Beld
    Department of Internal Medicine III, Room D4, Erasmus University Medical Center, 40 Dr Molewaterplein, 3015 GD Rotterdam, The Netherlands
    Eur J Endocrinol 148:627-34. 2003
    ....
  68. ncbi request reprint The role of vitamin D receptor gene polymorphisms in bone biology
    Andre G Uitterlinden
    Genomic Laboratory Room Ee575, Department of Internal Medicine, Erasmus University Medical School, Dr Molewaterplein 50, PO Box 1738, GD 3015 Rotterdam, The Netherlands
    Mol Cell Endocrinol 197:15-21. 2002
    ..The ultimate goal of this approach is to identify the combinations of functional sequence variants that modulate the vitamin D endocrine system and confer risk of disease...
  69. ncbi request reprint Higher estrogen levels are not associated with larger hippocampi and better memory performance
    Tom den Heijer
    Department of Epidemiology, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Arch Neurol 60:213-20. 2003
    ..Animal study findings have shown beneficial effects of estrogen on the brain, particularly on the hippocampus, a structure related to memory performance and early Alzheimer disease...
  70. ncbi request reprint The incidence of vertebral fractures in men and women: the Rotterdam Study
    Marjolein van der Klift
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 17:1051-6. 2002
    ..In both genders, the incidence increases with age. Furthermore, the presence of a prevalent vertebral fracture and a low BMD are strong independent predictors of incident vertebral fractures in men and women...
  71. ncbi request reprint A central dinucleotide within vitamin D response elements modulates DNA binding and transactivation by the vitamin D receptor in cellular response to natural and synthetic ligands
    Gert Jan C M van den Bemd
    Department of Internal Medicine, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
    J Biol Chem 277:14539-46. 2002
    ....
  72. ncbi request reprint Bone mineral density and the risk of breast cancer: the Rotterdam Study
    Marjolein van der Klift
    Institute for Medical Technology Assessment, Erasmus Medical Centre, Rotterdam, Netherlands
    Bone 32:211-6. 2003
    ..The results of this study suggest that in elderly women an association between especially lumbar spine BMD and incident breast cancer exists. Stimulating effects of estrogen on both trabecular bone and mammary cells may be responsible...
  73. ncbi request reprint Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    JAMA 292:2105-14. 2004
    ..Estrogen receptor alpha (ESR1) is a candidate gene for osteoporosis, but previous studies of ESR1 polymorphisms in this field were hampered by small sample size, lack of standardization, and inconclusive results...
  74. pmc Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study
    Stuart H Ralston
    Rheumatic Diseases Unit, University of Edinburgh, Western General Hospital Edinburgh, Edinburgh, United Kingdom
    PLoS Med 3:e90. 2006
    ....
  75. ncbi request reprint Relations between body composition, functional and hormonal parameters and quality of life in healthy postmenopausal women
    Corinne E I Lebrun
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands
    Maturitas 55:82-92. 2006
    ..To investigate whether body composition, functional status and serum hormone levels are associated with quality of life in healthy postmenopausal women...
  76. ncbi request reprint An insulin-like growth factor-I promoter polymorphism is associated with increased mortality in subjects with myocardial infarction in an elderly Caucasian population
    Mojgan Yazdanpanah
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Cardiol 97:1274-6. 2006
    ..10 to 2.10, p = 0.02). The risk of death increased with the number of variant alleles. Our study suggests that genetically determined low IGF-I activity is an important determinant of mortality in subjects with MI...
  77. ncbi request reprint Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts
    Amanda M Shearman
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Circ Res 98:590-2. 2006
    ..44; P<0.0001), after adjustment for established cardiovascular risk factors. After exclusion of younger subjects from 2 cohorts, because of age interaction, the odds ratio increased (to 1.63)...
  78. ncbi request reprint The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis
    Andre G Uitterlinden
    Erasmus MC, Rotterdam, The Netherlands
    Ann Intern Med 145:255-64. 2006
    ..Polymorphisms of the vitamin D receptor (VDR) gene have been implicated in the genetic regulation of bone mineral density (BMD). However, the clinical impact of these variants remains unclear...
  79. ncbi request reprint IGF-I gene promoter polymorphism is a predictor of survival after myocardial infarction in patients with type 2 diabetes
    Mojgan Yazdanpanah
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Endocrinol 155:751-6. 2006
    ....
  80. ncbi request reprint C-reactive protein levels, variation in the C-reactive protein gene, and cancer risk: the Rotterdam Study
    Claire Siemes
    Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Oncol 24:5216-22. 2006
    ..The aim of this study was to examine whether C-reactive protein (CRP) levels and CRP gene variations were associated with an altered risk of colorectal, lung, breast, or prostate cancer...
  81. ncbi request reprint Smoking-dependent effects of the angiotensin-converting enzyme gene insertion/deletion polymorphism on blood pressure
    Anna F C Schut
    Departments of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, The Netherlands
    J Hypertens 22:313-9. 2004
    ..Recent studies suggested that this gene might have smoking-dependent effects on the development of cardiovascular disease...
  82. ncbi request reprint Paget's disease of bone in The Netherlands: a population-based radiological and biochemical survey--the Rotterdam Study
    Marelise E M W Eekhoff
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Bone Miner Res 19:566-70. 2004
    ..Subjects with raised and normal ALP from a population cohort were matched (1 in 6, total 548), and radiographs were taken. ALP was an excellent marker of the disease (RR, 10.9), but the majority of those affected had normal ALP...
  83. ncbi request reprint Thiazide diuretics and the risk for hip fracture
    Mariette W C J Schoofs
    Erasmus MC, Rotterdam, The Netherlands
    Ann Intern Med 139:476-82. 2003
    ..Thiazides have been associated with reduced age-related bone loss by decreasing urinary calcium excretion...
  84. ncbi request reprint Estrogen receptor alpha gene haplotype is associated with radiographic osteoarthritis of the knee in elderly men and women
    Arjan P Bergink
    Erasmus University Medical Center, Rotterdam, The Netherlands
    Arthritis Rheum 48:1913-22. 2003
    ..We studied the association between polymorphisms in the estrogen receptor alpha (ERalpha) gene and the prevalence of radiographic OA of the knee...
  85. doi request reprint Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS study
    Bente L Langdahl
    Department of Endocrinology, Aarhus University Hospital, Aarhus, Denmark
    Bone 42:969-81. 2008
    ....
  86. pmc The -1997 G/T and Sp1 polymorphisms in the collagen type I alpha1 (COLIA1) gene in relation to changes in femoral neck bone mineral density and the risk of fracture in the elderly: the Rotterdam study
    Nahid Yazdanpanah
    Netherlands Institute for Health Science, Rotterdam, The Netherlands
    Calcif Tissue Int 81:18-25. 2007
    ..7, P = 0.001). We confirm that the COLIA1 Sp1 polymorphism influences BMD and the risk of fracture in postmenopausal Caucasian women. In contrast, we found no independent effect of the -1997 G/T promoter polymorphism on BMD or fracture...
  87. ncbi request reprint Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis: four-year results from a randomized clinical trial
    Pierre D Delmas
    University of Claude Bernard of Lyon, Hopital Edouard Herriot, Service de Rhumatologie et de Pathologie Osseuse, Lyon 69437, France
    J Clin Endocrinol Metab 87:3609-17. 2002
    ..The decreased vertebral fracture risk in yr 4 alone was not different from that observed in the first 3 yr...