R P Peeters

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Effects of thyroid state on the expression of hepatic thyroid hormone transporters in rats
    Robin P Peeters
    Departments of Internal Medicine and Nuclear Medicine, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 283:E1232-8. 2002
  2. ncbi request reprint The association of polymorphisms in the type 1 and 2 deiodinase genes with circulating thyroid hormone parameters and atrophy of the medial temporal lobe
    Frank Jan de Jong
    Department of Epidemiology, Biostatistics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:636-40. 2007
  3. ncbi request reprint Thyroid hormone independent associations between serum TSH levels and indicators of bone turnover in cured patients with differentiated thyroid carcinoma
    Karen A Heemstra
    Department of Endocrinology and Metabolism, C4 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Endocrinol 159:69-76. 2008
  4. doi request reprint Ethnic differences in maternal thyroid parameters during pregnancy: the Generation R study
    Tim I M Korevaar
    The Generation R Study Group and Department of Internal Medicine, Erasmus Medical Center, 3015 GE, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 98:3678-86. 2013
  5. pmc Cerebellar abnormalities in mice lacking type 3 deiodinase and partial reversal of phenotype by deletion of thyroid hormone receptor α1
    Robin P Peeters
    Erasmus University Medical Center, Department of Internal Medicine, Dr Molewaterplein 50, Room Ee502, 3015 GE Rotterdam, The Netherlands
    Endocrinology 154:550-61. 2013
  6. doi request reprint Maternal thyroid hormone parameters during early pregnancy and birth weight: the Generation R Study
    Marco Medici
    Department of Internal Medicine, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 98:59-66. 2013
  7. doi request reprint Maternal early pregnancy and newborn thyroid hormone parameters: the Generation R study
    Marco Medici
    The Generation R Study Group, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 97:646-52. 2012
  8. ncbi request reprint Non thyroidal illness: to treat or not to treat?
    R P Peeters
    Department of Internal Medicine, Erasmus University Medical Center, Room Ee 502, 50, Dr Molewaterplein, 3015 GE Rotterdam, The Netherlands
    Ann Endocrinol (Paris) 68:224-8. 2007
  9. ncbi request reprint The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men
    Robin P Peeters
    Department of Internal Medicine, Erasmus University Medical Cetnre, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 66:808-15. 2007
  10. ncbi request reprint A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters
    Robin P Peeters
    Department of Internal Medicine, Rm Ee 502, Erasmus University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 289:E75-81. 2005

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Effects of thyroid state on the expression of hepatic thyroid hormone transporters in rats
    Robin P Peeters
    Departments of Internal Medicine and Nuclear Medicine, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 283:E1232-8. 2002
    ..However, they do not exclude regulation of hepatic T4 transporters by thyroid hormone at the translational and posttranslational level...
  2. ncbi request reprint The association of polymorphisms in the type 1 and 2 deiodinase genes with circulating thyroid hormone parameters and atrophy of the medial temporal lobe
    Frank Jan de Jong
    Department of Epidemiology, Biostatistics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:636-40. 2007
    ..Variations in the deiodinase type 1 (DIO1) and type 2 (DIO2) genes that potentially alter thyroid hormone bioactivity may help in elucidating the role of thyroid function in AD...
  3. ncbi request reprint Thyroid hormone independent associations between serum TSH levels and indicators of bone turnover in cured patients with differentiated thyroid carcinoma
    Karen A Heemstra
    Department of Endocrinology and Metabolism, C4 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Eur J Endocrinol 159:69-76. 2008
    ..We also studied the contribution of the TSH receptor (TSHR)-Asp727Glu polymorphism to these relationships...
  4. doi request reprint Ethnic differences in maternal thyroid parameters during pregnancy: the Generation R study
    Tim I M Korevaar
    The Generation R Study Group and Department of Internal Medicine, Erasmus Medical Center, 3015 GE, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 98:3678-86. 2013
    ..Although interindividual differences in thyroid function tests can partially be explained by ethnicity, data on the influence of ethnicity on TSH and free T4 reference ranges during pregnancy are sparse...
  5. pmc Cerebellar abnormalities in mice lacking type 3 deiodinase and partial reversal of phenotype by deletion of thyroid hormone receptor α1
    Robin P Peeters
    Erasmus University Medical Center, Department of Internal Medicine, Dr Molewaterplein 50, Room Ee502, 3015 GE Rotterdam, The Netherlands
    Endocrinology 154:550-61. 2013
    ..These findings suggest that type 3 deiodinase constrains the timing of thyroid hormone action during cerebellar development...
  6. doi request reprint Maternal thyroid hormone parameters during early pregnancy and birth weight: the Generation R Study
    Marco Medici
    Department of Internal Medicine, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 98:59-66. 2013
    ..However, the effects of variation in maternal serum thyroid parameters within the normal range on birth weight are largely unknown...
  7. doi request reprint Maternal early pregnancy and newborn thyroid hormone parameters: the Generation R study
    Marco Medici
    The Generation R Study Group, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 97:646-52. 2012
    ..Although various studies have studied maternal thyroid parameters during the first half of pregnancy, little is known about their relations with thyroid parameters of the child...
  8. ncbi request reprint Non thyroidal illness: to treat or not to treat?
    R P Peeters
    Department of Internal Medicine, Erasmus University Medical Center, Room Ee 502, 50, Dr Molewaterplein, 3015 GE Rotterdam, The Netherlands
    Ann Endocrinol (Paris) 68:224-8. 2007
    ..Severity and duration of disease are related to the magnitude of these changes. This manuscript discusses whether these changes in thyroid hormone levels during critical illness should be treated, and was in part published elsewhere...
  9. ncbi request reprint The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men
    Robin P Peeters
    Department of Internal Medicine, Erasmus University Medical Cetnre, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 66:808-15. 2007
    ..In addition, we analysed the Thr92Ala polymorphism in the type 2 deiodinase (D2), which was recently associated with insulin resistance...
  10. ncbi request reprint A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters
    Robin P Peeters
    Department of Internal Medicine, Rm Ee 502, Erasmus University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 289:E75-81. 2005
    ..We hypothesize that this might be explained by the decline in skeletal muscle size during aging, resulting in a relative decrease in the contribution of D2 to serum T(3) production...
  11. ncbi request reprint A polymorphism in type I deiodinase is associated with circulating free insulin-like growth factor I levels and body composition in humans
    Robin P Peeters
    Department of Internal Medicine, Room Ee 502, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:256-63. 2005
    ..The association of D1 haplotype allele 2 with serum T(3) levels in the elderly population suggests a relative increase in its contribution to circulating T(3) in old age...
  12. ncbi request reprint Genetic variation in thyroid hormone pathway genes; polymorphisms in the TSH receptor and the iodothyronine deiodinases
    Robin P Peeters
    Department of Internal Medicine, Erasmus University Medical Center, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    Eur J Endocrinol 155:655-62. 2006
    ..We discuss the possible consequences of these studies for the individual patient and also the new insights in thyroid hormone action that can be obtained from these data...
  13. ncbi request reprint Thyroid hormones and aging
    Robin P Peeters
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Hormones (Athens) 7:28-35. 2008
    ..This review describes the changes in thyroid hormone levels with aging and the mechanisms behind these changes, and also discusses whether subclinical thyroid disease should be treated in the elderly...
  14. doi request reprint Impact of thyroid function and polymorphisms in the type 2 deiodinase on blood pressure: the Rotterdam Study and the Rotterdam Scan Study
    Wendy M van der Deure
    Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 71:137-44. 2009
    ..However studies conducted thus far were small with controversial results...
  15. ncbi request reprint Serum 3,3',5'-triiodothyronine (rT3) and 3,5,3'-triiodothyronine/rT3 are prognostic markers in critically ill patients and are associated with postmortem tissue deiodinase activities
    Robin P Peeters
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:4559-65. 2005
    ..All patients had been randomized for intensive or conventional insulin treatment. Seventy-one patients died, and postmortem liver and skeletal muscle biopsies were obtained from 50 of them for analysis of deiodinase (D1-3) activities...
  16. ncbi request reprint Polymorphisms in thyroid hormone pathway genes are associated with plasma TSH and iodothyronine levels in healthy subjects
    Robin P Peeters
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3000 DR The Netherlands
    J Clin Endocrinol Metab 88:2880-8. 2003
    ..We have analyzed eight SNPs in five thyroid hormone pathway genes and found significant associations of three SNPs in two genes (D1, TSHR) with plasma TSH or iodothyronine levels in a normal population...
  17. doi request reprint Thyroid hormone transport and metabolism by organic anion transporter 1C1 and consequences of genetic variation
    Wendy M van der Deure
    Department of Internal Medicine, Erasmus University Medical Center, Room Ee 502, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocrinology 149:5307-14. 2008
    ..In conclusion, OATP1C1 mediates transport of T4, T4S, and rT3 and increases the access of these substrates to the intracellular active sites of the deiodinases. No effect of genetic variation on the function of OATP1C1 was observed...
  18. ncbi request reprint Genetic variation in thyroid hormone transporters
    Wendy M van der Deure
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Best Pract Res Clin Endocrinol Metab 21:339-50. 2007
    ..However, with the characterization of specific thyroid hormone transporters, a new field of research is emerging...
  19. ncbi request reprint Reduced activation and increased inactivation of thyroid hormone in tissues of critically ill patients
    Robin P Peeters
    Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:3202-11. 2003
    ..These observed changes, in correlation with a low T(3)/rT(3) ratio, may represent tissue-specific ways to reduce thyroid hormone bioactivity during cellular hypoxia and contribute to the low T(3) syndrome of severe illness...
  20. ncbi request reprint Biochemical mechanisms of thyroid hormone deiodination
    George G J M Kuiper
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Thyroid 15:787-98. 2005
    ..These have resulted in the emerging view that the biological activity of thyroid hormone is regulated locally by tissue-specific regulation of the different deiodinases...
  21. ncbi request reprint Tissue thyroid hormone levels in critical illness
    Robin P Peeters
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:6498-507. 2005
    ..Furthermore, we investigated the relationship between tissue thyroid hormone levels, deiodinase activities, and monocarboxylate transporter 8 expression...
  22. ncbi request reprint Organic anion transporter 1B1: an important factor in hepatic thyroid hormone and estrogen transport and metabolism
    Wendy M van der Deure
    Department of Internal Medicine, Erasmus University Medical Center, Room Ee 502, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocrinology 149:4695-701. 2008
    ..OATP1B1-Ala174 displays decreased transport activity and thereby gives rise to higher bilirubin, E1S, and T4S levels in carriers of this polymorphism...
  23. doi request reprint The effect of genetic variation in the type 1 deiodinase gene on the interindividual variation in serum thyroid hormone levels: an investigation in healthy Danish twins
    Wendy M van der Deure
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 70:954-60. 2009
    ..Genetic factors have a considerable influence on serum thyroid hormone levels. The C785T and A1814G polymorphisms, located in the 3' untranslated region of the type 1 deiodinase (D1) gene have been associated with serum FT4 and rT3 levels...
  24. doi request reprint Molecular aspects of thyroid hormone transporters, including MCT8, MCT10, and OATPs, and the effects of genetic variation in these transporters
    Wendy M van der Deure
    Department of Internal Medicine, Erasmus University Medical School, Erasmus MC, GE Rotterdam, The Netherlands
    J Mol Endocrinol 44:1-11. 2010
    ..In this review, we will focus on the molecular aspects of thyroid hormone transporters, including MCT8, MCT10, organic anion transporting polypeptides, and the effects of genetic variation in these transporters...
  25. ncbi request reprint Increased thyroxine sulfate levels in critically ill patients as a result of a decreased hepatic type I deiodinase activity
    Robin P Peeters
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:6460-5. 2005
    ..In this study, we investigated whether T4S levels are increased in patients who died after intensive care and whether T4S levels are correlated with liver type I deiodinase (D1) or sulfotransferase (SULT) activity...
  26. doi request reprint High-normal thyroid function and risk of atrial fibrillation: the Rotterdam study
    Jan Heeringa
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Arch Intern Med 168:2219-24. 2008
    ..We aimed to investigate the association of high-normal thyroid function with the development of atrial fibrillation in a prospective population-based study in the elderly...
  27. doi request reprint Polymorphisms in the brain-specific thyroid hormone transporter OATP1C1 are associated with fatigue and depression in hypothyroid patients
    Wendy M van der Deure
    Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 69:804-11. 2008
    ..OATP1C1, a thyroid hormone transporter expressed at the blood-brain barrier, is considered to play a key role in delivering serum T4 to the brain...
  28. ncbi request reprint Effects of serum TSH and FT4 levels and the TSHR-Asp727Glu polymorphism on bone: the Rotterdam Study
    Wendy M van der Deure
    Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 68:175-81. 2008
    ..The TSHR-Asp727Glu polymorphism is associated with lower TSH levels. We therefore examined the association of this polymorphism with bone parameters...
  29. ncbi request reprint Changes within the thyroid axis during critical illness
    Robin P Peeters
    Department of Internal Medicine, Room Ee 502, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Crit Care Clin 22:41-55, vi. 2006
    ....
  30. ncbi request reprint Polymorphisms in type 2 deiodinase are not associated with well-being, neurocognitive functioning, and preference for combined thyroxine/3,5,3'-triiodothyronine therapy
    Bente C Appelhof
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, F5 171, P O Box 22700, 1100 DE Amsterdam, The Netherlands
    J Clin Endocrinol Metab 90:6296-9. 2005
    ..Levothyroxine-treated patients can be assumed to derive T3 exclusively from deiodination of T4, which, in the central nervous system, is regulated by type II deiodinase (DII)...
  31. ncbi request reprint Regulation of the somatotropic axis by intensive insulin therapy during protracted critical illness
    Dieter Mesotten
    Department of Intensive Care Medicine, University Hospital Gasthuisberg, B 3000 Leuven, Belgium
    J Clin Endocrinol Metab 89:3105-13. 2004
    ..GH resistance accompanied this suppression of the IGF-I axis. To what extent and through which mechanisms the changes in the GH-IGF-IGFBP axis contributed to the survival benefit under intensive insulin therapy remain elusive...
  32. ncbi request reprint The impact of a TSH receptor gene polymorphism on thyroid-related phenotypes in a healthy Danish twin population
    Pia Skov Hansen
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Clin Endocrinol (Oxf) 66:827-32. 2007
    ....
  33. ncbi request reprint Thyrotropin, but not a polymorphism in type II deiodinase, predicts response to paroxetine in major depression
    Jantien P Brouwer
    Department of Endocrinology, Academic Medical Center, The Netherlands
    Eur J Endocrinol 154:819-25. 2006
    ....
  34. ncbi request reprint Cortisol response to critical illness: effect of intensive insulin therapy
    Ilse Vanhorebeek
    Department of Intensive Care Medicine, Catholic University of Leuven, B 3000 Leuven, Belgium
    J Clin Endocrinol Metab 91:3803-13. 2006
    ..Both excessive and insufficient activation of the hypothalamic-pituitary-adrenal axis in response to critical illness is associated with increased mortality...
  35. ncbi request reprint Thyroid hormone receptor isoform expression in livers of critically ill patients
    Daphne C Thijssen-Timmer
    Department of Endocrinology and Metabolism, F5 171, Academic Medical Centre, Amsterdam, The Netherlands
    Thyroid 17:105-12. 2007
    ..The THRA gene encodes two isoforms of the thyroid hormone receptor (TR), TRalpha1 and TRalpha2. The ratio of these splice variants could have a marked influence on T3-regulated gene expression, especially during illness...