Research Topics
Species | R P PeetersSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
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Publications
Effects of thyroid state on the expression of hepatic thyroid hormone transporters in ratsRobin P Peeters
Departments of Internal Medicine and Nuclear Medicine, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
Am J Physiol Endocrinol Metab 283:E1232-8. 2002..However, they do not exclude regulation of hepatic T4 transporters by thyroid hormone at the translational and posttranslational level...- The association of polymorphisms in the type 1 and 2 deiodinase genes with circulating thyroid hormone parameters and atrophy of the medial temporal lobeFrank Jan de Jong
Department of Epidemiology, Biostatistics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
J Clin Endocrinol Metab 92:636-40. 2007..Variations in the deiodinase type 1 (DIO1) and type 2 (DIO2) genes that potentially alter thyroid hormone bioactivity may help in elucidating the role of thyroid function in AD... 
Thyroid hormone independent associations between serum TSH levels and indicators of bone turnover in cured patients with differentiated thyroid carcinomaKaren A Heemstra
Department of Endocrinology and Metabolism, C4 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Eur J Endocrinol 159:69-76. 2008..We also studied the contribution of the TSH receptor (TSHR)-Asp727Glu polymorphism to these relationships...
Cerebellar abnormalities in mice lacking type 3 deiodinase and partial reversal of phenotype by deletion of thyroid hormone receptor α1Robin P Peeters
Erasmus University Medical Center, Department of Internal Medicine, Dr Molewaterplein 50, Room Ee502, 3015 GE Rotterdam, The Netherlands
Endocrinology 154:550-61. 2013..These findings suggest that type 3 deiodinase constrains the timing of thyroid hormone action during cerebellar development...- Maternal thyroid hormone parameters during early pregnancy and birth weight: the Generation R StudyMarco Medici
Department of Internal Medicine, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
J Clin Endocrinol Metab 98:59-66. 2013..However, the effects of variation in maternal serum thyroid parameters within the normal range on birth weight are largely unknown... - Maternal early pregnancy and newborn thyroid hormone parameters: the Generation R studyMarco Medici
The Generation R Study Group, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
J Clin Endocrinol Metab 97:646-52. 2012..Although various studies have studied maternal thyroid parameters during the first half of pregnancy, little is known about their relations with thyroid parameters of the child... - The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly menRobin P Peeters
Department of Internal Medicine, Erasmus University Medical Cetnre, Rotterdam, The Netherlands
Clin Endocrinol (Oxf) 66:808-15. 2007..In addition, we analysed the Thr92Ala polymorphism in the type 2 deiodinase (D2), which was recently associated with insulin resistance... - Non thyroidal illness: to treat or not to treat?R P Peeters
Department of Internal Medicine, Erasmus University Medical Center, Room Ee 502, 50, Dr Molewaterplein, 3015 GE Rotterdam, The Netherlands
Ann Endocrinol (Paris) 68:224-8. 2007..Severity and duration of disease are related to the magnitude of these changes. This manuscript discusses whether these changes in thyroid hormone levels during critical illness should be treated, and was in part published elsewhere... - Thyroid hormones and agingRobin P Peeters
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
Hormones (Athens) 7:28-35. 2008..This review describes the changes in thyroid hormone levels with aging and the mechanisms behind these changes, and also discusses whether subclinical thyroid disease should be treated in the elderly... - Genetic variation in thyroid hormone pathway genes; polymorphisms in the TSH receptor and the iodothyronine deiodinasesRobin P Peeters
Department of Internal Medicine, Erasmus University Medical Center, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
Eur J Endocrinol 155:655-62. 2006..We discuss the possible consequences of these studies for the individual patient and also the new insights in thyroid hormone action that can be obtained from these data... - A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parametersRobin P Peeters
Department of Internal Medicine, Rm Ee 502, Erasmus University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Am J Physiol Endocrinol Metab 289:E75-81. 2005..We hypothesize that this might be explained by the decline in skeletal muscle size during aging, resulting in a relative decrease in the contribution of D2 to serum T(3) production... - A polymorphism in type I deiodinase is associated with circulating free insulin-like growth factor I levels and body composition in humansRobin P Peeters
Department of Internal Medicine, Room Ee 502, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
J Clin Endocrinol Metab 90:256-63. 2005..The association of D1 haplotype allele 2 with serum T(3) levels in the elderly population suggests a relative increase in its contribution to circulating T(3) in old age... - Impact of thyroid function and polymorphisms in the type 2 deiodinase on blood pressure: the Rotterdam Study and the Rotterdam Scan StudyWendy M van der Deure
Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands
Clin Endocrinol (Oxf) 71:137-44. 2009..However studies conducted thus far were small with controversial results... - Serum 3,3',5'-triiodothyronine (rT3) and 3,5,3'-triiodothyronine/rT3 are prognostic markers in critically ill patients and are associated with postmortem tissue deiodinase activitiesRobin P Peeters
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
J Clin Endocrinol Metab 90:4559-65. 2005..On d 5, T4, T3, but also TSH levels are higher in patients who will survive. Serum rT3 and T3/rT3 were correlated with postmortem tissue deiodinase activities... - Polymorphisms in thyroid hormone pathway genes are associated with plasma TSH and iodothyronine levels in healthy subjectsRobin P Peeters
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3000 DR The Netherlands
J Clin Endocrinol Metab 88:2880-8. 2003..We have analyzed eight SNPs in five thyroid hormone pathway genes and found significant associations of three SNPs in two genes (D1, TSHR) with plasma TSH or iodothyronine levels in a normal population... - Thyroid hormone transport and metabolism by organic anion transporter 1C1 and consequences of genetic variationWendy M van der Deure
Department of Internal Medicine, Erasmus University Medical Center, Room Ee 502, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Endocrinology 149:5307-14. 2008..In conclusion, OATP1C1 mediates transport of T4, T4S, and rT3 and increases the access of these substrates to the intracellular active sites of the deiodinases. No effect of genetic variation on the function of OATP1C1 was observed... - Genetic variation in thyroid hormone transportersWendy M van der Deure
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
Best Pract Res Clin Endocrinol Metab 21:339-50. 2007..However, with the characterization of specific thyroid hormone transporters, a new field of research is emerging... - Reduced activation and increased inactivation of thyroid hormone in tissues of critically ill patientsRobin P Peeters
Department of Internal Medicine, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands
J Clin Endocrinol Metab 88:3202-11. 2003..These observed changes, in correlation with a low T(3)/rT(3) ratio, may represent tissue-specific ways to reduce thyroid hormone bioactivity during cellular hypoxia and contribute to the low T(3) syndrome of severe illness... - Biochemical mechanisms of thyroid hormone deiodinationGeorge G J M Kuiper
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Thyroid 15:787-98. 2005..These have resulted in the emerging view that the biological activity of thyroid hormone is regulated locally by tissue-specific regulation of the different deiodinases... - Tissue thyroid hormone levels in critical illnessRobin P Peeters
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
J Clin Endocrinol Metab 90:6498-507. 2005..CONCLUSION: Our results suggest that, in addition to changes in the hypothalamus-pituitary-thyroid axis, tissue-specific mechanisms are involved in the reduced supply of bioactive thyroid hormone in critical illness... - The effect of genetic variation in the type 1 deiodinase gene on the interindividual variation in serum thyroid hormone levels: an investigation in healthy Danish twinsWendy M van der Deure
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
Clin Endocrinol (Oxf) 70:954-60. 2009..Genetic factors have a considerable influence on serum thyroid hormone levels. The C785T and A1814G polymorphisms, located in the 3' untranslated region of the type 1 deiodinase (D1) gene have been associated with serum FT4 and rT3 levels... - Organic anion transporter 1B1: an important factor in hepatic thyroid hormone and estrogen transport and metabolismWendy M van der Deure
Department of Internal Medicine, Erasmus University Medical Center, Room Ee 502, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Endocrinology 149:4695-701. 2008..OATP1B1-Ala174 displays decreased transport activity and thereby gives rise to higher bilirubin, E1S, and T4S levels in carriers of this polymorphism... - Molecular aspects of thyroid hormone transporters, including MCT8, MCT10, and OATPs, and the effects of genetic variation in these transportersWendy M van der Deure
Department of Internal Medicine, Erasmus University Medical School, Erasmus MC, GE Rotterdam, The Netherlands
J Mol Endocrinol 44:1-11. 2010..In this review, we will focus on the molecular aspects of thyroid hormone transporters, including MCT8, MCT10, organic anion transporting polypeptides, and the effects of genetic variation in these transporters... - Increased thyroxine sulfate levels in critically ill patients as a result of a decreased hepatic type I deiodinase activityRobin P Peeters
Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
J Clin Endocrinol Metab 90:6460-5. 2005..001). CONCLUSION: Serum T4S levels were clearly elevated compared with healthy references, and the decreased deiodination by liver D1 during critical illness appears to play a role in this increase in serum T4S levels... - High-normal thyroid function and risk of atrial fibrillation: the Rotterdam studyJan Heeringa
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
Arch Intern Med 168:2219-24. 2008..We aimed to investigate the association of high-normal thyroid function with the development of atrial fibrillation in a prospective population-based study in the elderly... - Polymorphisms in the brain-specific thyroid hormone transporter OATP1C1 are associated with fatigue and depression in hypothyroid patientsWendy M van der Deure
Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands
Clin Endocrinol (Oxf) 69:804-11. 2008..OATP1C1, a thyroid hormone transporter expressed at the blood-brain barrier, is considered to play a key role in delivering serum T4 to the brain... - Changes within the thyroid axis during critical illnessRobin P Peeters
Department of Internal Medicine, Room Ee 502, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Crit Care Clin 22:41-55, vi. 2006.... - Effects of serum TSH and FT4 levels and the TSHR-Asp727Glu polymorphism on bone: the Rotterdam StudyWendy M van der Deure
Department of Internal Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands
Clin Endocrinol (Oxf) 68:175-81. 2008..The TSHR-Asp727Glu polymorphism is associated with lower TSH levels. We therefore examined the association of this polymorphism with bone parameters... - Regulation of the somatotropic axis by intensive insulin therapy during protracted critical illnessDieter Mesotten
Department of Intensive Care Medicine, University Hospital Gasthuisberg, B 3000 Leuven, Belgium
J Clin Endocrinol Metab 89:3105-13. 2004..GH resistance accompanied this suppression of the IGF-I axis. To what extent and through which mechanisms the changes in the GH-IGF-IGFBP axis contributed to the survival benefit under intensive insulin therapy remain elusive... - Polymorphisms in type 2 deiodinase are not associated with well-being, neurocognitive functioning, and preference for combined thyroxine/3,5,3'-triiodothyronine therapyBente C Appelhof
Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, F5 171, P O Box 22700, 1100 DE Amsterdam, The Netherlands
J Clin Endocrinol Metab 90:6296-9. 2005..Levothyroxine-treated patients can be assumed to derive T3 exclusively from deiodination of T4, which, in the central nervous system, is regulated by type II deiodinase (DII)... - Thyrotropin, but not a polymorphism in type II deiodinase, predicts response to paroxetine in major depressionJantien P Brouwer
Department of Endocrinology, Academic Medical Center, The Netherlands
Eur J Endocrinol 154:819-25. 2006.... - The impact of a TSH receptor gene polymorphism on thyroid-related phenotypes in a healthy Danish twin populationPia Skov Hansen
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
Clin Endocrinol (Oxf) 66:827-32. 2007.... - Cortisol response to critical illness: effect of intensive insulin therapyIlse Vanhorebeek
Department of Intensive Care Medicine, Catholic University of Leuven, B-3000 Leuven, Belgium
J Clin Endocrinol Metab 91:3803-13. 2006..The lower cortisol levels were not related to altered cortisol-binding capacity... - Thyroid hormone receptor isoform expression in livers of critically ill patientsDaphne C Thijssen Timmer
Department of Endocrinology and Metabolism, F5 171, Academic Medical Centre, Amsterdam, The Netherlands
Thyroid 17:105-12. 2007..The THRA gene encodes two isoforms of the thyroid hormone receptor (TR), TRalpha1 and TRalpha2. The ratio of these splice variants could have a marked influence on T3-regulated gene expression, especially during illness...