Research Topics
Species | S E OverbeekSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
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Detail Information
Publications
Formoterol added to low-dose budesonide has no additional antiinflammatory effect in asthmatic patientsShelley E Overbeek
Department of Pulmonary Medicine, SV020, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, Netherlands
Chest 128:1121-7. 2005..An important, but as yet unresolved, question is whether this is due to an additional reduction of airway inflammation...- Effect of montelukast compared with inhaled fluticasone on airway inflammationS E Overbeek
Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands
Clin Exp Allergy 34:1388-94. 2004..Inhaled corticosteroids are currently regarded as the gold standard in anti-inflammatory therapy, however, leukotriene receptor antagonists have been ascribed anti-inflammatory properties... - Airway inflammation is present during clinical remission of atopic asthmaL M van den Toorn
Department of Pulmonary Medicine, Erasmus University Medical Center Rotterdam, The Netherlands
Am J Respir Crit Care Med 164:2107-13. 2001..Our study has shown ongoing airway inflammation and airway remodeling in adolescents in clinical remission of atopic asthma. Subclinical airway inflammation may well determine the risk of an asthma relapse later in life... - Adolescents in clinical remission of atopic asthma have elevated exhaled nitric oxide levels and bronchial hyperresponsivenessL M van den Toorn
Departments of Paediatrics Paediatric Respiratory Medicine and Pulmonary Medicine, Sophia Children s Hospital and Erasmus University University Hospital, Rotterdam, The Netherlands
Am J Respir Crit Care Med 162:953-7. 2000..We speculate that subclinical inflammation is a risk factor for asthma relapse later in life, and that eNO and responsiveness to both AMP and MCh can be used as different, noninvasive indices of the inflammatory process of the airways... - Interleukin 4 receptors on human bronchial epithelial cells. An in vivo and in vitro analysis of expression and functionV H van der Velden
Department of Immunology, Erasmus University and University Hospital Dijkzigt, Rotterdam, The Netherlands
Cytokine 10:803-13. 1998..Stimulation of human bronchial epithelial cells by IL-4 may result in the release of both pro- and anti-inflammatory mediators known to be upregulated in asthmatic airways... - Nasal allergen provocation induces adhesion molecule expression and tissue eosinophilia in upper and lower airwaysG J Braunstahl
Departments of Otorhinolaryngology and Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
J Allergy Clin Immunol 107:469-76. 2001..CONCLUSION: This study shows that NP in patients with AR results in generalized airway inflammation through upregulation of adhesion molecules... - Effect of dry powder inhaler resistance on the inspiratory flow rates and volumes of cystic fibrosis patients of six years and olderH A Tiddens
Department of Pediatric Pulmonology, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
J Aerosol Med 19:456-65. 2006..The recorded inspiratory patterns can be used on the bench to design and test new dry powder formulations and devices to target the largest proportion of the CF population... - Dyspnoea perception during clinical remission of atopic asthmaL M van den Toorn
Dept of Paediatrics Paediatric Respiratory Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands
Eur Respir J 19:1047-50. 2002..Other factors, including both physical and psychological ones, may play a role in the apparent absence of symptoms, thereby potentially leading to undertreatment... - Expression of aminopeptidase N and dipeptidyl peptidase IV in the healthy and asthmatic bronchusV H van der Velden
Department of Immunology, Erasmus University and University Hospital Dijkzigt, Rotterdam, The Netherlands
Clin Exp Allergy 28:110-20. 1998..The effects of peptides are modulated by peptidases, which are able to degrade peptides, mostly resulting in their inactivation... - Computed critiquing integrated into daily clinical practice affects physicians' behavior--a randomized clinical trial with AsthmaCriticM M Kuilboer
Department of Medical Informatics, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
Methods Inf Med 45:447-54. 2006..In addition, the physicians changed their data-recording habits... - Evaluation studies of the 13C-mixed triglyceride breath test in healthy controls and adult cystic fibrosis patients with exocrine pancreatic insufficiencyG R Swart
Department of Internal Medicine II, University Hospital Dijkzigt, Rotterdam, The Netherlands
Digestion 58:415-20. 1997..Exercise should be limited or strictly defined. Diet on the day preceding the test should not contain naturally 13C-enriched food. There is no need to measure individual CO2 production... - Comparison of conventional and molecular methods for the detection of bacterial pathogens in sputum samples from cystic fibrosis patientsA van Belkum
Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam EMCR, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
FEMS Immunol Med Microbiol 27:51-7. 2000.... - Initial improvements in lung function and bronchial hyperresponsiveness are maintained during 5 years of treatment with inhaled beclomethasone dipropionate and terbutalineW Rob Douma
Department of Pulmonology, University Hospital Groningen, Groningen, The Netherlands
Chest 121:151-7. 2002..Increasing the dose of BDP in a small group of patients with an accelerated fall in FEV(1) (initially treated with a moderate dose of BDP) resulted in no significant improvement in FEV(1), PC(20), PEF indexes, and symptom scores... - Asthma remission: does it exist?Leon M van den Toorn
Department of Pediatrics Pediatric Respiratory Medicine, Erasmus MC, Rotterdam, The Netherlands
Curr Opin Pulm Med 9:15-20. 2003..quot; The question is whether this percentage can be increased with prolonged antiinflammatory therapy and regular control... - Benefit from anti-inflammatory treatment during clinical remission of atopic asthmaLeon M van den Toorn
Department of Pulmonary Medicine, Erasmus MC Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Respir Med 99:779-87. 2005..In this study, we investigated whether a short course of combined anti-inflammatory treatment would, also in this specific patient population, diminish airway inflammation and/or remodeling... - Feasibility of AsthmaCritic, a decision-support system for asthma and COPD which generates patient-specific feedback on routinely recorded data in general practiceManon M Kuilboer
Department of Medical Informatics, Erasmus Medical Center Rotterdam, Ee2100, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Fam Pract 19:442-7. 2002..The big question concerns the feasibility of a true integration--if only routinely recorded data are used for such a system, can patient-specific feedback be produced?..