H G Niesters

Summary

Affiliation: Erasmus University
Country: The Netherlands

Publications

  1. pmc Development of a real-time quantitative assay for detection of Epstein-Barr virus
    H G Niesters
    Departments of Virology, University Hospital Rotterdam, Rotterdam, The Netherlands
    J Clin Microbiol 38:712-5. 2000
  2. ncbi request reprint Molecular and diagnostic clinical virology in real time
    H G M Niesters
    Department of Virology, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Clin Microbiol Infect 10:5-11. 2004
  3. ncbi request reprint Clinical virology in real time
    Hubert G M Niesters
    Department of Virology, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Clin Virol 25:S3-12. 2002
  4. ncbi request reprint Identification of a new variant in the YMDD motif of the hepatitis B virus polymerase gene selected during lamivudine therapy
    Hubert G M Niesters
    Department of Virology, University Hospital Rotterdam, The Netherlands
    J Med Microbiol 51:695-9. 2002
  5. ncbi request reprint Quantitation of viral load using real-time amplification techniques
    H G Niesters
    Department of Virology, University Hospital Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Methods 25:419-29. 2001
  6. pmc A multicenter study evaluation of the digene hybrid capture II signal amplification technique for detection of hepatitis B virus DNA in serum samples and testing of EUROHEP standards
    H G Niesters
    Department of Virology, University Hospital Rotterdam, Rotterdam, The Netherlands
    J Clin Microbiol 38:2150-5. 2000
  7. ncbi request reprint Identification of more than one mutation in the hepatitis B virus polymerase gene arising during prolonged lamivudine treatment
    H G Niesters
    Department of Gastroenterology, University Hospital Rotterdam, The Netherlands
    J Infect Dis 177:1382-5. 1998
  8. ncbi request reprint The nature of acute rejection is associated with development of graft vascular disease after clinical heart transplantation
    C C Baan
    Department of Internal Medicine 1, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    J Heart Lung Transplant 17:363-73. 1998
  9. ncbi request reprint Development of a real-time quantitative RT-PCR for the detection of HIV-2 RNA in plasma
    M Schutten
    Department of Virology, Erasmus Medical Centre Rotterdam, The Netherlands
    J Virol Methods 88:81-7. 2000
  10. ncbi request reprint The sequential occurrence of viral mutations in a liver transplant recipient re-infected with hepatitis B: hepatitis B immune globulin escape, famciclovir non-response, followed by lamivudine resistance resulting in graft loss
    R A de Man
    Department of Hepatogastroenterology, Erasmus University Hospital, Rotterdam, The Netherlands
    J Hepatol 29:669-75. 1998

Collaborators

Detail Information

Publications54

  1. pmc Development of a real-time quantitative assay for detection of Epstein-Barr virus
    H G Niesters
    Departments of Virology, University Hospital Rotterdam, Rotterdam, The Netherlands
    J Clin Microbiol 38:712-5. 2000
    ..Further studies revealed that the inhibitory effect of heparinized plasma could be efficiently removed by use of an extraction method with Celite as the absorbent...
  2. ncbi request reprint Molecular and diagnostic clinical virology in real time
    H G M Niesters
    Department of Virology, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Clin Microbiol Infect 10:5-11. 2004
    ..Finally, with the introduction of a universal internal control throughout the whole procedure, the accuracy of the results generated is warranted...
  3. ncbi request reprint Clinical virology in real time
    Hubert G M Niesters
    Department of Virology, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Clin Virol 25:S3-12. 2002
    ..Since so many targets do have clinical implications, laboratories might prefer to use universal internal controls before the in-house developed assays should be introduced in clinical virology...
  4. ncbi request reprint Identification of a new variant in the YMDD motif of the hepatitis B virus polymerase gene selected during lamivudine therapy
    Hubert G M Niesters
    Department of Virology, University Hospital Rotterdam, The Netherlands
    J Med Microbiol 51:695-9. 2002
    ..The mutation was followed by a leucine to methionine change at position 180 (rtL180M). The consequences of this mutation for disease management and diagnostic strategies are discussed...
  5. ncbi request reprint Quantitation of viral load using real-time amplification techniques
    H G Niesters
    Department of Virology, University Hospital Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Methods 25:419-29. 2001
    ....
  6. pmc A multicenter study evaluation of the digene hybrid capture II signal amplification technique for detection of hepatitis B virus DNA in serum samples and testing of EUROHEP standards
    H G Niesters
    Department of Virology, University Hospital Rotterdam, Rotterdam, The Netherlands
    J Clin Microbiol 38:2150-5. 2000
    ..This assay allows the accurate measurement of HBV DNA levels in serum and can be clinically used for the monitoring of responses to antiviral agents for patients chronically infected with HBV...
  7. ncbi request reprint Identification of more than one mutation in the hepatitis B virus polymerase gene arising during prolonged lamivudine treatment
    H G Niesters
    Department of Gastroenterology, University Hospital Rotterdam, The Netherlands
    J Infect Dis 177:1382-5. 1998
    ..After cessation of therapy, the wild type sequences reemerged...
  8. ncbi request reprint The nature of acute rejection is associated with development of graft vascular disease after clinical heart transplantation
    C C Baan
    Department of Internal Medicine 1, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    J Heart Lung Transplant 17:363-73. 1998
    ..To determine mechanisms that trigger graft vascular disease (GVD) after heart transplantation, we studied parameters that reflect both early and late intragraft allogeneic reactions...
  9. ncbi request reprint Development of a real-time quantitative RT-PCR for the detection of HIV-2 RNA in plasma
    M Schutten
    Department of Virology, Erasmus Medical Centre Rotterdam, The Netherlands
    J Virol Methods 88:81-7. 2000
    ....
  10. ncbi request reprint The sequential occurrence of viral mutations in a liver transplant recipient re-infected with hepatitis B: hepatitis B immune globulin escape, famciclovir non-response, followed by lamivudine resistance resulting in graft loss
    R A de Man
    Department of Hepatogastroenterology, Erasmus University Hospital, Rotterdam, The Netherlands
    J Hepatol 29:669-75. 1998
    ..The aims were to document the mutations occurring in the hepatitis B virus (HBV) polymerase gene as a consequence of HBIg escape, famciclovir non-response and subsequent lamivudine resistance...
  11. ncbi request reprint Characteristics of the early phase of chronicity in acute hepatitis B infection
    R A Heijtink
    Department of Virology, Erasmus University Rotterdam, The Netherlands
    J Med Virol 57:331-6. 1999
    ..Differentiation of the antibody response to HBeAg may help to find patients with an increased risk for this interrupted immune clearance who might be candidates for an early intervention therapy...
  12. ncbi request reprint Clinical utility of viral quantification as a tool for disease monitoring
    M Schutten
    Department of Virology, University Hospital Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Expert Rev Mol Diagn 1:153-62. 2001
    ..New guidelines for disease management, as well as extensive quality control and standardization programs must be introduced...
  13. ncbi request reprint Nucleoside analogues for chronic hepatitis B
    L M Wolters
    Department of Gastroenterology and Hepatology, University Hospital Rotterdam, The Netherlands
    Eur J Gastroenterol Hepatol 13:1499-506. 2001
    ..The best antiviral strategy in the future is probably combination therapy, either with several nucleoside analogues or with a nucleoside analogue and interferon...
  14. ncbi request reprint Early prediction of response in interferon monotherapy and in interferon-ribavirin combination therapy for chronic hepatitis C: HCV RNA at 4 weeks versus ALT
    J T Brouwer
    Department of Hepatogastroenterology, Erasmus University Hospital Dijkzigt, Rotterdam, The Netherlands
    J Hepatol 30:192-8. 1999
    ..The aim of this study was to assess the predictive value of an HCV RNA test at 4 weeks in comparison with ALT, both in interferon monotherapy and in interferon-ribavirin combination therapy...
  15. ncbi request reprint Intragraft platelet-derived growth factor-alpha and transforming growth factor-beta1 during the development of accelerated graft vascular disease after clinical heart transplantation
    H A de Groot-Kruseman
    Department of Internal Medicine I, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    Transpl Immunol 7:201-5. 1999
    ..These results suggest that intragraft PDGF-alpha and TGF-beta1 play a role in the pathogenesis of accelerated GVD after clinical heart transplantation...
  16. ncbi request reprint Evaluation of a fully automated glycoprotein G-2 based assay for the detection of HSV-2 specific IgG antibodies in serum and plasma
    J Groen
    Institute of Virology, Erasmus Medical Center Rotterdam, University Hospital Rotterdam, The Netherlands
    J Clin Virol 12:193-200. 1999
    ..Seroepidemiological studies on the prevalence of HSV-2 specific IgG antibodies are especially important to study the impact of this infection among risk groups...
  17. ncbi request reprint T cells activate the tumor necrosis factor-alpha system during hemodialysis, resulting in tachyphylaxis
    I C van Riemsdijk
    Department of Internal Medicine, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    Kidney Int 59:883-92. 2001
    ....
  18. pmc Intragraft interleukin 2 mRNA expression during acute cellular rejection and left ventricular total wall thickness after heart transplantation
    H A de Groot-Kruseman
    Department of Internal Medicine, University Hospital Rotterdam, Rotterdam, Netherlands
    Heart 87:363-7. 2002
    ..To assess whether diastolic graft function is influenced by intragraft interleukin 2 (IL-2) messenger RNA (mRNA) expression in rejecting cardiac allografts...
  19. ncbi request reprint Failure to down-regulate intragraft cytokine mRNA expression shortly after clinical heart transplantation is associated with high incidence of acute rejection
    H A de Groot-Kruseman
    Department of Internal Medicine, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    J Heart Lung Transplant 20:503-10. 2001
    ..Therefore, we evaluated intragraft cytokine mRNA expression at an early stage after clinical heart transplantation and related these data to ischemia, immunosuppression, and rejection...
  20. pmc Comparison of reverse hybridization, microarray, and sequence analysis for genotyping hepatitis B virus
    Suzan D Pas
    Erasmus MC, Department of Virology, L355, Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
    J Clin Microbiol 46:1268-73. 2008
    ..3% and a specificity of 100% compared to sequence analysis. HBV DNA-Chip assay showed a sensitivity and specificity of 97.5 and 97.8%, respectively...
  21. ncbi request reprint Paired measurements of quantitative hepatitis B virus DNA in saliva and serum of chronic hepatitis B patients: implications for saliva as infectious agent
    Annemiek A van der Eijk
    Department of Hepatology and Gastroenterology, Erasmus MC, University Medical Centre, Room Ca 326, Dr Molewaterplein 40, 3015 GD Rotterdam, Netherlands
    J Clin Virol 29:92-4. 2004
    ..After intensive source and contact tracing 20 % of acute Hepatitis B virus (HBV) infections remain unexplained. Saliva may be an unexpected vehicle of HBV DNA transmission...
  22. ncbi request reprint Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B
    Renate G van der Molen
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hepatology 40:738-46. 2004
    ..In conclusion, mDC and pDC are functionally impaired in patients with chronic hepatitis B. This might be an important way by which hepatitis B virus evades an adequate immune response, leading to viral persistence and disease chronicity...
  23. ncbi request reprint Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial
    Harry L A Janssen
    Department of Gastroenterology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
    Lancet 365:123-9. 2005
    ..Treatment of HBeAg-positive patients with chronic hepatitis B is not effective in most. A combination of immunomodulatory pegylated interferon alfa-2b and antiviral lamivudine might improve the rate of sustained response...
  24. ncbi request reprint Quantification of the newly detected lamivudine resistant YSDD variants of Hepatitis B virus using molecular beacons
    Suzan D Pas
    Department of Virology, ErasmusMC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Clin Virol 32:166-72. 2005
    ..With this technique, new information on the dynamics of variants during and after therapy was obtained...
  25. ncbi request reprint Paired, quantitative measurements of hepatitis B virus DNA in saliva, urine and serum of chronic hepatitis B patients
    Annemiek A van der Eijk
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Centre Rotterdam, The Netherlands
    Eur J Gastroenterol Hepatol 17:1173-9. 2005
    ..In a new approach, we evaluated quantitative HBV DNA content in serum, saliva and urine as a first step in exploring possible modes of horizontal transmission...
  26. ncbi request reprint The effect of pegylated interferon-alpha on the treatment of lamivudine resistant chronic HBeAg positive hepatitis B virus infection
    Wilhelmus F Leemans
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Hepatol 44:507-11. 2006
    ..To determine the response to pegylated interferon-alpha treatment of HBeAg-positive hepatitis B patients with proven lamivudine resistance...
  27. ncbi request reprint Analysis of intrahepatic HBV-specific cytotoxic T-cells during and after acute HBV infection in humans
    Dave Sprengers
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Hepatol 45:182-9. 2006
    ..In this study we aimed to characterize the virus-specific CD8 + T-cell response in the liver of patients with acute HBV infection using fine-needle aspiration-biopsy (FNAB)...
  28. pmc Cowpox virus transmission from rats to monkeys, the Netherlands
    Byron E E Martina
    Erasmus Medical Center Rotterdam, Rotterdam, Netherlands
    Emerg Infect Dis 12:1005-7. 2006
    ..Sequence comparison and serologic results showed that brown rats (Rattus norvegicus) transmitted the virus to monkeys...
  29. ncbi request reprint The dynamics of mutations in the YMDD motif of the hepatitis B virus polymerase gene during and after lamivudine treatment as determined by reverse hybridisation
    Suzan D Pas
    Department of Virology, University Hospital Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Clin Virol 25:63-71. 2002
    ..In three patients, no variant virus population could be detected at 25, 36 and 37 weeks, respectively, after cessation of treatment. This observation is important for the inclusion of the so-called naive patients in clinical trials...
  30. ncbi request reprint Viral dynamics in chronic hepatitis B patients during lamivudine therapy
    Lonieke M M Wolters
    Department of Hepatogastroenterology, University Hospital Rotterdam, The Netherlands
    Liver 22:121-6. 2002
    ..We therefore compared several mathematical models which are currently in use to describe the dynamics of various viruses and treatments...
  31. ncbi request reprint Detection of HBV DNA using real time analysis
    Suzan D Pas
    Department of Virology, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Clin Virol 25:93-4. 2002
  32. ncbi request reprint The influence of baseline characteristics on viral dynamic parameters in chronic hepatitis B patients treated with lamivudine
    Leonieke M M Wolters
    Department of Hepatogastroenterology, University Hospital Rotterdam, The Netherlands
    J Hepatol 37:253-8. 2002
    ..Viral decline during lamivudine therapy in chronic hepatitis B patients is bi-phasic. We studied the influence of lamivudine dose and baseline characteristics on parameters obtained from a mathematical model...
  33. ncbi request reprint Viral dynamics during and after entecavir therapy in patients with chronic hepatitis B
    Leonieke M M Wolters
    Department of Gastroenterology and Hepatology, University Hospital Rotterdam, Rotterdam, The Netherlands
    J Hepatol 37:137-44. 2002
    ..Mathematical description of changes in viral load during and after therapy may help to understand the several events that take place during nucleoside analogue treatment...
  34. ncbi request reprint Absolute level of Epstein-Barr virus DNA in human immunodeficiency virus type 1 infection is not predictive of AIDS-related non-Hodgkin lymphoma
    Debbie van Baarle
    Department of Clinical Viro Immunology, Sanquin Research at CLB, and Department of Hematology, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands
    J Infect Dis 186:405-9. 2002
    ..EBV DNA was also detectable in serum at some time points but at a lower level...
  35. ncbi request reprint Persistence of YMDD variants after withdrawal of Lamivudine
    Annemiek A van der Eijk
    J Hepatol 36:304-5. 2002
  36. ncbi request reprint Viral dynamics in chronic hepatitis B patients treated with lamivudine, lamivudine-famciclovir or lamivudine-ganciclovir
    Leonieke M M Wolters
    Department of Gastroenterology and Hepatology, University Hospital Rotterdam, 3000 CA Rotterdam, The Netherlands
    Eur J Gastroenterol Hepatol 14:1007-11. 2002
    ..However, combination therapy with more than one nucleoside analogue could possibly overcome the disadvantages of monotherapy...
  37. ncbi request reprint Molecular epidemiology of gibbon hepatitis B virus transmission
    Suwanna Noppornpanth
    Viral Hepatitis Research Unit, Department of Paediatrics, Chulalongkorn University and Hospital, Bangkok 10330, Thailand
    J Gen Virol 84:147-55. 2003
    ..Although some of the animal caretakers at the Krabok Koo Wildlife Breeding Centre were found to be chronic HBV carriers, genotype and sequence analysis did not reveal any evidence for zoonotic disease transmission...
  38. ncbi request reprint Human bocavirus and acute wheezing in children
    Tobias Allander
    Department of Microbiology Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
    Clin Infect Dis 44:904-10. 2007
    ..It has been detected primarily in children with acute lower respiratory tract infection, but its occurrence, clinical profile, and role as a causative agent of respiratory tract disease are not clear...
  39. ncbi request reprint Clinical, immunological and virological response to different antiretroviral regimens in a cohort of HIV-2-infected patients
    Marchina E van der Ende
    University Hospital Rotterdam, Dijkzigt, Rotterdam, The Netherlands
    AIDS 17:S55-61. 2003
    ..To assess the clinical, immunological and virological response and the emergence of resistance towards antiretroviral therapy (ART) in a cohort of HIV-2-infected patients...
  40. ncbi request reprint Respiratory viruses and acute asthma in children
    Tuomas Jartti
    J Allergy Clin Immunol 120:216; author reply 217. 2007
  41. pmc Accuracy of a referral guideline for patients with chronic hepatitis B in primary care to select patients eligible for evaluation by a specialist
    Irene K Veldhuijzen
    Gut 56:1027-8. 2007
  42. pmc Quality control of direct molecular diagnostics for methicillin-resistant Staphylococcus aureus
    Alex van Belkum
    Department of Medical Microbiology and Infectious Diseases, Unit Research and Development, Erasmus MC, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    J Clin Microbiol 45:2698-700. 2007
    ..Samples containing 10(2) to 10(3) MRSA cells were frequently reported to be negative. MRSE samples were scored as negative by all commercial tests but by only two out of three in-house tests...
  43. pmc Impact of human bocavirus on children and their families
    Susanna Esposito
    Institute of Pediatrics, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via Commenda 9, 20122 Milano, Italy
    J Clin Microbiol 46:1337-42. 2008
    ....
  44. ncbi request reprint Presence or absence of cytomegalovirus in cerebrospinal fluid from patients with Guillain-Barré syndrome?
    Mark L Kuijf
    J Infect Dis 193:1471-2; author reply 1472-3. 2006
  45. ncbi request reprint Prevention of Epstein-Barr virus-lymphoproliferative disease by molecular monitoring and preemptive rituximab in high-risk patients after allogeneic stem cell transplantation
    Joost W J van Esser
    Department of Hematology, Erasmus Medical Center Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Blood 99:4364-9. 2002
    ..04) at 6 months from EBV-DNA more than or equal to 1000 geq/mL. Frequent quantitative monitoring of EBV reactivation and preemptive therapy by rituximab improves outcome in patients at high risk of EBV-LPD. (Blood. 2002;99:4364-4369)..
  46. ncbi request reprint Detection of hepatitis B virus genotypes and mutants: current status
    Hubert G M Niesters
    Department of Virology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Clin Virol 34:S4-8. 2005
    ..Technologies enabling the detection and quantification of these variant populations are presented and discussed...
  47. ncbi request reprint Characterization of Epstein-Barr virus Type I variants based on linked polymorphism among EBNA3A, -3B, and -3C genes
    Irene Görzer
    Medical University of Vienna, Institute of Virology, Kinderspitalgasse 15, A 1095 Vienna, Austria
    Virus Res 118:105-14. 2006
    ..Thus, a combination of more than one polymorphic site in the EBV genome might be involved in determining disease characteristics...
  48. ncbi request reprint Real-time Epstein-Barr virus PCR for the diagnosis of primary EBV infections and EBV reactivation
    Rianne Luderer
    Unit Molecular Diagnostics, Diakonessenhuis Utrecht, Utrecht, The Netherlands
    Mol Diagn 9:195-200. 2005
    ..Recently, EBV PCR has been added as a diagnostic tool. Positive EBV PCR has been demonstrated in the serum of patients with primary EBV infections and EBV reactivation...
  49. ncbi request reprint Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection
    Koert J Stittelaar
    Department of Virology, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    Nature 439:745-8. 2006
    ..These data show that adequate preparedness for a biological threat involving smallpox should include the possibility of treating exposed individuals with antiviral compounds such as cidofovir or other selective anti-poxvirus drugs...
  50. ncbi request reprint Acquisition and clearance of perianal human papillomavirus infection in relation to HIV-positivity in men who have sex with men in the Netherlands
    Eric M van der Snoek
    Department of Dermatology and Venereology, Institute of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    Acta Derm Venereol 85:437-43. 2005
    ..036) while the incidence of type 16 may be associated with HIV positivity (p=0.059). In HIV-positive MSM significantly more high-risk HPV types were detected at the perianal region...
  51. ncbi request reprint Functional heme oxygenase-1 promoter polymorphism in relation to heart failure and cardiac transplantation
    Cecile T J Holweg
    Department of Internal Medicine, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Heart Lung Transplant 24:493-7. 2005
    ..No influence of the polymorphism on the development of heart failure, graft survival, acute rejection, or transplant atherosclerosis was found...
  52. ncbi request reprint Standardisation and controls, why can't we overcome the hurdles?
    Hubert G M Niesters
    J Clin Virol 31:81-3. 2004
  53. ncbi request reprint Polyarteritis nodosa associated with hepatitis B virus infection. The role of antiviral treatment and mutations in the hepatitis B virus genome
    Harry L A Janssen
    Department of Gastroenterology, Erasmus MC, University Medical Centre, and Virology, Erasmus University, Rotterdam, The Netherlands
    Eur J Gastroenterol Hepatol 16:801-7. 2004
    ..The efficacy of new generation nucleoside analogues should be further elucidated in future studies...
  54. doi request reprint Association between high nasopharyngeal viral load and disease severity in children with human metapneumovirus infection
    Samantha Bosis
    Institute of Pediatrics, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via Commenda 9, 20122 Milan, Italy
    J Clin Virol 42:286-90. 2008
    ..Previous studies have shown that viral genotype and viral load may play a significant role in the pathogenesis of viral infections...