Henriette A Moll

..The purpose of this study is to explore to what extent and in what direction HRQoL self-reports of adolescents with chronic conditions and those of their parents differ...

..To improve the Manchester Triage System (MTS) in paediatric emergency care...

..The aim of this review was to provide an overview of the literature on reliability and validity of current triage systems in paediatric emergency care..

..The aim of this study is to assess the influence of functional abdominal complaints (FAC) on health-related quality of life in a group of Dutch pre-school children...

..In the present paper we evaluate the diagnostic work-up in secondary health care according to existing consensus guidelines and study the frequency of underlying medical disorders...

..Triage systems, developed by consensus of experts and based on decision rules, are typically not validated. The objective is to discuss the challenges to evaluate the reliability and validity of triage systems...

..To examine whether the timing of introduction of the allergenic foods cow's milk, hen's egg, peanuts, tree nuts, soy, and gluten is associated with eczema and wheezing in children 4 years of age or younger...

..To study the association between Staphylococcus aureus nasal colonization and atopic dermatitis (AD) in infancy...

..Eventually, results forthcoming from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...

..These findings can form a basis for future epidemiological studies regarding dietary patterns and health outcomes in young children...

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..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...

..e. z= 0). We therefore conclude that differences in WFH in childhood are not the result of early introduction to solids...

..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...

..To examine the association of breastfeeding with maternal sensitive responsiveness and infant-mother attachment security and disorganization...

..This study compares HRQOL among subgroups of infants with asthma-like symptoms to a subgroup without such symptoms and examines independent associations between asthma-like symptoms during the first year of life and HRQOL at age 12 months...

..In the first year of life, no association between maternal IgG levels and colonization was seen. In addition, no association between the IgG and IgA levels in the child versus colonization status was seen...

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..Left kidney size tended to be smaller than right kidney size, except for kidney length. The reference curves can be used for assessing kidney structures by ultrasound in foetal life and early childhood...

..Lymphocytes (T, B and NK) and T lymphocyte subsets (helper, cytotoxic, naive and memory) in cord blood were immunophenotyped in 380 neonates by six-colour flow cytometry...

..Preterm born and low-birth-weight infants are at risk for severe infections in infancy. It has been suggested that these infants have an immature immune system...

..Hence, ethnic background was associated with respiratory symptoms during the first 2 years of life and this association was largely explained by mediating effects of known pre and postnatal risk factors for respiratory morbidity...

..We examined whether the PPARgamma2 Ala12 allele influences growth in early life and whether this association is modified by breast-feeding...

..The aim of this paper is to describe the Generation R study as a template that enables candidate gene study and genome-wide association study regarding health-related quality of life (HRQOL) of mothers and their young children...

..Growth in infancy was assessed at birth (weight) and at the ages of 6 weeks, 6 months and 14 months (head circumference, length, weight). The IGF1 promoter region genotype was determined in 738 children...

..The aims of this study are to examine whether kidney size tracks from fetal life to childhood and whether maternal and fetal characteristics are associated with kidney size at the age of 2 years...

..However, this association was partially explained by energy intake. A "Western" diet may increase the risk of frequent respiratory symptoms at 3 and 4 yrs of age. In some measure, this association was explained by energy intake...

..To assess whether timing of introduction of fish and the amount of fish consumption in infancy were associated with asthmalike symptoms at preschool age...

..Certain antibodies against pneumococcal virulence proteins, some of which are induced by colonization, are associated with a decreased number of RTIs in children. This should be taken into account in future pneumococcal vaccine studies...

..We examined cognitive and behavioural outcomes in preschool children with febrile seizures, including language and executive functioning outcomes...

..To validate use of the Manchester triage system in paediatric emergency care...

..We examined the associations of parental smoking during pregnancy with wheezing in preschool children and whether these associations are explained by postnatal smoke exposure or small for gestational age at birth...

..We examined whether these glucocorticoid receptor gene polymorphisms are associated with growth in fetal and early postnatal life...

..In order to tackle inequalities in birthweight, it is important that interventions are accessible for pregnant women in lower socio-economic strata...

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..Further studies are needed to assess the underlying mechanisms and whether these differences in fetal kidney volume have postnatal consequences for kidney function and blood pressure...

..These charts might be useful for use in epidemiological studies and in clinical practice...

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..Surprisingly, bacterial carriage in the first year of life did not add to this risk. Moreover, no association was observed between bacterial carriage in the first year of life and otitis in the second year of life...

..To examine which fetal and postnatal growth characteristics are associated with blood pressure (BP) in children at the age of 2 years...

..We compared children referred by a general practitioner (GP) with those self-referred on the basis of illness-severity markers...

..Although some inequalities can be explained by known determinants, research needs to be done to reach a full understanding of the pathways between social disadvantage and ill health in early childhood...

..This study explored the relationships of employment status, type of unemployment and number of weekly working hours, with a wide range of pregnancy outcomes...

..A second aim was to investigate the association of parent chronic pain and psychological problems with parent behavior and infant distress during the procedure...

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..The objective of this study was to examine whether this variant of the IGF-I gene is associated with blood pressure and left heart dimensions in early childhood...

..To assess the associations of maternal smoking during pregnancy and in the postnatal period with respiratory tract infections in young infants...

..Potential risks of high folate and vitamin B-12 concentrations on allergic outcomes should be evaluated when discussing mandatory fortification programs...

..To examine the association between the number of fever episodes and the risk of febrile seizures...

..Chlamydia trachomatis infection contributes significantly to early premature delivery and should be considered a public health problem, especially in young women and others at increased risk of C. trachomatis infection...

..Low birth weight is associated with an increased risk of wheezing in childhood...

..This diagnostic decision rule is a valuable tool for the clinician when deciding to treat these children for bacterial meningitis and thus improving their management...

..We sought to determine whether variances in cerebral ventricular size in fetuses and newborns are associated with temperamental difficulties in infants...

..e. content independent) SDE application to support the structured documentation of narrative data (called OpenSDE) can be used to model data obtained at history taking and physical examination of a broad specialty...

..The aim of this study was to compare parent-reported wheezing or shortness of breath among infants as assessed by questionnaire and physician-interview...

..The objective of this study was to examine whether T2D gene polymorphism TCF7L2 rs7903146 is associated with growth patterns from fetal life until infancy...

..We concluded that glutamine-enriched enteral nutrition in the neonatal period in VLBW infants decreased the risk of atopic dermatitis and gastrointestinal tract infections at 6 years of age...

..This suggests that "brain-sparing" does not completely spare the brain and indicates underlying pathology with consequences for later behavior...

..We examined the associations of exposure to ambient particulate matter (PM10) and nitrogen dioxide (NO2) with the risk of wheezing in preschool children, and assessed whether these associations were modified by tobacco smoke exposure...

..catarrhalis isolates, may be a result of immune evasion by this pathogen. Finally, the factors facilitating M. catarrhalis and H. influenzae co-colonization need to be further investigated...

..We also evaluated general practitioner (GP) services to determine if they met patients' needs compared to emergency department care...

..To study the prevalence, risk factors, and dynamics of pneumococcal carriage in infancy...

..It is unknown whether socioeconomic differences in HC are present in early childhood. Therefore, we investigated the association between socioeconomic position (SEP) and HC in early childhood, and potential underlying factors...

..This study examined the effects of attachment and temperament on infant distress during venipuncture...

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..Early detection and counselling is expected to reduce the prevalence of asthma symptoms and improve health-related quality of life at age 6 years...

..To determine whether intrauterine growth trajectories are associated with temperamental difficulties in infancy...

..catarrhalis has not matured at 2 years of age. We provide evidence that a humoral antibody response to OMPs UspA1, UspA2 and Hag/MID may play a role in the immune response to community acquired M. catarrhalis colonization events...

..Smoking in early pregnancy only, seems not to affect fetal growth adversely. Health care strategies for pregnant women should be aimed at quitting smoking completely rather than reducing the number of cigarettes...

..Such a correlation was observed for Staphylococcus aureus and Haemophilus influenzae. Direct transmission, genetic susceptibility and/or unidentified environmental factors may play a role here...

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..1% at the age of 1.5 months to 12.9% at 14 months. Persistent carriage, defined as continuous carriage of the same S. aureus strain at the three sampling moments, was rarely detected in early infancy...

..Oral FE(NO) values were significantly lower than mixed (oral + nasal) FE(NO), and breastfeeding did not influence FE(NO). Short-term reproducibility in awake healthy infants was good...

..To examine the incidence of paroxysmal epileptic and non-epileptic disorders and the associated prenatal and perinatal factors that might predict them in the first year of life in a population-based cohort...

..To compare polytomous and dichotomous logistic regression analyses in diagnosing serious bacterial infections (SBIs) in children with fever without apparent source (FWS)...

..We conclude that, in the general population, lymphocyte subset counts in neonates increase with increasing stress- and hypoxia-related perinatal factors...

..To examine the extent to which infant neuromotor development is determined by gestational duration and birth weight within the normal range...

..Our age specific protocol for the sonographic measurement of central subcutaneous and preperitoneal fat is a reproducible method that can be instrumental for investigating fat distribution in early life...

..To examine whether maternal socioeconomic status, as indicated by maternal educational level, is associated with preeclampsia, and if so, to what extent known risk factors for preeclampsia mediate the effect of educational level...

..Moreover, the naturally occurring enlargement of ventricles during infancy should be considered in interpreting reports on increased ventricular volumes in several neuropsychiatric disorders...

..Our findings, therefore, do not support a general dysfunction of the cerebellum in children with NF1...

..To examine whether parental, foetal and postnatal characteristics and growth patterns in foetal life and infancy are associated with bone mass at 6 months, as bone acquisition seems to be associated with genetic and environmental factors...

..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...

..CONCLUSIONS: We found little indication of an independent association between intra-uterine growth trajectories and temperamental difficulties in infants. Genetic and socio-economic factors explain the majority of the found associations...

..The influence of rapid weight gain on body composition in early infancy is still unknown and the critical periods of weight gain for later disease are debated...

..To assess whether socioeconomic inequalities were already present in preschool children...

..To examine the associations of alcohol consumption in different periods of pregnancy with the risks of low birth weight and preterm birth...

..The differences in data representation largely result from initial design decisions for OpenSDE...

..Taken together, it was shown that neurofibromatosis type 1 has profound impact on school performance. Awareness of these problems may facilitate timely recognition and appropriate support...

..From previous research it is known that maternal depression is related to excessive crying, but so far little is known about the influence of paternal depression...

..The larger effect on femur length suggests that smoking during pregnancy affects primarily peripheral tissues...

..The aim of this study was to examine whether the insulin gene variable number of tandem repeats (INS VNTR) is associated with growth patterns in fetal life and infancy...

..The objective was to study parental fever management and attitude toward fever from the perspective of the child's ethnicity and age...

..All this could contribute to more frequent and appropriate use of routine care data in diagnostic research. The discussed methods to overcome the above problems may well be similarly useful to prospective diagnostic studies...

..05). In conclusion, decreases in HRQOL among preschoolers with parent-reported respiratory symptoms are measurable with the TAPQOL. We recommend studying the impact of doctor-diagnosed respiratory symptoms on HRQOL in future studies...

..A generic SDE application (OpenSDE) to support documentation of patient history and physical examination findings was developed and tailored for the domain of general pediatrics...

..The study entered its pilot phase to test the logistics in December 2001. Full participant recruitment and complete data collection started in 2002...

..For external validation, substantial sample sizes should be used for sufficient power to detect clinically important changes in performance as compared with the internally validated estimate...