Daphne Merkus

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. Zhou Z, de Beer V, de Wijs Meijler D, Bender S, Hoekstra M, Laughlin M, et al. Pulmonary vasoconstrictor influence of endothelin in exercising swine depends critically on phosphodiesterase 5 activity. Am J Physiol Lung Cell Mol Physiol. 2014;306:L442-52 pubmed publisher
    ....
  2. Taverne Y, de Wijs Meijler D, te Lintel Hekkert M, Moon Massat P, Dubé G, Duncker D, et al. Normalization of hemoglobin-based oxygen carrier-201 induced vasoconstriction: targeting nitric oxide and endothelin. J Appl Physiol (1985). 2017;122:1227-1237 pubmed publisher
    ..However, hemodynamic normalization is more easily achieved via administration of an ET receptor blocker. ..
  3. de Wijs Meijler D, Danser A, Reiss I, Duncker D, Merkus D. Sex differences in pulmonary vascular control: focus on the nitric oxide pathway. Physiol Rep. 2017;5: pubmed publisher
    ....
  4. de Wijs Meijler D, Stam K, van Duin R, Verzijl A, Reiss I, Duncker D, et al. Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine. J Vis Exp. 2016;:e53772 pubmed publisher
    ..Moreover, cardiopulmonary function can be assessed repeatedly during disease development and during chronic treatment, thereby increasing statistical power and hence limiting the number of animals required for a study. ..
  5. request reprint
    Merkus D, Haitsma D, Fung T, Assen Y, Verdouw P, Duncker D. Coronary blood flow regulation in exercising swine involves parallel rather than redundant vasodilator pathways. Am J Physiol Heart Circ Physiol. 2003;285:H424-33 pubmed
    ..These findings suggest a parallel rather than a redundancy design of CBF regulation in the porcine circulation...
  6. request reprint
    Merkus D, Houweling B, van den Meiracker A, Boomsma F, Duncker D. Contribution of endothelin to coronary vasomotor tone is abolished after myocardial infarction. Am J Physiol Heart Circ Physiol. 2005;288:H871-80 pubmed
    ....
  7. request reprint
    Merkus D, Brzezinska A, Zhang C, Saito S, Chilian W. Cardiac myocytes control release of endothelin-1 in coronary vasculature. Am J Physiol Heart Circ Physiol. 2005;288:H2088-92 pubmed
    ....
  8. Zhou Z, Sorop O, de Beer V, Heinonen I, Cheng C, Jan Danser A, et al. Altered purinergic signaling in uridine adenosine tetraphosphate-induced coronary relaxation in swine with metabolic derangement. Purinergic Signal. 2017;: pubmed publisher
    ..Future studies are warranted to investigate the effects of severe metabolic derangement on coronary responses to Up4A. ..
  9. van Duin R, Houweling B, Uitterdijk A, Duncker D, Merkus D. Pulmonary vasodilation by phosphodiesterase 5-inhibition is enhanced and nitric oxide-independent in early pulmonary hypertension after myocardial infarction. Am J Physiol Heart Circ Physiol. 2017;:ajpheart.00370.2017 pubmed publisher
    ..These observations indicate that PDE5-inhibition represents an interesting pharmacotherapeutic approach in early PH following a recent MI, to prevent overt PH...
  10. de Wijs Meijler D, van Duin R, Duncker D, Scherrer U, Sartori C, Reiss I, et al. Structural and functional changes of the pulmonary vasculature after hypoxia exposure in the neonatal period - a new swine model of pulmonary vascular disease. Am J Physiol Heart Circ Physiol. 2017;:ajpheart.00362.2017 pubmed publisher
    ..In conclusion, we developed a neonatal swine model that allows examination of the long-term sequelae of damage to the developing neonatal lung, the course of the disease, and the effect of therapy on long-term outcome...

Detail Information

Publications11

  1. Zhou Z, de Beer V, de Wijs Meijler D, Bender S, Hoekstra M, Laughlin M, et al. Pulmonary vasoconstrictor influence of endothelin in exercising swine depends critically on phosphodiesterase 5 activity. Am J Physiol Lung Cell Mol Physiol. 2014;306:L442-52 pubmed publisher
    ....
  2. Taverne Y, de Wijs Meijler D, te Lintel Hekkert M, Moon Massat P, Dubé G, Duncker D, et al. Normalization of hemoglobin-based oxygen carrier-201 induced vasoconstriction: targeting nitric oxide and endothelin. J Appl Physiol (1985). 2017;122:1227-1237 pubmed publisher
    ..However, hemodynamic normalization is more easily achieved via administration of an ET receptor blocker. ..
  3. de Wijs Meijler D, Danser A, Reiss I, Duncker D, Merkus D. Sex differences in pulmonary vascular control: focus on the nitric oxide pathway. Physiol Rep. 2017;5: pubmed publisher
    ....
  4. de Wijs Meijler D, Stam K, van Duin R, Verzijl A, Reiss I, Duncker D, et al. Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine. J Vis Exp. 2016;:e53772 pubmed publisher
    ..Moreover, cardiopulmonary function can be assessed repeatedly during disease development and during chronic treatment, thereby increasing statistical power and hence limiting the number of animals required for a study. ..
  5. request reprint
    Merkus D, Haitsma D, Fung T, Assen Y, Verdouw P, Duncker D. Coronary blood flow regulation in exercising swine involves parallel rather than redundant vasodilator pathways. Am J Physiol Heart Circ Physiol. 2003;285:H424-33 pubmed
    ..These findings suggest a parallel rather than a redundancy design of CBF regulation in the porcine circulation...
  6. request reprint
    Merkus D, Houweling B, van den Meiracker A, Boomsma F, Duncker D. Contribution of endothelin to coronary vasomotor tone is abolished after myocardial infarction. Am J Physiol Heart Circ Physiol. 2005;288:H871-80 pubmed
    ....
  7. request reprint
    Merkus D, Brzezinska A, Zhang C, Saito S, Chilian W. Cardiac myocytes control release of endothelin-1 in coronary vasculature. Am J Physiol Heart Circ Physiol. 2005;288:H2088-92 pubmed
    ....
  8. Zhou Z, Sorop O, de Beer V, Heinonen I, Cheng C, Jan Danser A, et al. Altered purinergic signaling in uridine adenosine tetraphosphate-induced coronary relaxation in swine with metabolic derangement. Purinergic Signal. 2017;: pubmed publisher
    ..Future studies are warranted to investigate the effects of severe metabolic derangement on coronary responses to Up4A. ..
  9. van Duin R, Houweling B, Uitterdijk A, Duncker D, Merkus D. Pulmonary vasodilation by phosphodiesterase 5-inhibition is enhanced and nitric oxide-independent in early pulmonary hypertension after myocardial infarction. Am J Physiol Heart Circ Physiol. 2017;:ajpheart.00370.2017 pubmed publisher
    ..These observations indicate that PDE5-inhibition represents an interesting pharmacotherapeutic approach in early PH following a recent MI, to prevent overt PH...
  10. de Wijs Meijler D, van Duin R, Duncker D, Scherrer U, Sartori C, Reiss I, et al. Structural and functional changes of the pulmonary vasculature after hypoxia exposure in the neonatal period - a new swine model of pulmonary vascular disease. Am J Physiol Heart Circ Physiol. 2017;:ajpheart.00362.2017 pubmed publisher
    ..In conclusion, we developed a neonatal swine model that allows examination of the long-term sequelae of damage to the developing neonatal lung, the course of the disease, and the effect of therapy on long-term outcome...
  11. Stam K, van Duin R, Uitterdijk A, Cai Z, Duncker D, Merkus D. Exercise Facilitates Early Recognition of Cardiac and Vascular Remodeling in Chronic Thrombo-Embolic Pulmonary Hypertension in a Novel CTEPH Swine Model. Am J Physiol Heart Circ Physiol. 2017;:ajpheart.00380.2017 pubmed publisher
    ..In conclusion, embolization in combination with endothelial dysfunction results in CTEPH in swine. Exercise increased RV afterload, exacerbated the V/Q mismatch and unmasked RV dysfunction...