Research Topics
Genomes and Genes | Daphne MerkusSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
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Publications
Nitric oxide production is maintained in exercising swine with chronic left ventricular dysfunctionDavid B Haitsma
Experimental Cardiology, Thoraxcenter, Erasmus University, Rotterdam, The Netherlands
Am J Physiol Heart Circ Physiol 282:H2198-209. 2002....- KCa+ channels contribute to exercise-induced coronary vasodilation in swineDaphne Merkus
Experimental Cardiology, Thoraxcenter Erasmus MC, Univ Medical Center Rotterdam, Box 1738, 3000DR Rotterdam, The Netherlands
Am J Physiol Heart Circ Physiol 291:H2090-7. 2006..Furthermore, in swine K(Ca)(+) and K(ATP)(+) channels contribute to coronary resistance vessel control in a linear additive fashion... 
Exercise limits the production of endothelin in the coronary vasculatureVincent J de Beer
Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, he Netherlands
Am J Physiol Heart Circ Physiol 300:H1950-9. 2011..The decreased ET production during exercise likely contributes to metabolic coronary vasodilation...- Coronary vasoconstrictor influence of angiotensin II is reduced in remodeled myocardium after myocardial infarctionDaphne Merkus
Experimental Cardiology, Thoraxcenter, Erasmus MC, Univ Medical Center Rotterdam, Box 1738, 3000DR Rotterdam, The Netherlands
Am J Physiol Heart Circ Physiol 291:H2082-9. 2006..This reduction in ANG II-induced coronary vasoconstriction may serve to maintain perfusion of the remodeled myocardium... - Cardiac myocytes control release of endothelin-1 in coronary vasculatureDaphne Merkus
Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Am J Physiol Heart Circ Physiol 288:H2088-92. 2005.... - Contribution of KATP+ channels to coronary vasomotor tone regulation is enhanced in exercising swine with a recent myocardial infarctionDaphne Merkus
Experimental Cardiology, Thoraxcenter, Cardiovascular Research School COEUR, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Am J Physiol Heart Circ Physiol 288:H1306-13. 2005..Although the net vasodilator influence of adenosine was unchanged in remodeled myocardium, it became exclusively dependent on K(ATP)(+) channel opening... - Contribution of endothelin to coronary vasomotor tone is abolished after myocardial infarctionDaphne Merkus
Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Am J Physiol Heart Circ Physiol 288:H871-80. 2005.... - Alterations in endothelial control of the pulmonary circulation in exercising swine with secondary pulmonary hypertension after myocardial infarctionDaphne Merkus
Experimental Cardiology, Thoraxcentre, Cardiovascular Research School COEUR, Erasmus MC, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
J Physiol 580:907-23. 2007..In conclusion, an increased ET-mediated vasoconstriction, which does not appear to be the result of loss of endothelial vasodilators, contributes to pulmonary hypertension after MI... 
Control of pulmonary vascular tone during exercise in health and pulmonary hypertensionDaphne Merkus
Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus MC, University Medical Center Rotterdam, The Netherlands
Pharmacol Ther 119:242-63. 2008....- NO and prostanoids blunt endothelin-mediated coronary vasoconstrictor influence in exercising swineDaphne Merkus
Experimental Cardiology, Thoraxcenter, Erasmus MC, Univ Medical Center Rotterdam, Box 1738, 3000DR Rotterdam, The Netherlands
Am J Physiol Heart Circ Physiol 291:H2075-81. 2006.... - Coronary blood flow regulation in exercising swine involves parallel rather than redundant vasodilator pathwaysDaphne Merkus
Division of Experimental Cardiology, Thoraxcenter, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
Am J Physiol Heart Circ Physiol 285:H424-33. 2003..These findings suggest a parallel rather than a redundancy design of CBF regulation in the porcine circulation... - Contribution of endothelin and its receptors to the regulation of vascular tone during exercise is different in the systemic, coronary and pulmonary circulationDaphne Merkus
Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
Cardiovasc Res 59:745-54. 2003..The aim of this study was to identify the contribution of ET-1 through the ET(A) and ET(B) receptors to the regulation of tone in the systemic, coronary and pulmonary beds at rest and during exercise... - Interaction between prostanoids and nitric oxide in regulation of systemic, pulmonary, and coronary vascular tone in exercising swineDaphne Merkus
Experimental Cardiology, Thoraxcenter, Erasmus MC, Univ Medical Center Rotterdam, Box 1738, 3000 DR Rotterdam, The Netherlands
Am J Physiol Heart Circ Physiol 286:H1114-23. 2004..Endogenous prostanoids are not mandatory for the regulation of pulmonary resistance vessel tone. Finally, NO blunts the contribution of prostanoids to vascular tone regulation in the systemic but not in the coronary and pulmonary beds... - Integrative control of coronary resistance vessel tone by endothelin and angiotensin II is altered in swine with a recent myocardial infarctionVincent J de Beer
Division of Experimental Cardiology, Thoraxcenter, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands
Am J Physiol Heart Circ Physiol 294:H2069-77. 2008..e., with negligible cross-talk. In contrast, in the remodeled myocardium, cross-talk between ANG II and ET emerges, resulting in nonlinear redundant control of coronary resistance vessel tone... - Nitric oxide blunts the endothelin-mediated pulmonary vasoconstriction in exercising swineBirgit Houweling
Experimental Cardiology, Thoraxcentre, Erasmus MC, University Medical Centre Rotterdam, The Netherlands
J Physiol 568:629-38. 2005..In conclusion, endogenous endothelin limits pulmonary vasodilatation in response to treadmill exercise. This vasoconstrictor influence is blunted by NO but not by prostanoids... - Functional and structural adaptations of coronary microvessels distal to a chronic coronary artery stenosisOana Sorop
Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands
Circ Res 102:795-803. 2008..These structural and functional alterations may aggravate flow abnormalities distal to a chronic coronary artery stenosis... - Role of endothelin receptor activation in secondary pulmonary hypertension in awake swine after myocardial infarctionBirgit Houweling
Experimental Cardiology, Thoraxcentre, Erasmus MC, University Medical Centre Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
J Physiol 574:615-26. 2006..This vasoconstrictor influence is the result of an emergent tonic ET(A)-mediated vasoconstriction in addition to the exercise-induced ET(B)-mediated vasoconstriction that is already present in normal swine... - Nitroso-redox balance in control of coronary vasomotor toneYannick J H J Taverne
Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
J Appl Physiol 112:1644-52. 2012.... - Cytochrome P-450 2C9 exerts a vasoconstrictor influence on coronary resistance vessels in swine at rest and during exerciseZhichao Zhou
Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Cardiovascular Research School Erasmus University Rotterdam, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands
Am J Physiol Heart Circ Physiol 302:H1747-55. 2012..Pharmacological stimulation with bradykinin resulted in vasodilator CYP 2C9 metabolite production when administered in vivo, whereas vasoconstrictor CYP 2C9 metabolites, most likely ROS, were dominant when administered in vitro... - Integrated control of pulmonary vascular tone by endothelin and angiotensin II in exercising swine depends on genderVincent J de Beer
Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Cardiovascular Research School COEUR, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
Am J Physiol Heart Circ Physiol 298:H1976-85. 2010..This interaction is gender specific. The observation that plasma ET levels were not altered by AT(1) blockade in either gender suggests that the interaction between these vasoconstrictors occurs locally in the vasculature... - Prostanoids suppress the coronary vasoconstrictor influence of endothelin after myocardial infarctionVincent J de Beer
Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Cardiovascular Research School COEUR, Erasmus Medical Center, Rotterdam, The Netherlands
Am J Physiol Heart Circ Physiol 301:H1080-9. 2011..In contrast, while the overall prostanoid vasodilator influence was maintained, its inhibition of ET vasoconstrictor influences was enhanced in post-MI remote myocardium... - Both beta1- and beta2-adrenoceptors contribute to feedforward coronary resistance vessel dilation during exerciseFen Gao
Dept of Cardiology, Univ Medical Center Rotterdam, The Netherlands
Am J Physiol Heart Circ Physiol 298:H921-9. 2010..In conclusion, both beta(1)- and beta(2)-adrenoceptors contribute to the beta-feedforward coronary resistance vessel dilation during exercise... - Initiation of ventricular contraction as reflected in the aortic pressure waveformMarc J van Houwelingen
Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Physiol Meas 33:557-69. 2012..Consequently, AIC(start) is useful in the determination of the isovolumic contraction period, a well-known marker to quantify cardiac dysfunction... - Sunitinib-induced systemic vasoconstriction in swine is endothelin mediated and does not involve nitric oxide or oxidative stressMariette H W Kappers
Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Hypertension 59:151-7. 2012..The sunitinib-mediated systemic hypertension is principally attributed to an increased vasoconstrictor influence of endothelin, with no apparent contributions of a loss of NO bioavailability or increased oxidative stress... - Endothelial dysfunction enhances the pulmonary and systemic vasodilator effects of phosphodiesterase-5 inhibition in awake swine at rest and during treadmill exerciseBirgit Houweling
Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus University Medical Center, Dr Molewaterplein 50, Rotterdam, The Netherlands
Exp Biol Med (Maywood) 237:201-10. 2012.... - Vasomotor control in mice overexpressing human endothelial nitric oxide synthaseElza D van Deel
Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, The Netherlands
Am J Physiol Heart Circ Physiol 293:H1144-53. 2007..In conclusion, the vasodilator effects of eNOS overexpression are attenuated by a blunted NO responsiveness, likely at the level of guanylyl cyclase, without evidence of eNOS uncoupling or adaptations in other vasoregulatory pathways... - Exercise unmasks autonomic dysfunction in swine with a recent myocardial infarctionDirk J Duncker
Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
Cardiovasc Res 65:889-96. 2005..In the present study, we investigated the influence of alterations in autonomic balance on cardiovascular function in 11 swine with left ventricular (LV) dysfunction produced by a 2- to 3-week-old myocardial infarction (MI)... - Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodelingDirk J Duncker
Department of Biochemistry, Cardiovascular Research School COEUR, Erasmus MC, University Medical Center Rotterdam, Thoraxcenter, Rotterdam, The Netherlands
Circ Heart Fail 2:233-42. 2009..Here, we investigated whether beta-blocker therapy could restore myofilament contractility... - Regulation of coronary resistance vessel tone in response to exerciseDirk J Duncker
Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
J Mol Cell Cardiol 52:802-13. 2012..This article is part of a Special Issue entitled "Coronary Blood Flow"... - Left ventricular remodeling in swine after myocardial infarction: a transcriptional genomics approachDiederik W D Kuster
Division of Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
Basic Res Cardiol 106:1269-81. 2011..Thus, using an unbiased approach to study post-MI LV remodeling in a physiologically relevant large animal model, we identified COUP-TFII and GR as potential key mediators of post-MI remodeling... - Acute adaptations of the coronary circulation to exerciseDirk J Duncker
Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Box 1738, 3000 DR Rotterdam, The Netherlands
Cell Biochem Biophys 43:17-35. 2005.... - Coronary-aortic interaction during ventricular isovolumic contractionMarc J van Houwelingen
Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
Med Biol Eng Comput 49:917-24. 2011..03) or increased coronary conductance (P = 0.04) during hyperemia. These results show that the pre-systolic aortic pressure perturbation does not originate from the coronary arteries... - Alterations in vasomotor control of coronary resistance vessels in remodelled myocardium of swine with a recent myocardial infarctionDirk J Duncker
Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, P O Box 2040, 3000 CA Rotterdam, The Netherlands
Med Biol Eng Comput 46:485-97. 2008..However, adaptive alterations in coronary resistance vessel control, consisting of increased vasodilator influences in conjunction with blunted vasoconstrictor influences, act to minimize the impairments of myocardial oxygen balance... - Nuclear protein extraction from frozen porcine myocardiumDiederik W D Kuster
Department of Biochemistry, Cardiovascular Research Institute COEUR, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
J Physiol Biochem 67:165-73. 2011..This nuclear protein extraction protocol is therefore well-suited for nuclear proteome analysis of frozen heart tissue collected in biobanks... - Mitochondrial adaptations within chronically ischemic swine myocardiumEdward O McFalls
Experimental Cardiology, Thoraxcenter, Cardiovascular Research School COEUR, Erasmus MC, Rotterdam, The Netherlands
J Mol Cell Cardiol 41:980-8. 2006..Uncoupling protein 2 expression is enhanced in the mitochondria, providing a potential mechanism for these favorable mitochondrial adaptations... - Exercise hyperaemia in the heart: the search for the dilator mechanismDirk J Duncker
Experimental Cardiology, Thoraxcentre, Erasmus MC, University Medical Center Rotterdam, Box 2040, 3000 CA Rotterdam, The Netherlands
J Physiol 583:847-54. 2007..In view of these remarkable species differences in coronary vasomotor control during exercise, future studies are required to determine whether exercise hyperaemia in humans follows a canine or porcine control design... - 'Integrative Physiology 2.0': integration of systems biology into physiology and its application to cardiovascular homeostasisDiederik W D Kuster
Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
J Physiol 589:1037-45. 2011..We therefore advocate that systems biology should not become/stay a separate discipline with '-omics' as its playing field, but should be integrated into physiology to create 'Integrative Physiology 2.0'... - Uridine adenosine tetraphosphate is a novel vasodilator in the coronary microcirculation which acts through purinergic P1 but not P2 receptorsZhichao Zhou
Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Cardiovascular Research School COEUR, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Pharmacol Res 67:10-7. 2013..In conclusion, Up4A exerts a vasodilator rather than a vasoconstrictor influence in coronary microvessels, which is mediated via A(2A) receptors and is partly endothelium-dependent... - In vivo role of heme oxygenase in ischemic coronary vasodilationYasuhiro Nishikawa
Department of Physiology, Medical College of Wisconsin, Watertown, WI 53226, USA
Am J Physiol Heart Circ Physiol 286:H2296-304. 2004..This vasodilatory pathway appears to play a backup role and is activated only when other mechanisms of vasodilation during ischemia are exhausted... - Metabolic communication from cardiac myocytes to vascular endothelial cellsAnna K Brzezinska
Department of Physiology, and the Cardiovascular Center, Medical College of Wisconsin, Milwaukee Wisconsin, USA
Am J Physiol Heart Circ Physiol 288:H2232-7. 2005..Thus cardiac myocytes seem to communicate metabolic information to the endothelium, which could potentially influence vascular tone... - Metabolic regulation of coronary vascular tone: role of endothelin-1Daphne Merkus
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53227, USA
Am J Physiol Heart Circ Physiol 283:H1915-21. 2002..Thus endothelin has a tonic constrictor influence through the ET(A) receptor at low myocardial metabolic demand but its influence decreased during increased metabolism... - Sarcomeric dysfunction in heart failureNazha Hamdani
Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, Amsterdam, The Netherlands
Cardiovasc Res 77:649-58. 2008..Novel therapies, which specifically target phosphorylation sites within sarcomeric proteins or the kinases and phosphatases involved, might improve cardiac function in heart failure...