Daphne Merkus

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Nitric oxide production is maintained in exercising swine with chronic left ventricular dysfunction
    David B Haitsma
    Experimental Cardiology, Thoraxcenter, Erasmus University, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 282:H2198-209. 2002
  2. pmc Reduced contribution of endothelin to the regulation of systemic and pulmonary vascular tone in severe familial hypercholesterolaemia
    Shawn B Bender
    Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Physiol 592:1757-69. 2014
  3. pmc Pulmonary vasoconstrictor influence of endothelin in exercising swine depends critically on phosphodiesterase 5 activity
    Zhichao Zhou
    Experimental Cardiology, Thoraxcenter, Erasmus MC, Univ Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 306:L442-52. 2014
  4. doi request reprint Phosphodiesterase 5 inhibition-induced coronary vasodilation is reduced after myocardial infarction
    Daphne Merkus
    Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 304:H1370-81. 2013
  5. doi request reprint Control of pulmonary vascular tone during exercise in health and pulmonary hypertension
    Daphne Merkus
    Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Pharmacol Ther 119:242-63. 2008
  6. pmc Alterations in endothelial control of the pulmonary circulation in exercising swine with secondary pulmonary hypertension after myocardial infarction
    Daphne Merkus
    Experimental Cardiology, Thoraxcentre, Cardiovascular Research School COEUR, Erasmus MC, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Physiol 580:907-23. 2007
  7. pmc Exercise limits the production of endothelin in the coronary vasculature
    Vincent J de Beer
    Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, he Netherlands
    Am J Physiol Heart Circ Physiol 300:H1950-9. 2011
  8. ncbi request reprint Coronary vasoconstrictor influence of angiotensin II is reduced in remodeled myocardium after myocardial infarction
    Daphne Merkus
    Experimental Cardiology, Thoraxcenter, Erasmus MC, Univ Medical Center Rotterdam, Box 1738, 3000DR Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 291:H2082-9. 2006
  9. ncbi request reprint NO and prostanoids blunt endothelin-mediated coronary vasoconstrictor influence in exercising swine
    Daphne Merkus
    Experimental Cardiology, Thoraxcenter, Erasmus MC, Univ Medical Center Rotterdam, Box 1738, 3000DR Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 291:H2075-81. 2006
  10. ncbi request reprint KCa+ channels contribute to exercise-induced coronary vasodilation in swine
    Daphne Merkus
    Experimental Cardiology, Thoraxcenter Erasmus MC, Univ Medical Center Rotterdam, Box 1738, 3000DR Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 291:H2090-7. 2006

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Nitric oxide production is maintained in exercising swine with chronic left ventricular dysfunction
    David B Haitsma
    Experimental Cardiology, Thoraxcenter, Erasmus University, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 282:H2198-209. 2002
    ....
  2. pmc Reduced contribution of endothelin to the regulation of systemic and pulmonary vascular tone in severe familial hypercholesterolaemia
    Shawn B Bender
    Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Physiol 592:1757-69. 2014
    ..This may represent a unique vascular consequence of severe familial hypercholesterolaemia. ..
  3. pmc Pulmonary vasoconstrictor influence of endothelin in exercising swine depends critically on phosphodiesterase 5 activity
    Zhichao Zhou
    Experimental Cardiology, Thoraxcenter, Erasmus MC, Univ Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 306:L442-52. 2014
    ....
  4. doi request reprint Phosphodiesterase 5 inhibition-induced coronary vasodilation is reduced after myocardial infarction
    Daphne Merkus
    Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 304:H1370-81. 2013
    ....
  5. doi request reprint Control of pulmonary vascular tone during exercise in health and pulmonary hypertension
    Daphne Merkus
    Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Pharmacol Ther 119:242-63. 2008
    ....
  6. pmc Alterations in endothelial control of the pulmonary circulation in exercising swine with secondary pulmonary hypertension after myocardial infarction
    Daphne Merkus
    Experimental Cardiology, Thoraxcentre, Cardiovascular Research School COEUR, Erasmus MC, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Physiol 580:907-23. 2007
    ..In conclusion, an increased ET-mediated vasoconstriction, which does not appear to be the result of loss of endothelial vasodilators, contributes to pulmonary hypertension after MI...
  7. pmc Exercise limits the production of endothelin in the coronary vasculature
    Vincent J de Beer
    Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, he Netherlands
    Am J Physiol Heart Circ Physiol 300:H1950-9. 2011
    ..The decreased ET production during exercise likely contributes to metabolic coronary vasodilation...
  8. ncbi request reprint Coronary vasoconstrictor influence of angiotensin II is reduced in remodeled myocardium after myocardial infarction
    Daphne Merkus
    Experimental Cardiology, Thoraxcenter, Erasmus MC, Univ Medical Center Rotterdam, Box 1738, 3000DR Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 291:H2082-9. 2006
    ..This reduction in ANG II-induced coronary vasoconstriction may serve to maintain perfusion of the remodeled myocardium...
  9. ncbi request reprint NO and prostanoids blunt endothelin-mediated coronary vasoconstrictor influence in exercising swine
    Daphne Merkus
    Experimental Cardiology, Thoraxcenter, Erasmus MC, Univ Medical Center Rotterdam, Box 1738, 3000DR Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 291:H2075-81. 2006
    ....
  10. ncbi request reprint KCa+ channels contribute to exercise-induced coronary vasodilation in swine
    Daphne Merkus
    Experimental Cardiology, Thoraxcenter Erasmus MC, Univ Medical Center Rotterdam, Box 1738, 3000DR Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 291:H2090-7. 2006
    ..Furthermore, in swine K(Ca)(+) and K(ATP)(+) channels contribute to coronary resistance vessel control in a linear additive fashion...
  11. ncbi request reprint Contribution of endothelin to coronary vasomotor tone is abolished after myocardial infarction
    Daphne Merkus
    Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 288:H871-80. 2005
    ....
  12. ncbi request reprint Coronary blood flow regulation in exercising swine involves parallel rather than redundant vasodilator pathways
    Daphne Merkus
    Division of Experimental Cardiology, Thoraxcenter, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 285:H424-33. 2003
    ..These findings suggest a parallel rather than a redundancy design of CBF regulation in the porcine circulation...
  13. ncbi request reprint Cardiac myocytes control release of endothelin-1 in coronary vasculature
    Daphne Merkus
    Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 288:H2088-92. 2005
    ....
  14. ncbi request reprint Contribution of endothelin and its receptors to the regulation of vascular tone during exercise is different in the systemic, coronary and pulmonary circulation
    Daphne Merkus
    Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Cardiovasc Res 59:745-54. 2003
    ..The aim of this study was to identify the contribution of ET-1 through the ET(A) and ET(B) receptors to the regulation of tone in the systemic, coronary and pulmonary beds at rest and during exercise...
  15. ncbi request reprint Contribution of KATP+ channels to coronary vasomotor tone regulation is enhanced in exercising swine with a recent myocardial infarction
    Daphne Merkus
    Experimental Cardiology, Thoraxcenter, Cardiovascular Research School COEUR, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 288:H1306-13. 2005
    ..Although the net vasodilator influence of adenosine was unchanged in remodeled myocardium, it became exclusively dependent on K(ATP)(+) channel opening...
  16. ncbi request reprint Interaction between prostanoids and nitric oxide in regulation of systemic, pulmonary, and coronary vascular tone in exercising swine
    Daphne Merkus
    Experimental Cardiology, Thoraxcenter, Erasmus MC, Univ Medical Center Rotterdam, Box 1738, 3000 DR Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 286:H1114-23. 2004
    ..Endogenous prostanoids are not mandatory for the regulation of pulmonary resistance vessel tone. Finally, NO blunts the contribution of prostanoids to vascular tone regulation in the systemic but not in the coronary and pulmonary beds...
  17. doi request reprint Integrative control of coronary resistance vessel tone by endothelin and angiotensin II is altered in swine with a recent myocardial infarction
    Vincent J de Beer
    Division of Experimental Cardiology, Thoraxcenter, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 294:H2069-77. 2008
    ..e., with negligible cross-talk. In contrast, in the remodeled myocardium, cross-talk between ANG II and ET emerges, resulting in nonlinear redundant control of coronary resistance vessel tone...
  18. doi request reprint Functional and structural adaptations of coronary microvessels distal to a chronic coronary artery stenosis
    Oana Sorop
    Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands
    Circ Res 102:795-803. 2008
    ..These structural and functional alterations may aggravate flow abnormalities distal to a chronic coronary artery stenosis...
  19. pmc Nitric oxide blunts the endothelin-mediated pulmonary vasoconstriction in exercising swine
    Birgit Houweling
    Experimental Cardiology, Thoraxcentre, Erasmus MC, University Medical Centre Rotterdam, The Netherlands
    J Physiol 568:629-38. 2005
    ..In conclusion, endogenous endothelin limits pulmonary vasodilatation in response to treadmill exercise. This vasoconstrictor influence is blunted by NO but not by prostanoids...
  20. doi request reprint Cytochrome P-450 2C9 exerts a vasoconstrictor influence on coronary resistance vessels in swine at rest and during exercise
    Zhichao Zhou
    Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Cardiovascular Research School Erasmus University Rotterdam, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 302:H1747-55. 2012
    ..Pharmacological stimulation with bradykinin resulted in vasodilator CYP 2C9 metabolite production when administered in vivo, whereas vasoconstrictor CYP 2C9 metabolites, most likely ROS, were dominant when administered in vitro...
  21. pmc Role of endothelin receptor activation in secondary pulmonary hypertension in awake swine after myocardial infarction
    Birgit Houweling
    Experimental Cardiology, Thoraxcentre, Erasmus MC, University Medical Centre Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Physiol 574:615-26. 2006
    ..This vasoconstrictor influence is the result of an emergent tonic ET(A)-mediated vasoconstriction in addition to the exercise-induced ET(B)-mediated vasoconstriction that is already present in normal swine...
  22. doi request reprint Nitroso-redox balance in control of coronary vasomotor tone
    Yannick J H J Taverne
    Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Appl Physiol (1985) 112:1644-52. 2012
    ....
  23. pmc Phosphodiesterase-5 activity exerts a coronary vasoconstrictor influence in awake swine that is mediated in part via an increase in endothelin production
    Zhichao Zhou
    Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Cardiovascular Research School COEUR, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 306:H918-27. 2014
    ..In conclusion, PDE5 activity exerts a vasoconstrictor influence on coronary resistance vessels that is mediated, in part, via an increase in endothelial ET production. ..
  24. doi request reprint Prostanoids suppress the coronary vasoconstrictor influence of endothelin after myocardial infarction
    Vincent J de Beer
    Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Cardiovascular Research School COEUR, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 301:H1080-9. 2011
    ..In contrast, while the overall prostanoid vasodilator influence was maintained, its inhibition of ET vasoconstrictor influences was enhanced in post-MI remote myocardium...
  25. doi request reprint Integrated control of pulmonary vascular tone by endothelin and angiotensin II in exercising swine depends on gender
    Vincent J de Beer
    Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Cardiovascular Research School COEUR, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 298:H1976-85. 2010
    ..This interaction is gender specific. The observation that plasma ET levels were not altered by AT(1) blockade in either gender suggests that the interaction between these vasoconstrictors occurs locally in the vasculature...
  26. ncbi request reprint Vasomotor control in mice overexpressing human endothelial nitric oxide synthase
    Elza D van Deel
    Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 293:H1144-53. 2007
    ..In conclusion, the vasodilator effects of eNOS overexpression are attenuated by a blunted NO responsiveness, likely at the level of guanylyl cyclase, without evidence of eNOS uncoupling or adaptations in other vasoregulatory pathways...
  27. doi request reprint Both beta1- and beta2-adrenoceptors contribute to feedforward coronary resistance vessel dilation during exercise
    Fen Gao
    Dept of Cardiology, Univ Medical Center Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 298:H921-9. 2010
    ..In conclusion, both beta(1)- and beta(2)-adrenoceptors contribute to the beta-feedforward coronary resistance vessel dilation during exercise...
  28. doi request reprint Sunitinib-induced systemic vasoconstriction in swine is endothelin mediated and does not involve nitric oxide or oxidative stress
    Mariette H W Kappers
    Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Hypertension 59:151-7. 2012
    ..The sunitinib-mediated systemic hypertension is principally attributed to an increased vasoconstrictor influence of endothelin, with no apparent contributions of a loss of NO bioavailability or increased oxidative stress...
  29. doi request reprint Initiation of ventricular contraction as reflected in the aortic pressure waveform
    Marc J van Houwelingen
    Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Physiol Meas 33:557-69. 2012
    ..Consequently, AIC(start) is useful in the determination of the isovolumic contraction period, a well-known marker to quantify cardiac dysfunction...
  30. ncbi request reprint A novel approach to assess hemorrhagic shock severity using the arterially determined left ventricular isovolumic contraction period
    Marc J van Houwelingen
    Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute, Cardiovascular Research School Erasmus University Rotterdam, Erasmus University Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 305:H1790-7. 2013
    ..Importantly, ΔAIC determined from either the carotid or aortic pressure waveform are interchangeable, suggesting that, in contrast with ΔPEP, ΔAIC may be site independent. ..
  31. doi request reprint Endothelial dysfunction enhances the pulmonary and systemic vasodilator effects of phosphodiesterase-5 inhibition in awake swine at rest and during treadmill exercise
    Birgit Houweling
    Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus University Medical Center, Dr Molewaterplein 50, Rotterdam, The Netherlands
    Exp Biol Med (Maywood) 237:201-10. 2012
    ....
  32. ncbi request reprint Exercise unmasks autonomic dysfunction in swine with a recent myocardial infarction
    Dirk J Duncker
    Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Cardiovasc Res 65:889-96. 2005
    ..In the present study, we investigated the influence of alterations in autonomic balance on cardiovascular function in 11 swine with left ventricular (LV) dysfunction produced by a 2- to 3-week-old myocardial infarction (MI)...
  33. ncbi request reprint Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling
    Dirk J Duncker
    Department of Biochemistry, Cardiovascular Research School COEUR, Erasmus MC, University Medical Center Rotterdam, Thoraxcenter, Rotterdam, The Netherlands
    Circ Heart Fail 2:233-42. 2009
    ..Here, we investigated whether beta-blocker therapy could restore myofilament contractility...
  34. doi request reprint Regulation of coronary resistance vessel tone in response to exercise
    Dirk J Duncker
    Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Mol Cell Cardiol 52:802-13. 2012
    ..This article is part of a Special Issue entitled "Coronary Blood Flow"...
  35. pmc Left ventricular remodeling in swine after myocardial infarction: a transcriptional genomics approach
    Diederik W D Kuster
    Division of Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Basic Res Cardiol 106:1269-81. 2011
    ..Thus, using an unbiased approach to study post-MI LV remodeling in a physiologically relevant large animal model, we identified COUP-TFII and GR as potential key mediators of post-MI remodeling...
  36. ncbi request reprint Acute adaptations of the coronary circulation to exercise
    Dirk J Duncker
    Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Box 1738, 3000 DR Rotterdam, The Netherlands
    Cell Biochem Biophys 43:17-35. 2005
    ....
  37. pmc Coronary-aortic interaction during ventricular isovolumic contraction
    Marc J van Houwelingen
    Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Med Biol Eng Comput 49:917-24. 2011
    ..03) or increased coronary conductance (P = 0.04) during hyperemia. These results show that the pre-systolic aortic pressure perturbation does not originate from the coronary arteries...
  38. pmc Alterations in vasomotor control of coronary resistance vessels in remodelled myocardium of swine with a recent myocardial infarction
    Dirk J Duncker
    Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 50, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Med Biol Eng Comput 46:485-97. 2008
    ..However, adaptive alterations in coronary resistance vessel control, consisting of increased vasodilator influences in conjunction with blunted vasoconstrictor influences, act to minimize the impairments of myocardial oxygen balance...
  39. pmc Familial hypercholesterolemia impairs exercise-induced systemic vasodilation due to reduced NO bioavailability
    Vincent J de Beer
    Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Cardiovascular Research School Erasmus University Rotterdam, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Appl Physiol (1985) 115:1767-76. 2013
    ..This reduction appears to be the principal result of a decrease in NO bioavailability, which is mitigated by a lower PDE5 activity. ..
  40. doi request reprint Quantification of myocardial blood flow by adenosine-stress CT perfusion imaging in pigs during various degrees of stenosis correlates well with coronary artery blood flow and fractional flow reserve
    Alexia Rossi
    Department of Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Eur Heart J Cardiovasc Imaging 14:331-8. 2013
    ....
  41. doi request reprint Uridine adenosine tetraphosphate is a novel vasodilator in the coronary microcirculation which acts through purinergic P1 but not P2 receptors
    Zhichao Zhou
    Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Cardiovascular Research School COEUR, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Pharmacol Res 67:10-7. 2013
    ..In conclusion, Up4A exerts a vasodilator rather than a vasoconstrictor influence in coronary microvessels, which is mediated via A(2A) receptors and is partly endothelium-dependent...
  42. doi request reprint Nuclear protein extraction from frozen porcine myocardium
    Diederik W D Kuster
    Department of Biochemistry, Cardiovascular Research Institute COEUR, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Physiol Biochem 67:165-73. 2011
    ..This nuclear protein extraction protocol is therefore well-suited for nuclear proteome analysis of frozen heart tissue collected in biobanks...
  43. ncbi request reprint Mitochondrial adaptations within chronically ischemic swine myocardium
    Edward O McFalls
    Experimental Cardiology, Thoraxcenter, Cardiovascular Research School COEUR, Erasmus MC, Rotterdam, The Netherlands
    J Mol Cell Cardiol 41:980-8. 2006
    ..Uncoupling protein 2 expression is enhanced in the mitochondria, providing a potential mechanism for these favorable mitochondrial adaptations...
  44. ncbi request reprint Exercise training in adverse cardiac remodeling
    Dirk J Duncker
    Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000, CA, Rotterdam, The Netherlands
    Pflugers Arch 466:1079-91. 2014
    ..Together such studies will aid in optimizing the therapy of exercise training in the setting of cardiovascular disease. ..
  45. doi request reprint Blunted coronary vasodilator response to uridine adenosine tetraphosphate in post-infarct remodeled myocardium is due to reduced P1 receptor activation
    Zhichao Zhou
    Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Cardiovascular Research School COEUR, The Netherlands
    Pharmacol Res 77:22-9. 2013
    ..In conclusion, blunted coronary vasodilation in response to Up4A in MI swine is most likely due to reduced activation of P1, rather than P2, receptors and does not involve a loss of NO bioavailability...
  46. pmc Exercise hyperaemia in the heart: the search for the dilator mechanism
    Dirk J Duncker
    Experimental Cardiology, Thoraxcentre, Erasmus MC, University Medical Center Rotterdam, Box 2040, 3000 CA Rotterdam, The Netherlands
    J Physiol 583:847-54. 2007
    ..In view of these remarkable species differences in coronary vasomotor control during exercise, future studies are required to determine whether exercise hyperaemia in humans follows a canine or porcine control design...
  47. pmc 'Integrative Physiology 2.0': integration of systems biology into physiology and its application to cardiovascular homeostasis
    Diederik W D Kuster
    Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Physiol 589:1037-45. 2011
    ..We therefore advocate that systems biology should not become/stay a separate discipline with '-omics' as its playing field, but should be integrated into physiology to create 'Integrative Physiology 2.0'...
  48. pmc Reactive oxygen species and the cardiovascular system
    Yannick J H J Taverne
    Department of Experimental Cardiology, Erasmus Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Oxid Med Cell Longev 2013:862423. 2013
    ..Further, we review the function of ROS in cardiovascular pathology and the effects of AOs on cardiovascular outcomes with emphasis on the so-called oxidative paradox...
  49. ncbi request reprint Metabolic communication from cardiac myocytes to vascular endothelial cells
    Anna K Brzezinska
    Department of Physiology, and the Cardiovascular Center, Medical College of Wisconsin, Milwaukee Wisconsin, USA
    Am J Physiol Heart Circ Physiol 288:H2232-7. 2005
    ..Thus cardiac myocytes seem to communicate metabolic information to the endothelium, which could potentially influence vascular tone...
  50. ncbi request reprint In vivo role of heme oxygenase in ischemic coronary vasodilation
    Yasuhiro Nishikawa
    Department of Physiology, Medical College of Wisconsin, Watertown, WI 53226, USA
    Am J Physiol Heart Circ Physiol 286:H2296-304. 2004
    ..This vasodilatory pathway appears to play a backup role and is activated only when other mechanisms of vasodilation during ischemia are exhausted...
  51. ncbi request reprint Metabolic regulation of coronary vascular tone: role of endothelin-1
    Daphne Merkus
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53227, USA
    Am J Physiol Heart Circ Physiol 283:H1915-21. 2002
    ..Thus endothelin has a tonic constrictor influence through the ET(A) receptor at low myocardial metabolic demand but its influence decreased during increased metabolism...
  52. ncbi request reprint Sarcomeric dysfunction in heart failure
    Nazha Hamdani
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, Amsterdam, The Netherlands
    Cardiovasc Res 77:649-58. 2008
    ..Novel therapies, which specifically target phosphorylation sites within sarcomeric proteins or the kinases and phosphatases involved, might improve cardiac function in heart failure...