Roland J W Meesters

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi Incurred sample reanalysis comparison of dried blood spots and plasma samples on the measurement of lopinavir in clinical samples
    Roland J W Meesters
    Department of Neurology, Laboratory of Neuro Oncology and Clinical and Cancer Proteomics, University Medical Center Rotterdam ErasmusMC, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Bioanalysis 4:237-40. 2012
  2. doi Cytochrome P450-catalysed arene-epoxidation of the bioactive tea tree oil ingredient p-cymene: indication for the formation of a reactive allergenic intermediate?
    R J W Meesters
    Laboratories of Neuro Oncology Clinical and Cancer Proteomics, Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Xenobiotica 39:663-71. 2009
  3. pmc Ultrafast and high-throughput mass spectrometric assay for therapeutic drug monitoring of antiretroviral drugs in pediatric HIV-1 infection applying dried blood spots
    Roland J W Meesters
    Department of Neurology, Laboratory of Neuro Oncology and Clinical and Cancer Proteomics, University Medical Center Rotterdam Erasmus MC, Dr Molewaterplein 50, Room Ee 1981, 3015 GE Rotterdam, The Netherlands
    Anal Bioanal Chem 398:319-28. 2010
  4. pmc A new ultrafast and high-throughput mass spectrometric approach for the therapeutic drug monitoring of the multi-targeted anti-folate pemetrexed in plasma from lung cancer patients
    Roland J W Meesters
    Department of Neurology, Laboratory of Neuro Oncology and Clinical and Cancer Proteomics, University Medical Center Rotterdam ErasmusMC, Dr Molewaterplein 50, Room Ee 1981, 3015 GE Rotterdam, The Netherlands
    Anal Bioanal Chem 398:2943-8. 2010
  5. doi Determination of the antiretroviral drug tenofovir in plasma from HIV-infected adults by ultrafast isotope dilution MALDI-triple quadrupole tandem mass spectrometry
    Roland J W Meesters
    Laboratory of Neuro Oncology and Clinical and Cancer Proteomics, Department of Neurology, University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Mass Spectrom 46:282-9. 2011
  6. doi Ultrafast selective quantification of methotrexate in human plasma by high-throughput MALDI-isotope dilution mass spectrometry
    Roland J W Meesters
    Laboratories of Neuro Oncology and Clinical and Cancer Proteomics, Department of Neurology, University Medical Center Rotterdam ErasmusMC, Dr Molewaterplein 50, Room Ee 1981, 3015 GE Rotterdam, The Netherlands
    Bioanalysis 3:1369-78. 2011
  7. doi Assessment of intracellular methotrexate and methotrexate-polyglutamate metabolite concentrations in erythrocytes by ultrafast matrix-assisted laser desorption/ionization triple quadrupole tandem mass spectrometry
    Roland J W Meesters
    Department of Neurology, University Medical Center Rotterdam ErasmusMC, Rotterdam, The Netherlands
    Rapid Commun Mass Spectrom 25:3063-70. 2011
  8. doi Impact of internal standard addition on dried blood spot analysis in bioanalytical method development
    Roland Meesters
    Laboratory of Neuro Oncology and Clinical and Cancer Proteomics, Department of Neurology, University Medical Center Rotterdam Erasmus MC, Rotterdam, The Netherlands
    Bioanalysis 3:2357-64. 2011
  9. pmc Dried blood spot UHPLC-MS/MS analysis of oseltamivir and oseltamivircarboxylate--a validated assay for the clinic
    Gero P Hooff
    Department of Neurology, Laboratory of Neuro Oncology and Clinical and Cancer Proteomics, University Medical Center Rotterdam Erasmus MC, Rotterdam, The Netherlands
    Anal Bioanal Chem 400:3473-9. 2011
  10. doi A U-HPLC-ESI-MS/MS-based stable isotope dilution method for the detection and quantitation of methotrexate in plasma
    Ethan den Boer
    Department of Clinical Chemistry, Erasmus MC, Sophia Children s Hospital, Erasmus MC, University Medical Centre Rotterdam, s Gravendijkwal, Rotterdam, The Netherlands
    Ther Drug Monit 34:432-9. 2012

Collaborators

Detail Information

Publications13

  1. doi Incurred sample reanalysis comparison of dried blood spots and plasma samples on the measurement of lopinavir in clinical samples
    Roland J W Meesters
    Department of Neurology, Laboratory of Neuro Oncology and Clinical and Cancer Proteomics, University Medical Center Rotterdam ErasmusMC, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Bioanalysis 4:237-40. 2012
    ..In this article, we report results from an ISR study on DBS specimen and their corresponding plasma samples. Incurred samples were reanalyzed on their concentration of the antiretroviral drug lopinavir (LPV)...
  2. doi Cytochrome P450-catalysed arene-epoxidation of the bioactive tea tree oil ingredient p-cymene: indication for the formation of a reactive allergenic intermediate?
    R J W Meesters
    Laboratories of Neuro Oncology Clinical and Cancer Proteomics, Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Xenobiotica 39:663-71. 2009
    ....
  3. pmc Ultrafast and high-throughput mass spectrometric assay for therapeutic drug monitoring of antiretroviral drugs in pediatric HIV-1 infection applying dried blood spots
    Roland J W Meesters
    Department of Neurology, Laboratory of Neuro Oncology and Clinical and Cancer Proteomics, University Medical Center Rotterdam Erasmus MC, Dr Molewaterplein 50, Room Ee 1981, 3015 GE Rotterdam, The Netherlands
    Anal Bioanal Chem 398:319-28. 2010
    ..DBS is perfectly suited for TDM of HIV-1-infected children; but nevertheless, DBS can also easily be applied for TDM of patients in areas with limited or no laboratory facilities...
  4. pmc A new ultrafast and high-throughput mass spectrometric approach for the therapeutic drug monitoring of the multi-targeted anti-folate pemetrexed in plasma from lung cancer patients
    Roland J W Meesters
    Department of Neurology, Laboratory of Neuro Oncology and Clinical and Cancer Proteomics, University Medical Center Rotterdam ErasmusMC, Dr Molewaterplein 50, Room Ee 1981, 3015 GE Rotterdam, The Netherlands
    Anal Bioanal Chem 398:2943-8. 2010
    ..7 (1.4) and 142.7 (20.3) pmol/μL (SD). The newly developed mass spectrometric assay is applicable for (routine) therapeutic drug monitoring of pemetrexed concentrations in plasma from non-small cell lung cancer patients...
  5. doi Determination of the antiretroviral drug tenofovir in plasma from HIV-infected adults by ultrafast isotope dilution MALDI-triple quadrupole tandem mass spectrometry
    Roland J W Meesters
    Laboratory of Neuro Oncology and Clinical and Cancer Proteomics, Department of Neurology, University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Mass Spectrom 46:282-9. 2011
    ..Observed plasma TNV concentrations ranged between 0.11 and 0.76 µmol/l and measured plasma TNV concentrations were within the therapeutically relevant concentration range...
  6. doi Ultrafast selective quantification of methotrexate in human plasma by high-throughput MALDI-isotope dilution mass spectrometry
    Roland J W Meesters
    Laboratories of Neuro Oncology and Clinical and Cancer Proteomics, Department of Neurology, University Medical Center Rotterdam ErasmusMC, Dr Molewaterplein 50, Room Ee 1981, 3015 GE Rotterdam, The Netherlands
    Bioanalysis 3:1369-78. 2011
    ..2→308.2, 458.2→311.2, 471.2→324.2 and 474.2→327.2 for methotrexate, methotrexate-d3, 7-hydroxymethotrexate and 7-hydroxymethotrexate-d3, respectively...
  7. doi Assessment of intracellular methotrexate and methotrexate-polyglutamate metabolite concentrations in erythrocytes by ultrafast matrix-assisted laser desorption/ionization triple quadrupole tandem mass spectrometry
    Roland J W Meesters
    Department of Neurology, University Medical Center Rotterdam ErasmusMC, Rotterdam, The Netherlands
    Rapid Commun Mass Spectrom 25:3063-70. 2011
    ..The highest observed glutamylation degree of MTX was MTXPG5, the very long chain MTX-polyglutamate metabolites MTXPG6 and MTXPG7 were not detected in the packed erythrocyte pellets collected from rheumatoid arthritis patients...
  8. doi Impact of internal standard addition on dried blood spot analysis in bioanalytical method development
    Roland Meesters
    Laboratory of Neuro Oncology and Clinical and Cancer Proteomics, Department of Neurology, University Medical Center Rotterdam Erasmus MC, Rotterdam, The Netherlands
    Bioanalysis 3:2357-64. 2011
    ....
  9. pmc Dried blood spot UHPLC-MS/MS analysis of oseltamivir and oseltamivircarboxylate--a validated assay for the clinic
    Gero P Hooff
    Department of Neurology, Laboratory of Neuro Oncology and Clinical and Cancer Proteomics, University Medical Center Rotterdam Erasmus MC, Rotterdam, The Netherlands
    Anal Bioanal Chem 400:3473-9. 2011
    ..As a proof of concept, oseltamivir and oseltamivircarboxylate levels were determined in DBS obtained from healthy volunteers who received a single oral dose of Tamiflu®...
  10. doi A U-HPLC-ESI-MS/MS-based stable isotope dilution method for the detection and quantitation of methotrexate in plasma
    Ethan den Boer
    Department of Clinical Chemistry, Erasmus MC, Sophia Children s Hospital, Erasmus MC, University Medical Centre Rotterdam, s Gravendijkwal, Rotterdam, The Netherlands
    Ther Drug Monit 34:432-9. 2012
    ..The authors aimed to develop a liquid chromatography, electrospray ionization, tandem mass spectrometry (LC-ESI-MS/MS)-based method to determine MTX in plasma for therapeutic drug monitoring and pharmacokinetic studies...
  11. doi Characterization of β-lactamase enzyme activity in bacterial lysates using MALDI-mass spectrometry
    Gero P Hooff
    Department of Neurology, Laboratory of Neuro Oncology and Clinical and Cancer Proteomics, Erasmus University Medical Center Erasmus MC, Rotterdam, The Netherlands
    J Proteome Res 11:79-84. 2012
    ..The assay is reproducible and builds the basis for future in-depth investigations of β-lactamase activity in various bacterial strains by mass spectrometry...
  12. pmc Analytical investigations of toxic p-phenylenediamine (PPD) levels in clinical urine samples with special focus on MALDI-MS/MS
    Gero P Hooff
    Department of Neurology, Laboratory of Neuro Oncology and Clinical and Cancer Proteomics, University Medical Center Rotterdam, ErasmusMC, Rotterdam, The Netherlands
    PLoS ONE 6:e22191. 2011
    ..Finally, PPD concentrations were determined in clinical urine samples of cases of acute intoxication and the applied technique was expanded to identify MAPPD and DAPPD in the identical samples...
  13. doi Latent acyclovir-resistant herpes simplex virus type 1 in trigeminal ganglia of immunocompetent individuals
    Monique van Velzen
    Department of Virology, Laboratory of Neuro Oncology and Clinical and Cancer Proteomics, Erasmus Medical Center, The Netherlands
    J Infect Dis 205:1539-43. 2012
    ..Contrary to minor variants, major TK variants were shared between paired TG. The data demonstrate the coexistence of phylogenetic-related ACV(S) and ACV(R) latent HSV-1 in human TG...