Andrew Maas

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc Traumatic brain injury: simple data collection will improve the outcome
    Andrew I R Maas
    Wien Klin Wochenschr 119:20-2. 2007
  2. ncbi request reprint Clinical trials in traumatic brain injury: current problems and future solutions
    A I R Maas
    Department of Neurosurgery, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Acta Neurochir Suppl 89:113-8. 2004
  3. ncbi request reprint Prognostic value of computerized tomography scan characteristics in traumatic brain injury: results from the IMPACT study
    Andrew I R Maas
    Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurotrauma 24:303-14. 2007
  4. ncbi request reprint Prediction of outcome in traumatic brain injury with computed tomographic characteristics: a comparison between the computed tomographic classification and combinations of computed tomographic predictors
    Andrew I R Maas
    Department of Neurological Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurosurgery 57:1173-82; discussion 1173-82. 2005
  5. ncbi request reprint Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial
    Andrew I R Maas
    Department of Neurosurgery, Erasmus MC Rotterdam, Rotterdam, Netherlands
    Lancet Neurol 5:38-45. 2006
  6. ncbi request reprint Prognosis and clinical trial design in traumatic brain injury: the IMPACT study
    Andrew I R Maas
    Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurotrauma 24:232-8. 2007
  7. ncbi request reprint Statistical approaches to the univariate prognostic analysis of the IMPACT database on traumatic brain injury
    Gillian S McHugh
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 24:251-8. 2007
  8. ncbi request reprint Prognostic value of demographic characteristics in traumatic brain injury: results from the IMPACT study
    Nino A Mushkudiani
    Center for Medical Decision Making, Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurotrauma 24:259-69. 2007
  9. ncbi request reprint Prognostic value of the Glasgow Coma Scale and pupil reactivity in traumatic brain injury assessed pre-hospital and on enrollment: an IMPACT analysis
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23219, USA
    J Neurotrauma 24:270-80. 2007
  10. ncbi request reprint IMPACT database of traumatic brain injury: design and description
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical School, Richmond, Virginia 23219, USA
    J Neurotrauma 24:239-50. 2007

Collaborators

Detail Information

Publications45

  1. pmc Traumatic brain injury: simple data collection will improve the outcome
    Andrew I R Maas
    Wien Klin Wochenschr 119:20-2. 2007
  2. ncbi request reprint Clinical trials in traumatic brain injury: current problems and future solutions
    A I R Maas
    Department of Neurosurgery, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Acta Neurochir Suppl 89:113-8. 2004
    ..The complexity of problems occurring in clinical trial design and analysis in TBI is such that a strong and sustained multidisciplinary input and effort is required from all experts involved in the field of neurotrauma...
  3. ncbi request reprint Prognostic value of computerized tomography scan characteristics in traumatic brain injury: results from the IMPACT study
    Andrew I R Maas
    Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurotrauma 24:303-14. 2007
    ..We conclude that both the CT classification and individual CT characteristics are important predictors of outcome in TBI. For clinical trials, a central review process is advocated to minimize observer variability in CT assessment...
  4. ncbi request reprint Prediction of outcome in traumatic brain injury with computed tomographic characteristics: a comparison between the computed tomographic classification and combinations of computed tomographic predictors
    Andrew I R Maas
    Department of Neurological Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurosurgery 57:1173-82; discussion 1173-82. 2005
    ..This classification is increasingly used as a predictor of outcome. We aimed to examine the predictive value of the Marshall CT classification in comparison with alternative CT models...
  5. ncbi request reprint Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial
    Andrew I R Maas
    Department of Neurosurgery, Erasmus MC Rotterdam, Rotterdam, Netherlands
    Lancet Neurol 5:38-45. 2006
    ..Traumatic brain injury is a major cause of death and disability. We sought to assess the safety and efficacy of dexanabinol, a synthetic cannabinoid analogue devoid of psychotropic activity, in severe traumatic brain injury...
  6. ncbi request reprint Prognosis and clinical trial design in traumatic brain injury: the IMPACT study
    Andrew I R Maas
    Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurotrauma 24:232-8. 2007
    ....
  7. ncbi request reprint Statistical approaches to the univariate prognostic analysis of the IMPACT database on traumatic brain injury
    Gillian S McHugh
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 24:251-8. 2007
    ..Many of our approaches are based on simple graphical displays of the data, but, where appropriate, we have also used methods that although established in the statistical literature are relatively novel in their application to TBI...
  8. ncbi request reprint Prognostic value of demographic characteristics in traumatic brain injury: results from the IMPACT study
    Nino A Mushkudiani
    Center for Medical Decision Making, Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurotrauma 24:259-69. 2007
    ..We conclude that outcome following TBI is dependent on age, race, to a lesser extent on education, but not on gender...
  9. ncbi request reprint Prognostic value of the Glasgow Coma Scale and pupil reactivity in traumatic brain injury assessed pre-hospital and on enrollment: an IMPACT analysis
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical Center, Richmond, Virginia 23219, USA
    J Neurotrauma 24:270-80. 2007
    ..0001). Pupil reactivity was more robust between these time points. It is recommended that the study hospital enrollment GCS and pupil reactivity be used for prognostic analysis...
  10. ncbi request reprint IMPACT database of traumatic brain injury: design and description
    Anthony Marmarou
    Department of Neurosurgery, Virginia Commonwealth University Medical School, Richmond, Virginia 23219, USA
    J Neurotrauma 24:239-50. 2007
    ....
  11. ncbi request reprint Prognostic value of cause of injury in traumatic brain injury: results from the IMPACT study
    Isabella Butcher
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 24:281-6. 2007
    ..Falls were found to be associated with an older age and with a higher incidence of mass lesions. Following adjustment for age in the analysis, the relationship between cause of injury and outcome was lost...
  12. ncbi request reprint Prognostic value of secondary insults in traumatic brain injury: results from the IMPACT study
    Gillian S McHugh
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 24:287-93. 2007
    ..The occurrence of secondary insults prior to or on admission to hospital in TBI patients is strongly related to poorer outcome and should therefore be a priority for emergency department personnel...
  13. ncbi request reprint Prognostic value of admission blood pressure in traumatic brain injury: results from the IMPACT study
    Isabella Butcher
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 24:294-302. 2007
    ..Our finding of a smooth relationship with improving outcome as SBP increases up to 135 mm Hg, while not supporting a strong causal inference, does suggest that current guidelines need to be reconsidered...
  14. pmc Classification of traumatic brain injury for targeted therapies
    Kathryn E Saatman
    University of Kentucky, Lexington, KY, USA
    J Neurotrauma 25:719-38. 2008
    ..Recommendations were made for enhancing the utility of available or emerging tools in order to facilitate implementation of a pathoanatomic classification approach for clinical trials...
  15. pmc Effects of Glasgow Outcome Scale misclassification on traumatic brain injury clinical trials
    Juan Lu
    Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA, USA
    J Neurotrauma 25:641-51. 2008
    ..An awareness of this procedural error and methods to reduce misclassification should be incorporated in TBI clinical trials...
  16. doi request reprint Progression of traumatic intracerebral hemorrhage: a prospective observational study
    Raj K Narayan
    Department of Neurosurgery, University of Cincinnati, The Neuroscience Institute at University Hospital and The Mayfield Clinic, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Neurotrauma 25:629-39. 2008
    ..The time frame during which hemorrhagic expansion occurs provides an opportunity for early intervention to limit a process with adverse prognostic implications...
  17. doi request reprint A systematic review finds methodological improvements necessary for prognostic models in determining traumatic brain injury outcomes
    Nino A Mushkudiani
    Center for Medical Decision Making, Department of Public Health, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Epidemiol 61:331-43. 2008
    ..To describe the modeling techniques used for early prediction of outcome in traumatic brain injury (TBI) and to identify aspects for potential improvements...
  18. ncbi request reprint Ethical implications of time frames in a randomized controlled trial in acute severe traumatic brain injury
    Erwin J O Kompanje
    Department of Intensive Care, Erasmus MC University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands, and Ospedale Policlinico IRCCS, Milan, Italy
    Prog Brain Res 161:243-50. 2007
    ..To analyze factors determining the time between injury and study drug administration (SDA) in a randomized controlled trial (RCT) of acute severe traumatic brain injury (TBI) and to discuss the ethical implications...
  19. pmc Neurological picture. Armoured brain: case report of a symptomatic calcified chronic subdural haematoma
    Ruben Dammers
    Department of Neurosurgery, Erasmus Medical Centre, s Gravendijkwal 230, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 78:542-3. 2007
  20. ncbi request reprint Multivariable prognostic analysis in traumatic brain injury: results from the IMPACT study
    Gordon D Murray
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 24:329-37. 2007
    ....
  21. ncbi request reprint Prognostic value of admission laboratory parameters in traumatic brain injury: results from the IMPACT study
    Jackelien G M Van Beek
    Center for Clinical Decision Making, Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurotrauma 24:315-28. 2007
    ..60-0.78). Higher glucose values were associated with increasing age, but on adjusted analysis, the strength of the association with outcome remained. Whether treatment of abnormal values may improve outcome needs further rigorous study...
  22. ncbi request reprint Some prognostic models for traumatic brain injury were not valid
    Chantal W P M Hukkelhoven
    Center for Medical Decision Making Sciences, Department of Public Health, Erasmus MC University Medical Center Rotterdam, P O Box 1739, 3000 DR Rotterdam, The Netherlands
    J Clin Epidemiol 59:132-43. 2006
    ..We aimed to determine the validity of six models that used baseline clinical and computed tomographic characteristics to predict mortality or unfavorable outcome at 6 months or later after severe or moderate TBI...
  23. ncbi request reprint Magnesium for neuroprotection after traumatic brain injury
    Andrew I R Maas
    Lancet Neurol 6:20-1. 2007
  24. ncbi request reprint Admission of patients with severe and moderate traumatic brain injury to specialized ICU facilities: a search for triage criteria
    Chantal W P M Hukkelhoven
    Department of Public Health, Center for Clinical Decision Science, Erasmus MC, Rotterdam, The Netherlands
    Intensive Care Med 31:799-806. 2005
    ..To investigate whether triage for direct admission of patients with traumatic brain injury to a trauma center is facilitated by predicting the risk of potentially removable lesions or raised intracranial pressure (ICP)...
  25. ncbi request reprint 'Treat first, ask later?' Emergency research in acute neurology and neurotraumatology in the European Union
    Erwin J O Kompanje
    Intensive Care Med 30:168-9. 2004
  26. ncbi request reprint Patient age and outcome following severe traumatic brain injury: an analysis of 5600 patients
    Chantal W P M Hukkelhoven
    Center for Clinical Decision Sciences, Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurosurg 99:666-73. 2003
    ..The authors studied the shape and strength of the relationship between age and outcome, that is, the 6-month mortality rate and unfavorable outcome based on the Glasgow Outcome Scale...
  27. ncbi request reprint Predicting outcome after traumatic brain injury: development and validation of a prognostic score based on admission characteristics
    Chantal W P M Hukkelhoven
    Center for Clinical Decision Sciences, Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    J Neurotrauma 22:1025-39. 2005
    ..The high discriminative ability indicates the potential of this model for classifying patients according to prognostic risk...
  28. ncbi request reprint Advanced monitoring in the intensive care unit: brain tissue oxygen tension
    Iain K Haitsma
    Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands
    Curr Opin Crit Care 8:115-20. 2002
    ..Pathophysiologic evidence warrants targeting therapy for patients with traumatic brain injury and subarachnoid hemorrhage toward improvement of cerebral oxygenation guided by continuous monitoring of brain tissue oxygen tension...
  29. ncbi request reprint Subgroup analysis and covariate adjustment in randomized clinical trials of traumatic brain injury: a systematic review
    Adrian V Hernandez
    Center for Clinical Decision Sciences, Department of Public Health Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Neurosurgery 57:1244-53; discussion 1244-53. 2005
    ..We critically reviewed the use of two types of secondary analyses, covariate adjustment and subgroup analysis, which are common in TBI trials...
  30. ncbi request reprint Regional differences in patient characteristics, case management, and outcomes in traumatic brain injury: experience from the tirilazad trials
    Chantal W P M Hukkelhoven
    Center for Clinical Decision Sciences, Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurosurg 97:549-57. 2002
    ..The goal of this study was to examine what regional differences in patient characteristics, case management, and outcomes exist between continents and among countries within a patient population included in a randomized clinical trial...
  31. ncbi request reprint Adjustment for strong predictors of outcome in traumatic brain injury trials: 25% reduction in sample size requirements in the IMPACT study
    Adrian V Hernandez
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Neurotrauma 23:1295-303. 2006
    ..A major reduction in sample size can be obtained with covariate adjustment in TBI trials. Covariate adjustment for strong predictors should be incorporated in the analysis of future TBI trials...
  32. ncbi request reprint Design and analysis of phase III trials with ordered outcome scales: the concept of the sliding dichotomy
    Gordon D Murray
    Public Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
    J Neurotrauma 22:511-7. 2005
    ..The approach raises issues of clinical, statistical, and regulatory importance, and we initiate what we believe needs to become a widespread debate amongst the community involved in clinical research in head injury and stroke...
  33. doi request reprint Recombinant factor VIIA in traumatic intracerebral hemorrhage: results of a dose-escalation clinical trial
    Raj K Narayan
    Department of Neurosurgery, University of Cincinnati, Cincinnati, Ohio, USA
    Neurosurgery 62:776-86; discussion 786-8. 2008
    ..This first prospective, randomized, placebo-controlled, dose-escalation study evaluated the safety and preliminary effectiveness of rFVIIa to limit tICH progression...
  34. doi request reprint Changes of cerebral blood flow during the secondary expansion of a cortical contusion assessed by 14C-iodoantipyrine autoradiography in mice using a non-invasive protocol
    Doortje C Engel
    Department of Neurosurgery, University of Munich Medical Center, Munich, Germany
    J Neurotrauma 25:739-53. 2008
    ..3 to 25.1 mm3). The current data therefore suggest that the delayed secondary expansion of a cortical contusion following traumatic brain injury may not be caused by a reduction of CBF alone...
  35. ncbi request reprint Observer variation in the assessment of outcome in traumatic brain injury: experience from a multicenter, international randomized clinical trial
    J T Lindsay Wilson
    Department of Psychology, University of Stirling, Stirling, Scotland, United Kingdom
    Neurosurgery 61:123-8; discussion 128-9. 2007
    ..We aimed to explore observer variation in the assessment of outcome in a recently completed trial of dexanabinol in head injury and to consider steps to reduce such variation...
  36. ncbi request reprint Monitoring cerebral oxygenation in traumatic brain injury
    Iain K Haitsma
    Department of Neurosurgery, Erasmus Medical Center, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Prog Brain Res 161:207-16. 2007
    ..We present technical data including strengths and weaknesses of these systems, information from clinical studies and formulate a vision for the future...
  37. pmc Differences in completion of screening logs between Europe and the United States in an emergency phase III trial resulting from HIPAA requirements
    Andrew I R Maas
    Ann Surg 241:382-3. 2005
  38. ncbi request reprint A review and rationale for the use of cellular transplantation as a therapeutic strategy for traumatic brain injury
    Joost W Schouten
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 21:1501-38. 2004
    ..Further refinements in future research are likely to improve results from transplantation-based treatments for TBI...
  39. ncbi request reprint Hyperventilation in head injury: a review
    Nino Stocchetti
    Neuroscience ICU, Ospedale Maggiore Policlinico, Milan University, IRCCS, Milan
    Chest 127:1812-27. 2005
    ..This review has specific reference to traumatic brain injury, and is based on an extensive evaluation of the literature and on expert opinion...
  40. ncbi request reprint Guidelines for head injury: their use and limitations
    Andrew I R Maas
    Department of Neurosurgery, Academic Hospital Rotterdam, The Netherlands
    Neurol Res 24:19-23. 2002
    ....
  41. ncbi request reprint Combined effects of mechanical and ischemic injury to cortical cells: secondary ischemia increases damage and decreases effects of neuroprotective agents
    Doortje C Engel
    Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands
    Neuropharmacology 49:985-95. 2005
    ....
  42. ncbi request reprint The management of patients with intradural post-traumatic mass lesions: a multicenter survey of current approaches to surgical management in 729 patients coordinated by the European Brain Injury Consortium
    Christian Compagnone
    World Health Organization Neurotrauma Collaborating Centre and Department of Neurosurgery, M Bufalini Hospital, Cesena, Italy
    Neurosurgery 57:1183-92; discussion 1183-92. 2005
    ..The aim of this study was to survey contemporary approaches to the treatment of head injured patients with an intradural lesion, placing a particular focus on the utilization of decompressive craniectomy...
  43. ncbi request reprint Organ donations and unused potential donations in traumatic brain injury, subarachnoid haemorrhage and intracerebral haemorrhage
    Erwin J O Kompanje
    Department of Neurosurgery, Erasmus MC University Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Intensive Care Med 32:217-22. 2006
    ..1 million inhabitants)...
  44. ncbi request reprint Is the Glasgow Coma Scale score protected health information?The effect of new United States regulations (HIPAA) on completion of screening logs in emergency research trials
    Erwin J O Kompanje
    Intensive Care Med 32:313-4. 2006
  45. doi request reprint Moderate and severe traumatic brain injury in adults
    Andrew I R Maas
    Department of Neurosurgery, University Hospital Antwerp, Antwerp, Belgium
    Lancet Neurol 7:728-41. 2008
    ..Suggestions are provided for the way forward, with an emphasis on epidemiological monitoring, trauma organisation, and approaches to management...

Research Grants9

  1. Clinical trial design/analysis in traumatic brain injury
    Andrew Maas; Fiscal Year: 2005
    ..The global aim is to optimize chances for demonstrating benefit of an effective new therapy or therapeutic agent in the field of TBI. ..
  2. Clinical trial design and analysis in traumatic brain injury
    Andrew Maas; Fiscal Year: 2009
    ..IMPACT: International Mission on Prognosis and Analysis of Clinical Trials in TBI. ..
  3. Clinical trial design and analysis in traumatic brain injury
    Andrew Maas; Fiscal Year: 2009
    ..IMPACT: International Mission on Prognosis and Analysis of Clinical Trials in TBI. ..