B Lowenberg

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc A standardized microarray assay for the independent gene expression markers in AML: EVI1 and BAALC
    Jaap Brand
    Skyline Diagnostics BV, Rotterdam Science Tower, Marconistraat 16, 3029 AK, Rotterdam, The Netherlands
    Exp Hematol Oncol 2:7. 2013
  2. doi request reprint Sense and nonsense of high-dose cytarabine for acute myeloid leukemia
    Bob Lowenberg
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 121:26-8. 2013
  3. pmc SNPExpress: integrated visualization of genome-wide genotypes, copy numbers and gene expression levels
    Mathijs A Sanders
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Genomics 9:41. 2008
  4. pmc HeatMapper: powerful combined visualization of gene expression profile correlations, genotypes, phenotypes and sample characteristics
    Roel G W Verhaak
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Bioinformatics 7:337. 2006
  5. pmc The effect of oligonucleotide microarray data pre-processing on the analysis of patient-cohort studies
    Roel G W Verhaak
    Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Bioinformatics 7:105. 2006
  6. doi request reprint Cytarabine dose for acute myeloid leukemia
    Bob Lowenberg
    Erasmus University Medical Center, Department of Hematology L413, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    N Engl J Med 364:1027-36. 2011
  7. ncbi request reprint Effect of priming with granulocyte colony-stimulating factor on the outcome of chemotherapy for acute myeloid leukemia
    Bob Lowenberg
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 349:743-52. 2003
  8. ncbi request reprint [The diagnosis of acute myeloid leukaemia enhanced by using DNA microarrays]
    B Lowenberg
    Erasmus Medisch Centrum, Afd Hematologie, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 149:623-5. 2005
  9. doi request reprint High-dose daunorubicin in older patients with acute myeloid leukemia
    Bob Lowenberg
    Erasmus University Medical Center, Department of Hematology L413, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    N Engl J Med 361:1235-48. 2009
  10. doi request reprint Gemtuzumab ozogamicin as postremission treatment in AML at 60 years of age or more: results of a multicenter phase 3 study
    Bob Lowenberg
    Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 115:2586-91. 2010

Detail Information

Publications42

  1. pmc A standardized microarray assay for the independent gene expression markers in AML: EVI1 and BAALC
    Jaap Brand
    Skyline Diagnostics BV, Rotterdam Science Tower, Marconistraat 16, 3029 AK, Rotterdam, The Netherlands
    Exp Hematol Oncol 2:7. 2013
    ..We have developed a highly standardized molecular assay for the independent gene expression markers EVI1 and BAALC...
  2. doi request reprint Sense and nonsense of high-dose cytarabine for acute myeloid leukemia
    Bob Lowenberg
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 121:26-8. 2013
    ..Recent evidence has challenged the need for these exceptionally high-dose levels of cytarabine. In this review, we present a reappraisal of the usefulness of high-dose cytarabine for acute myeloid leukemia treatment...
  3. pmc SNPExpress: integrated visualization of genome-wide genotypes, copy numbers and gene expression levels
    Mathijs A Sanders
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Genomics 9:41. 2008
    ..In fact, obtaining an integrated view of both large scale SNP genotyping and gene expression is currently complicated since only a limited number of appropriate software tools are available...
  4. pmc HeatMapper: powerful combined visualization of gene expression profile correlations, genotypes, phenotypes and sample characteristics
    Roel G W Verhaak
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Bioinformatics 7:337. 2006
    ..Here, we describe an approach to visually integrate the results of unsupervised and supervised cluster analysis using a correlation plot and additional sample metadata...
  5. pmc The effect of oligonucleotide microarray data pre-processing on the analysis of patient-cohort studies
    Roel G W Verhaak
    Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Bioinformatics 7:105. 2006
    ..By focusing on practical applications of microarray-based research, this study provides insight into the relevance of pre-processing procedures to biology-oriented researchers...
  6. doi request reprint Cytarabine dose for acute myeloid leukemia
    Bob Lowenberg
    Erasmus University Medical Center, Department of Hematology L413, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    N Engl J Med 364:1027-36. 2011
    ..Intermediate dose levels have not been thoroughly evaluated...
  7. ncbi request reprint Effect of priming with granulocyte colony-stimulating factor on the outcome of chemotherapy for acute myeloid leukemia
    Bob Lowenberg
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 349:743-52. 2003
    ..Sensitization of leukemic cells with hematopoietic growth factors may enhance the cytotoxicity of chemotherapy in acute myeloid leukemia (AML)...
  8. ncbi request reprint [The diagnosis of acute myeloid leukaemia enhanced by using DNA microarrays]
    B Lowenberg
    Erasmus Medisch Centrum, Afd Hematologie, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 149:623-5. 2005
    ..One comprehensive DNA chip may in the future replace a variety of cytogenetic, immunological and molecular techniques that are currently used in combination...
  9. doi request reprint High-dose daunorubicin in older patients with acute myeloid leukemia
    Bob Lowenberg
    Erasmus University Medical Center, Department of Hematology L413, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    N Engl J Med 361:1235-48. 2009
    ..Daunorubicin is a cornerstone of the induction regimen, but the optimal dose is unknown. In older patients, it is usual to give daunorubicin at a dose of 45 to 50 mg per square meter of body-surface area...
  10. doi request reprint Gemtuzumab ozogamicin as postremission treatment in AML at 60 years of age or more: results of a multicenter phase 3 study
    Bob Lowenberg
    Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 115:2586-91. 2010
    ..The HOVON-43 study is registered at The Netherlands Trial Registry (number NTR212) and at http://www.controlled-trials.com as ISRCTN77039377...
  11. doi request reprint Phase I/II clinical study of Tosedostat, an inhibitor of aminopeptidases, in patients with acute myeloid leukemia and myelodysplasia
    Bob Lowenberg
    Department of Hematology, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Oncol 28:4333-8. 2010
    ..To identify the maximum-tolerated dose (MTD) and to evaluate the antileukemic activity of tosedostat (formerly CHR-2797), an orally bioavailable aminopeptidase inhibitor...
  12. doi request reprint Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia
    Bob Lowenberg
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 118:6030-6. 2011
    ..Toxicity was manageable and barasertib treatment resulted in an overall hematologic response rate of 25%. This study is registered at www.ClinicalTrials.gov as NCT00497991...
  13. ncbi request reprint Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G-CSF-mediated activation of signaling complexes of the p21ras route
    R M Barge
    Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
    Blood 87:2148-53. 1996
    ....
  14. ncbi request reprint Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain
    D C van der Plas
    Department of Hematology, Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Leukemia 10:1317-25. 1996
    ..The data further indicate that the IL-7R alpha chains are directly involved in the activation of JAKs and STATs and have a major role in proliferative signaling in precursor B cells...
  15. ncbi request reprint Dose-finding study of valspodar (PSC 833) with daunorubicin and cytarabine to reverse multidrug resistance in elderly patients with previously untreated acute myeloid leukemia
    P Sonneveld
    Department of Hematology, Cancer Center, University Hospital Rotterdam Dijkzigt Room L407, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Hematol J 1:411-21. 2000
    ....
  16. ncbi request reprint Mitoxantrone versus daunorubicin in induction-consolidation chemotherapy--the value of low-dose cytarabine for maintenance of remission, and an assessment of prognostic factors in acute myeloid leukemia in the elderly: final report. European Organization
    B Lowenberg
    Daniel den Hoed Cancer Center, University Hospital, Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    J Clin Oncol 16:872-81. 1998
    ....
  17. ncbi request reprint STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kip1)
    J P de Koning
    Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
    Oncogene 19:3290-8. 2000
    ..These findings indicate that STAT3 controls myeloid differentiation, at least partly, via upregulation of p27(Kip1)...
  18. ncbi request reprint Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia
    F Dong
    Department of Hematology, Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    N Engl J Med 333:487-93. 1995
    ..Abnormalities in the signal-transduction pathways for granulocyte colony-stimulating factor (G-CSF) may play a part in the progression to acute myeloid leukemia...
  19. pmc Intense T cell depletion followed by autologous bone marrow transplantation for severe multiple sclerosis
    J P A Samijn
    Department of Neurology, MS Centre ErasErasmus MC, Postbox 2040, 3000 CA Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 77:46-50. 2006
    ..Certain stem cell transplantation procedures might slow down inflammatory pathology in multiple sclerosis (MS)...
  20. ncbi request reprint The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro
    M von Lindern
    Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
    Blood 94:550-9. 1999
    ..Sustained proliferation of erythroid progenitors could be induced equally well from purified erythroid burst-forming units (BFU-E), from CD34(+) blast cells, and from bone marrow depleted from CD34(+) cells...
  21. ncbi request reprint Somatostatin modulates G-CSF-induced but not interleukin-3-induced proliferative responses in myeloid 32D cells via activation of somatostatin receptor subtype 2
    S P Oomen
    Institute of Hematology, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Hematol J 2:322-9. 2001
    ..While 0.1-1 x 10(-9) M of somatostatin, or its synthetic stable analog octreotide, can inhibit G-CSF-induced proliferation of AML cells, little or no effects are seen on GM-CSF- or IL-3-induced responses...
  22. pmc An in vitro model for cytogenetic conversion in CML. Interferon-alpha preferentially inhibits the outgrowth of malignant stem cells preserved in long-term culture
    J J Cornelissen
    Department of Hematology, Daniel den Hoed Cancer Center, Rotterdam, 3075 EA, The Netherlands
    J Clin Invest 102:976-83. 1998
    ..These findings provide the first in vitro model for cytogenetic conversion and suggest that direct antiproliferative effects of IFN-alpha account for the cytogenetic response observed clinically...
  23. ncbi request reprint Complete remission of t(11;17) positive acute promyelocytic leukemia induced by all-trans retinoic acid and granulocyte colony-stimulating factor
    J H Jansen
    Institute of Hematology, The Department of Clinical Genetics, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Blood 94:39-45. 1999
    ..These observations may encourage the investigation of combinations of all-trans retinoic acid and hematopoietic growth factors in other types of leukemia...
  24. ncbi request reprint Specific involvement of tyrosine 764 of human granulocyte colony-stimulating factor receptor in signal transduction mediated by p145/Shc/GRB2 or p90/GRB2 complexes
    J P de Koning
    Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
    Blood 87:132-40. 1996
    ..In addition, tyrosine 764 also specifically mediated binding of GRB2 to p90 without the involvement of Shc. These findings indicate that tyrosine 764 of G-CSF-R has a prominent role in G-CSF signal transduction...
  25. ncbi request reprint Tetramer-based quantification of cytomegalovirus (CMV)-specific CD8+ T lymphocytes in T-cell-depleted stem cell grafts and after transplantation may identify patients at risk for progressive CMV infection
    J W Gratama
    Department of Clinical and Tumor Immunology, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Blood 98:1358-64. 2001
    ..002). Thus, enumeration of HLA-restricted, CMV-specific CD8+ T cells in the grafts and monitoring of these T cells after SCT may constitute a rapid and sensitive tool to identify SCT recipients at risk for developing CMV disease...
  26. doi request reprint Flow cytometric differential of leukocyte populations in normal bone marrow: influence of peripheral blood contamination
    R A Brooimans
    Department of Medical Oncology, Erasmus MC Daniel den Hoed, Rotterdam, The Netherlands
    Cytometry B Clin Cytom 76:18-26. 2009
    ....
  27. ncbi request reprint Unrelated marrow transplantation for adult patients with poor-risk acute lymphoblastic leukemia: strong graft-versus-leukemia effect and risk factors determining outcome
    J J Cornelissen
    University Hospital Rotterdam Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Blood 97:1572-7. 2001
    ....
  28. doi request reprint Predictive impact of allele-matching and EBMT risk score for outcome after T-cell depleted unrelated donor transplantation in poor-risk acute leukemia and myelodysplasia
    T Lodewyck
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Leukemia 25:1548-54. 2011
    ..These data underscore the importance of incorporating both the EBMT risk score and the degree of high-resolution HLA-matching in the risk assessment prior to URD alloSCT...
  29. ncbi request reprint Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells
    T B van Dijk
    Institute of Hematology, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Blood 96:3406-13. 2000
    ..These findings suggest that p62Dok-1 may function as an important scaffold molecule in cKit-mediated signaling...
  30. ncbi request reprint Intensive postremission chemotherapy without maintenance therapy in adults with acute lymphoblastic leukemia. Dutch Hemato-Oncology Research Group
    A W Dekker
    Department of Hematology, University Hospital Utrecht, The Netherlands
    J Clin Oncol 15:476-82. 1997
    ..To investigate the value of intensive consolidation chemotherapy not followed by maintenance therapy in adult acute lymphoblastic leukemia (ALL)...
  31. doi request reprint The prognostic relevance of miR-212 expression with survival in cytogenetically and molecularly heterogeneous AML
    S M Sun
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Leukemia 27:100-6. 2013
    ..MiR-212 may improve the current prognostic risk stratification of mixed AML including normal karyotype AML and AML with cytogenetic and molecular abnormalities...
  32. ncbi request reprint T-lymphocyte reconstitution following rigorously T-cell-depleted versus unmodified autologous stem cell transplants
    P A W te Boekhorst
    Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    Bone Marrow Transplant 37:763-72. 2006
    ..This susceptibility to apoptosis would interfere with a swift and sustained CD4(+) T-cell regeneration post SCT...
  33. ncbi request reprint Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia
    M H Hermans
    Institute of Hematology, Daniel den Hoed Cancer Center and Erasmus University Rotterdam, Rotterdam, The Netherlands
    Blood 92:32-9. 1998
    ..These findings indicate that depending on G-CSF levels in mice, the triangle Delta715 mutation can contribute both to neutropenia and to neutrophilia...
  34. ncbi request reprint Treatment costs and quality of life with granulocyte-macrophage colony-stimulating factor in patients with antineoplastic therapy-related febrile neutropenia. Results of a randomised placebo-controlled trial
    C A Uyl-de Groot
    Institute for Medical Technology Assessment, Erasmus University, Rotterdam, The Netherlands
    Pharmacoeconomics 12:351-60. 1997
    ..Sensitivity analyses indicate that GM-CSF would produce savings if the duration of hospitalisation with GM-CSF was < or = 76.5% of that in the placebo group...
  35. ncbi request reprint High-vs low-dose cytarabine combined with interferon alfa in patients with first chronic phase chronic myeloid leukemia. A prospective randomized phase III study
    W Deenik
    Department of Hematology, Erasmus University Medical Center Daniel Den Hoed, Groene Hillendijk, Rotterdam, The Netherlands
    Ann Hematol 86:117-25. 2007
    ..Although intensified cytarabine induced a higher initial percentage of major and complete cytogenetic responses, responses were not sustained by IFN-alpha maintenance therapy...
  36. ncbi request reprint Splenectomy for the treatment of thrombotic thrombocytopenic purpura
    M C Kappers-Klunne
    Department of Haematology, Erasmus Medical Centre, Centre Location, Rotterdam, The Netherlands
    Br J Haematol 130:768-76. 2005
    ....
  37. ncbi request reprint Prognostic factors in acute myeloid leukaemia
    B Lowenberg
    Erasmus University and University Hospital Rotterdam, Rotterdam, 3000 CA, The Netherlands
    Best Pract Res Clin Haematol 14:65-75. 2001
    ..This furnishes clinically relevant insights into the probability of treatment response and survival in individual cases of AML and it provides a lead in treatment management...
  38. ncbi request reprint Managing therapy in older adult patients with acute myeloid leukemia
    B Lowenberg
    Department of Hematology, Erasmus University, Rotterdam, The Netherlands
    Semin Hematol 38:10-6. 2001
    ..Novel approaches including antibody-targeted and molecular-targeted chemotherapy may have the potential to improve the prognosis for older adults with AML...
  39. pmc Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2
    P J Valk
    Institute of Hematology, Erasmus University Rotterdam, 3000 DR, Rotterdam, The Netherlands
    J Virol 73:3595-602. 1999
    ..Additional studies are required to determine whether Tra1/Grp94 or another candidate proto-oncogene in Evi12 is involved in leukemogenesis...
  40. ncbi request reprint Dexamethasone does not counteract the response of acute promyelocytic leukaemia cells to all-trans retinoic acid
    M C de Ridder
    Institute of Haematology, Erasmus University of Rotterdam, Rotterdam, The Netherlands
    Br J Haematol 106:107-10. 1999
    ..Finally, dexamethasone did not inhibit the anti-proliferative effect of retinoic acid but rather showed anti-proliferative activity itself...
  41. pmc Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia
    F Dong
    Dr Daniel den Hoed Cancer Center, Department of Hematology, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 91:4480-4. 1994
    ..The mutant receptor chain may act in a dominant negative manner to block granulocytic maturation...
  42. ncbi request reprint Cytogenetic clonality analysis of megakaryocytes in myelodysplastic syndrome by dual-color fluorescence in situ hybridization and confocal laser scanning microscopy
    K van Lom
    Department of Hematology, University Hospital Rotterdam, Dijkzigt, The Netherlands
    Genes Chromosomes Cancer 25:332-8. 1999
    ..These results add direct evidence that in MDS megakaryocytes are involved in the malignant clone. Genes Chromosomes Cancer 25:332-338, 1999...